Maxime Descoteaux

Maxime Descoteaux
Université de Sherbrooke | UdeS · Department of Computer Science

PhD

About

424
Publications
96,646
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11,657
Citations
Citations since 2017
217 Research Items
8130 Citations
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201720182019202020212022202305001,0001,500
Introduction
My work focuses on brain connectivity from state-of-the-art diffusion MRI acquisition, reconstruction, processing & visualization. The aim of my work is to better understand anatomical connectivity between cortical regions and characterize white matter integrity.
Additional affiliations

Publications

Publications (424)
Preprint
Full-text available
Since 2015, research groups seek to produce the nec-plus-ultra tractography algorithms using the ISMRM 2015 Tractography Challenge as evaluation. In particular, since 2017, machine learning has made its entrance into the tractography world. The ISMRM 2015 Tractography Challenge is the most used phantom during tractography validation, although it co...
Article
The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS‐ND) cohort of the pan‐Canadian Consortium on Neurodegeneration in Aging (CCNA) provides imaging on participants following a standardized protocol. This imaging contribution to deep phenotyping is done to study the full spectrum of age‐related dementias in more than 1,100 indivi...
Preprint
Full-text available
Numerous filtering methods have been proposed for estimating asymmetric orientation distribution functions (ODFs) for diffusion magnetic resonance imaging (dMRI). It can be hard to make sense of all these different methods, which share similar features and result in similar outputs. Furthermore, these methods are not readily available as part of a...
Preprint
Full-text available
White matter bundle segmentation is a cornerstone of modern tractography to study the brain's structural connectivity in domains such as neurological disorders, neurosurgery, and aging. In this study, we present FIESTA (FIbEr Segmentation in Tractography using Autoencoders), a reliable and robust, fully automated, and easily semi-automatically cali...
Chapter
Clustering Tractographytractography streamlines is an important step to characterize the brain White matterwhite matter structural connectivity. Numerous methods have been proposed to group whole-brain tractography streamlines into anatomically coherent bundles. However, the time complexity, or the initial streamline sorting in conventional methods...
Preprint
Full-text available
Assessing the consistency of quantitative MRI measurements is critical for inclusion in longitudinal studies and clinical trials. Intraclass coefficient correlation and coefficient of variation were used to evaluate the different consistency aspects of diffusion- and myelinbased MRI measures. Multi-shell diffusion and inhomogeneous magnetization tr...
Article
While higher levels of Aβ and tau pathology are typically associated with more pronounced cognitive decline in Alzheimer’s disease (AD), some older adults exhibit normal cognition even with a substantial burden of AD pathology. This phenomenon is known as ‘cognitive resilience’. The potential role of structural connectivity in cognitive resilience...
Article
Full-text available
TractoInferno is the world’s largest open-source multi-site tractography database, including both research- and clinical-like human acquisitions, aimed specifically at machine learning tractography approaches and related ML algorithms. It provides 284 samples acquired from 3 T scanners across 6 different sites. Available data includes T1-weighted i...
Article
Full-text available
Background: Fatigue and cognitive complaints are the most frequent persistent symptoms in patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to assess fatigue and neuropsychological performance and investigate changes in the thickness and volume of gray matter (GM) and microstructural abnormaliti...
Article
The apparent increase in the prevalence of the attention deficit hyperactivity disorder (ADHD) diagnosis raises many questions regarding the variability of the subjective diagnostic method. This comprehensive review reports findings in studies assessing white matter (WM) bundles in diffusion MRI and symptom severity in children with ADHD. These stu...
Article
Full-text available
Medial temporal structures, namely the hippocampus, the entorhinal cortex and the parahippocampal gyrus, are particularly vulnerable to Alzheimer’s disease and hypoxemia. Here, we tested the associations between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes in 114 participants aged 55–86 years (35 % women). We also investi...
Preprint
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The value of preclinical diffusion MRI (dMRI) is substantial. While dMRI enables in vivo non-invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity. Ex vivo dMRI has several experimental advantages including higher signal-to-noise ratio and spatial resolution compared to in...
Preprint
Full-text available
The value of in vivo preclinical diffusion MRI (dMRI) is substantial. Small-animal dMRI has been used for methodological development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. Many of the influential works in this field were first performed in small animals or ex vivo samples. The steps from...
Article
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The physical and clinical constraints surrounding diffusion-weighted imaging (DWI) often limit the spatial resolution of the produced images to voxels up to eight times larger than those of T1w images. The detailed information contained in accessible high-resolution T1w images could help in the synthesis of diffusion images with a greater level of...
Preprint
Full-text available
Objectives The aim of this study was to characterize the sensory responses observed when stimulating electrically the white matter surrounding the posterior insular point. Methods We reviewed patients operated on under awake conditions for a glioma located in the vicinity of the posterior insular point. Patients’ reports of perceived sensations un...
Article
Full-text available
Modern tractography algorithms such as anatomically-constrained tractography (ACT) are based on segmentation maps of white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). These maps are generally estimated from a T1-weighted (T1w) image and then registered in diffusion weighted images (DWI) space. Registration of T1w to diffusion spac...
Preprint
Full-text available
This study aimed to characterize the sensory responses observed when stimulating electrically the white matter surrounding the posterior insular point. We thus reviewed patients operated on under awake conditions for a glioma located in the temporo-parietal junction. Patients’ perceptions under electrical stimulation were retrieved from operating r...
Article
Full-text available
The human brain is a complex system that can be efficiently represented as a network of structural connectivity. Many imaging studies would benefit from such network information, which is not always available. In this work, we present a whole-brain multi-scale structural connectome atlas. This tool has been derived from a cohort of 66 healthy subje...
Preprint
Full-text available
Background Fatigue and cognitive complaints are the most frequent persistent symptoms in patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This study aimed to assess fatigue and neuropsychological performance and investigate changes in the thickness and volume of gray matter (GM) and microstructural abnormalitie...
Article
Full-text available
The angular gyrus (AG) has been described in numerous studies to be consistently activated in various functional tasks. The angular gyrus is a critical connector epicenter linking multiple functional networks due to its location in the posterior part of the inferior parietal cortex, namely at the junction between the parietal, temporal, and occipit...
Article
Full-text available
Efficient communication across fields of research is challenging, especially when they are at opposite ends of the physical and digital spectrum. Neuroanatomy and neuroimaging may seem close to each other. When neuroimaging studies try to isolate structures of interest, according to a specific anatomical definition, a variety of challenges emerge....
Preprint
Full-text available
Sleep spindles (SS) are crucial to brain functions like memory and learning. SS characteristics result from the propagation of nerve impulses along white matter (WM) projections underlying an intricate loop between the thalamus and the cortex. SS amplitude and density have been associated with WM diffusion microarchitecture but physiological mechan...
Article
Diffusion tensor imaging (DTI) is widely used to extract valuable tissue measurements and white matter (WM) fiber orientations, even though its lack of specificity is now well-known, especially for WM fiber crossings. Models such as constrained spherical deconvolution (CSD) take advantage of high angular resolution diffusion imaging (HARDI) data to...
Preprint
Full-text available
Current tractography methods use the local orientation information to propagate streamlines from seed locations. Many such seeds provide streamlines that stop prematurely or fail to map the true pathways because some white matter bundles are "harder-to-track" than others. This results in tractography reconstructions with poor white and gray matter...
Article
Full-text available
Brain injury and dysmaturation is common in fetuses and neonates with congenital heart disease (CHD) and is hypothesized to result in persistent myelination deficits. This study aimed to quantify and compare myelin content in vivo between youth born with CHD and healthy controls. Youth aged 16 to 24 years born with CHD and healthy age- and sex-matc...
Article
Ketones, the brain's alternative fuel to glucose, bypass the brain glucose deficit and improve cognition in mild cognitive impairment (MCI). Our goal was to assess the impact of a 6-month ketogenic intervention on the functional connectivity within eight major brain resting-state networks, and its possible relationship to improved cognitive outcome...
Preprint
Full-text available
The angular gyrus (AG) has been described in numerous studies to be consistently activated in various functional tasks. The angular gyrus is a critical connector epicenter linking multiple functional networks regarding its location in the posterior part of the inferior parietal cortex, namely at the junction between the parietal, temporal, and occi...
Article
Full-text available
OBJECTIVE The aim of this study was to predict set-shifting deterioration after resection of low-grade glioma. METHODS The authors retrospectively analyzed a bicentric series of 102 patients who underwent surgery for low-grade glioma. The difference between the completion times of the Trail Making Test parts B and A (TMT B-A) was evaluated preoper...
Preprint
Full-text available
Efficient communication across fields of research is challenging, especially when they are at opposite ends of the physical and digital spectrum. Neuroanatomy and neuroimaging may seem close to each other, but the terminology and processes to study the brain can be very different. More specifically, investigations of white matter anatomy are suscep...
Article
Full-text available
The segmentation of brain structures is a key component of many neuroimaging studies. Consistent anatomical definitions are crucial to ensure consensus on the position and shape of brain structures, but segmentations are prone to variation in their interpretation and execution. White‐matter (WM) pathways are global structures of the brain defined b...
Article
Full-text available
Virtual dissection of white matter (WM) using diffusion MRI tractography is confounded by its poor reproducibility. Despite the increased adoption of advanced reconstruction models, early region-of-interest driven protocols based on diffusion tensor imaging (DTI) remain the dominant reference for virtual dissection protocols. Here we bridge this ga...
Article
Purpose: Mapping brain white matter (WM) is essential for building an understanding of brain anatomy and function. Tractography-based methods derived from diffusion-weighted MRI (dMRI) are the principal tools for investigating WM. These procedures rely on time-consuming dMRI acquisitions that may not always be available, especially for legacy or t...
Article
Full-text available
Characterizing and understanding the limitations of diffusion MRI fiber tractography is a prerequisite for methodological advances and innovations which will allow these techniques to accurately map the connections of the human brain. The so-called "crossing fiber problem" has received tremendous attention and has continuously triggered the communi...
Article
Combining MRI modalities is a growing trend in neurosciences. It provides opportunities to investigate the brain architecture supporting cognitive functions. Integrating fMRI activation to guide dMRI tractography offers potential advantages over standard tractography methods. A quick glimpse of the literature on this topic reveals that this techniq...
Article
The capacity of ketones to improve cognition in mild cognitive impairment (MCI) may depend on ApoE4 status. In the BENEFIC RCT (NCT02551419), improvement in three cognitive domains was directly related to ketones from medium chain triglyceride (kMCT) improving global brain energy status. Post‐kMCT, ketone uptake increased 2.9‐fold in total white ma...
Article
Recent studies have suggested that obstructive sleep apnea (OSA) could be a modifiable risk factor for dementia. Consequently, efforts have been made to better understand the role of OSA on brain structure integrity, but results between studies are inconsistent. Discrepancies could be partly due to moderating factors (e.g., sex) or complex physiolo...
Article
Full-text available
Ketones, the brain’s alternative fuel to glucose, bypass the brain glucose deficit in mild cognitive impairment (MCI). The BENEFIC trial conducted in MCI showed improved measures of cognition in multiple domains after a 6‐month ketogenic intervention [Fortier et al. 2019]. Functional connectivity in the dorsal‐attention network (DAN) deteriorates e...
Preprint
Full-text available
TractoInferno is the world's largest open-source multi-site tractography database, including both research- and clinical-like human acquisitions, aimed specifically at machine learning tractography approaches and related ML algorithms. It provides 284 datasets acquired from 3T scanners across 6 different sites. Available data includes T1-weighted i...
Preprint
Full-text available
The validation of advanced methods in diffusion MRI requires finer acquisition resolutions, which is hard to acquire with decent Signal-to-Noise Ratio (SNR) in humans. The use of Non-Human Primates (NHP) and anaesthesia is key to unlock valid microstructural maps, but tools must be adapted and configured finely for them to work well. Here, we propo...
Article
Full-text available
Introduction: White matter (WM) energy supply is crucial for axonal function and myelin maintenance. An exogenous source of ketones, the brain's alternative fuel to glucose, bypasses the brain's glucose-specific energy deficit and improves cognitive outcomes in mild cognitive impairment (MCI). How an additional supply of ketones affects glucose or...
Preprint
Full-text available
Virtual dissection of white matter (WM) using diffusion MRI tractography is confounded by its poor reproducibility. Despite the increased adoption of advanced reconstruction models, early region-of-interest driven protocols based on diffusion tensor imaging (DTI) remain the dominant reference for virtual dissection protocols. Here we bridge this ga...
Chapter
Diffusion-weighted magnetic resonance imaging is a technique aimed at measuring the displacement of water molecules inside biological tissues. From High Angular Resolution Diffusion Imaging acquisitions, it is possible to reconstruct fiber orientation distribution functions (fODF) describing the apparent quantity of white matter fibers going throug...
Article
Full-text available
In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 par...
Article
Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. Th...
Article
Full-text available
Objective To characterize microstructural white matter changes related to relapsing-remitting multiple sclerosis using advanced diffusion MRI modeling and tractography. The association between imaging data and patient’s cognitive performance, fatigue severity and depressive symptoms is also explored. Methods In this cross-sectional study, 24 relap...
Preprint
Full-text available
The physical and clinical constraints surrounding diffusion-weighted imaging (DWI) often limit the spatial resolution of the produced images to voxels up to 8 times larger than those of T1w images. Thus, the detailed information contained in T1w images could help in the synthesis of diffusion images in higher resolution. However, the non-Euclidean...
Article
Full-text available
Operculo-insular epilepsy (OIE) is an under-recognized condition that can mimic temporal and extratemporal epilepsies. Previous studies have revealed structural connectivity changes in the epileptic network of focal epilepsy. However, most reports use the debated streamline-count to quantify ‘connectivity strength’ and rely on standard tracking alg...
Article
Full-text available
Background The visualization and analysis of brain data such as white matter diffusion tractography and magnetic resonance imaging (MRI) volumes is commonly used by neuro-specialist and researchers to help the understanding of brain structure, functionality and connectivity. As mobile devices are widely used among users and their technology shows a...
Article
Full-text available
Brain atlases have proven to be valuable neuroscience tools for localizing regions of interest and performing statistical inferences on populations. Although many human brain atlases exist, most do not contain information about white matter structures, often neglecting them completely or labelling all white matter as a single homogenous substrate....
Article
Purpose Diffusion-weighted imaging allows investigators to identify structural, microstructural, and connectivity-based differences between subjects, but variability due to session and scanner biases is a challenge. Methods To investigate DWI variability, we present MASiVar, a multisite data set consisting of 319 diffusion scans acquired at 3 T fr...
Preprint
Full-text available
Characterizing and understanding the limitations of diffusion MRI fiber tractography is a prerequisite for methodological advances and innovations which will allow these techniques to accurately map the connections of the human brain. The so-called "crossing fiber problem" has received tremendous attention and has continuously triggered the communi...
Article
Full-text available
In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However, such methods report voxel-wise estimates, which vary from voxel-to-voxel for the same white...
Cover Page
Cover image of JMRI Volume 53, Issue 6, June 2021. DOI of the article: 10.1002/jmri.27188. Image caption: The effects of the misalignment between image‐intensity‐based tissue segmentation and brain parcellation on the assignment of streamlines to network nodes: Upper panel: (a) With the application of anatomical constraints (e.g., Ref. 35), streaml...
Article
Full-text available
Current brain white matter fiber tracking techniques show a number of problems, including: generating large proportions of streamlines that do not accurately describe the underlying anatomy; extracting streamlines that are not supported by the underlying diffusion signal; and under-representing some fiber populations, among others. In this paper, w...
Article
Background: Mapping diffusion MRI tractography streamlines to the cortical surface facilitates the integration of white matter features onto gray matter, especially for connectivity analysis. Method: In this work, we present methods that combine cortical surface meshes with tractography reconstruction to improve endpoint precision and coverage. Th...
Conference Paper
Full-text available
Tractography involves complicated processing and connectomics include even more complexity. To facilitate structural connectome reconstructionwe present: Connectoflow. Connectoflow requires simple inputs, has simple options and provides simple outputs, all with cutting-edge processing.By leveraging the simplicity of Nextflow and Docker/Singularity,...
Conference Paper
Full-text available
The validation of advanced diffusion MRI methods requires acquisition at high-resolution and high SNR, which is difficult to obtain in humans. The use of anesthetized Non-Human Primates (NHPs) is key to unlocking valid microstructural maps. However, data acquisition and analysis tools must be adapted and configured for successful application to NHP...
Article
Full-text available
Beta-amyloid (Aβ) and tau proteins, the pathological hallmarks of Alzheimer's disease (AD), are believed to spread through connected regions of the brain. Combining diffusion imaging and positron emission tomography, we investigated associations between white matter microstructure specifically in bundles connecting regions where Aβ or tau accumulat...
Article
Full-text available
There has been increasing interest in jointly studying structural connectivity (SC) and functional connectivity (FC) derived from diffusion and functional MRI. Previous connectome integration studies almost exclusively required predefined atlases. However, there are many potential atlases to choose from and this choice heavily affects all subsequen...
Article
Diffusion MRI tractography is currently the only non-invasive tool able to assess the white-matter structural connectivity of a brain. Since its inception, it has been widely documented that tractography is prone to producing erroneous tracks while missing true positive connections. Recently, supervised learning algorithms have been proposed to lea...