Maurizio Strippoli

Maurizio Strippoli
Università degli Studi di Milano-Bicocca | UNIMIB · Department of Biotechnology and Biosciences

BSc

About

27
Publications
2,339
Reads
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616
Citations
Citations since 2017
2 Research Items
295 Citations
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20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Introduction
Skills and Expertise
Additional affiliations
February 2013 - January 2016
Università degli Studi di Milano-Bicocca
Position
  • PostDoc Position
January 2012 - January 2013
Università Vita-Salute San Raffaele
Position
  • PostDoc Position
July 2008 - January 2012
Università degli Studi di Bari Aldo Moro
Position
  • PostDoc Position

Publications

Publications (27)
Article
Full-text available
Resveratrol (RSV) is a naturally occurring polyphenolic compound endowed with interesting biological properties/functions amongst which are its activity as an antioxidant and as Sirtuin activating compound towards SIRT1 in mammals. Sirtuins comprise a family of NAD⁺-dependent protein deacetylases that are involved in many physiological and patholog...
Article
Full-text available
Nicotinamide (NAM), a form of vitamin B3, is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD+-dependent deacetylases that are well-known critical regulators of metabolism and aging and whose founding member is Sir2 of _Saccharomyces cerevisiae_. H...
Article
Aims: Sporadic inclusion body myositis (s-IBM) is characterized by rimmed vacuole formation and misfolded protein accumulation. Intracellular protein aggregates are cleared by autophagy. When autophagy is blocked aggregates accumulate, resulting in abnormal rimmed vacuole formation. This study investigated the autophagy-lysosome pathway contributi...
Article
Full-text available
This study investigates glio-vascular interactions in human fetal brain at midgestation, specifically examining the expression and immunolocalization of the CXCL12/CXCR4/CXCR7 ligand-receptor axis and its possible role in the vascular patterning of the developing brain. At midgestation, the telencephalic vesicles are characterized by well developed...
Article
The pathophysiology of cerebral cortical lesions in multiple sclerosis (MS) is not understood. We investigated cerebral cortex microvessels during immune-mediated demyelination in the MS model chronic murine experimental autoimmune encephalomyelitis (EAE) by immunolocalization of the endothelial cell tight junction (TJ) integral proteins claudin-5...
Article
Full-text available
During human foetal brain vascularization, activated CD31+/CD105+ endothelial cells are characterized by the emission of filopodial processes which also decorate the advancing tip of the vascular sprout. Together with filopodia, both the markers also reveal a number of plasma membrane-derived microvesicles (MVs) which are concentrated around the ti...
Data
Supplementary material 3 . Online Resource 3. A typical, initial vascular sprout shown by horseradish peroxidase injection during chick embryo optic tectum development (Roncali et al., Acta Neuropathol. 70:193–201, 1986 and unpublished observations)
Article
Full-text available
Experimentally induced autoimmune encephalomyelitis (EAE) in mice provides an animal model that shares many features with human demyelinating diseases such as multiple sclerosis (MS). To what extent the cerebral cortex is affected by the process of demyelination and how the corollary response of the oligodendrocyte lineage is explicated are still n...
Article
In this work we addressed the putative role of NG2 in the control of endothelial tight junction (TJ) dismantling, blood-brain barrier (BBB) breakdown, and leukocyte transendothelial migration in inflammatory/degenerative neurological disorders. During CNS development two cell types are known to express the transmembrane proteoglycan NG2, namely oli...
Article
Experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS), is characterized by vascular changes, particularly endothelial tight junction (TJ) protein (claudin-5 and occludin) alterations. During blood-brain barrier function, the vascular wall components, endothelial cells, pericytes and perivascular astrocyte...
Article
Full-text available
In the CNS, pericytes are microvessel wall-encircling cells that, together with endothelial cells, perivascular glial endfeet and basement membrane, form the blood-brain barrier (BBB). Dysfunction of the BBB and migration of autoreactive T lymphocytes into the CNS are histopathological hallmarks of both Multiple Sclerosis (MS), a chronic demyelinat...
Article
The identification of stem cells resident in the adult central nervous system has redirected the focus of research into demyelinating diseases, such as multiple sclerosis, mainly affecting the brain white matter. This immunocytochemical and morphometrical study was carried out by confocal microscopy in the adult mouse cerebral cortex, with the aim...
Article
Full-text available
We report that oxytocin (OT), a primitive neurohypophyseal hormone, hitherto thought solely to modulate lactation and social bonding, is a direct regulator of bone mass. Deletion of OT or the OT receptor (Oxtr) in male or female mice causes osteoporosis resulting from reduced bone formation. Consistent with low bone formation, OT stimulates the dif...
Article
Full-text available
During space flight, severe losses of bone mass are observed. Both bone formation and resorption are probably involved, but their relative importance remains unclear. The purpose of this research is to understand the role of osteoclasts and their precursors in microgravity-induced bone loss. Three experiments on isolated osteoclasts (OCs) and on th...
Article
During space exploration, astronauts are exposed to the microgravity environment, which has an immediate impact on many biological systems. Osteoporosis-like bone mass loss is one of the most significant effects of microgravity, ranging around 1-2% reduction per month in flight. An uncoupling of bone remodeling could be responsible for this process...
Article
Full-text available
Anabolic skeletal agents have recently broadened the therapeutic options for osteoporosis by directly stimulating bone formation and improving bone turnover, bone density, bone size, and bone microarchitecture. We recently demonstrated that two new L: -carnitine derivatives, L: -carnitine fumarate (LC) and isovaleryl-L: -carnitine fumarate (Iso-V-L...
Article
Osteoblast (OB) activities have been studied on hydroxyapatite three-dimensional (3D) scaffolds in comparison with traditional planar substrata. OBs cultured on 3D displayed increased proliferation, differentiation, and matrix protein synthesis, when compared to 2D cultures on the same substrata. Confluent cultures, however, could not be maintained...

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