Max Brzezicki

Max Brzezicki
University of Oxford | OX · Nuffield Department of Clinical Neurosciences

BMedSci FNS MB ChB
Oxford Quantification in Parkinsonism

About

18
Publications
5,409
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
37
Citations
Introduction
My research is about measuring the disease progression and efficacy of treatment in neurological disorders of movement, cognition, memory, and executive function. I believe we can use the recent developments in computational neurology, artificial intelligence and bioinformatics to achieve our aims quicker and more efficiently. I am passionate about a prompt and practical introduction of our findings right into the frontline clinical practice.
Additional affiliations
August 2020 - August 2021
Oxford University Hospitals NHS Trust
Position
  • Academic junior doctor (SHO/ST1)
August 2019 - August 2021
University of Oxford
Position
  • Academic Foundation Doctor
August 2019 - August 2020
Milton Keynes Hospital NHS Foundation Trust
Position
  • Academic Foundation Doctor
Education
October 2021 - August 2022
University of Oxford
Field of study
  • Clinical Neurosciences
January 2018 - May 2018
University of Gothenburg
Field of study
  • Clinical Trials in Medicine
August 2015 - July 2019
University of Bristol
Field of study
  • Medical doctor

Publications

Publications (18)
Article
Full-text available
Progressive Supranuclear Palsy (PSP) is a rapidly progressive neurodegenerative tauopathy without any disease-modifying treatment. To aid development and evaluation of new treatments, we need a clear understanding of the deficits PSP produces and their progression. PSP patients develop multiple deficits in executive function (cognitive inflexibili...
Article
Full-text available
Generalised anxiety disorder (GAD) displays a variety of psychological and physical symptoms. These are difficult to rapidly control with currently available pharmacological options. This review summarises the evidence for an acute use of microbiological modification drugs targeting vagal nerve stimulation. A systematic search was conducted in Medl...
Article
The recent COVID-19 pandemic has demonstrated how infectious diseases can quickly spread and complicate the management of emergencies, even in a young and fit population. Pathogens in space could be more infectious and difficult to eradicate due to extra-terrestrial contamination, proliferation in weightlessness, thicker cell walls and more antibio...
Article
Objectives: Neurosurgical audits are an important part of improving the safety, efficiency and quality of care but require considerable resources, time, and funding. To that end, the advent of the Artificial Intelligence-based algorithms offered a novel, more economically viable solution. The aim of the study was to evaluate whether the algorithm...
Article
Full-text available
Clinical experience of perampanel overdoses is markedly limited and the relevant literature is sparse. Perampanel is a novel antiepileptic drug (an amino-3-hydroxy-5-methyl-4-isoxazlepropionic acid glutamate receptor antagonist) with a long half-life, which is used for the adjunctive treatment of epilepsy. The literature available identifies a pote...
Poster
Full-text available
The aetiology of generalised anxiety disorder (GAD) is poorly understood. As a result, treatment efforts so far have been suboptimal. Only half of the patients respond to the best quality psychotherapy, with 40% of all anxiety disorder cases being treatment-resistant. Thus, a chronic form of GAD can be debilitating to patients, the economy, and the...
Article
Full-text available
We would like to thank you for your letter regarding our case. We are extremely pleased that this article has caught your attention. First of all, we welcome your comments re the MR imaging. For the sake of integrity, we presented the report as given by the specialist in neuroradiology. Your findings would definitely enhance the readers’ understan...
Article
Purpose: Frontotemporal dementia (FTD) is a neurodegenerative disorder associated with a poor prognosis and a substantial reduction in quality of life. The rate of misdiagnosis of FTD is very high, with patients often waiting for years without a firm diagnosis. This study investigates the current state of the misdiagnosis of FTD using a novel artif...
Article
We report an interesting case of a central nervous system vasculitis, presenting with a relapsing remitting nature and a previously unreported profile of cognitive deficits in this variant of the disease. The patient presented with bilateral headache, left eye upper temporal quarter visual field loss, dyschromatopsia and a transient loss of consci...
Chapter
Over the past half-century, electrical stimulation of specific areas of the brain has revolutionised the treatment of movement disorders. The insertion of electrodes into the brain for therapeutic purposes also provides a unique opportunity for research into human brain function and pathophysiology. Deep brain stimulation (DBS) of parts of the basa...
Article
Full-text available
It was a pleasure to read an interesting case of a patient with Lewy body dementia (DLB), published in Neurology and Therapy recently. The author shared an insightful story of how the treatment of this disease affects the patient’s wellbeing and the different pharmacological interventions that he had experienced. Especially interesting was the pati...
Poster
Full-text available
A study of the AI-powered algorithm in improving the diagnostic accuracy of the FrontoTemporal Dementia
Article
Full-text available
INTRODUCTION Complex Regional Pain Syndrome (CRPS) is a neurological disorder, where one or more limbs are affected by pain disproportionate to the stimulus. Its exact pathology remains widely debated and there are currently several treatments available for the disease. No single treatment regimen has been proven to be superior, and there are no st...
Article
Full-text available
Background: Despite a wide variety of current analgesia regimens, chronic pain is an incredibly difficult condition to treat. Its pathophysiology, initiation, development and course involve a range of different receptors and transmitters. The acid-sensing ion channels (ASICs) are being attributed to an increasingly larger significance in pain aeti...
Article
Full-text available
Aim: Using the latest evidence and following EBM guidelines is the best way to achieve high standards of care in neurosurgical practice. The aim of the Frideswide algorithm (FwA) is to analyse hundreds of clinical letters, decisions, successes, and failures, and to use the artificial intelligence (AI) deep learning method to draw conclusions and re...
Article
Full-text available
INTRODUCTION Clinical audits are an integral part of the neurosurgical practice. This requires extensive resources, staff engagement, and data processing. We believe this process can be made more economically viable by introducing the artificial intelligence-based Frideswide Algorithm (FwA). MATERIALS & METHODS FwA uses multiple sources of clinica...
Article
Clinical audits are an integral part of the neurosurgical practice. The process of continually improving the quality, efficiency and safety of the service currently requires extensive resources, staff engagement, and manual data entry. We believe this process can be made more economically viable by using recent developments in the field of computat...

Network

Cited By

Projects

Projects (5)
Project
The goal is to collect all the published work within the OrphaNET of European Reference Network of Rare Diseases in Clinical Neurosciences
Project
Collection of papers about chronic pain and the possible methods of treatment