Mazlyfarina Mohamad

Mazlyfarina Mohamad
Universiti Kebangsaan Malaysia | ukm · School of Diagnostic and Applied Health Sciences

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56
Publications
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243
Citations

Publications

Publications (56)
Article
Full-text available
Working memory is developed in one region of the brain called the dorsolateral prefrontal cortex (DLPFC). The dysfunction of this region leads to synaptic neuroplasticity impairment. It has been reported that several biochemical parameters and anthropometric measurements play a vital role in cognition and brain health. This study aimed to investiga...
Article
Full-text available
The characteristics of smartphone addiction (SPA) can be evaluated by neuroimaging studies. Information on the brain structural alterations, and effects on psychosocial wellbeing, however, have not been concurrently evaluated. The aim of this study was to identify abnormalities in gray matter volume using voxel-based morphometry (VBM) and neuronal...
Article
Full-text available
Background Alzheimer’s disease (AD) is a major neurocognitive disorder identified by memory loss and a significant cognitive decline based on previous level of performance in one or more cognitive domains that interferes in the independence of everyday activities. The accuracy of imaging helps to identify the neuropathological features that differe...
Article
Background: Gaming can be very entertaining and through it, gamers are able to develop skills. However, it also may result in one’s getting too obsessed with video games regardless of any circumstances. Unnoticed, it may develop an Internet gaming disorder (IGD). This study aimed to investigate the neural activation involved in cognitive flexibilit...
Article
Purpose This study aimed at investigating the topographical pattern of whole-brain structural alterations in association with apolipoprotein E ε4 (APOE ε4), cerebrospinal fluid (CSF) [amyloid-beta 42 (Aβ42), and neurofibrillary tau protein], positron emission tomography (PET) biomarkers [Aβ, tau, and 2-[18F]fluoro-2-deoxy-d-glucose (FDG)], and neur...
Article
Background Cosmos caudatus (CC) is traditional Asian vegetable, commonly consumed among the Southeast Asian population. It has been reported to be high in flavonoids and might potentially improve brain activity among older adults with mild cognitive impairment (MCI). The effect of CC in brain activation improvement using neuroimaging is yet to be d...
Article
Full-text available
Background: Cognitive frailty (CF) is identified as one of the main precursors of dementia. Multidomain intervention has been found to delay or prevent the onset of CF. Objective: The aim of our present study is to determine the effectiveness of a comprehensive, multidomain intervention on CF; to evaluate its cost effectiveness and the factors i...
Article
Full-text available
Resting-state fMRI (rs-fMRI) detects functional connectivity (FC) abnormalities that occur in the brains of patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI). FC of the default mode network (DMN) is commonly impaired in AD and MCI. We conducted a systematic review aimed at determining the diagnostic power of rs-fMRI to iden...
Article
Full-text available
Introduction: Risk factors for cardiovascular disease (CVD) have been increasingly implicated in the development of dementia but little is known about the effects in a Malaysian population. We aimed to determine the interaction between sociodemographic and CVD risk factors among the dementia and mild cognitive impairment (MCI) patients in Malaysia...
Article
Full-text available
Cosmos caudatus (CC) contains high flavonoids and might be beneficial in neuroprotection. It has the potential to prevent neurodegenerative diseases. Therefore, we aimed to investigate the effects of 12 weeks of Cosmos caudatus supplement on cognitive function, mood status, blood biochemical profiles and biomarkers among older adults with mild cogn...
Preprint
Full-text available
Introduction The effect of apolipoprotein E (APOE) genotype, particularly APOE E4, the main genetic risk factor for late-onset Alzheimers disease (LOAD), has been widely explored in neuroimaging studies pertaining to older adults. The goal of this systematic review was to review the literature on the relationship between carriage of the APOE E4 all...
Preprint
Full-text available
Rationale and Objectives Although neuroimaging studies suggest that the cerebral ventricle is independently associated with APOE ε4, cerebrospinal fluid (CSF) biomarkers, and neuropsychological scores in aging and Alzheimer’s disease (AD), there is no formal synthesis of these findings. We summarized the association of ventricular changes with APOE...
Article
Full-text available
Problematic Instagram Use (PIGU) is a specific Internet addiction disorder observed among the youth of today. Functional magnetic resonance imaging (fMRI) can objectively assess regional brain activation in response to addiction-specific rewards, e.g. viewing picture flashcards. Pictures that were uploaded onto Instagram by users with PIGU issue ha...
Article
Full-text available
Background: Problematic Instagram use (PIGU), a specific type of internet addiction, is prevalent among adolescents and young adults. In certain instances, Instagram acts as a platform for exhibiting photos of risk-taking behavior that the subjects with PIGU upload to gain likes as a surrogate for gaining peer acceptance and popularity. Aims: The...
Article
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Background Persicaria minor extract exhibits antioxidant and anti-inflammatory properties and has potential effects on cognitive function and mood. However, the effects of P.minor on brain activation and biomarkers have not been studied among older adults. This multicentre, randomized, double-blinded, placebo-controlled study aimed to investigate t...
Article
Background There is compelling evidence that neurochemical changes measured by proton magnetic resonance spectroscopy (¹H-MRS) occur at different phases of Alzheimer's disease (AD). However, the extent to which these neurochemical changes are associated with validated AD biomarkers and/or apolipoprotein (APOE) ε4 is yet to be established. Objectiv...
Article
Full-text available
The present study examined the impact of white noise on word recall performance and brain activity in 40 healthy adolescents, split in two groups (normal and low) depending on their auditory working memory capacity (AWMC). Using functional magnetic resonance imaging, participants performed a backward recall task under four different signal-to-noise...
Article
Full-text available
The rapid development of Internet gaming technology in Malaysia has come with a cost of greater vulnerability in becoming addicted to video games especially for an adolescent whose mental abilities were not matured yet. This study aimed to investigate the differences in human neural activation using fMRI that being triggered by gaming video among M...
Conference Paper
Full-text available
The present study examined the relationship between effective connectivity among frontotemporal brain regions and auditory working memory (AWM) performance. Twenty healthy participants performed a word-based backward recall task in four signal-to-noise ratio (SNR) conditions during functional magnetic resonance imaging scans. Functional data were p...
Article
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Objective: To identify regions of the brain affected during cognitive working memory during tasks to assess attention, planning and decision making among military aviation personnel who have chronic intermittent exposure to high altitude environment. Method: A case-control study was conducted in the Universiti Putra Malaysia among eight military...
Preprint
Full-text available
Problematic Instagram Use (PIGU) is a type of behavioural addiction (BA), and is one of the types of specific−Internet addiction disorders in Malaysia. Most studies have relied on questionnaire−based assessment e.g. Smartphone Addiction Scale−Malay version (SAS−M) and modified Instagram Addiction Test (IGAT), to establish commonalities between PIGU...
Article
Background: The auditory and prefrontal cortex supports auditory working memory processing. Many neuroimaging studies have shown hemispheric lateralization of auditory working memory brain regions in the presence of background noise, but few studies have focused on the lateralization of these regions during stochastic resonance. Purpose: To inve...
Conference Paper
Full-text available
Global warming and climate change cause sea level to rise, which will result in the coastline being impacted by higher waves and higher tide levels. The increase in waves and tide level will influence the design, effectiveness and stability of the coastal structures. To ensure that the coastal structures are adequately designed and perform satisfac...
Article
Full-text available
Research suggests that white noise may facilitate auditory working memory performance via stochastic resonance. Stochastic resonance is quantified by plotting cognitive performance as a function of noise intensity. The plot would appear as an inverted U-curve, that is, a moderate noise is beneficial for performance whereas too low and too much nois...
Article
Full-text available
Background: Working memory and cognitive flexibility are supported by the dorsolateral prefrontal cortex (DLPFC). Aging adults from low-income households are individuals with a high risk of cognitive decline who incorporate ulam in their daily diet. Purpose: To examine relationship between ulam consumption and the working memory and cognitive fl...
Conference Paper
Full-text available
The relationship between resting effective connectivity (EC) among default mode network (DMN) regions and auditory working memory (AWM) performance is still poorly understood. In this work, resting-state functional magnetic resonance imaging (rsfMRI) was used to determine the optimum connectivity model between posterior cingulate cortex (PCC) and m...
Article
Objective: This study aims to investigate the public pattern in seeking breast cancer screening information in Malaysia using Google Trends. Methods: The Google Trends database was evaluated for the relative Internet search popularity of breast cancer and screening-related search terms from 2007 to 2018. Results: Result showed downward trends in br...
Article
Full-text available
Background: Many studies on biochemical and psychological variables have aimed to elucidate the association between aging and cognitive function. Demographic differences and protein expression have been reported to play a role in determining the cognitive capability of a population. Objective: This study aimed to determine the effect of age on t...
Article
Full-text available
Background: Dorsolateral prefrontal cortex (DLPFC) is a key node in the cognitive control network that supports working memory. DLPFC dysfunction is related to cognitive impairment. It has been suggested that dietary components and high-density lipoprotein cholesterol (HDL-C) play a vital role in brain health and cognitive function. Purpose: Thi...
Poster
Full-text available
Lipids are involved in the regulation of neural functions in the central nervous system through local mechanisms that are linked to systemic lipid metabolism. Emerging evidence suggests that high-density lipoprotein cholesterol (HDL-C) may play a pivotal role in preserving cognitive function under normal and pathological conditions. We reasoned tha...
Article
Rationale and objective: This study is a dedicated 2D-shear wave elastography (2D-SWE) review aimed at systematically eliciting up-to-date evidence of its clinical value in differential diagnosis of benign and malignant thyroid nodules. Methods: PubMed, Web of Science, and Scopus databases were searched for studies assessing the diagnostic value...
Poster
Full-text available
Both prefrontal cortex (PFC) and hippocampus (HPC) are involved in working memory and episodic memory task that can be determined using various cognitive tests. Dietary components can affect brain functions by modulating neurotransmitter pathways, synaptic transmission and signal-transduction pathways. We reasoned that dietary nutrient intake may a...
Article
Full-text available
The assessment for patient with duct-dependent pulmonary circulation (DDPC) during the inter-stage intervals before first stage palliation commonly includes imaging of the heart with multiple imaging modalities. Recently, three-dimensional echocardiography (3DE) was found with the ability to delineate cardiac structure that is able to do 360 o rota...
Article
Full-text available
Aging is associated with a decline in cognitive and motor function. But, the relationships with motor performance are less well understood. In this study, functional magnetic resonance imaging (fMRI) was used to assess cortical activation in older adults. This study employed power grip task that utilised block paradigm consisted of alternate 30s re...
Poster
Full-text available
Computed Tomogram angiography (CTA) is usually performed to delineate patent ductus arteriosus (PDA) tortuosity morphology in duct-dependent pulmonary circulation (DDPC) if two-dimensional echocardiography fails to provide PDA morphology information. Recently three-dimensional echocardiography color flow (3DECF) is able to create three dimensional...
Article
High sensitivity signal detection for a sparse temporal sampling (STS) functional magnetic resonance imaging (fMRI) is compensated by the increase in the number of scans (Ns) and consequently the scan time. A long scan time would result in fatigue and restlessness in participants, while a short scan time is undesirable for an STS-fMRI due to insuff...
Article
Higher level of education is associated with better cognitive performance and lower risk of developing dementia. However, the effect of education on cognitive performance varies across different cognitive domains and in different populations. The aim of this study was to determine the relationship between education and performance of different cogn...
Article
Picture archiving and communication system know as (PACS) is a rapidly growing technology in the healthcare industry in Malaysia and provides a positive development for patient services and one of the factors that influence the success of this system is the level of user acceptance. However, the acceptance level of the radiographers in using PACS a...
Article
Full-text available
Several methods of motor tasks for fMRI scanning have been evolving from simple to more complex tasks. Motor tasks on upper extremity were applied in order to excite the increscent of motor activation on contralesional and ipsilateral hemispheres in brain. The main objective of this study is to study the different conditions for motor tasks on uppe...
Article
This study was carried out to investigate the effects of noisy background on brain activation during a working memory task. Fourteen healthy male subjects underwent silent functional Magnetic Resonance Imaging (fMRI) scans while listening to words presented verbally against quiet (WIS) and noisy (WIN) backgrounds. The stimuli were binaurally presen...
Article
Full-text available
A study on the radiation dose associated with cerebral CT angiography (CTA) and CT perfusion (CTP) was conducted on an anthropomorphic phantom with the aim of estimating the effective dose (E) and entrance skin dose (ESD) in the eyes and thyroid gland during different CTA and CTP protocols. The E was calculated to be 0.61 and 0.28 mSv in CTA with 1...
Article
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In spite of extensive research conducted in studying pitch memory processing, knowledge about the functional anatomy of the brain while performing pitch discrimination task is still lacking. The purpose of this study was to investigate the effects of background noise and tonal frequencies on brain activation during a pitch discrimination task. Thir...
Article
Full-text available
This fMRI study is about modelling the effective connectivity between Heschl's gyrus (HG) and the superior temporal gyrus (STG) in human primary auditory cortices. MATERIALS #ENTITYSTARTX00026; Ten healthy male participants were required to listen to white noise stimuli during functional magnetic resonance imaging (fMRI) scans. Statistical parametr...
Article
This multiple-subject fMRI study continue to further investigate brain activation within and effective connectivity between the significantly (p<0.001) activated primary motor area (M1), supplementary motor area (SMA) with the inclusion of BA44 during unimanual (UNIright and UNI left) and bimanual (BIM) self-paced tapping of hand fingers. Methods:...
Article
A study on the effective connectivity characteristics in auditory cortices was conducted on five healthy Malay male subjects with the age of 20 to 40 years old using functional magnetic resonance imaging (fMRI), statistical parametric mapping (SPM5) and dynamic causal modelling (DCM). A silent imaging paradigm was used to reduce the scanner sound a...
Article
Full-text available
In spite of extensive research conducted to study how human brain works, little is known about a special function of the brain that stores and manipulates information-the working memory-and how noise influences this special ability. In this study, Functional magnetic resonance imaging (fMRI) was used to investigate brain responses to arithmetic pro...
Article
Functional magnetic resonance imaging (fMRI) was used to investigate brain responses due to arithmetic working memory. Nine healthy young male subjects were given simple addition and subtraction instructions in noise and in quiet. The general linear model (GLM) and random field theory (RFT) were implemented in modelling the activation. The results...
Article
This fMRI study is about modeling the intrinsic connectivity between Heschl' gyrus (HG) and superior temporal gyrus (STG) in human primary auditory cortices. Ten healthy male subjects participated and required to listen to white noise stimulus during the fMRI scans. Two intrinsic connectivity models comprising bilateral HG and STG were constructed...
Article
Objective: This study investigates functional specialisation in, and effective connectivity between the precentral gyrus (PCG) and supplementary motor area (SMA) in seven right handed female subjects. Methods: Unimanual (UNIright and UNIleft) and bimanual (BIM) self-paced tapping of hand fingers were performed by the subjects to activate PCG and SM...
Article
A functional magnetic resonance imaging (fMRI) study was conducted on 4 healthy male and female subjects to investigate brain activation during passive and active listening. Two different experimental conditions were separately used in this study. The first condition requires the subjects to listen to a simple arithmetic instruction (e.g. one-plus-...
Article
This preliminary study investigates the spatial (activation area) and height (percentage of signal change - PSC) extent of brain activation in the cerebral cortices evoked by white noise and speech perception. A healthy young male subject underwent silent functional Magnetic Resonance Imaging (fMRI) scans while listening to the given stimulus. Thre...

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Projects (3)
Archived project
Project
Study the patterns of neuronal connectivity in Asians using BOLD imaging.
Project
Utilization of 3D echocardiography in heart congenital disease