Maykel Hernández-Mesa

Maykel Hernández-Mesa
University of Granada | UGR · Departamento de Química Analítica

PhD

About

40
Publications
7,755
Reads
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654
Citations
Citations since 2016
31 Research Items
619 Citations
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2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
Introduction
Maykel Hernández-Mesa currently works at the LABERCA - Laboratory of Food Contaminants and Residue Analysis, École Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique. Maykel does research in Green Chemistry, Analytical Chemistry, Food Chemistry and Environmental Chemistry.
Additional affiliations
August 2014 - December 2014
Italian National Research Council
Position
  • PhD Student
March 2012 - March 2016
University of Granada
Position
  • PhD Student

Publications

Publications (40)
Article
Full-text available
Steroids play key roles in various biological processes and are characterized by many isomeric variants, which makes their unambiguous identification challenging. Ion mobility-mass spectrometry (IM-MS) has been proposed as a suitable platform for this application, particularly using collision cross section (CCS) databases obtained from different co...
Article
This work evaluates the potential of ion mobility spectrometry (IMS) to improve the analytical performance of current liquid chromatography-mass spectrometry (LC-MS) workflows applied to the determination of ergot alkaloids (EAs) in cereal samples. Collision cross section (CCS) values for EA epimers are reported for the first time to contribute to...
Article
Full-text available
The major benefits of integrating ion mobility (IM) into LC–MS methods for small molecules are the additional separation dimension and especially the use of IM-derived collision cross sections ( CCS ) as an additional ion-specific identification parameter. Several large CCS databases are now available, but outliers in experimental interplatform IM-...
Preprint
Full-text available
Steroids play key roles in various biological processes and are characterized by many isomeric variants which makes their unambiguous identification challenging. Ion mobility-mass spectrometry (IM-MS) has been proposed as a suitable platform for this application, particularly using collision cross section (CCS) databases obtained from differ-ent co...
Article
Full-text available
The extensive use of pesticides represents a risk to human health. Consequently, legal frameworks have been established to ensure food safety, including control programs for pesticide residues. In this context, the performance of analytical methods acquires special relevance. Such methods are expected to be able to determine the largest number of c...
Chapter
There is growing interest in ion mobility spectrometry in the field of food analysis as a consequence of its hyphenation with mass spectrometry and increased commercialization of ion mobility-mass spectrometry instruments. In this regard, ion mobility spectrometry brings several advantages to traditional liquid chromatography-mass spectrometry work...
Article
Recent epidemiological studies show that current levels of exposure to polychlorinated biphenyls (PCBs) remain of great concern, as there is still a link between such exposures and the development of chronic environmental diseases. In this sense, most studies have focused on the health effects caused by exposure to dioxin-like PCBs (DL-PCBs), altho...
Article
Exposure to chemical hazards is a growing concern in today’s society, and it is of utmost interest to know the levels of exposure to chemicals and the risks associated with such exposure in order to implement effective health prevention strategies. Chemical risk analysis represents a complex and laborious task due to the large number of known subst...
Article
The global concern about food safety and environment quality has produced the development of a legal framework to control residues of organic compounds (e.g. pesticides and veterinary and human drugs). In this context, the establishment of analytical methods achieving satisfactory performances in terms of sensitivity, selectivity, resolution, ident...
Article
A wide range of Collision Cross Section (CCS) databases for different families of compounds have recently been established from Ion Mobility Mass Spectrometry (IM-MS) measurements. Nevertheless, the need to validate these new data sets in order to provide the necessary confidence about the use of this parameter is increasingly expressed by the scie...
Article
Collision cross section (CCS) databases based on single-laboratory measurements must be cross-validated to extend their use in peak annotation. This work addresses the validation of the first comprehensive TWCCSN2 database for steroids. First, its long-term robustness was evaluated (i.e. a year and a half after database generation; Synapt G2-S inst...
Article
This work proposes a novel Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) method in combination with ultra-high performance liquid chromatography-tandem mass spectrometry for the determination of sulfonylurea residues in edible seeds. The chromatographic separation of nine sulfonylureas was accomplished in less than 5.5 min, using a Lun...
Article
Full-text available
In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical separation technique, especially due to the commercialization of ion mobility mass spectrometers. Its applicability has been extended beyond classical applications such as the determination of chemical warfare agents and nowadays it is widely used for the characteriz...
Chapter
Forensic science is a strongly expanding research field and encompasses all the scientific disciplines that can be used to support law enforcement at any level. Just limiting the attention to the analytical aspect of forensic sciences, it involves an extremely wide application area that includes forensic toxicology, personal identification, analysi...
Article
Full-text available
In recent years, the commercialization of hybrid ion mobility-mass spectrometers and their integration in traditional LC-MS workflows provide new opportunities to extend the current boundaries of targeted and non-targeted analyses. When coupled to LC-MS, ion mobility spectrometry (IMS) provides a novel characterization parameter, the so-called aver...
Article
In the context of human and veterinary drugs identification, ion mobility spectrometry (IMS) in combination with mass spectrometry (MS) may provide a relevant complementary piece of information to mass-to-charge ratio (m/z), the so-called collision-cross-section (CCS). Up to now, however, the application of CCS as identification parameter has not b...
Article
A novel multiresidue method is proposed for the determination of 12 5-nitroimidazoles and their metabolites in fish roe samples using UHPLC-MS/MS. A salting-out assisted liquid-liquid extraction procedure was performed prior to sample analysis. The separation of compounds was accomplished using a C18 Zorbax Eclipse Plus column (50 mm × 2.1 mm, 1.8...
Chapter
Food safety is related to the monitoring of hazards in food to protect the consumer health. In order to guarantee safe and good-quality food and to meet international trade requirements, the development of selective, sensitive, and accurate analytical methods is mandatory for the control of a great number of toxicants, including chemical hazards. I...
Article
QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) methodology in combination with UHPLC-MS/MS is proposed for the determination of 5-nitroimidazole (5-NDZ) residues in infant milk-based products. Chromatographic separation was accomplished in a C18 Zorbax Eclipse Plus RRHD (50 × 2.1 mm, 1.8 μm) column under gradient elution conditions. Mobi...
Article
Ion mobility spectrometry enhances the performance characteristics of liquid chromatography-mass spectrometry workflows intended to steroid profiling by providing a new separation dimension and a novel characterization parameter, the so-called collision cross section (CCS). This work proposes the first CCS database for 300 steroids (i.e. endogenous...
Chapter
In this article capillary electrophoresis (CE) is presented as a well-established separation technique, applied in food analysis because of its advantages related with the high separation efficiency, short analysis time and low cost. Its applications in the field of food analysis cover the determination of major compounds such as proteins, carbohyd...
Article
Full-text available
Capillary liquid chromatography with UV detection is proposed for the determination of 5-nitroimidazole residues in aquaculture products. The separation was carried out in a C18 column at 20 °C, using a mobile phase consisting of water and acetonitrile, at 7 μL/min and 320 nm as detection wavelength. Furthermore, full loop injection mode (8 μL) was...
Article
A novel salting-out assisted liquid-liquid extraction (SALLE) method has been developed for the extraction of eight 5-NDZ antibiotics from milk samples prior to their analysis by UHPLC. An exhaustive study of the parameters involved in the SALLE procedure has been carried out, optimizing the extraction solvent volume, the amount of the salt agent,...
Article
Ion mobility spectrometry (IMS) has recently caught the attention of researchers from different fields including food safety. In general, IMS has been considered as analytical detection tool for the analysis of residues and contaminants in foodstuffs due to its high sensitivity, quick response and portability. However, IMS also provides an extra se...
Article
A novel capillary electrophoresis-tandem mass spectrometry approach is proposed for the determination of eleven 5-nitroimidazoles in urine samples for therapeutical drug monitoring purposes. A comparison between two separation modes, namely micellar electrokinetic chromatography and capillary zone electrophoresis was carried out, obtaining higher s...
Article
A novel method for the analysis of benzimidazole residues in water samples by capillary electrochromatography-UV detection (290 nm), using laboratory-made packed columns is presented. Capillaries (25 cm packed length×75 µm inner diameter, 34 cm total length, 25.5 cm effective capillary length) were packed with C18 particles (5 µm, non-encapped) fol...
Article
The simultaneous determination of usually employed anaesthetics (procaine, lidocaine and bupivacaine) has been developed and validated using capillary electrophoresis with ultraviolet detection at 212 nm. The separation of these three drugs has been achieved in less than 7 min, using a temperature of 25º C and 25 kV, with a 150 mM citrate buffer (p...
Article
The separation of eight antibiotics belonging to 5-nitroimidazole family was carried out by means of CEC coupled with MS. Preliminary experiments were carried out with ultraviolet detection in order to select the proper stationary and mobile phase. Among the different stationary phases studied (namely Lichrospher C18, 5 μm particle size; Cogent(TM)...
Article
Cation selective exhaustive injection and sweeping followed by a micellar electrokinetic chromatography separation is evaluated for the sensitive analysis of 5-nitroimidazoles in untreated human serum and urine. Deproteinized serum and urine samples were diluted 76 and 143 times, respectively, in a low conductivity solvent (5.00 mM orthophosphoric...
Article
A novel method consisting of cation-selective exhaustive injection and sweeping (CSEI-sweeping) as on-line preconcentration followed by a micellar electrokinetic chromatography (MEKC) separation has been developed for the determination of 5-nitroimidazoles (5-NDZ) in environmental waters. Moreover, dispersive liquid-liquid microextraction (DLLME) h...
Article
Dispersive liquid-liquid microextraction has been proposed as an extraction technique combined with MEKC for the analysis of eight 5-nitroimidazole compounds, including some metabolites, in water samples. Determination has been carried out using a diode array detector, employing 20 mM sodium phosphate and 150 mM SDS as the separation buffer. Separa...
Article
Full-text available
A method based on micellar electrokinetic chromatography (MEKC) with UV detection has been developed for the determination of nine 5-nitroimidazoles (5-NDZs), including metabolites in river water samples. Due to the relative insensitivity of UV detection in MEKC, a solid-phase extraction (SPE) method has been proposed that preconcentrates water sam...
Article
Full-text available
A method based on micellar electrokinetic chromatography (MEKC) with UV detection has been developed for the determination of nine 5-nitroimidazoles (5-NDZs), including metabolites in river water samples. Due to the relative insensitivity of UV detection in MEKC, a solid-phase extraction (SPE) method has been proposed that preconcentrates water sam...

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Projects (4)
Project
Goal: This Special Issue presents the latest advances in the analysis of drug metabolites in various fields, addressing the development of drugs for medical purposes, doping control, new drugs of abuse, etc. Within this framework, this Special Issue covers recent analytical methods focused on the determination of metabolites of pharmaceutical, abuse and/or performance-enhancing drugs in biological samples from in vitro or in vivo studies. The scope is broad, and the submission of research papers and reviews covering those analytical methods based, among others, on chromatographic and related separation techniques (e.g., capillary electrophoresis), mass spectrometry and hyphenated techniques (e.g., ion mobility spectrometry), spectroscopic techniques, or biosensors is encouraged. New sample preparation protocols are also of special interest, since the extraction of metabolites in complex biological samples is one of the main challenges of the metabolite analysis. Finally, this Special Issue also includes metabolomics approaches as a novel strategy to study the mode of action of drugs, which has an impact on the development of pharmacologically analogous drugs, or to discover the consumption of novel abuse drugs not previously reported, but showing an identical or similar mode of action of known abuse drugs. Deadline for manuscript submissions: 20 June 2022. More information on this Special Issue can be found at: https://www.mdpi.com/journal/separations/special_issues/trends_identifying_drug_metabolites
Project
This Special Issue is dedicated to introducing the latest trends and methodological advances in the field of food analysis, including, but not limited to, chromatographic and related separation techniques (e.g., capillary electrophoresis), mass spectrometry and hyphenated techniques (e.g., ion mobility spectrometry), spectroscopic techniques, sensors, etc., as well as sample preparation methods. The scope is broad and the submission of research papers and reviews covering the analysis of macronutrients and micronutrients in food is encouraged, with special interest in those methods aimed at detecting bioactive molecules or applying foodomics approaches. Targeted and non-targeted methods for the determination of residues, contaminants or additives in food are welcome. Finally, this Special Issue will also include new analytical strategies developed for food authentication purposes. Deadline for manuscript submissions: 19 March 2021. More information on this Special Issue can be found at: https://www.mdpi.com/journal/separations/special_issues/food_analytical
Project
Explore the possibilities of ion mobility (especially high-resolution ion mobility) coupled to mass spectrometry in the structural determination of natural carbohydrates.