Mayowa OwolabiUniversity of Ibadan
Mayowa Owolabi
MBBS, MD, DrM, FRCP, FAAN, FANA FAS
About
542
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Publications
Publications (542)
We review neuroimaging research investigating self-referential processing (SRP), that is, how we respond to stimuli that reference ourselves, prefaced by a lexical-thematic analysis of words indicative of “self-feelings”. We consider SRP as occurring verbally (V-SRP) and non-verbally (NV-SRP), both in the controlled, “top-down” form of introspectiv...
With the aging of the world's population and the well-advanced epidemiological transition that is occurring in low-and middle-income countries (LMICs), the major burden of global diseases now lies with noncommunicable diseases (NCDs). Funding in global health, however, remains focused on human immunodeficiency virus, tuberculosis , and malaria with...
Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. In the past 30 years, the absolute numbers of deaths and people with disabilities owing to neurological diseases have risen substantially, particularly in low-income and middle-income countries, and further increases are expected globally as...
Background: Co-existence of metabolic syndrome (MetS) and electrocardiography (ECG) abnormalities heightens the risk of sudden cardiac death. However, there is a gap in evidence of how ECG changes cluster among continental Africans with or without MetS.
Methods: We included 491 participants with interpretable ECG tracings who were consecutively rec...
Introduction
Worldwide, 2 million patients aged 18–50 years suffer a stroke each year, and this number is increasing. Knowledge about global distribution of risk factors and aetiologies, and information about prognosis and optimal secondary prevention in young stroke patients are limited. This limits evidence-based treatment and hampers the provisi...
Background:
This study determined the frailty status and its association with mortality among older patients.
Design:
A prospective cohort design.
Setting:
Study was conducted at the medical wards of University College Hospital, Ibadan, Nigeria.
Participants and study tools:
Four hundred and fifty older patients (>60 years) were followed up...
Background:
Although highly heritable, few genes have been linked to spontaneous intracerebral hemorrhage (SICH), which does not currently have any evidence-based disease-modifying therapy. Individuals of African ancestry are especially susceptible to SICH, even more so for indigenous Africans. We systematically reviewed the genetic variants assoc...
Since 2000, many countries have achieved considerable success in improving child survival, but localized progress
remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child
deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends....
EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fer...
EVIDENCE REVIEW We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fer...
Background: Biomarkers, shock index and modified early warning score (MEWS) are of public health importance because identification and prompt attention to them have been found to reduce mortality among older patients on admission.Objectives: A study was undertaken to determine the biomarkers, shock index and MEWS that predict mortality on admission...
The management and analyses of large datasets is one of the grand challenges of modern biomedical research. Establishing methods to harmonise and standardise data collection, reporting, sharing and the employed data dictionaries, can support the resolution of these challenges whilst improving research quality, data quality and integrity, allowing s...
Background
Little is known about the relationship between echocardiographic abnormalities and outcome among patients with acute stroke. We investigated the pattern and association of baseline echocardiographic variables with 1‐month disability and mortality among patients with stroke in the SIREN (Stroke Investigative Research and Education Network...
Background
Laboratory-based studies of neurological disease patterns and mechanisms are sparse in sub-Saharan Africa. However, availability of human brain tissue resource depends on willingness towards brain donation. This study evaluated the level of willingness among outpatient clinic attendees in a Nigerian teaching hospital.
Methods
Under the...
Objectives: To identify the most and least preferred rheumatology lectures, the proportional increase in students able to identify rheumatic conditions after the lectures as well as evaluate resident teaching effectiveness. Methods: All 134 clinical students in the University of Uyo Medical School, South-south Nigeria were asked to evaluate their r...
Background: seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and locati...
Summary
Background
Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide i...
Over three-quarters of deaths from cardiovascular disease and diabetes occur in low- and middle-income countries, which include many African countries. Global studies showed that the prevalence of the cardiac arrhythmia atrial fibrillation (AF) appeared to be lower in Africa. A systematic search of PubMed and African Journals Online was conducted t...
This appendix formed part of the original submission and has been peer reviewed.
Supplement to: GBD 2017 SDG Collaborators. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017. L...
Background: Biomarkers, shock index and modified early warning score (MEWS) are of public health importance because identification and prompt attention to them have been found to reduce mortality among older patients on admission.
Objectives: A study was undertaken to determine the biomarkers, shock index and MEWS that predict mortality on admissio...
Introduction
Understanding context and how this can be systematically assessed and incorporated is crucial to successful implementation. We describe how context has been assessed (including exploration or evaluation) in Global Alliance for Chronic Diseases (GACD) implementation research projects focused on improving health in people with or at risk...
Themes identified to describe methodology or approach used to assess context at each context level.
FGDs: Focus Group Discussions; NGO: Non-governmental organizations; OOP: Out-of-pocket; STAR: Socio-Technical Allocation of Resources; EPOCH: Environmental Profile of a Community's Health; HAP: Household Air pollution; NCDs: Non-communicable diseases...
Themes identified to describe how contextual lessons are incorporated into the intervention.
SE: social economic; SMS: Short Message Service; T2DM:Type II Diabetes Mellitus; TASSH: Task-shifting strategy for hypertension.
(DOCX)
Themes identified to describe how contextual lessons are incorporated into the implementation process.
*This table is populated with data from the open-ended questions in the semi-structured interviews to illustrate how teams reported addressing context based on the different themes identified. FGDs: Focus Group Discussions; TASSH: Task-shifting st...
(quantitative and qualitative) and codebook.
(XLSX)
Definitions for the components of the Socio-ecological Levels of Context framework.
(DOCX)
Background:
Older people face the biggest challenges in the overburdened healthcare services in Nigeria especially when hospitalized. There is no reliable data on the predictors of mortality in this population.
Aims:
To determine the predictors of mortality among older patients on admission in the medical wards of University College Hospital, Ib...
Objectives:
Hypertension occurs frequently among black populations around the world. In the United States (US) health system, interventions since the 1960s resulted in improvements in hypertension awareness, management and control among African Americans. This is in stark contrast to current health systems in African countries. To objectively asse...
Background and Purpose—
The interplay between sex and the dominant risk factors for stroke occurrence in sub-Saharan Africa has not been clearly delineated. We compared the effect sizes of risk factors of stroke by sex among West Africans.
Methods—
SIREN study (Stroke Investigative Research and Educational Networks) is a case-control study conduct...
Supplement to: GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 2019; published online March 14. http://dx.doi.org/10.1016/S1474-4422(18)30499-X.
Summary
Background
Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide inf...
Background Stroke is a leading cause of mortality and disability worldwide and the economic costs of treatment and post-stroke care are substantial. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic, comparable method of quantifying health loss by disease, age, sex, year, and location to provide information...
Stroke is a leading cause of global morbidity and mortality. Sub-Saharan Africa (SSA), where an unprecedented rise in stroke burden is currently raging, has the highest age-standardized stroke incidence, stroke prevalence, and stroke mortality rates. This is in sharp contrast to the relative decline in stroke incidence in high-income countries over...
This initiative is led by members of Global Alliance for Chronic Diseases (GACD) Mental Health Guidelines Working Group. Guidelines for the management of chronic diseases need to be sufficiently contextualized and communicated to facilitate their adoption and use in clinical practice. Moreover, the development of translatable and transformative pra...
Background:
Seizures and their consequences contribute to the burden of epilepsy because they can cause health loss (premature mortality and residual disability). Data on the burden of epilepsy are needed for health-care planning and resource allocation. The aim of this study was to quantify health loss due to epilepsy by age, sex, year, and locati...
Rationale:
Stroke etiology and risk factors vary by age, sex, setting (hospital or community-based) and by region. Identifying these differences would improve our understanding of stroke etiology, diagnosis, and treatment.
Aim:
The Age, Sex and Setting in the Etiology of Stroke Study (ASSESS) is a multicenter cohort study to assess differences i...
OBJECTIVES
To use the estimates from the Global Burden of
Disease Study 2016 to describe patterns of suicide
mortality globally, regionally, and for 195 countries
and territories by age, sex, and Socio-demographic
index, and to describe temporal trends between 1990
and 2016.
DESIGN
Systematic analysis.
MAIN OUTCOME MEASURES
Crude and age standardis...
Background:
Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised as global health priorities in view of the preventability of most injuries and the complex and expensive medical care they necessitate. We aimed to measure the incidence, prevalence, and years of life lived with disability (YLDs) for TBI and SCI from a...
Background: The number of individuals living with dementia is increasing, negatively affecting families, communities, and healthcare systems around the world. A successful response to these challenges requires an accurate understanding of the dementia disease burden. We aimed to present the first detailed analysis of the global prevalence, mortalit...
BACKGROUND: The number of individuals living with dementia is increasing, negatively affecting families, communities, and health-care systems around the world. A successful response to these challenges requires an accurate understanding of the dementia disease burden. We aimed to present the first detailed analysis of the global prevalence, mortali...
Background:
Uncontrolled hypertension is a major risk for major cardiovascular events. While medication adherence determines blood pressure (BP) control, studies on treatment adherence among apparently uncontrolled hypertensives are sorely lacking in sub-Saharan Africa. We report the pattern and correlate of medication adherence among the uncontro...
Background: Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes. Methods: The Global Burde...
Background
Lifetime stroke risk has been calculated in a limited number of selected populations. We determined lifetime risk of stroke globally and at the regional and country level.
Methods
Using Global Burden of Disease Study estimates of stroke incidence and the competing risks of non-stroke mortality, we estimated the cumulative lifetime risk...
Introduction
Stroke is a prominent cause of death, disability, and dementia in sub-Saharan Africa (SSA). The Stroke Investigative Research and Education Network works collaboratively with stroke survivors and individuals serving as community controls to comprehensively characterize the genomic, sociocultural, economic and behavioral risk factors fo...