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March 2013 - October 2015
Publications
Publications (27)
Resumen Las enfermedades cardiovasculares (ECV) son la principal causa de muerte en el mundo y en Colombia siendo consideradas un serio problema de salud pública. El objetivo de este estudio fue analizar espacial y temporalmente la mortalidad por ECV en la región Pacifico de Colombia durante el periodo 2002-2015 y su asociación con algunos indicado...
Aim: Studies have shown that the prevalence of the periodontal disease among young people is relatively low; however, periodontitis is a public health problem and prevalence among adults has been increasing. This study aimed to assess the prevalence of periodontitis among young adults and adults in Colombia and to propose an alternative approach fo...
Objetivo:
Describir el perfil y la tendencia de la mortalidad general y específica, durante el periodo 2002-2014, de los departamentos de la región del Pacífico de Colombia: Cauca, Chocó, Nariño y Valle del Cauca.
Metodología:
Estudio descriptivo-ecológico que usa datos secundarios de mortalidad, nacimientos y proyecciones poblacionales provenient...
p class="Pa12"> Este estudio tuvo como objetivo analizar la mortalidad por VIH/sida en Cali, Colombia, en el periodo 1986-2012, y a partir de ahí, comprender, desde el punto de vista conceptual, los determinantes sociales relacionados. Se llevó a cabo un estudio observacional, longitudinal, retrospectivo, con un total de 14 192 casos. Se encontró u...
Objective:
The aim of this study was to design and validate a health services access survey for households in Colombia to provide a methodological tool that allows the country to accumulate evidence of real-life access conditions experienced by the Colombian population.
Methods:
A validation study with experts and a pilot study were performed. I...
The objective of this research was to identify environmental risk factors for cutaneous leishmaniasis (CL) in Colombia and map high-risk municipalities. The study area was the Colombian Andean region, comprising 715 rural and urban municipalities. We used 10 years of CL surveillance: 2000-2009. We used spatial-temporal analysis - conditional autore...
The objective for this study was to estimate the dental age through six radiographic methods in two Colombian ethnic groups (Afro-descendent and mixed Caucasoid) and determine which method more accurately approximates the chronological age. For this, descriptive transversal quantitative study to estimated dental age through six methods (Logan & Kro...
A number of issues affect adherence to treatment and quality of life among women living with HIV/AIDS. In particular, women living in poverty have a higher risk of mortality due to their vulnerable conditions and socioeconomic exclusion. The objective of this study was to evaluate the effectiveness of an intervention that combines microfinance, ent...
The vector competence (VC) of Aedes aegypti (Linnaeus) (Diptera: Culicidae) varies geographically and is affected by both genetic and environmental factors. Understanding the molecular mechanisms that influence VC may help develop novel control strategies. The selection of susceptible and refractory strains is the first step in this process. We col...
Objective:
To evaluate the environmental and ecological factors associated with Leishmania transmission and vector abundance in Chaparral, Tolima-Colombia.
Methods:
First, we compared the ecological characteristics, abundance of phlebotomies and potential reservoir hosts in the peridomestic environment (100 m radius) of randomly selected houses,...
Resistance to antimonial drugs has been documented in Leishmania isolates transmitted in South America, Europe, and Asia. The frequency and distribution of resistance to these and other
antileishmanial drugs are unknown. Technical constraints have limited the assessment of drug susceptibility of clinical strains
of Leishmania. Susceptibility of exp...
Children have a lower response rate to antimonial drugs and higher elimination rate of antimony (Sb) than adults. Oral miltefosine has not been evaluated for pediatric cutaneous leishmaniasis.
A randomized, noninferiority clinical trial with masked evaluation was conducted at 3 locations in Colombia where Leishmania panamensis and Leishmania guyane...
Phlebotomine vector ecology was studied in the largest recorded outbreak of American cutaneous leishmaniasis in Colombia in 2004. In two rural townships that had experienced contrasting patterns of case incidence, this study evaluated phlebotomine species composition, seasonal abundance, nocturnal activity, blood source, prevalence of Leishmania in...
Dos formulaciones de oxcarbazepina (Trileptal®, Novartis, y Oxcarbazepina®, Tecnoquímicas S. A.), previamente demostradas como equivalentes farmacéuticos, fueron evaluadas en cuanto a bioequivalencia por medio de un estudio aleatorizado, cruzado, en dos períodos, con dosis oral única de 1.200 mg, en 24 hombres adultos voluntarios sanos entre 18–35...
Introducción. Los virus del dengue transmitidos principalmente por el mosquito urbano Aedes aegypti, causan uno de los mayores problemas de salud pública que confrontan las ciudades tropicales. La aplicación de insecticidas ha sido la base para el control de mosquitos; sin embargo, su continuo uso ha servido para seleccionar individuos resistentes...
Dengue viruses transmitted principally by the urban mosquito Aedes aegypti, cause one of the major public health problems confronting tropical cities. Insecticide spraying has been the mainstay of mosquito control; however, its continuous use has selected for resistance. Other important methods of control involve community participation.
This study...
Introduction:
In Cali, Colombia, catch basins (streetside storm drains) are one of the main larval habitats of Aedes aegypti and Culex quinquefasciatus. Since 1999, these mosquitoes have been controlled by the Secretaría de Salud Municipal (Secretary of Municipal Public Health) using the larvicide triflumuron. Because of high densities of these mo...
Introducción. En Cali los sumideros son uno de los principales criaderos de Aedes aegypti y Culex quinquefasciatus que son controlados por la Secretaría de Salud Municipal utilizando el insecticida triflumurón desde 1999. Se sospecha falla al tratamiento.
Objetivos. Evaluar la eficacia del Starycide® (triflumurón) y VectoMax® (mezcla bacteriana de...
Introduction. In Cali, Colombia, catch basins (streetside storm drains) are one of the main larval habitats of Aedes aegypti and Culex quinquefasciatus. Since 1999, these mosquitoes have been controlled by the Secretaria de Salud Municipal (Secretary of Municipal Public Health) using the larvicide triflumuron. Because of high densities of these mos...
Introducción: El concepto de validación se refiere a la evaluación estadística de los resultados obtenidos en la aplicación de técnicas analíticas, mediante pruebas convenientemente documentadas y demostrativas de que un método es lo suficientemente fiable a fin de producir el resultado previsto bajo condiciones definidas, como son: sistema analíti...
Introduction: The validation concept refers to the statistical evaluation of the results obtained in the application of analytic technics, by appropriately documented and demonstrative tests that a method is sufficiently reliable to produce the result foreseen under defined conditions, like they are: analytic system, concentration interval, infrast...
American cutaneous leishmaniasis is considered to be a zoonotic disease transmitted by sand flies that feed on infected sylvatic mammals. However, the "domestication" of transmission and the increase in treatment failure with antimonial drugs have raised the suspicion of anthroponotic transmission of American cutaneous leishmaniasis.
The objective...
Leptospirosis is a zoonotic disease with varying modes of transmission and clinical expression that affects humans inhabiting urban and rural areas worldwide. In Colombia, little is known regarding leptospirosis in urban settings.
To establish the seroprevalence of leptospiral infection in humans, to assess the serological reactivity and to identif...
Introduction. Leptospirosis is a zoonotic disease with varying modes of transmission andclinical expression that affects humans inhabiting urban and rural areas worldwide. In Colombia,little is known regarding leptospirosis in urban settings.Objectives. To establish the seroprevalence of leptospiral infection in humans, to assess theserological rea...
Introducción: Los estudios de bioequivalencia o equivalencia comparada se realizan para demostrar que el producto en estudio, conocido como producto genérico, tiene la misma biodisponibilidad del producto de referencia, también conocido como producto innovador o de marca. Si los dos productos son bioequivalentes, se espera que tengan las mismas car...
Introduction: Bioequivalence or compared equivalence studies are used to demonstrate claims that the new product, named generic product, will have the same bioavailability as the reference product, named brand product. If two products are bioequivalent it means that they would expect to have the same efficacy and security. Bioequivalence is establi...
A method for detection and quantification of Glimepiride in human plasma has been developed using an isocratic elution on reversed phase liquid chromatography with ultraviolet detection at a single wavelength (231 nm) and the addition standard method. Glibenclamide was used as an internal standard. This method involves a liquid-liquid drug extracti...
