Mauricio Martinez

• Master of Science
• PhD Student at Texas Tech University

Endothelial dysfunction decreases exercise limb blood flow (BF) and muscle oxygenation. Acute L-Citrulline supplementation (CIT) improves muscle tissue oxygen saturation index (TSI) and deoxygenated hemoglobin (HHb) during exercise. Although CIT improves endothelial function (flow-mediated dilation [FMD]) in hypertensive women, the impact of CIT on...

Type 2 diabetes (T2D) is strongly associated with increased risk of cardiovascular diseases via endothelial dysfunction. Hyperglycemia causes microvascular endothelial dysfunction and reduces muscle perfusion. Near-infrared spectroscopy (NIRS) measures microvascular reactivity in skeletal muscle during vascular occlusion/reperfusion. However, the i...

Menopause and hypertension are associated with macro- and microvascular endothelial dysfunction at rest. Arginine deficiency and low nitric oxide (NO) synthesis may contribute to reduced muscle blood flow (BF) and oxygen delivery to exercising muscles. Improving BF to calf muscles may enhance physical activity. L-Citrulline supplementation (CIT) ha...

Background: Obesity (OB) is highly prevalent in postmenopausal women; particularly increased abdominal visceral adipose tissue contributes to endothelial dysfunction and cardiovascular risk. The endothelium plays an important role on blood flow (BF) and pressure control at rest and during exercise. However, it is unknown how different body mass ind...

Purpose Postmenopausal women experience augmented aortic hemodynamic responses to isometric handgrip (IHG) exercise and metaboreflex activation post-exercise muscle ischemia (PEMI). Relationships between endothelial function brachial artery flow-mediated dilation (FMD) and aortic stiffness carotid-femoral pulse wave velocity (cfPWV) with aortic pul...

Background Obesity (OB) is highly prevalent in females after menopause, especially visceral adipose tissue (VAT) accumulation which contributes to endothelial dysfunction. The endothelium assists in regulating blood flow (BF) during exercise and is attenuated in females with OB. The purpose of this study was to examine upper and lower limb flow-med...

Postmenopausal women have augmented pressure wave responses to low-intensity isometric handgrip exercise (IHG) due to an overactive metaboreflex (postexercise muscle ischemia, PEMI), contributing to increased aortic systolic blood pressure (SBP). Menopause-associated endothelial dysfunction via arginine (ARG) and nitric oxide deficiency may contrib...

Aging and menopause lead to low L-arginine (ARG) availability, the substrate for nitric oxide (NO) synthesis, causing endothelial dysfunction. Endothelial dysfunction is associated with muscle mass loss in older adults. L-citrulline supplementation (CIT), the precursor of ARG and NO, has improved endothelial function in older women and lean mass (L...

Postmenopausal women (PMW) may experience endothelial dysfunction associated with arginine (ARG) deficiency relative to asymmetric dimethylarginine (ADMA) caused by oxidative stress. Endothelial dysfunction contributes to increased blood pressure (BP) responsiveness to sympathoexcitation induced by the cold pressor test (CPT). We investigated the e...

Hypertension is highly prevalent in postmenopausal women. Endothelial dysfunction is associated with hypertension and the age-related decreases in muscle mass and strength. L-citrulline supplementation (CIT) and slow velocity low-intensity resistance training (SVLIRT) have improved vascular function, but their effect on muscle mass is unclear. We i...

Aging and menopause are associated with decreased nitric oxide bioavailability due to reduced L-arginine (L-ARG) levels contributing to endothelial dysfunction (ED). ED precedes arterial stiffness and hypertension development, a major risk factor for cardiovascular disease. This study investigated the effects of L-citrulline (L-CIT) on endothelial...

Aging and hypertension are related to exaggerated peripheral blood pressure (BP) responses to exercise and metaboreflex activation (post-exercise muscle ischemia, PEMI). Postmenopausal (POST) women have greater risk of heart failure with preserved ejection fraction due to increased aortic pulsatile load on the left ventricle induced by increased sy...

INTRODUCTION: The exaggerated peripheral blood pressure (BP) response to metaboreflex activation (post-exercise muscle ischemia, PEMI) is similar in medicated and unmedicated hypertensives. The systolic BP (SBP) overload on the left ventricle (LV) may augment the risk of adverse cardiovascular events in hypertensives. However, aortic SBP is more re...

INTRODUCTION: The exaggerated peripheral blood pressure (BP) response to metaboreflex activation (post-exercise muscle ischemia, PEMI) is similar in medicated and unmedicated hypertensives. The systolic BP (SBP) overload on the left ventricle (LV) may augment the risk of adverse cardiovascular events in hypertensives. However, aortic SBP is more re...

Purpose: Hypertensive postmenopausal women (PMW) have exaggerated exercise systolic blood pressure (BP) due to impaired functional sympatholysis. L-Citrulline (CIT) supplementation attenuates aortic systolic BP (SBP) responses to cold pressor test (CPT) induced vasoconstriction in young men. We hypothesized that acute CIT ingestion would attenuate...

It is unclear whether men and women perceive thermal stress differently when changes in intestinal temperature (ΔTin) and metabolic heat production (MHprod) are matched between sexes during exercise hyperthermia. This study tested the hypothesis that females have enhanced sensitivity to comfort and perception of thermal stress during exercise hyper...

Introduction Cerebral blood flow and thermal perception during physical exercise under hyperthermia conditions in females are poorly understood. Because sex differences exist for blood pressure control, resting middle cerebral artery velocity (MCAVmean), and pain, we tested the hypothesis that females would have greater reductions in MCAvmean and i...

Background Females are reported to have lower thermosenstivity for evaporative heat loss and skin blood flow (SKbF) response to an increase in mean body temperature during exercise compared to men. However, sweat rate (SR) and SkBF are typically examined only on the forearm. It is unclear if SR and SkBF differ between sex in various body regions du...

Background Cardiorespiratory fitness and exercise training are associated with improved cerebral vasoreactivity of the middle cerebral artery (MCAvmean). High‐intensity interval exercise training (HIIT) is an effective time‐efficient alternative to long‐duration lower‐intensity exercise that offers similar vascular benefits. It is currently unclear...