Maurizio Corbetta

Maurizio Corbetta
University of Padova | UNIPD · Department of Neurosciences

MD

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390
Publications
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Publications

Publications (390)
Article
Full-text available
Understanding the relationships between brain organization and behavior is a central goal of neuroscience. Traditional teaching emphasizes that the human cerebrum includes many distinct areas for which damage or dysfunction would lead to a unique and specific behavioral syndrome. This teaching implies that brain areas correspond to encapsulated mod...
Preprint
Full-text available
Attention is a core cognitive function that lters and selects behaviourally relevant information in the environment. The cortical mapping of attentional systems identi ed two segregated networks that mediate stimulus-driven and goal-driven processes, the Ventral and the Dorsal Attention Networks (VAN, DAN). Deep brain electrophysiological recording...
Article
Full-text available
Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i...
Article
Full-text available
Background Functional neurological disorders (FND) are disabling medical conditions commonly seen in neurological practice. Neurologists play an essential role in managing FND, from establishing a diagnosis to coordination of multidisciplinary team-based treatment for patients. With this study, we investigated the knowledge and the clinical experie...
Article
Full-text available
The brain consumes the most energy per relative mass amongst the organs in the human body. Theoretical and empirical studies have shown that behavioral processes are relatively inexpensive metabolically, and that most energy goes to maintaining the status quo, i.e., the balance of cell membranes’ resting potentials and subthreshold spontaneous acti...
Article
Full-text available
Most neuroimaging studies of post-stroke recovery rely on analyses derived from standard node-centric functional connectivity to map the distributed effects in stroke patients. Here, given the importance of nonlocal and diffuse damage, we use an edge-centric approach to functional connectivity in order to provide an alternative description of the e...
Article
Full-text available
Assessment of impaired/preserved cortical regions in brain tumours is typically performed via intraoperative direct brain stimulation of eloquent areas or task-based functional MRI. One main limitation is that they overlook distal brain regions or networks that could be functionally impaired by the tumour. This study aims: 1) to investigate the imp...
Preprint
Hands are regularly in sight in everyday life. This visibility affects motor control, perception, and attention, as visual information is integrated into an internal model of sensorimotor control. Spontaneous brain activity, i.e., ongoing activity in the absence of an active task (rest), is correlated among somatomotor regions that are jointly acti...
Article
Functional magnetic resonance imaging (fMRI) has been widely employed to study stroke pathophysiology. In particular, analyses of fMRI signals at rest were directed at quantifying the impact of stroke on spatial features of brain networks. However, brain networks have intrinsic time features that were, so far, disregarded in these analyses. In cons...
Article
Full-text available
Background Glioblastoma (GBM) is the most commonly occurring primary malignant brain tumor, and it carries a dismal prognosis. Focusing on the tumor microenvironment may provide new insights into pathogenesis, but no clinical tools are available to do this. We hypothesized that the infiltration of different leukocyte populations in the tumoral and...
Article
Plasticity after stroke is a complex phenomenon. Functional reorganization occurs not only in the perilesional tissue but throughout the brain. However, the local connection mechanisms generating such global network changes remain largely unknown. To address this question, time must be considered as a formal variable of the problem rather than a si...
Article
COVER ILLUSTRATION In this figure the two boxes display for the young (on the left) and old (on the right) subjects the T1-weighted image of a representative subject and the three topmost likely transition probabilities between inferred functional dynamic brain states. Inside each circle the spatial pattern of mean BOLD activation within the state...
Article
Clinicians and scientists alike have long sought to predict the course and severity of chronic post-stroke cognitive and motor outcomes, as the ability to do so would inform treatment and rehabilitation strategies. However, it remains difficult to make accurate predictions about chronic post-stroke outcomes due, in large part, to high inter-individ...
Article
Full-text available
Human behaviour is complex and multifaceted, and is studied by a broad range of disciplines across the social and natural sciences. To mark our 5th anniversary, we asked leading scientists in some of the key disciplines that we cover to share their vision of the future of research in their disciplines. Our contributors underscore how important it i...
Preprint
Full-text available
Stroke significantly impacts quality of life. However, the long-term cognitive evolution in stroke is poorly predictable at the individual level. There is an urgent need for a better prediction of long-term symptoms based on acute clinical neuroimaging data. Previous works have demonstrated a strong relationship between the location of white matter...
Preprint
Full-text available
Motricity is the most commonly affected ability after a stroke. While many clinical studies attempt to predict motor symptoms at different chronic time points after a stroke, longitudinal acute-to-chronic studies remain scarce. Taking advantage of recent advances in mapping brain disconnections, we predict motor outcomes in 62 patients assessed lon...
Article
Full-text available
Damage to specific brain circuits can cause specific neuropsychiatric symptoms. Therapeutic stimulation to these same circuits may modulate these symptoms. To determine whether these circuits converge, we studied depression severity after brain lesions (n = 461, five datasets), transcranial magnetic stimulation (n = 151, four datasets) and deep bra...
Preprint
Full-text available
Motricity is the most commonly affected ability after a stroke. While many clinical studies attempt to predict motor symptoms at different chronic time points after a stroke, longitudinal acute-to-chronic studies remain scarce. Taking advantage of recent advances in mapping brain disconnections, we predict motor outcomes in 62 patients assessed lon...
Preprint
Full-text available
Gliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i...
Article
Full-text available
Background: Early and affordable identification of subjects with amnestic mild cognitive impairment (aMCI) who will convert to Alzheimer’s disease (AD) is a major scientific challenge. Objective: To investigate the neurophysiological hallmarks of sensorimotor cortex function in aMCI under the hypothesis that some may represent the plastic rearrange...
Article
Full-text available
Background: Early and affordable identification of subjects with amnestic mild cognitive impairment (aMCI) who will convert to Alzheimer’s disease (AD) is a major scientific challenge. Objective: To investigate the neurophysiological hallmarks of sensorimotor cortex function in aMCI under the hypothesis that some may represent the plastic rearrang...
Article
Full-text available
During normal aging, the brain undergoes structural and functional changes. Many studies applied static functional connectivity (FC) analysis on resting state functional magnetic resonance imaging (rs-fMRI) data showing a link between aging and the increase of between-networks connectivity. However, it has been demonstrated that FC is not static bu...
Article
Full-text available
Lesion network mapping estimates functional network abnormalities caused by a focal brain lesion. The method requires embedding the volume of the lesion into a normative functional connectome and using the average functional magnetic resonance imaging signal from that volume to compute the temporal correlation with all other brain locations. Lesion...
Article
Full-text available
The default mode (DMN) and the salience (SN) networks show functional hypo-connectivity in Alzheimer's disease (AD) and the behavioral variant of frontotemporal dementia (bvFTD), respectively, along with patterns of hyper-connectivity. We tested the clinical and neurobiological effects of non-invasive stimulation over these networks in 45 patients...
Conference Paper
Metabolic connectivity is conventionally calculated in terms of correlation of static positron emission tomography (PET) measurements across subjects. There is increasing interest in deriving metabolic connectivity at the single-subject level from dynamic PET data, in a similar way to functional magnetic resonance imaging. However, the strong multi...
Article
Full-text available
Recent resting-state functional MRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity between homotopic regions of the same network, and an abnormal increase of ipsi-lesional functional connectivity between task-negative and task-positive resting-sta...
Article
Alzheimer's disease (AD) is characterized by different clinical entities. Although AD phenotypes share a common molecular substrate (i.e., amyloid beta and tau accumulation), several clinicopathological differences exist. Brain functional networks might provide a macro-scale scaffolding to explain this heterogeneity. In this review, we summarize th...
Article
Full-text available
When looking at visual images, the eyes move to the most salient and behaviourally relevant objects. Saliency and semantic information significantly explain where people look. Less is known about the spatiotemporal properties of eye movements (i.e., how people look). We show that three latent variables explain 60% of eye movement dynamics of more t...
Article
Full-text available
Beyond causing local ischemia and cell damage at the site of injury, stroke strongly affects long-range anatomical connections, perturbing the functional organization of brain networks. Several studies reported functional connectivity abnormalities parallelling both behavioral deficits and functional recovery across different cognitive domains. FC...
Article
As we move in the environment, attention shifts to novel objects of interest based on either their sensory salience or behavioral value (reorienting). This study measures with magnetoencephalography (MEG) different properties (amplitude, onset-to-peak duration) of event-related desynchronization/synchronization (ERD/ERS) of oscillatory activity dur...
Article
Full-text available
Strokes to the left and right hemisphere lead to distinctive behavioral profiles. Are left and right hemisphere strokes (LHS and RHS) associated with distinct or common poststroke neuroplasticity patterns? Understanding this issue would reveal hemispheric neuroplasticity mechanisms in response to brain damage. To this end, we investigated poststrok...
Preprint
Full-text available
Brain glucose metabolism as assessed by [18F]FDG positron emission tomography (PET) is expected to be significantly related to resting-state functional MRI (rs-fMRI) activity and functional connectivity (FC), but the underlying coupling model is still incompletely understood. Employing simultaneous acquisitions, we related [18F]FDG standard uptake...
Article
Brains at rest generate dynamical activity that is highly structured in space and time. We suggest that spontaneous activity, as in rest or dreaming, underlies top-down dynamics of generative models. During active tasks, generative models provide top-down predictive signals for perception, cognition, and action. When the brain is at rest and stimul...
Article
Background: The endogenous allocation of spatial attention to selected environmental stimuli is controlled by prefrontal (frontal eye field-FEF) and parietal (superior parietal lobe-SPL and intraparietal sulcus-IPS) regions belonging to the dorsal attention network(DAN) with a subdivision in subsystems devoted to reorienting (or shifting) of atten...
Article
Full-text available
Neurological deficits following stroke are traditionally described as syndromes related to damage of a specific area or vascular territory. Recent studies indicate that, at the population level, post-stroke neurological impairments cluster in three sets of correlated deficits across different behavioural domains. To examine the reproducibility and...
Article
The brain is a dynamic system that generates a broad repertoire of perceptual, motor, and cognitive states by the integration and segregation of different functional domains represented in large-scale brain networks. However, the fundamental mechanisms underlying brain network integration remain elusive. Here, for the first time to our knowledge, w...
Article
Background: Recurrent complex visual hallucinations (VH) are common in dementia with Lewy bodies (DLB). Previous investigations suggest that VH are associated with connectivity changes within and between large scale networks involved in visual processing and attention. Aim: To examine more directly whether VH in DLB reflects direct changes in ne...
Preprint
Full-text available
Functional magnetic resonance imaging (fMRI) has been widely employed to study stroke pathophysiology. In particular, analyses of fMRI signals at rest were directed at quantifying the impact of stroke on spatial features of brain networks. However, brain networks have intrinsic time features that were, so far, disregarded in these analyses. In cons...
Article
Objective functional alterations of the visual attention networks in a setting of impaired visual information processing have a role in the genesis of visual hallucinations (VH) in dementia with Lewy bodies (DLB). This multimodal MRI study aims at exploring structural and functional basis of VH. Methods 23 DLB patients (10 with and 13 without VH)...
Article
Full-text available
Lesion studies are an important tool for cognitive neuroscientists and neurologists. However, while brain lesion studies have traditionally aimed to localize neurological symptoms to specific anatomical loci, a growing body of evidence indicates that neurological diseases such as stroke are best conceptualized as brain network disorders. While rese...
Preprint
Full-text available
It is often assumed that we look at objects that are salient and behaviorally relevant, and that we pay attention differently depending on individual genetics, development, and experience. This view should imply high interindividual variability in eye movements. Conversely, we show that 60% of eye movements variance of more than a hundred observers...
Article
Full-text available
The functional architecture of the resting brain, as measured with the blood oxygenation level-dependent functional connectivity (BOLD-FC), is slightly modified during task performance. In previous work, we reported behaviorally relevant BOLD-FC modulations between visual and dorsal attention regions when subjects performed a visuospatial attention...
Preprint
Full-text available
Beyond causing local ischemia and cell damage at the site of injury, stroke strongly affects long-range anatomical connections, perturbing the functional organization of brain networks. Several studies reported functional connectivity abnormalities parallelling both behavioral deficits and functional recovery across different cognitive domains. FC...
Preprint
Full-text available
The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal and external inputs. Criticality thus provides optimal function and behavioral capabilities. We test this hypothesis by examining the influence of brain injury...
Preprint
Full-text available
Recent resting-state fMRI studies in stroke patients have identified two robust biomarkers of acute brain dysfunction: a reduction of inter-hemispheric functional connectivity (FC) between homotopic regions of the same network, and an abnormal increase of ipsilesional FC between task-negative and task-positive resting-state networks (RSNs). Whole-b...
Article
It has been proposed that at least two distinct processes are engaged during task switching: reconfiguration of the currently relevant task-set and interference resolution arising from the competing task-set. While in healthy individuals the two are difficult to disentangle, their disruption is thought to cause different impairments in brain-damage...
Preprint
Brains at rest spontaneously generate dynamical activity that is not mere noise but highly structured in space and time. As our most vivid dreams exemplify, spontaneous brain activity can give rise to the most sophisticated cognition. We suggest that spontaneous brain activity as in rest, mind wandering, or dreaming, underlies top-down dynamics of...
Article
The function of spontaneous brain activity is an important issue in neuroscience. Here we test the hypothesis that patterns of spontaneous activity code representational patterns evoked by stimuli. We compared in human visual cortex multi-vertex patterns of spontaneous activity to patterns evoked by ecological visual stimuli (faces, bodies, scenes)...
Article
Objective We conducted a multi‐site, randomized, double‐blinded controlled trial to examine the effectiveness of a digital health intervention targeting the intrinsic regulation of goal‐directed alertness in patients with chronic hemispatial neglect. Methods Forty‐nine participants with hemispatial neglect that demonstrated significant spatially b...
Preprint
Full-text available
Lesion studies are an important tool for cognitive neuroscientists and neurologists. However, while brain lesion studies have traditionally aimed to localize neurological symptoms to specific anatomical loci, a growing body of evidence indicates that neurological diseases such as stroke are best conceptualized as brain network disorders. While rese...
Conference Paper
Full-text available
Hand and foot movements are topographically represented in specific patches of the sensorimotor cortex and associated to strong reductions of beta (β) oscillations during preparation and execution in parallel to increments of β power occurring 300 to 1000 ms after their end, as evident through Magneto-and Electro-Encephalography (M/EEG) (Betti, 202...
Article
Full-text available
Behavioural deficits in stroke reflect both structural damage at the site of injury, and widespread network dysfunction caused by structural, functional, and metabolic disconnection. Two recent methods allow for the estimation of structural and functional disconnection from clinical structural imaging. This is achieved by embedding a patient's lesi...