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This preclinical study on two data sets looks at the local tumor heterogeneity by analyzing information from three techniques: Dynamic Contrast-Enhanced Ultrasound (DCE-US); Immunohistochemistry (IHC) and Quantitative Ultrasound, (QUS). The first data set included DCE-US sequences and whole slice IHC data acquired 14 days after the start of an anti...
Objectives The impact of recirculation on the quantification of perfusion is often neglected. It can however introduce a bias or some variability in the estimation of perfusion parameters and thus hamper comparison between exams. Methods Time-intensity curves (TICs) were simulated using a one-compartment model fed by an arterial input function (AI...
Dynamic Contrast Enhanced Ultrasound has been proposed to monitor tumor therapy, in complement to volume measurements. To assess the variability of perfusion parameters in ideal conditions, four consecutive test-retest studies were acquired in a tumor model of mouse, using controlled injections. The impact of mathematical modeling on parameter vari...