Max Brzezicki

University of Oxford | OX · Nuffield Department of Clinical Neurosciences

Wearable devices offer the potential to track motor symptoms in neurological disorders. Kinematic data used together with machine learning algorithms can accurately identify people living with movement disorders and the severity of their motor symptoms. In this study we aimed to establish whether a combination of wearable sensor data and machine le...

Patients not yet receiving medication provide insight to drug-naïve early physiology of Parkinson's Disease (PD). Wearable sensors can measure changes in motor features before and after introduction of antiparkinsonian medication. We aimed to identify features of upper limb bradykinesia, postural stability, and gait that measurably progress in de n...

Parkinson’s disease and “Parkinson’s plus” syndromes such as Progressive Supranuclear Palsy are a group of neurodegenerative conditions characterised by changes in movement amongst other abnormalities. Motor symptoms, such as tremors, gait changes, and bradykinesia, emerge due to loss of neurons in the basal ganglia of the deep brain. No simple, sp...

Progressive Supranuclear Palsy (PSP) is a rapidly progressive neurodegenerative tauopathy without any disease-modifying treatment. To aid development and evaluation of new treatments, we need a clear understanding of the deficits PSP produces and their progression. PSP patients develop multiple deficits in executive function (cognitive inflexibili...

Generalised anxiety disorder (GAD) displays a variety of psychological and physical symptoms. These are difficult to rapidly control with currently available pharmacological options. This review summarises the evidence for an acute use of microbiological modification drugs targeting vagal nerve stimulation. A systematic search was conducted in Medl...

The recent COVID-19 pandemic has demonstrated how infectious diseases can quickly spread and complicate the management of emergencies, even in a young and fit population. Pathogens in space could be more infectious and difficult to eradicate due to extra-terrestrial contamination, proliferation in weightlessness, thicker cell walls and more antibio...

Objectives: Neurosurgical audits are an important part of improving the safety, efficiency and quality of care but require considerable resources, time, and funding. To that end, the advent of the Artificial Intelligence-based algorithms offered a novel, more economically viable solution. The aim of the study was to evaluate whether the algorithm...

Clinical experience of perampanel overdoses is markedly limited and the relevant literature is sparse. Perampanel is a novel antiepileptic drug (an amino-3-hydroxy-5-methyl-4-isoxazlepropionic acid glutamate receptor antagonist) with a long half-life, which is used for the adjunctive treatment of epilepsy. The literature available identifies a pote...

The aetiology of generalised anxiety disorder (GAD) is poorly understood. As a result, treatment efforts so far have been suboptimal. Only half of the patients respond to the best quality psychotherapy, with 40% of all anxiety disorder cases being treatment-resistant. Thus, a chronic form of GAD can be debilitating to patients, the economy, and the...

We would like to thank you for your letter regarding our case. We are extremely pleased that this article has caught your attention. First of all, we welcome your comments re the MR imaging. For the sake of integrity, we presented the report as given by the specialist in neuroradiology. Your findings would definitely enhance the readers’ understan...

Purpose: Frontotemporal dementia (FTD) is a neurodegenerative disorder associated with a poor prognosis and a substantial reduction in quality of life. The rate of misdiagnosis of FTD is very high, with patients often waiting for years without a firm diagnosis. This study investigates the current state of the misdiagnosis of FTD using a novel artif...

We report an interesting case of a central nervous system vasculitis, presenting with a relapsing remitting nature and a previously unreported profile of cognitive deficits in this variant of the disease. The patient presented with bilateral headache, left eye upper temporal quarter visual field loss, dyschromatopsia and a transient loss of consci...

Over the past half-century, electrical stimulation of specific areas of the brain has revolutionised the treatment of movement disorders. The insertion of electrodes into the brain for therapeutic purposes also provides a unique opportunity for research into human brain function and pathophysiology. Deep brain stimulation (DBS) of parts of the basa...

It was a pleasure to read an interesting case of a patient with Lewy body dementia (DLB), published in Neurology and Therapy recently. The author shared an insightful story of how the treatment of this disease affects the patient’s wellbeing and the different pharmacological interventions that he had experienced. Especially interesting was the pati...

A study of the AI-powered algorithm in improving the diagnostic accuracy of the FrontoTemporal Dementia

INTRODUCTION Complex Regional Pain Syndrome (CRPS) is a neurological disorder, where one or more limbs are affected by pain disproportionate to the stimulus. Its exact pathology remains widely debated and there are currently several treatments available for the disease. No single treatment regimen has been proven to be superior, and there are no st...

Background: Despite a wide variety of current analgesia regimens, chronic pain is an incredibly difficult condition to treat. Its pathophysiology, initiation, development and course involve a range of different receptors and transmitters. The acid-sensing ion channels (ASICs) are being attributed to an increasingly larger significance in pain aeti...

Aim: Using the latest evidence and following EBM guidelines is the best way to achieve high standards of care in neurosurgical practice. The aim of the Frideswide algorithm (FwA) is to analyse hundreds of clinical letters, decisions, successes, and failures, and to use the artificial intelligence (AI) deep learning method to draw conclusions and re...

INTRODUCTION Clinical audits are an integral part of the neurosurgical practice. This requires extensive resources, staff engagement, and data processing. We believe this process can be made more economically viable by introducing the artificial intelligence-based Frideswide Algorithm (FwA). MATERIALS & METHODS FwA uses multiple sources of clinica...

Clinical audits are an integral part of the neurosurgical practice. The process of continually improving the quality, efficiency and safety of the service currently requires extensive resources, staff engagement, and manual data entry. We believe this process can be made more economically viable by using recent developments in the field of computat...