Md Jamal Uddin

Md Jamal Uddin
ABEx Bio-Research Center · Pharmaceutical and Biomedical Sciences

"Research collaborating internationally"

About

107
Publications
85,361
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,142
Citations
Introduction
Currently, I am working as CEO at ABEx Bio-Research Center, Bangladesh. My expertise focuses on the area of Pharmaceutical and Biomedical Sciences. Also, I am working as a Co-Editor-in-Chief at the Journal of Advanced Biotechnology and Experimental Therapeutics (JABET, Scopus indexed), and editor/reviewer in various journals. Notably, I worked as Research Professor in Pharmaceutical Sciences at Ewha Womans University, South Korea. For collaboration, please email to hasan800920@gmail.com
Additional affiliations
August 2017 - December 2021
Ewha Womans University
Position
  • Research Professor
Description
  • Researching and teaching on the disease mechanisms and therapeutics
March 2013 - May 2015
University of Ulsan
Position
  • PostDoc Position
September 2009 - November 2012
University of Ulsan
Position
  • PhD Research Fellow
Description
  • Worked on Biomedical Gases, Immune science and molecular biotechnology etc
Education
September 2009 - February 2013
University of Ulsan
Field of study
  • Biological Sciences

Publications

Publications (107)
Article
Full-text available
Citation: Ahmed, M.S.; Uddin, M.J.; Hossen, M.J.; Rahman, M.A.; Mohibbullah, M.; Hannan, M.A.; Choi, J.-S. Dendritic Cells (DCs)-Based Cancer Immunotherapy: A Review on the Prospects of Medicinal Plants and Their Phytochemicals as Potential Pharmacological Modulators. Appl. Sci. 2022, 12, 9452. https://doi.
Article
Full-text available
In Ayurvedic system of medicine, a variety of medicinal herbs are being prescribed for brain disorders, including mental dysfunction, indifference, and memory impairment. Neuropharmacological mechanisms of these herbs are poorly understood. A total of nineteen indigenous medicinal herbs of Bangladesh were investigated for their neuropharmacological...
Article
Full-text available
Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), have become critical clinical, socioeconomic, and public health concerns worldwide. The kidney requires a lot of energy, and mitochondria act as the central organelle for the proper functioning of the kidney. Mitochondrial dysfunction has been associated with the...
Article
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism of lipid and reactive oxygen species. The present study examined the role of peroxisomes in high-fat diet (HFD)-induced NAFLD usin...
Article
Background Plant triterpenoids are major sources of nutraceuticals that provide many health benefits to humans. Lupeol is one of the pentacyclic dietary triterpenoids commonly found in many fruits and vegetables, which is highly investigated for its pharmacological effect and benefit to human health. Purpose This systematic review critically discu...
Article
Full-text available
Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceu-tical and pharmaceutical uses of fucoxanthin for boosting huma...
Article
Full-text available
Background Chronic kidney disease (CKD) is a worldwide public health concern. Nutritional interventions become a primary concern in managing various diseases, including CKD. Ketogenic diets (KD) are a popular diet and an increasingly used diet for weight loss. Main body With the increasing cases of CKD, KD has been proposed as a treatment by many...
Article
Chronic kidney disease (CKD) is a major public health concern that costs millions of lives worldwide. Natural products are consistently being explored for the development of novel therapeutics in the management of CKD. Fucoidan is a sulfated polysaccharide predominantly extracted from brown seaweed, which has multiple pharmacological benefits again...
Article
Full-text available
Ducks are the natural reservoir of influenza A virus and the central host for the avian influenza virus (AIV) subtype H5N1, which is highly pathogenic. Semi-scavenging domestic ducks allow for the reemergence of new influenza subtypes which could be transmitted to humans. We collected 844 cloacal swabs from semi-scavenging ducks inhabiting seven mi...
Article
Full-text available
Both acute and chronic kidney diseases substantially contribute to the morbidities and mortality of patients worldwide. The existing therapeutics, which are mostly developed from synthetic sources, present some unexpected effects in patients, provoking researchers to explore potential novel alternatives. Natural products that have protective effect...
Article
Full-text available
The SARS-CoV-2 infection leads to liver injury and promotes other viral infections such as hepatitis B virus (HBV) in COVID-19 patients. Obesity is involved with an increased risk of mortality in hepatocellular carcinoma (HCC) patients. In the current study, we analyzed the SARS-CoV-2 entry receptor ACE2 expression patterns in various HCC patients...
Article
Full-text available
The key tumor suppressor protein p53, additionally known as p53, represents an attractive target for the development and management of anti-cancer therapies. p53 has been implicated as a tumor suppressor protein that has multiple aspects of biological function comprising energy metabolism, cell cycle arrest, apoptosis, growth and differentiation, s...
Preprint
Full-text available
As the pathobiology of coronavirus disease-19 (COVID-19) has been complicated by pre-existing conditions such as diabetes, cardiovascular diseases (CVD), chronic kidney disease (CKD) and respiratory illness to which inflammation, oxidative stress, and immune dysfunction are critically implicated, natural products with multitargeted pharmacological...
Article
Full-text available
Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various pathophysiological conditions in various disease mo...
Chapter
Autoimmunity is a phenomenon in which the body’s immune system fights off its own tissues and causes harmful complications for the body. Abnormalities in T-cell activities and expression of autoantibodies are the main causes of this phenomenon. Besides, metabolic disorders are also a matter of concern. In particular, in this chapter, the relationsh...
Article
Full-text available
Kidney diseases are regarded as one of the major public health issues in the world. The objectives of this study were: (i) to investigate the causative factors involved in kidney disease and the therapeutic aspects of Moringa oleifera, as well as (ii) the effectiveness of M. oleifera in the anti-inflammation and antioxidant processes of the kidney...
Article
Full-text available
CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular comprising four distinct modules. CCN Proteins achieve their pri...
Article
Full-text available
COVID-19 is one of the most severe global health crises that humanity has ever faced. Researchers have restlessly focused on developing solutions for monitoring and tracing the viral culprit, SARS-CoV-2, as vital steps to break the chain of infection. Even though biomedical engineering (BME) is considered a rising field of medical sciences, it has...
Article
Full-text available
Neuropilin-1 (NRP1) is a recently identified glycoprotein that is an important host factor for SARS-CoV-2 infection. On the other hand, angiotensin-converting enzyme-2 (ACE2) acts as a receptor for SARS-CoV-2. Additionally, both NRP1 and ACE2 express in the kidney and are associated with various renal diseases, including renal carcinoma. Therefore,...
Article
Full-text available
The prevalence of chronic kidney disease (CKD) is increasing worldwide, and a close association between acute kidney injury (AKI) and CKD has recently been identified. Black cumin (Nigella sativa) has been shown to be effective in treating various kidney diseases. Accumulating evidence shows that black cumin and its vital compound, thymoquinone (TQ...
Article
Full-text available
Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (Aβ) aggregates in multiple brain regions, including the hippocampus and cortex. The exact etiology of AD has not yet been confirmed. However, epidemiological reports sugges...
Article
Full-text available
Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects have attracted growing interest from the scientific c...
Preprint
Full-text available
Alzheimer’s disease (AD) is one of the most prevailing neurodegenerative diseases, characterized by memory dysfunction and the presence of hyperphosphorylated tau and amyloid β (Aβ) aggregate in multiple brain regions, including the hippocampus and cortex. The exact etiology of AD has not yet been confirmed. However, epidemiological reports suggest...
Article
Full-text available
Coronavirus disease-19 (COVID-19) pandemic is a global threat caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The viral infection dysregulates the functions of the renin-angiotensin system (RAS) through an interaction between SARS-CoV-2 spike protein and angiotensin-converting enzyme 2 (ACE2), leading to an upregulated level...
Article
Full-text available
Acute kidney injury (AKI) most commonly appears in critically ill patients in hospitals. AKI is characterized as a quick deterioration of kidney function and has recently been identified to be tightly interlinked with chronic kidney diseases. The emerging major mediators of AKI include oxidative stress and endoplasmic reticulum (ER) stress. Carbon...
Article
Full-text available
Recently, Lumpy Skin Disease (LSD) has been portrayed as a terrifying threat to cattle in Southeast Asia. A lump like nodules in the external skin and mucous membrane with fever and swollen lymph nodes are the preliminary noticeable clinical signs of this devastating disease. It is commonly an arthropod-borne contagious illness, correspondingly the...
Article
Full-text available
Glial cells comprise the non-sensory parts of the central nervous system as well as the peripheral nervous system. Glial cells, also known as neuroglia, constitute a significant portion of the mammalian nervous system and can be viewed simply as a matrix of neural cells. Despite being the “Nervenkitt” or “glue of the nerves”, they aptly serve multi...
Article
Full-text available
Insulin is a polypeptide hormone mainly secreted by β cells in the islets of Langerhans of the pancreas. The hormone potentially coordinates with glucagon to modulate blood glucose levels; insulin acts via an anabolic pathway, while glucagon performs catabolic functions. Insulin regulates glucose levels in the bloodstream and induces glucose storag...
Article
Full-text available
Mounting evidence support the potential benefits of functional foods or nutraceuticals for human health and diseases. Black cumin (Nigella sativa L.), a highly valued nutraceutical herb with a wide array of health benefits, has attracted growing interest from health-conscious individuals, the scientific community, and pharmaceutical industries. The...
Article
Full-text available
Lactoferrin (LF) is an iron-binding multifunctional glycoprotein, act as a natural protective agent. In general, LF is involved in various physiological activities, including antibacterial, antifungal, antiviral, antiparasitic, anticarcinogenic and iron metabolism. The LF is most frequently found in milk as well as many other exocrine secretions su...
Article
Bioactive plant derived compounds are important for a wide range of therapeutic applications, and some display promising anticancer properties. Further evidence suggests that phytochemicals modulate autophagy and apoptosis, the two crucial cellular pathways involved in the underlying pathobiology of cancer development and regulation. Pharmacologica...
Article
Full-text available
Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer's agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesi...
Article
Full-text available
The global burden of chronic kidney disease (CKD) intertwined with cardiovascular disease has become a major health problem. Oxidative stress (OS) plays an important role in the pathophysiology of CKD. The nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant responsive element (ARE) antioxidant system plays a critical role in kidney prote...
Preprint
Full-text available
CCNs are specific type of matricellular proteins, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members in mammals. The architecture of CCN proteins is multimodular and comprises four distinct motifs. CCN proteins achieve their specific physiological fu...
Article
The aim of this cross‐sectional study was to assess the knowledge, attitudes, prevention practices (KAP) among the garment factory workers population in Bangladesh that suffered a historical dengue outbreak in 2019. A total of 400 participants were selected by simple random sampling and questionnaire‐based interviews were conducted. The average sco...
Article
Citation: Rahman, M.A.; Rahman, M.S.; Rahman, M.H.; Rasheduzzaman, M.; Mamun-Or-Rashid, A.; Uddin, M.J.; Rahman, M.R.; Hwang, H.; Pang, M.-G.; Rhim, H. Modulatory Effects of Autophagy on APP Processing as a Potential Treatment Target for Alzheimer's Disease. Biomedicines 2021, 9, 5. https://dx.
Article
Citation: Rahman, M.A.; Rahman, M.H.; Biswas, P.; Hossain, M.S.; Islam, R.; Hannan, M.A.; Uddin, M.J.; Rhim, H. Potential Therapeutic Role of Phytochemicals to Mitigate Mitochondrial Dysfunctions in Alzheimer's Disease. Antioxidants 2021, 10, 23. https://dx.
Article
Full-text available
Honey and its compounds are drawing attention as an effective natural therapy because of its ability to attenuate acute inflammation through enhancing immune response. Several studies have proved its potential healing capability against numerous chronic diseases/conditions, including pulmonary disorders, cardiac disorders, diabetes , hypertension,...
Article
Microplastics (MPs; <5 mm) are found in all aquatic environments. Due to harmful impacts, MPs pose a great threat to the aquatic ecology. Therefore, this review aims to provide an overview of the risk, bioavailability, and toxicity of MPs in aquatic organisms. Various factors affecting MPs bioavailability and level of risks at cellular and molecula...
Article
Full-text available
Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements. Latest observations have hypothesized that exposure of environmental factors may increase the prospective risk of Alzheimer’s diseases (AD). However, the role of environ...
Article
Full-text available
Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to anti-microbial functions. Evidence suggests that vitamin C acts against inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance the immune system makes this versatile vitamin...
Article
Full-text available
Autophagy is a vacuolar, lysosomal degradation pathway for injured and damaged protein molecules and organelles in eukaryotic cells, which is controlled by nutrients and stress responses. Dysregulation of cellular autophagy may lead to various diseases such as neurodegenerative disease, obesity, cardiovascular disease, diabetes, and malignancies. R...
Article
Full-text available
Acute kidney injury (AKI), a critical syndrome characterized by a rapid decrease of kidney function, is a global health problem. Src family kinases (SFK) are proto-oncogenes that regulate diverse biological functions including mitochondrial function. Since mitochondrial dysfunction plays an important role in the development of AKI, and since unbala...
Poster
Honey; a type of sweet liquid made by bee using flower nectar has been in limelight as an effective natural therapy because it has the ability to attenuate acute inflammation through encouraging immune response. Among numerous benefits having honey, its capability to fight against several chronic diseases, bacterial, viral and fungal infection have...
Conference Paper
Full-text available
While the whole world is hoping for an effective drug or vaccine to combat COVID-19, we have tried to draw our attention on the pharmacological potentials of black cumin (Nigella sativa) seed and its bioactive compounds for further scientific concern to adopt an alternative strategic plan. Black cumin seed and its essential components already have...
Article
Full-text available
Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can establish a balanced inflammatory response by suppressing chronic inflammation and promoting healthy immune response. The essential oil and other preparations of N. sativa seed have substantial therapeutic outcomes against immune d...
Preprint
Autophagy refers to the degradation of cytoplasmic constituents by a lysosomal-mediated pathway, which plays a critical role in maintaining cellular homeostasis. Importantly, dysregulation of autophagy has been implicated in multiple neurodegenerative disorders. Previous studies reported that autophagy affects the processing of amyloid precursor pr...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of a global pandemic which is demolishing global health and economy. SARS-CoV-2 infected patients are hospitalized with pneumonia where almost 20-30% of patients are led to kidney failure. The entry of SARS-CoV-2 into the systemic circulation leads to acute kidney injury (AKI) wh...
Preprint
Autophagy is a vacuolar, lysosomal degradation pathway of injured/damaged protein molecules as well as organelles in eukaryotic cells which is controlled by nutrients and stress responses. Dysregulation of autophagy may lead to improvement of various cellular diseases, for instance neurodegenerative disease, obesity, cardiovascular disease, diabete...
Preprint
Full-text available
Vitamin C, also known as L-ascorbic acid, is an essential vitamin with pleiotropic functions, ranging from antioxidant to antiviral function. Numerous evidence suggests that vitamin C fights off inflammation, oxidative stress, autophagy chaos, and immune dysfunction. The ability to activate and enhance immune system makes this vitamin a prospective...
Article
Full-text available
Burn wound associated injury management is one of the major unresolved clinical concerns. Most of the drugs and dressing materials found in the market cause dose escalation and even exert side effects. Besides, a severe burn injury is susceptible to microbial infection that leads to prolonged hospital stay which ultimately causes a financial crisis...
Preprint
Full-text available
Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can establish a balanced inflammatory response by suppressing chronic inflammation and promoting healthy immune response. The essential oil and other preparations of N. sativa seed have substantial therapeutic outcomes against immune d...
Article
Full-text available
Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered to be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance and anti-amyloidogenic potentials of algal meta...
Article
Full-text available
Coronavirus disease‐19 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is one of the most contagious diseases in human history that has already affected millions of lives worldwide. To date, no vaccines or effective therapeutics have been discovered yet that may successfully treat COVID‐19 patients or contain the...
Article
Full-text available
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public health across the world. Although there is no clear gender or socioeconomic discrimination in the incidence of COVID-19, individuals who are older adults and/or with c...
Preprint
Full-text available
Honey and its various ingredients have been in limelight as an effective natural therapy capable of normalizing the situation by attenuating acute inflammation through encouraging immune response. Several studies have proved its potential healing capability against numerous chronic diseases/conditions, including diabetes, hypertension, autophagy dy...
Article
Full-text available
Since there is no specific treatment for COVID-19 yet, the only means to survive this disease is to consolidate the immune system. In addition, as the immune system is closely linked to the neuroendocrine system, any kind of psychological stresses that overwhelm this association causes immune dysfunction. In this context, self-confidence that can m...
Preprint
Full-text available
Beyond their significant contribution to the dietary and industrial supplies, marine 24 algae are considered to be a potential source of some unique metabolites with diverse health 25 benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol 26 homeostasis, protein clearance and anti-amyloidogenic potentials of a...
Preprint
Full-text available
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public health across the world. Although there is no clear gender or socioeconomic discrimination in the incidence of COVID-19, individuals who are older adults and/or with c...
Article
Full-text available
Acute kidney injury (AKI) is a common disease with a complex pathophysiology which significantly contributes to the development of chronic kidney disease and end stage kidney failure. Preventing AKI can consequently reduce mortality, morbidity, and healthcare burden. However, there are no effective drugs in use for either prevention or treatment of...