Md. Arju Hossain

Khwaja Yunus Ali University · Department of Biochemistry and Biotechnology

Background: About 10-15% of all breast cancers comprise triple-negative breast cancer (TNBC), defined as cancer cells that lack ER, PR, and HER2 protein receptors. Due to the absence of these receptors, treating TNBC using conventional chemotherapy is challenging and, therefore, requires the discovery of novel chemotherapeutic agents derived from n...

Clinical observations indicate a pronounced exacerbation of Cardiovascular Diseases (CVDs) in individuals grappling with Alcohol Use Disorder (AUD), suggesting an intricate interplay between these maladies. Pinpointing shared risk factors for both conditions has proven elusive. To address this, we pioneered a sophisticated bioinformatics framework...

The X-ray repair cross-complementing 5 (XRCC5) gene plays a pivotal role in the classical non-homologous end joining (NHEJ) pathway further responding to DNA double-strand breaks. Our study aims to explore harmful non-synonymous single nucleotide polymorphisms (nsSNPs) within the coding region of the XRCC5 gene, potentially impacting protein functi...

Owing to the recent emergence of COVID-19, there is a lack of published research and clinical recommendations for posttraumatic stress disorder (PTSD) risk factors in patients who contracted or received treatment for the virus. This research aims to identify potential molecular targets to inform therapeutic strategies for this patient population. R...

Aims: The main objective of the current study is to investigate the pathways and therapeutic targets linked to stevioside in the management of T2D using computational approaches. Methods: We collected RNA-seq datasets from NCBI, then employed GREIN to retrieve differentially expressed genes (DEGs). Computer-assisted techniques DAVID, STRING and Net...

Zanthoxylum rhetsa (ZR) is used traditionally to manage a variety of ailments, including diabetes. Oxidative stress may accelerate the diabetic condition. The available antidiabetic and antioxidant drugs have many shortcomings including resistance, inefficiency, higher dose, side effects and costs. The goal of the current investigation was to asses...

Background and aims The single nucleotide polymorphisms (SNPs) in SLC30A8 gene have been recognized as contributing to type 2 diabetes (T2D) susceptibility and colorectal cancer. This study aims to predict the structural stability, and functional impacts on variations in non-synonymous SNPs (nsSNPs) in the human SLC30A8 gene using various computati...

Despite therapeutic advancements, cervical cancer caused by high-risk subtypes of the human papillomavirus (HPV) remains a leading cause of cancer-related deaths among women worldwide. This study aimed to discover potential drug candidates from the Asian medicinal plant Andrographis paniculata, demonstrating efficacy against the E6 protein of high-...

Abstract Pancreatic cancer (PC) is a devastating malignancy with intricate genetic underpinnings and a complex etiology. Emerging evidence suggests the presence of lynch syndrome (LS) and type 2 diabetes (T2D) associated susceptibility to PC. This study presents integrated computational and systems biology approaches to identify the genetic risk fa...

Breast cancer (BC) is the most widespread cancer worldwide. Over 2 million new cases of BC were identified in 2020 alone. Despite previous studies, the lack of specific biomarkers and signaling pathways implicated in BC impedes the development of potential therapeutic strategies. We employed several RNAseq datasets to extract differentially express...

Shigella stands as a major contributor to bacterial dysentery worldwide scale, particularly in developing countries with inadequate sanitation and hygiene. The emergence of multidrug-resistant strains exacerbates the challenge of treating Shigella infections, particularly in regions where access to healthcare and alternative antibiotics is limited....

Variations in DNA repair genes affect cancer risk by influencing DNA repair efficacy, particularly in acute myeloid leukemia (AML). XRCC5, a non-homologous end-joining DNA repair gene, may mitigate AML risk, while mutations in XRCC5 could heighten susceptibility. We utilized diverse computational tools to compare the structures of both native and m...

Leptin binds with leptin receptor (LEPR) is responsible for appetite regulation, insulin sensitivity and glucose homeostasis. Single nucleotide polymorphisms (SNPs) in LEPR may alter the native structure of LEPR and disrupt its binding with the leptin hormone, leading to obesity and related complications like type 2 diabetes. This study employed co...

Clinical investigations showed that individuals with Alcohol Use Disorder (AUD) have worse Neurological Disease (ND) development, pointing to possible pathogenic relationships between AUD and NDs. It remains difficult to identify risk factors that are predisposing between AUD and NDs. In order to fix these issues, we created the bioinformatics pipe...

Purpose Ultraviolet radiation causes skin cancer, but the exact mechanism by which it occurs and the most effective methods of intervention to prevent it are yet unknown. For this purpose, our study will use bioinformatics and systems biology approaches to discover potential biomarkers of skin cancer for early diagnosis and prevention of disease wi...

Schizophrenia (SZ) is a chronic and devastating mental illness that affects around 20 million individuals worldwide. Cognitive deficits and structural and functional changes of the brain, abnormalities of brain ECM components, chronic neuroinflammation, and devastating clinical manifestation during SZ are likely etiological factors shown by affecte...

Coronavirus disease-19 (COVID-19) are deadly and infectious disease that impacts individuals in a variety of ways. Scientists have stepped up their attempts to find an antiviral drug that targets the spike protein (S) of Angiotensin converting enzyme 2 (ACE2) (receptor protein) as a viable therapeutic target for coronavirus. The most recent study e...

Aim and objective Due to the a lot of unexplored proteins in HIV-1, this research aimed to explore the functional roles of a hypothetical protein (AAB33144.1) that might play a key role in HIV-1 pathogenicity. Methods The homologous protein was identified along with building and validating the 3D structure by searching several bioinformatics tools...

Background: A form of cancer called astrocytoma can develop in the brain or spinal cord and sometimes causes death. A detailed overview of the precise signaling cascade underlying astrocytoma formation has not yet been revealed, although various factors have been investigated. Therefore, our objective was to unravel and summarize our current under...

Chikungunya (CHIK) patients may be vulnerable to coronavirus disease (COVID-19). However, presently there are no anti-COVID-19/CHIK therapeutic alternatives available. The purpose of this research was to determine the pharmacological mechanism through which kaempferol functions in the treatment of COVID-19-associated CHIK co-infection. We have used...

Mucormycosis co-infection with COVID-19 patients has a poor prognosis for fatality. However, they do not have any therapeutic choices right now. Galangin is prone to both COVID-19 and Mucormycosis, according to an ongoing study; galangin was investigated as a prospective molecular mechanism against COVID-19 with Mucormycosis co-infection to determi...

Background: The most common and deadly cancer in female is breast cancer (BC) and new incidence and deaths related to this cancer are rising. Aims: Several issues, that is, high cost, toxicity, allergic reactions, less efficacy, multidrug resistance, and the economic cost of conventional anti-cancer therapies, has prompted scientists to discover...

Background and Aims: Worldwide, prostate cancer (PC) is the most commonly diagnosed male malignancy and the fifth leading cause of cancer death in men. On the other hand, male with Lynch syndrome (LS) have an increased risk of developing prostate cancer. The molecular mechanism underlying oncogenesis and the development of PC remain poorly known, p...

Moraxella catarrhalis is a symbiotic as well as mucosal infection-causing bacterium unique to humans. Currently, it is considered as one of the leading factors of acute middle ear infection in children. As M. catarrhalis is resistant to multiple drugs, the treatment is unsuccessful; therefore, innovative and forward-thinking approaches are required...

Colorectal cancer (CRC) is a severe health concern that results from a cocktail of genetic, epigenetic, and environmental abnormalities. Because it is the second most lethal malignancy in the world and the third-most common malignant tumor, but the treatment is unavailable. The goal of the current study was to use bioinformatics and systems biology...

Background: With high inflammatory states from both COVID-19 and HIV conditions further result in complications. The ongoing confrontation between these two viral infections can be avoided by adopting suitable management measures. Purpose: The aim of this study was to figure out the pharmacological mechanism behind apigenin's role in the synerge...

Female infertility may be caused by several medical conditions and environmental factors that induce fallopian tube damage or hormonal difficulties. Several metabolic comorbidities like polycystic ovarian syndrome (PCOS), type 2 diabetes (T2D), obesity, and cardiovascular disease (CVD) have been associated with female infertility (FI). However, the...

Despite modern treatment, infertility remains one of the most common gynecologic diseases causing severe health effects worldwide. The clinical and epidemiological data have shown that several cancerous risk factors are strongly linked to Female Infertility (FI) development, but the exact causes remain unknown. Understanding how these risk factors...

Pancreatic Cancer (PC) is a devastating malignancy with intricate genetic underpinnings and a complex etiology. Emerging evidence suggests the presence of Lynch Syndrome (LS) and Type 2 Diabetes (T2D) associated pancreatic cancer susceptibility. This study presents integrated computational and systems biology approaches to identify the genetic risk...

Background Polycystic ovarian syndrome (PCOS) is a common condition of hyperandrogenism, chronic ovulation, and polycystic ovaries in females during the reproduction and maturation of the ovum. Although PCOS has been associated with metabolic disorders, including type 2 diabetes (T2D), obesity (OBE), and cardiovascular disease (CVD), Causal connect...

Polycystic ovarian syndrome (PCOS) was effectively treated with Caesalpinia bonducella (CB) although its active components and molecular mechanisms remain undetermined. Through network pharmacology and molecular docking technology, the ultimate goal of this study was to investigate the active ingredients and functions of CB against PCOS. A literatu...

The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has created an urgent global situation. Therefore, it is necessary to identify the differentially expressed genes (DEGs) in COVID-19 patients to understand disease pathogenesis and the genetic factor(s) responsible for inter-individual variability and dis...

Prostate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, su...

Aims Due to traditional endocrinological techniques, there is currently no shared work available, and no therapeutic choices have been presented in type 2 diabetes (T2D), rheumatoid arthritis (RA), and tuberculosis (TB). The purpose of this research is to summarize the prospective molecular complications and potential therapeutic targets associated...

Breast cancer (BC) is one of the most common malignancies in women. Although widespread successful synthetic drugs are available, natural compounds can also be considered as significant anticancer agents for treating BC. Some natural compounds have similar effects as synthetic drugs with fewer side effects on normal cells. Therefore, we aimed to un...

The use of dietary phytochemical rather than conventional therapies to treat numerous cancers is now a well-known approach in medical science. Easily available and less toxic dietary phytochemicals present in plants should be introduced in the list of phytochemical-based treatment areas. Sesamin, a natural phytochemical, may be a promising chemopre...

Background Cancer has become a significant concern in the medical sector with increasing disease complexity. Although some available conventional treatments are still a blessing for cancer patients, short-and long-term adverse effects and poor efficiency make it more difficult to treat cancer patients, demonstrating the need for new potent and sele...

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection results in the development of a highly contagious respiratory ailment known as new coronavirus disease (COVID-19). Despite the fact that the prevalence of COVID-19 continues to rise, it is still unclear how people become infected with SARS-CoV-2 and how patients with COVID-19 be...

In the 21st century, any pandemic, especially, SARS-CoV-2 is a global burden due to high incidence, mortality, and mutation rate. Although several techniques have already been identified to control the pandemic or treat patients and causes of adverse impact on mental health, relatively only, fewer researchers have little concern about finding effec...

Background: Asthma is a chronic incurable disease of respiratory system with have no specific reason of occurrence, but can be influence by both genetics and environmental factors. Asthma is a common disease among people of both under develop and developed countries. Khagrachari Hill district is less developed district with less medical facilities...