Maya Frankfurt

Maya Frankfurt
Hofstra Northwell School of Nursing and Physician Assistant Studies · Science Education

Ph.D.

About

103
Publications
9,832
Reads
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8,197
Citations
Additional affiliations
September 2010 - April 2022
Hofstra Northwell School of Medicine
Position
  • Professor (Full)
March 2005 - August 2010
City College of New York
Position
  • Research Associate
January 1988 - August 1994
The Rockefeller University
Position
  • Professor (Assistant)
Education
January 1979 - June 1983
Icahn School of Medicine at Mount Sinai
Field of study
  • Neuroscience

Publications

Publications (103)
Article
Spatial memory, mediated primarily by the hippocampus, is responsible for orientation in space and retrieval of information regarding location of objects and places in an animal's environment. Since the hippocampus is dense with steroid hormone receptors and is capable of robust neuroplasticity, it is not surprising that changes in spatial memory p...
Article
Estrogen replacement has been repeatedly shown to enhance memory and increase dendritic spine density in the hippocampus and prefrontal cortex of ovariectomized (OVX) female rats. Given the potential deleterious effects of chronic estrogen administration, the present study assessed cognitive function using recognition memory tasks and measured dend...
Article
Cardiac arrest (CA) produces global ischemia/reperfusion injury resulting in substantial multiorgan damage. There are limited efficacious therapies to save lives despite CA being such a lethal disease process. The small population of surviving patients suffer extensive brain damage that results in substantial morbidity. Mitochondrial dysfunction in...
Preprint
Full-text available
Cardiac arrest (CA) produces global ischemia/reperfusion injury resulting in substantial multiorgan damage. There are limited efficacious therapies to save lives despite CA being such a lethal disease process. Surviving patients suffer extensive brain damage with mitochondrial dysfunction implicated as a major source of injury. Metformin, a first-l...
Chapter
Developmental exposure to Bisphenol A (BPA), an endocrine disrupting chemical, alters many behaviors and neural parameters in rodents and non-human-primates. The effects of BPA are mediated via gonadal hormone, primarily, estrogen receptors, and are not limited to the perinatal period since recent studies show impairments further into development....
Chapter
This chapter reviews the relationship between estrogens, memory, and dendritic spine plasticity. Estrogens, given systemically or directly into the hippocampus, enhance memory consolidation in object recognition and object placement tasks within minutes of application. Dendritic spine density in the CA1 area of the hippocampus and medial prefrontal...
Article
This review highlights fifty years of progress in research on estradiol's role in regulating behavior(s). It was initially thought that estradiol was only involved in regulating estrus/menstrual cycles and concomitant sexual behavior, but it is now clear that estradiol also influences the higher order neural function of cognition. We provide a brie...
Article
Alzheimer's disease and other forms of cognitive decline are significantly more prevalent in post-menopausal women. Decreased estrogen levels, due to menopause or ovariectomy, may contribute to memory impairments and neurodegeneration. Another result of decreased estrogen levels is elevated luteinizing hormone (LH). Elevated LH after menopause/ovar...
Article
The endocrine disruptor, Bisphenol-A (BPA), alters many behavioral and neural parameters in rodents. BPA administration to gonadally intact adolescent rats increases anxiety, impairs spatial memory, and decreases dendritic spine density when measured in adulthood. Since BPA's action seems to be mediated through gonadal steroid receptors, the curren...
Article
Neurons of the medullary reticular nucleus gigantocellularis (NGC) and their targets have recently been a focus of research on mechanisms supporting generalized CNS arousal (GA) required for proper cognitive functions. Using the retro-TRAP method, we characterized transcripts enriched in NGC neurons which have projections to the thalamus. The uniqu...
Article
Rapid, neurosteroid-like effects of estrogens on memory consolidation during recognition memory tasks in both male and female rodents are described. We discuss how these mnemonic changes are related to rapid estrogenic effects on dendritic spine density, the distribution of spine types and the expression of PSD95 and GluA2 within spines in the hipp...
Chapter
Prenatal cocaine exposure has profound consequences on neurobehavioral parameters, which persist into adulthood. The underlying mechanisms for cocaine’s immediate and long-term effects, although not completely understood, appear to involve plasticity of specific neural circuits. Both dendritic spine turnover and glutamatergic neurotransmission are...
Article
Full-text available
Long-term sepsis survivors sustain cryptic brain injury that leads to cognitive impairment, emotional imbalance, and increased disability burden. Suitable animal models of sepsis, such as cecal ligation and puncture (CLP), have permitted the analysis of abnormal brain circuits that underlie post-septic behavioral phenotypes. For instance, we have p...
Article
17β-Estradiol (E2) rapidly, within minutes, activates behaviors and cognition by binding to membrane estrogen receptors (ERs), activating cell signaling cascades and increasing dendritic spines. In female rodents, E2 enhancesspatial memory within 2-4 h, and spine density is increased in the CA1 area of the hippocampus within 30-60 min. While chroni...
Article
Unlabelled: Dendritic spine plasticity underlies the formation and maintenance of memories. Both natural fluctuations and systemic administration of 17β-estradiol (E2) alter spine density in the dorsal hippocampus (DH) of rodents. DH E2 infusion enhances hippocampal-dependent memory by rapidly activating extracellular signal-regulated kinase (ERK)...
Article
Full-text available
Cocaine addiction has been associated with changes in synaptic plasticity, mediated in part by neurotrophin cascades. Given sex differences in cocaine addiction, we wanted to assess whether estradiol alters signaling of the brain-derived neurotrophic factor (BDNF), through interaction with its cognate receptor, tyrosine kinase B (Trk B), after repe...
Article
Full-text available
There is a growing awareness of the chronic brain injury that results from the sepsis syndrome. We review experiments in several animal models of sepsis and show in one model, cecal ligation and puncture (CLP), that permanent structural pathology matures after the initial event. Specifically, we observed after exposure to CLP significant decreased...
Article
Full-text available
Memory processing is presumed to depend on synaptic plasticity, which appears to have a role in mediating the acquisition, consolidation, and retention of memory. We have studied the relationship between estrogen, recognition memory, and dendritic spine density in the hippocampus and medial prefrontal cortex, areas critical for memory, across the l...
Article
We have previously demonstrated that adolescent exposure of rats to bisphenol-A (BPA), an environmental endocrine disrupter, increases anxiety, impairs spatial memory, and decreases dendritic spine density in the CA1 region of the hippocampus (CA1) and medial prefrontal cortex (mPFC) when measured in adolescence in both sexes. The present study exa...
Article
Bisphenol-A (BPA), a common environmental endocrine disruptor, modulates estrogenic, androgenic, and anti-androgenic effects throughout the lifespan. We recently showed that low dose BPA exposure during adolescence increases anxiety and impairs spatial memory independent of sex. In the current study, six week old Sprague Dawley rats (n=24 males, n=...
Article
Full-text available
Expression of A53T mutant human alpha-synuclein under the mouse prion promoter is among the most successful transgenic models of Parkinson's disease. Accumulation of A53T alpha-synuclein causes adult mice to develop severe motor impairment resulting in early death at 8-12 months of age. In younger, pre-symptomatic animals, altered motor activity an...
Data
NET distribution and function. Expression and distribution of NET in the hippocampus was analyzed by immunoblot on protein from (A) total lysates (TL) or synaptosomal plasma membrane fractions (SPM). Actin or cadherin expression, respectively, were analyzed as loading controls. Representative blot images from each genotype at each age are presented...
Data
Motor activity. OFT, EPM, and rotarod tests were performed on WT and A53T mice at 2-12 months of age (n = 14–18 per group) to analyze motor activity and function. (A) Total line breaks (transition between any two regions) on the OFT and (B) total distance traveled on the EPM were measured over a ten min period by automated video tracking using ANY-...
Data
Synuclein accumulation and aggregation in the hippocampus. (A) Expression of Syn proteins was analyzed by immunoblot on hippocampal total lysates with actin expression analyzed as a loading control. (B) Band optical density (OD) relative to actin is presented as percent of two month old A53T mice (A53T human α-Syn) or two month old WT (total α-Syn...
Data
Hippocampal accumulation of PHF-1 Tau and Tau kinase activation. (A) Phosphorylation of Tau protein at the PHF-1 epitope, expression of Tau kinases, and phosphorylation of kinases at activating sites was analyzed by immunoblot on hippocampal total lysates. (B) Band optical density (OD) relative to appropriate loading controls is presented as percen...
Data
Anxiety-like behavior. Anxiety-like behavior was analyzed by the OFT and EPM on WT and A53T mice at 2-12 months of age (n = 14-18 per group). (A) Total center zone entries on the OFT and (B) total open arm entries on the EPM were measured by automated video tracking using ANY-maze software. Results are presented as mean ± SEM and were analyzed by t...
Article
Full-text available
The letter from Dal-Pizzol et al.(1) addresses the question of brain cell activation in sepsis survivors. The data demonstrate that RAGE (receptor for advanced glycation end products) expression in the hippocampus and in the prefrontal cortex is significantly increased 4 wks after septic insult. This is an interesting observation because it indicat...
Article
Several lines of evidence have converged to indicate that memory formation involves plasticity of dendritic spines in the medial prefrontal cortex (PFC) and the hippocampus. Memory varies with estrogen levels throughout the lifespan of the female. Generally, increased levels of estrogen are related to greater dendritic spine density on pyramidal ce...
Article
Full-text available
PTI-125 is a novel compound demonstrating a promising new approach to treating Alzheimer's disease (AD), characterized by neurodegeneration and amyloid plaque and neurofibrillary pathologies. We show that the toxic signaling of amyloid-β(42) (Aβ(42)) by the α7-nicotinic acetylcholine receptor (α7nAChR), which results in tau phosphorylation and form...
Article
Full-text available
Severe sepsis, a syndrome that complicates infection and injury, affects 750,000 annually in the United States. The acute mortality rate is approximately 30%, but, strikingly, sepsis survivors have a significant disability burden: up to 25% of survivors are cognitively and physically impaired. To investigate the mechanisms underlying persistent cog...
Article
Full-text available
Acute effects of bisphenol (BPA), an environmental chemical, on estradiol (17α or β-E2)-dependent recognition memory and dendritic spines in the medial prefrontal cortex and hippocampus were investigated in adult female rats. Ovariectomized rats received BPA 30 min before or immediately after a sample trial (viewing objects), and retention trials w...
Article
Reports an error in "Bisphenol-A impairs memory and reduces dendritic spine density in adult male rats" by Tehila Eilam-Stock, Peter Serrano, Maya Frankfurt and Victoria Luine (Behavioral Neuroscience, Advanced Online Publication, Oct 17, 2011, np). The Online First version of the article contained several production-related errors. In the second p...
Article
Full-text available
Exposure to Bisphenol-A (BPA), an endocrine disruptor used in plastics, occurs in the United States on a daily basis. Recent studies suggest exposure during development causes memory deficits later in life; however, the ramifications of exposure in adulthood are unclear. We examined the effects of acute BPA administration (40 μg/kg) on memory and s...
Article
Cocaine use during pregnancy induces profound neural and behavioral deficits in both mother and offspring. The present study was designed to compare the effects of cocaine exposure on spine density of postpartum and virgin female rat brains. Timed, pregnant, primiparous rats were injected with either cocaine (30 mg/kg) or saline, once daily, from g...
Article
Full-text available
Effects of aging on memory and brain morphology were examined in aged, 21-month-old, and young, 4-month-old, Fischer 344 female rats. Spatial memory was assessed using the object placement task, and dendritic spine density was determined on pyramidal neurons in the hippocampus following Golgi impregnation. Consistent with previous studies, aged fem...
Article
Cocaine exposure during pregnancy can impact brain development and have long-term behavioral consequences. The present study examined the lasting consequences of prenatal cocaine (PN-COC) exposure on the performance of cognitive tasks and dendritic spine density in adult male and female rats. From gestational day 8 to 20, dams were treated daily wi...
Article
Beta-amyloid (Abeta) enables Alzheimer's disease (AD) plaque and neurofibrillary pathogenesis. Soluble Abeta promotes intraneuronal Abeta aggregates and tau phosphorylation by interacting with alpha7 nicotinic receptors (alpha7nAChRs). The current study assessed whether the novel alpha7nAChR partial agonist 2-(2-(4-bromophenyl)-2-oxoethyl)-1-methyl...
Article
Full-text available
Alterations in dendritic spine density following prenatal cocaine exposure were examined in the present study. Timed pregnant rats were injected daily with 30 mg/kg cocaine or saline during gestation. At postnatal day 21, male and female animals were separated and spine density was assessed following Golgi impregnation. In prenatal cocaine-exposed...
Article
Full-text available
We report an ex-vivo study on Raman spectra of adipose tissue covered by layers of aortic intimal wall tissue with different thicknesses. The Raman vibration modes of 1435cm-1, 2850cm-1 and 2892cm-1 were investigated for the first time on fresh porcine aortic adipose tissue with 633 nm laser excitation. The adipose tissue was taken from adventitial...
Article
Full-text available
Ultra-low-dose opioid antagonists enhance opioid analgesia and reduce analgesic tolerance and dependence by preventing a G protein coupling switch (Gi/o to Gs) by the mu opioid receptor (MOR), although the binding site of such ultra-low-dose opioid antagonists was previously unknown. Here we show that with approximately 200-fold higher affinity tha...
Article
Full-text available
Cognitive responses to stress follow the temporally dependent pattern originally established by Selye (1) wherein short-term stressors elicit adaptive responses whereas continued stress (chronic) results in maladaptive changes--deleterious effects on physiological systems and impaired cognition. However, this pattern for cognitive effects appears t...
Article
Females have been demonstrated repeatedly to be more sensitive to cocaine. The role of the frontal cortex (FCX) in mediating behavioral sensitization and the underlying signaling pathways are unclear. The study was designed to characterize the role of FCX calcium/calmodulin-dependent protein kinase II (CaMKII) activity in the behavioral supersensit...
Article
Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spines in aged rats were 16% lower i...
Article
Long-term maintenance of ovariectomized rats (9 weeks) on chow containing high phytoestrogen levels (Purina LabDiet 5001) as compared to chow with minimal phytoestrogens (Harlan 2016 Teklad) was associated with better performance of the spatial memory task, object placement, increased dendritic spine density in CA1 and prefrontal cortex pyramidal n...
Article
Effects of ovariectomy (OVX) on performance of the memory tasks, Object Recognition (OR) and Object Placement (OP), and on dendritic spine density in pyramidal neurons in layer II/III of the prefrontal cortex and the CA1 and CA3 regions of the hippocampus were determined. OVX was associated with a significant decline in performance of the memory ta...
Article
Full-text available
Exposure to stress during gestation results in physiological and behavioral alterations that persist into adulthood. This study examined the effects of prenatal stress on the postnatal expression of sexually differentiated cognitive, hormonal, and neurochemical profiles in male and female rats. Pregnant dams were subjected to restraint stress three...
Article
Atrophy and dysfunction of the human hippocampus is a feature of aging in some individuals, and this dysfunction predicts later dementia. There is reason to believe that adrenal glucocorticoids may contribute to these changes, since the elevations of glucocorticoids in Cushing's syndrome and during normal aging are associated with atrophy of the en...
Article
Full-text available
Tianeptine is an atypical tricyclic antidepressant that facilitates serotonin (5-HT) reuptake. Tianeptine (10 mg/kg) or saline was administered intraperitoneally to male rats daily for 4 days. Monoamine levels were measured in micropunches of discrete brain nuclei that are implicated in mood and cognition. In addition, the rates of 5-HT and norepin...
Article
Full-text available
Treatment of male rats at birth with an aromatase inhibitor (Letrazole), followed by adult gonadectomy GDX, led to an increase in dendritic spine density on ventromedial hypothalamic neurons (VMN) when treated with estrogen as compared to a decrease when vehicle animals were given estrogen. In contrast, estrogen-treatment increased dendritic spine...
Article
In this chapter, recent studies on gonadal steroid-induced neural plasticity in the adult rat hypothalamus have been described. Neurons in the VMN and DMN are capable of rapid, reversible structural alterations in response to a changing hormonal environment. Given the importance of the VMN in mediating lordosis in female rats, the present studies s...
Article
In the rat hippocampus, neuronal morphology and survival are profoundly affected by adrenal steroids, and synaptic plasticity can be modulated by the ovarian sex steroids estrogen and progesterone. beta-amyloid peptides, which accumulate in neuritic plaques and are derived from the amyloid precursor protein (APP), have been shown to be both trophic...
Article
In the rat hippocampus, neuronal morphology and survival are profoundly affected by adrenal steroids, and synaptic plasticity can be modulated by the ovarian sex steroids estrogen and progesterone, β-amyloid peptides, which accumulate in neuritic plaques and are derived from the amyloid precursor protein (APR), have been shown to be both trophic an...
Article
The effects of short-term fluoxetine administration on monoamine levels and turnover were assessed in discrete brain nuclei. Adult male rats received fluoxetine HCl (10 mg/kg) or saline injections intraperitoneally for 4 days and monoamine levels determined by high performance liquid chromatography. The major metabolite of 5-HT, 5-hydroxyindoleacet...
Article
Full-text available
Quantitative autoradiography was used to assess alterations in serotonin (5-HT) receptor binding in the hypothalamus and hippocampus following denervation with 5,7-dihydroxytryptamine (5,7-DHT), ovariectomy (OVX) and gonadal steroid manipulation. Seven days after 5,7-DHT injection, 5-HT1a receptor density was significantly increased in the ventrome...
Article
Full-text available
Quantitative autoradiography was used to determine the effect of acute serotonergic denervation with 5,7-dihydroxytryptamine (5,7-DHT) or serotonin 5HT1a and 5-HT1b receptors in male rats. Seven days after intrahypothalamic 5,7-DHT injection there was a significant increase in the density of 5HT1a receptors in the ventromedial and dorsomedial hypot...
Article
Full-text available
The role of 5-HT (serotonin) in regulating lordosis was investigated by combining peripheral administration of the 5-HT agonists 8-OH-DPAT (8-hydroxy-2-[di-N-propylamino]tetralin) or TFMPP (1-[m-trifluoromethylphenyl]piperazine), with intrahypothalamic application of the 5-HT neurotoxin 5,7-DHT (5,7-dihydroxytryptamine). The 5-HT1A agonist, 8-OH-DP...
Article
Full-text available
THE role of 5-HT (serotonin) in regulating lordosis was investigated by combining peripheral administration of the 5-HT agonists 8-OH-DPAT (8-hydroxy-2-[di-N-propylamino]tetralin) or TFMPP (1-[m-trifluoromethylphenyl] piperazine), with intrahypothalamic application of the 5-HT neurotoxin 5,7-DHT (5,7-dihydroxytryptamine). The 5-HT1A agonist, 8-OH-D...
Article
Full-text available
Golgi impregnation was used to examine changes in dendritic spine density in the ventromedial hypothalmic nucleus (VMN) of intact and gonadectomized (GDX) rats treated with 5,7-dihydroxytryptamine (5,7-DHT) and/or estrogen. In intact rats of both sexes 5,7-DHT injection resulted in a large increase in dendritic spine density in the VMN. The combina...