Md. Shafiqul Islam

Md. Shafiqul Islam
Bangladesh Agricultural University | BAU · Department of Pharmacology

Professor

About

88
Publications
12,872
Reads
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626
Citations
Citations since 2017
54 Research Items
324 Citations
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Introduction
Drugs residues in food chain and ultimate hazards to human health. 2. Antibiotic resistance (AMR) and Public health hazards. 3. Development of national capacity to analyze, monitoring and establishment of legislation on drug residues to save the human. 4. Establishment of alternative antibiotic therapy. 5. Pharmacology of bioactive Natural compound. 6. Interactions of drugs- signal transduction study in the cells. 7. Inflammatory Bowel Disease, GIT complaints, Colon cancer etc.
Additional affiliations
October 2017 - present
Bangladesh Agricultural University
Position
  • Professor
Description
  • Full time researcher and Academician
January 2014 - March 2017
The University of Tokyo
Position
  • Professor (Associate)
Description
  • Full time Researcher and academician
January 2013 - January 2014
The University of Tokyo
Position
  • Professor (Associate)
Description
  • Full time Academician and researchers
Education
September 2010 - October 2012
The University of Tokyo
Field of study
  • Pharmacology and molecular biology
October 2005 - September 2009
The University of Tokyo
Field of study
  • Pharmacology and molecular biology

Publications

Publications (88)
Article
Full-text available
We have recently reported that phytosteryl ferulates isolated from rice bran inhibit nuclear factor-kappaB (NF-kappaB) activity in macrophages. In the present study, we investigated the effect of gamma-oryzanol (gamma-ORZ), a mixture of phytosteryl ferulates, cycloartenyl ferulate (CAF), one of the components of gamma-ORZ, and ferulic acid (FA), a...
Article
Full-text available
Some of the pharmacological properties of phytosteryl ferulates may be linked to their antioxidant potential. In this study, 2,2-diphenyl-1-picrylhydrazyl (DPPH), electron spin resonance (ESR), and thiobarbituric acid-reactive substances (TBARS) assays demonstrated that phytosteryl ferulates such as cycloartenyl ferulate (CAF), 24-methylenecycloart...
Article
Full-text available
Rice bran contains important bioactive phytochemicals. Among these phytochemicals, steryl ferulates including γ-oryzanol and its major components such as cycloartenyl ferulate (CAF), 24-methylenecycloartanyl ferulate (24-mCAF), β-sitosteryl ferulate (β-SF), and campesteryl ferulate have been intensively studied due to their crucial roles in patholo...
Article
Full-text available
Tenascin-C (TnC) is a multi-domain extracellular matrix glycoprotein that is expressed at a high level during embryogenesis but is almost absent during normal postnatal life. This multi-domain complex molecule is reported to associate with both pro-inflammatory and anti-inflammatory signaling cascades. In this study we examined how TnC molecule mod...
Article
Full-text available
Background and purpose: IL-33 is a novel cytokine that is believed to be involved in inflammation and carcinogenesis; however, its source, its production and its secretion process remain unclear. Recently we have reported that interleukin-33(IL-33) is up regulated in dextran sulfate sodium (DSS) colitis in mice. Experimental approach: We examine...
Article
Full-text available
Background and Aim: The bovine industry is threatened by one of the most serious and deadly enteric diseases, calf diarrhea, particularly in developing nations like Bangladesh. In this context, bacterial resistance to antimicrobial drugs and its detrimental consequences have become a critical public health issue that is difficult to address globall...
Article
Full-text available
Objectives: Drug safety and efficacy are the most important characteristics of a drug to be decided for the preventive and therapeutic purposes. A comprehensive research work of Tolfenamic acid has been investigated on poultry, pet, small and large animals before launching the drug in veterinary practices in Bangladesh. In this study, we have inves...
Article
Full-text available
Antibiotics are the most widely injudiciously used drugs for therapeutic purposes throughout the world. This study aimed to detect cephalexin residue after discriminate and indiscriminate administration of cephalexin antibiotic in broiler. Eighteen broiler chicks, DOC (Cobb-500) were collected & reared for up to 31 days. The chicks were randomly di...
Article
Full-text available
The aim of this study was to evaluate the effects of discriminate and indiscriminate use of colistin sulfate on body weight and haematological parameters in broiler. Day-old-broiler chicks were collected and reared for up to 31 days. The chicks were randomly divided into control, discriminate and indiscriminate antibiotic group. The discriminate gr...
Article
Full-text available
Hematological indication is an important finding for pathophysiological analysis of biological science. This study was designed with the aim to investigate the effects of residual antibiotics on hematological parameters of broiler following discriminate and indiscriminate use. The day old broiler chicks were collected and reared up to 31 days. The...
Article
Full-text available
Antibiotic residues remain in edible portion of meat animals that have been treated with antibiotics. The aim of this study was to detect enrofloxacin residue after discriminate and indiscriminate administration and investigate the effect of enrofloxacin in growth of poultry. 18 broilers DOC (Cobb-500) were collected & reared up to 31 days. On day...
Article
Full-text available
Residues of antibiotic drugs in food and food products have been received much attention in recent years because of growing food safety concerns for public health. There are serious effects of antibiotic residues in meat for human consumption (e.g., increasing antimicrobial resistance, carcinogenicity, mutagenicity, and hypersensitivity). In this s...
Article
Full-text available
Hematological indication is an important finding for pathophysiology analysis of biological science. This study was designed with the aim to investigate the effects of residual antibiotics on hematological parameters of broiler following discriminate and indiscriminate use. 18 broiler DOC (Cobb-500) were reared up to 31 days. On day 16, they were r...
Article
Full-text available
Effects of Experimentally Induced Toxicosis with Arsenic Trioxide on Body Weight and Different Organs in Mice. In this article, we have found that arsenic is stored mainly in liver, kidney, spleen, heart & dermis and affects mainly the digestive & musculoskeletal system.
Article
Full-text available
Twenty 50 day-old Long-Evans male rats (Rattus norvegicus) weighing between 200-380 gm were randomly divided into one of four equal groups (n=5). Group A was kept as control and given normal rat pellets aiad water nJ libifulii. In addition to normal feed, rats of groups B, C and D were treated with mercuric chloride 100 mg/1.5 L, mercuric chloride...
Article
Full-text available
In this article we have investigated the effect of country bean (Lablab purpureas) seed meal in diets for growing chicken on performance, body weight gain, food consumption, intestinal physiology and organ weight.
Article
Full-text available
Bffects of Levamisole Hydrochloride on Haematological Parameters in Immunized Rabbits M. M. Rahman, M. A. Awal, A. S. M. Barir, S. Begumr, M. A. Ahad2 and M. S. Islam Departtnent of Pharmacology. Faculty of Veterinary Science, Bangladesh Agricultural University. Mymensingh - 2202, Bangladesh ABSTRACT 'l'he eIl'ect oflevarrrisole hydrochloride rv...
Article
Full-text available
The,efficacy b wt given of combined preparation of triclabendazole and levamisole HCI @ once orally was evaluated against mixed parasitic infection in 4i lactating Shahiwal cross-bred cows in Takerhat milk shed area (Milk vitai, Madaripur, Bangladesh. Its efficacy was 74-97%0, 49'93% and 6l-980/o against fascioliasis, p*urnpi,irioriiis ana nemato...
Article
Full-text available
Effects of oxytetracycline (Renamycin) on certain clinical parameters and on serum calcium level were studied in mice. The experiment was conducted on 4 groups of adult mice (each group consisting of 1 male and 3 females) for a period of 42 days. One group served as control without giving oxytetracycline. The remaining 3 groups were given oxytetrac...
Article
Full-text available
Carbofuran (Furadan®, 5G, Padma Oil Company Ltd, Bangladesh) at different five doses i.e. 0.4, 4, 8, 12 and 16 mg/kg body, weight were administered orally to five groups of adult guinea pigs (each group consisting of 5 guinea pigs) for studying the toxic symptoms and lethality, haemato-biochemical Parameters & treatment of its toxicity in guinea pi...
Article
Full-text available
The single oral administration of fenthion (Labaycid@, 50 EC. Mc Donald Bangladesh pvt. Limited)@ 2OO, 250, 300, 350, and 400 mglkg to adult guineapigs (1=4/"u"h group) induced"varying degrees of toxicity and mortality. Characteristic of anti-cholinesteiaie (ChE) poisoning. Based on *o.iau[, raie the oral acut-e LD, was calculated as 320 mg/kg in a...
Article
Full-text available
one hundred feed and one hundred water samples (25 samples from each thana/farm/locality) from each of fbur districts (Chittagong, Pirujpur, Brahman Baria and Mymensingh; were collected for examining the tevet of dangerous amount of arsenic. Twenty five feeds and water samples of uottah Dairy Farm, patenga, Chitiagong and all the water samples of N...
Article
Full-text available
We have recently reported that phytosteryl ferulates isolated from rice bran inhibit nuclear factor-κB (NF-κB) activity in macrophages. In the present study, we investigated the effect of γ-oryzanol (γ-ORZ), a mixture of phytosteryl ferulates, cycloartenyl ferulate (CAF), one of the components of γ-ORZ, and ferulic acid (FA), a possible metabolite...
Conference Paper
Full-text available
Article
Full-text available
Objective: Natural substances found in dietary sources and medicinal plants have attracted considerable attention in recent years as chemopreventive agents. Spirulina is a blue-green alga that possesses chemopreventive properties. The purpose of this study was to determine the effect of spirulina on rats with inorganic arsenic (As) [sodium arsenite...
Article
Full-text available
Majority of the people in Bangladesh are still not aware about the health hazards of antibiotic residues. In this perspective, a survey was undertaken at five different poultry farms in the Dinajpur district. One hundred liver, one hundred thigh muscle and one hundred breast muscle samples were collected from different farms & market places and eva...
Article
Full-text available
Abuse of antibiotics is more common in developing countries. This study was undertaken to investigate the presence of ciprofloxacin residue in broiler tissues and effects of antibiotics misuse on hematological parameters in broilers. Day old chicks (DOC) were collected and reared up to 31 days. The treatment was started from 16th day until sacrific...
Article
Full-text available
Antibiotics are the most widely injudiciously used drugs for therapeutic purposes throughout the world. This study aimed to detect cephalexin residue after discriminate and indiscriminate administration of cephalexin antibiotic in broiler. Eighteen broiler chicks, DOC (Cobb-500) were collected & reared for up to 31 days. The chicks were randomly di...
Article
Full-text available
Lead poisoning is a continuing crisis impacting learning, neurological and behavioral development in children. This study investigated an important outcome from the environmental lead contamination which cause retardation of infant’s brain development. A total of 30 Swiss albino mice of both sexes were used in this study and divide into three group...
Article
Full-text available
This study was designed with the aim to determine the impact of residual antibiotics on poultry muscle (breast and thigh), kidney, spleen, fat and liver and effects of discriminate and indiscriminate use of antibiotic on haematological constituents in broiler chickens. The chickens were properly reared and on the day of 16, chicks were randomly div...
Article
Full-text available
Background: In open grazing dairy cattle farming, it is critical to identify and monitor health status and disease incidence. Testing of physiological parameters is essential to monitoring the health status of dairy herds. Therefore, the present study was carried out to evaluate the comparative status of serum chemistry and corresponding milk chemi...
Article
Full-text available
This study was designed with the aim to determine the impact of residual antibiotics on poultry muscle (breast and thigh), kidney, spleen, fat and liver and effects of discriminate and indiscriminate use of antibiotic on haematological constituents in broiler chickens. The chickens were properly reared and on the day of 16, chicks were randomly div...
Article
Full-text available
Abuse of antibiotics is more common in developing countries including Bangladesh. The aim of this study was to detect doxycycline residue after discriminate and indiscriminate administration in broiler poultry. Eighteen broiler chicks, DOC (Cobb-500) was collected & reared up to 31 days. On day 16, they were randomly divided into 3 groups, namely g...
Article
Full-text available
Antibiotic residue is a burning question in the present world. Antibiotic remain in edible tissues of poultry as a residue due to indiscriminate use in the veterinary field. Human health is at risk of antibiotics due to poultry edible tissues. In this study, we used broiler chicks as a laboratory animal to investigate the judicial use of amoxicilli...
Article
Full-text available
Hematological indication is an important finding for pathophysiology analysis of biological science. This study was designed with the aim to investigate the effects of residual antibiotics on hematological parameters of broiler following discriminate and indiscriminate use. Broiler chicks were reared accordingly upto 30 days and on day 14 the chick...
Article
Full-text available
Abstract: Hematological indication is an important finding for pathophysiology analysis of biological science. This study was designed with the aim to investigate the effects of residual antibiotics on hematological parameters of broiler following discriminate and indiscriminate use. Broiler chicks were reared accordingly upto 30 days and on day 14...
Article
Full-text available
Epithelial-mesenchymal transition (EMT) is an orchestral and functional change in epithelial cells. Many signaling pathways are involved in EMT, and transforming growth factor-beta (TGF-β) is considered to be one of the most important factors in induction of EMT. In this study, we treated the rat intestinal epithelial cell line (IEC-6) with TGF-β1...
Article
Full-text available
The study was undertaken to investigate the effects of Spirulina platensis on body weight, blood glucose and lipid profile on alloxan induced diabetic rats. Fifteen Long Evans male rats at six weeks of age were used for the experiment. Diabetes was induced by intraperitoneal injection of alloxan@ 150 mg/kg and experiment was carried out for a perio...
Article
Full-text available
Knowledge, attitude and practice of broiler sellers about the indiscriminate use of antibiotic in poultry feed and antibiotic residue status of broiler in the live bird market of Mymensingh city was investigated. Twenty live poultry selling shops were randomly interviewed and six broilers from each market (5x6= 30) were randomly selected for detect...
Article
Full-text available
p>Cycloartenyl ferulate (CAF) is a major bioactive phytosteryl ferulate purified from rice bran γ- oryzanol. Previously we reported that CAF ameliorates DSS-induced colitis in mice. The present study was undertaken to investigate the effects of CAF on LPS (lipopolysaccharide) stimulated murine RAW 264.7 macrophages. Immunohistochemistry analysis de...
Article
Full-text available
p>Interlukin-33 (IL-33) is a novel cytokine of the IL-1 superfamily that is expressed mainly in stromal cells, such as epithelial and endothelial cells. It is believed to be involved in inflammation and carcinogenesis. Recently we have reported that IL-33 is up regulated in azoxymethane-dextran sulfate sodium salt (AOM/DSS)- induced in colitis in m...
Article
Full-text available
p>Tenascin-C, an extracellular matrix glycoprotein, expresses high level during embryogenesis and almost absent during the normal postnatal life. However, it is re-appeared in a diverse condition such as tissue injury and in the stroma of various carcinomas. In this study, we investigated the appearance of tenascin-C in dextran sulfate sodium (DSS)...
Conference Paper
Islam MS, Horiguchi K , Iino S, Kaji N, Mikawa S, Hori M, Ozaki H (2016). EGF is a Critical regulator of the Interleukin-33 in Intestinal Epithelial Cells. Speech no, 128, presented in the seminar, held on 23th April, 2016 in The University of Tokyo,Tokyo, Komaba Campus, Japan, pp 20.
Article
Full-text available
Endotoxin causes gastrointestinal motility disorder. Aim of this study is to clarify inhibitory mechanisms of lipopolysaccharide (LPS) on smooth muscle contraction in rat ileum. Ileal tissues were isolated from control rat or from LPS-induced peritonitis model rat. Treatment with LPS inhibited carbachol (CCh)-mediated contraction in a time-dependen...
Article
Full-text available
Abstract Maropitant is a neurokinin1 receptor (NK1R) antagonist that is clinically used as a new anti-emetic drug for dogs. Substance P (SP) and its receptor NK1R are considered to modulate gastrointestinal peristalsis. In addition, SP works as an inflammatory mediator in gastrointestinal diseases. Aim of this study is to clarify the effects of mar...
Article
A pot experiment was carried out to study the performance of BARI ghom–26 under saline stressed condition in order to find out the optimum salinity level for cultivation. The study was consists of three salinity stressed levels viz. 4.0, 8.0 and 12.0 dS m -1 together with a control 0.0 dSm -1 for the observing the field performance under saline str...
Conference Paper
Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H, 2014. PDGF and TGF- β signaling pathways promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice. Speech no, 168, presented in the seminar, held on 26th April, 2014 in T...
Conference Paper
Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H, 2014. Up regulation of Tenascin-C in subepithelial myofibroblasts is critical for intestinal mucosal protection in mice. Speech no, 2S31J-2, presented in the 91st Physiological Society of Japan, held on 16-18th March, 2014 in Kagos...
Article
Full-text available
Rice is one of the world's most important food crops, and more than half the people in the world eat rice as the main part of their diet. Rice bran is a component of raw rice that is obtained when it is removed from the starchy endosperm in the rice milling process. Antioxidants in rice bran have professed health benefits, as well as antioxidant ch...
Article
Full-text available
Abstract: Some of the pharmacological properties of spirulina (Spirulina platensis) may be linked to its antioxidant potential, which mitigates oxidative stresses. In this study we examined whether spirulina mitigated arsenic-induced toxicity in the Black Bengal goat (Capra hircus). Nonpregnant female goats of approximately 12 months old were used...
Data
Primary cell culture is a valuable tool that extensively used in the basic research of organ specific functions, physiology, pathology, pharmacology and so on. The aim of this study was to derive primary mesenchyme cell line representative of colon tissues. First, we identified the location of sub-epithelial myofibroblast in the colon tissues in ra...
Data
A total of 30 day-old chicks were divided into 3 groups to investigate the effects of country bean seeds as a dietary protein supplement in broiler feeds on the performance, body weight gain, food consumption, intestinal physiology and organ weight of growing chickens. Group A was fed rations with ground raw country bean 250 mg/kg diet, group B wit...
Data
The effects of long-term intramuscular injection of gentamicin (Gentin® inj., Opsonin, Bangladesh Ltd.) were studied clinicopathologically on twenty 60 day-old Swiss Albino mice of either sex for 42 days during January to March 2002. All the mice were grouped into four, each consisting of one male and four female mice, of which one group (group A)...
Data
The effects of selenium, iron and zinc supplementation along with arsenic on clinical signs, body weight and haematobiochemical parameters were studied in 25 mature male long Evans rats (Ratus norvegicus) of one month old during the period from August to October 2003. These 25 rats were randomly divided into five equal groups (A, B, C, D and E) of...
Data
The study was carried out to know the effects of selenium, iron and zinc supplementation on gross pathology and tissue arsenic concentration in Long Evans rats during the period from August to October 2003. A total of 25, one-month-old male rats were randomly divided into 5 equal groups as A, B, C, D and E. Rats of group A were kept as control with...
Conference Paper
Islam MS, Ozaki H, 2012. Motile and immune functions of intestinal subepithelial myofibroblasts. Speech no, S16-4, presented in the 117th Annual Meeting of the Japanese Association of Anatomists, held on 26-28th March, 2012, held in the Department of Anatomy and Molecular organization, Graduate School of Medical and Engineering Research unit, Yaman...
Data
Myeloperoxidase (MPO) is an enzyme present in neutrophils and at a much lower concentration in monocytes and macrophages. In the present study we designed to examine the MPO activity in relation with inflammatory bowel disease (IBD) in dextran sulfate sodium (DSS)-induced colitis in mice. Mice were given o.5 % DSS ad libitum daily for 16 days; moni...
Conference Paper
Islam MS, Yoshida H, Matsuki N, Ono K, Murata T, Hori M, Ozaki H, 2010. Molecular mechanisms of anti-inflammatory effects of Cycloartenyl ferulate in LPS stimulated RAW 264.7 macrophages. 16th BSVER Annual Scientific Conference, held on 6-7th January’ 2010 at Bangladesh Agricultural University Campus, Mymensingh, Bangladesh, pp48.