How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
June 2020 - June 2020
Institut de Neurosciences de la Timone
- Principal Investigator
January 2015 - June 2020
Grenoble Institute of Neuroscience
Using computational modeling and in vitro screening, we design structure-based mimetics of BDNF to develop promising therapeutic drugs.
SARABANDe is based on the emergence of a new concept in connectomics: the adult brain constantly rewires with experience. The goal of the present study is to understand how brain rewiring is regulated, how it is relevant for learning and cognition, and how it can be targeted to treat brain disorders.
Studying how axonal transport translates neuronal activity into efficient targeting of synaptic and BDNF vesicles toward active synapses. Methods: Viral expression of fluorescent cargoes, superresolution videomicroscopy, multi array electrophysiology, 2-photon imaging, microfluidics, molecular and cellular biology, mathematical models