Mayara Ingrid Sousa Lima

Objective To investigate the association between the FTO gene polymorphism with obesity in Brazilian adolescents from the Northeast region. Method This was a case‐control study with adolescents aged 18 to 19 years. The case group consisted of 378 obese individuals and the control group of 378 non‐obese individuals. Obesity was measured by percenta...

Diffuse cutaneous leishmaniasis (DCL) is a rare type of leishmaniasis characterized by diffuse skin lesions. In Brazil, Leishmania (L.) amazonensis is the main etiological agent of this clinical form. The state of Maranhão has the highest prevalence of this disease in the country, as well as a high rate of HIV infection. Here, we report the first c...

Phenolic glycolipid I (PGL-I) is an abundant antigen on the Mycobacterium leprae cell wall, commonly used for operational classification of leprosy patients. Our aim was to develop PGL-I mimotopes with similar characteristics and functions of the native antigen. We have used a random peptide phage display (PD) library for selections against the mon...

The first serum diagnosis of leprosy based on the detection of antibodies of patients using a recombinant mimetic peptide (PGL1M3R) as recognition element and exploiting a photoelectrochemical sensor is presented in this work. The photoeletrochemical platform consists of cadmium sulphide and nickel hydroxide electrodeposited on fluorine-doped tin o...

Objective: To investigate the association between the FTO gene polymorphism with obesity in Brazilian adolescents from the Northeast region. Method: This was a case-control study with adolescents aged 18-19 years. The case group consisted of 378 obese individuals and the control group of 378 non-obese individuals. Obesity was measured by percent...

Enzyme-linked immunosorbent assay values (absorbances at 492 nm) of anti-lipoarabinomannan (LAM) sIgA detection in patients at diagnosis, patients at MDT discharge, household contacts, and endemic controls. Median comparisons performed with the Kruskal–Wallis test.

Leprosy causes the most common peripheral neuropathy of infectious etiology, posing an important public health problem worldwide. Understanding the molecular and immunological mechanisms of nerve damage induced by M. leprae is mandatory to develop tools for early diagnosis and preventive measures. The phenolic glycolipid 1 (PGL-1) and lipoarabinoma...

Safety and biocompatibility assessment of biomaterials are themes of constant concern as advanced materials enter the market as well as products manufactured by new techniques emerge. Within this context, this review provides an up-to-date approach on current methods for the characterization and safety assessment of biomaterials and biomedical devi...

Two mimotopes of Leishmania infantum identified by phage display were evaluated as vaccine candidates in BALB/c mice against Leishmania amazonensis infection. The epitope-based immunogens, namely B10 and C01, presented as phage-fused peptides; were used without association of a Th1 adjuvant, and they were administered isolated or in combination int...

Background The development of cost-effective prophylactic strategies to prevent leishmaniasis has become a high-priority. The present study has used the phage display technology to identify new immunogens, which were evaluated as vaccines in the murine model of visceral leishmaniasis (VL). Epitope-based immunogens, represented by phage-fused peptid...

Visceral leishmaniasis (VL) is an endemic zoonotic disease in Brazil, where dogs are the main domestic parasite reservoirs, and percentages of infected dogs living in endemic canine VL (CVL) regions ranged from 10% to 62%. Despite technological advances, some problems have been reported in CVL serodiagnosis. The present study describes a sequential...

Leishmaniasis is caused by species of the protozoan parasite Leishmania. It is the third most important vector-borne disease and is widely distributed throughout the world. The World Health Organization recommends pentavalent antimonials as drugs of first choice in its treatment. Although Glucantime has traditionally been used to treat leishmaniasi...