Md. Masud Parvez

Md. Masud Parvez
AbbVie | ABBVIE

PhD.
San Francisco, CA, USA.

About

38
Publications
4,689
Reads
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245
Citations

Publications

Publications (38)
Article
para-Aminosalicylic acid (PAS) is a second-line anti-tuberculosis drug used to treat multidrug-resistant and extensively drug-resistant tuberculosis for more than 60 years. Renal secretion and glomerular filtration are the major pathways for elimination of PAS. We comprehensively studied PAS transport by using cell lines that overexpressed various...
Article
Currently marketed 22 anti-tuberculosis drugs were comprehensively evaluated for the inhibitory effect on organic anionic (OAT) and cation transporter (OCT)-mediated uptake using stably transfected HEK293 cells in vitro We observed moderate to strong inhibitory effects on OAT1-, OAT3-mediated para-aminohippurate (PAH) and OCT1- and OCT2-mediated N-...
Article
We investigated the inhibitory interaction potential of 22 currently marketed antituberculosis (TB) drugs on organic anion-transporting polypeptide 1B1 (OATP1B1)-, OATP2B1-, and OATP1B3-mediated uptake using in vitro Xenopus oocytes and HEK cells. Rifabutin, ethambutol, amoxicillin, linezolid, p-amino salicylic acid, and rifapentine exhibited mild...
Article
Aim: Tenofovir and para-aminosalicylic acid (PAS) may be co-prescribed to treat patients with concomitant infections of human immunodeficiency virus and Mycobacterium tuberculosis bacteria. Both drugs are known to have remarkable renal uptake transporter-mediated clearance. Owing to the lack of clinical studies on drug-drug interaction between the...
Chapter
Almost 50% of prescription drugs lack age-appropriate dosing guidelines and therefore are used “off-label.” Only ~10% drugs prescribed to neonates and infants have been studied for safety or efficacy. Immaturity of drug metabolism in children is often associated with drug toxicity. This chapter summarizes data on the ontogeny of major human metabol...
Article
Full-text available
Anticancer drug, irinotecan shows serious dose-limiting gastrointestinal toxicity regardless of intravenous dosing. Although enzymes and transporters involved in irinotecan disposition are known, quantitative contributions of these mechanisms in complex in vivo disposition of irinotecan are poorly understood. We explained intestinal disposition and...
Article
Sorafenib was suggested to cause drug-drug interaction (DDI) with the common anticoagulant, warfarin based on published studies. The inhibition on CYP2C9 enzyme was thought to be the mechanism, but further studies are warranted. Thus, a mechanistic PBPK/PD model for warfarin enantiomers was developed to predict DDI potential with sorafenib, aiming...
Article
Rifampin (RIF) has been widely used for the treatment of bacterial infections, including tuberculosis (TB). Treatment of drug-resistant TB is a global problem because of reduced drug efficacy. The present study determined the effect of RIF on MDR1 gene (P-glycoprotein, P-gp) expression in THP1 macrophages and analyzed the intracellular concentratio...
Article
The widely used second‐line antituberculosis drug ethionamide shows wide interindividual variability in its disposition; however, the relevant factors affecting this phenomenon have not been characterized. We previously reported the major contribution of flavin‐containing monooxygenase 3 (FMO3) in the reductive elimination pathway of ethionamide. I...
Article
Volume 62, no. 9, e00512-18, 2018, https://doi.org/10.1128/AAC.00512-18. Table 2: in the last 2 rows of this table, the [I]/IC50 values were incorrectly listed. For ibuprofen with isoniazid as the substrate, the [I]/IC50 should read 43.6 instead of 16.7, and for probenicid with amoxicillin as the substrate, the [I]/IC50 should read 16.9 instead of...
Article
Substrate potential of antituberculosis drugs on SLC transporters are not well characterized to date, despite a well-established understanding of their drug dispositions and pharmacokinetics. In this study, we investigated comprehensively the substrate potentials of the 22 currently available antituberculosis drugs for solute carrier (SLC) family t...
Article
Currently, ethionamide is the most frequently prescribed second‐line antituberculosis drug in children. After extensive metabolism by flavin‐containing monooxygenase (FMO) isoform 3 in the liver, the drug may exert cytotoxic effects. The comparison of children in different age groups revealed a significant age‐related increase in ethionamide elimin...
Article
Full-text available
Drug-drug interactions is one of the major determinant in drug development and clinical applications. Individual differences in pharmacokinetics may cause extensive variability in drug efficacy, toxicity and adverse drug reactions, and represent a major concern in drug development. According to world health organization, an estimated 1.2 million pa...
Article
Clinical implementation of pharmacogenomics (PGx) leads to personalized medicine, which improves the efficacy, safety, and cost-effectiveness of treatments. Although PGx-based research has been conducted for more than a decade, several barriers have slowed down its widespread implementation in clinical practice. Globally, there is an imbalance in p...
Conference Paper
BACKGROUND: Multidrug-resistant tuberculosis is growing and may be threat among patients infected with human immunodeficiency virus (HIV). Para-amino salicylic acid (PAS), a 2nd line anti-tuberculosis drug, has been recently reported as a strong inhibitor of OAT transporters. Adefovir/tenofovir, used for the treatment of hepatitis B virus and HIV,...
Article
Full-text available
Antiepileptic drugs have been known to induce potentially life-threatening cutaneous adverse drug reactions such as Stevens-Johnson syndrome (SJS). Despite of studies for examining the mechanism associated with HLA, the association between lamotrigine (LTG)-induced cutaneous adverse drug reactions and HLA alleles is still unclear. We investigated H...
Article
Telmisartan, an angiotensin II receptor blocker, is widely used for the treatment of hypertension and cardiovascular risk reduction. It is mainly metabolized by UDP-glucuronyltransferases (UGTs) and UGT1A3 is predominantly involved in the glucuronidation of telmisartan. Clinical studies showed the large inter-individual variation in the exposure of...
Article
Full-text available
Drug exposures are not often high enough to estimate maximum effect (Emax) to avoid drug toxicity, bring about difficulties in estimating unbiased and precise PD parameter estimates or inevitably simplified models such as linear model and log-linear model. The purpose of this simulation study is to investigate the accuracy and precision of PD param...
Article
Full-text available
Platelet aggregation and coagulation play a key role in cardiovascular disease. However, there was limited data about the effects of environmental and clinical factors on the basal platelet aggregation and coagulation factors. The adenosine diphosphate (ADP)-, arachidonic acid (AA)-, thrombin receptor activating peptide (TRAP)-, collagen (COL)- and...
Data
Full-text available
Anisoptera scaphula (Roxb.) belonging to the family Dipterocarpaceae, has been studied for isolation of its secondary metabolites and evaluation of biological activities of the extractives, with special emphasis on TLC chromatographic data. The stem bark of A. scaphula was extracted with organic solvents and the extracts were fractionated with stan...
Data
Full-text available
In the present study the in vitro antimicrobial activity, along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), of different extracts of Seeds of Mesua nagassarium were evaluated against 13 pathogenic microorganisms. The methanol extract and its pet-ether and carbon tetrachloride soluble fractions showed th...
Data
Full-text available
In this study, the methanol extracts and their different organic soluble fractions i.e. pet-ether, carbon tetrachloride, chloroform and aqueous soluble fractions of Mesua nagassarium and Kigelia Pinnata were subjected to study for membrane stabilizing activity. The extractives inhibited heat-as well as hypotonic solution-induced haemolysis of eryth...
Data
Full-text available
In the present study the in vitro antimicrobial activity, along with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), of different extracts of leaves of Mesua nagassarium were evaluated against 13 pathogenic microorganisms. The methanol extract and its pet-ether and carbon tetrachloride soluble fractions showed t...
Data
Full-text available
Different extractives of leaves of Kigelia pinnata and Mesua nagassarium were screened for total phenolic constituents and free radical scavenging activity by using butylated hydroxytoluene (BHT) and ascorbic acid (ASA) as standard antioxidants. The total phenolic content was determined and expressed in gallic acid equivalent/ gm of extractives. Am...

Questions

Question (1)
Question
As example: Drug A (Km=2uM), drug B (Km=45 uM). If we do inhibition or DDI study with known inhibitor and found IC50 for drug A is higher than drug B. what will be the explanation of the result (IC50 or Ki) for two drugs (A and B)?

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Projects

Project (1)
Project
Role of drug transporters and enzymes key role in the drug interactions. In vitro to in vivo translational research.