Mauricio T. Caballero

Mauricio T. Caballero
Fundación Infant · Molecular epidemiology and Global Health

MD Pediatrician
Surveillance of respiratory pathogens at hospital and community level in children from Buenos Aires, Argentina

About

49
Publications
5,924
Reads
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1,966
Citations
Citations since 2016
43 Research Items
1590 Citations
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20162017201820192020202120220100200300400500600
20162017201820192020202120220100200300400500600
Introduction
Mauricio Caballero is a Pediatrician who develops traslational research in respiratory diseases (bronchiolitis, LRTI, BPD, recurrent wheezing and asthma) in Buenos Aires, Argentina.
Additional affiliations
August 2020 - August 2020
National Scientific and Technical Research Council
Position
  • Research Assistant
January 2013 - June 2013
Vanderbilt University
Position
  • Research visitor
June 2011 - present
Fundación Infant
Position
  • Role of TLR4 SNP in severity of bronchiolitis by RSV.
Education
July 2013 - July 2015
Universidad de Buenos Aires
Field of study
  • Master in Molecular Biology
June 2008 - June 2011
Ministerio de Salud de la Provincia de Buenos Aires
Field of study
  • Pediatrics
March 2001 - April 2008
Universidad de Buenos Aires
Field of study
  • Medicine

Publications

Publications (49)
Article
Full-text available
Background Bronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by impaired pulmonary development which persists into later life. While advances in neonatal care have improved survival rates of premature infants, cases of BPD have been increasing with limited therapeutic...
Article
Full-text available
Background Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young children. We previously estimated that in 2015, 33·1 million episodes of RSV-associated acute lower respiratory infection occurred in children aged 0-60 months, resulting in a total of 118 200 deaths worldwide. Since then, several com...
Article
Full-text available
Bronchopulmonary dysplasia (BPD) is a lung disease in premature infants characterized by impaired pulmonary development which persists into later life. While advances in neonatal care have improved survival rates of premature infants, cases of BPD have been increasing with limited therapeutic options for prevention and treatment. This study was des...
Article
Full-text available
Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per country. Among those without symptoms, the rate of pre-symptomatic illness is unclear, and potential predictors...
Article
Full-text available
Background: Precise determination of the causal chain that leads to community deaths in children in low- and middle-income countries is critical to estimating all causes of mortality accurately and to planning preemptive strategies for targeted allocation of resources to reduce this scourge. Methods: An active surveillance population-based study...
Article
Background COVID-19 disproportionally affects pregnant women and their newborn, yet little is known about the variables that modulate the maternal-fetal immune response to infection. Methods We prospectively studied socioeconomic, biologic and clinical factors affecting humoral immunity in 87 unvaccinated pregnant women admitted to hospital in the...
Article
In 1967, two toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (FIRSV) in the United States died from enhanced RSV disease (ERD), a severe form of illness resulting from aberrant priming of the antiviral immune response during vaccination. Up to 80% of immunized children subsequently exposed to wild-type vir...
Poster
Full-text available
We reported cases of community mortality due to RSV in low settings of Buenos Aires, Argentina.
Article
Full-text available
Background Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods The RSV Global Onlin...
Article
Full-text available
Background Many deaths in infants from low-middle income countries (LMICs) occur at home or upon arrival to health facilities. Although acute lower respiratory tract illness plays an important role in community mortality, the accuracy of mortality rates due to respiratory syncytial virus (RSV) remains unknown. Methods An active surveillance study...
Article
Full-text available
Background Estimating the real impact of respiratory syncytial virus (RSV) disease is key for the development of vaccines and treatments. Ascertaining the burden of community mortality due to RSV is challenging due to the lack of primary data. Therefore, conducting observational studies to determine the factors associated with community mortality d...
Article
Full-text available
Background: SARS-CoV-2 infected individuals ≥60 years old have the highest hospitalization rates and represent >80% fatalities. Within this population, those in long-term facilities represent >50% of the total COVID-19 related deaths per country. Among those without symptoms, the rate of pre-symptomatic illness is unclear, and potential predictors...
Article
Background Bronchopulmonary dysplasia (BPD) affects 20-40% of very low birth weight infants (VLBW) who endure short and long-term limitations throughout their life. Experts have classified the disease based on oxygen and pressure exposure at different time points, on the continuum of disease progression, ignoring the rich respiratory and clinical h...
Article
Full-text available
Background Therapies to interrupt the progression of early coronavirus disease 2019 (Covid-19) remain elusive. Among them, convalescent plasma administered to hospitalized patients has been unsuccessful, perhaps because antibodies should be administered earlier in the course of illness. Methods We conducted a randomized, double-blind, placebo-cont...
Preprint
Full-text available
Background Therapies to interrupt progression of early COVID-19 remain elusive. Among them, convalescent plasma in hospitalized patients was unsuccessful, perhaps because antibody should be administered earlier. We advanced plasma infusions to the first 72 hours of symptoms to arrest COVID-19 progression. Methods A randomized, double-blind, placeb...
Article
Full-text available
Background Human metapneumovirus is a common virus associated with acute lower respiratory infections (ALRIs) in children. No global burden estimates are available for ALRIs associated with human metapneumovirus in children, and no licensed vaccines or drugs exist for human metapneumovirus infections. We aimed to estimate the age-stratified human m...
Article
Full-text available
Article Summary: This prospective, population-based, cross-sectional studied factors associated with respiratory failure (RF) and fatal LRTI in premature infants in developing countries. 664 premature children participated, 60 developed respiratory failure and 15 died. Several risk factors could be identified for future interventions. Abstract Back...
Article
Full-text available
Background: Efforts to better understand the risk factors associated with respiratory failure (RF) and fatal LRTI in premature children in developing countries are necessary to elaborate evidenced-based preventive interventions. We aim to characterize the burden of RSV and hMPV LRTI in premature children and determine risk factors for RF and fatal...
Article
Full-text available
Background: Severity of human metapneumovirus (hMPV) lower respiratory illness (LRTI) is considered similar to that observed for respiratory syncytial virus (RSV). However, differences in severity between both pathogens have been noted, suggesting degree of illness may vary in different populations. Moreover, a potential association between hMPV a...
Article
Full-text available
The Toll-Like Receptor 8 (TLR8) has an important role in innate immune responses to RNA viral infections including respiratory syncytial virus (RSV). We reported previously that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP: rs3761624) in the TLR8 promoter, ther...
Article
Full-text available
Severe respiratory syncytial virus (RSV) infection is a major cause of morbidity and mortality in infants <2 years-old. Here we describe that high-fiber diet protects mice from RSV infection. This effect was dependent on intestinal microbiota and production of acetate. Oral administration of acetate mediated interferon-β (IFN-β) response by increas...
Article
Full-text available
Background: Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung ill...
Article
Full-text available
Background: Numerous deaths in children under five years (U5) of age in the developing world occur at home. Acute respiratory infections (ARI) are thought to play an important role in these deaths. Risk factors, and pathogens linked to fatal episodes remain unclear. Methods: A case-control study to define risk factors and viral pathogens in comm...
Article
To assess MUC5AC as a biomarker for respiratory syncytial virus (RSV) disease severity, we tested nasal aspirates from RSV+ children with mild, moderate, and severe disease. Levels were significantly higher in those in the severe and moderate groups compared to mild group, indicating MUC5AC may be a useful biomarker for RSV disease severity.
Article
Full-text available
Respiratory syncytial virus (RSV), responsible for more than three million yearly hospitalizations and up to 118 000 deaths in children under 5 years, is the leading pulmonary cause of death for this age group that lacks a licensed vaccine. Ninety‐nine percent of deaths due to the virus occur in developing countries. In‐hospital RSV fatalities affe...
Article
Full-text available
Objective The aim of this review was to address advances in management and treatment of acute viral bronchiolitis in infants. Sources A systematic review search was made including all articles published in English between 2010 and 2017, and available in the electronic databases PubMed and Cochrane Central Register of Controlled Trials (CENTRAL) an...
Article
Background: Infection with dengue virus (DENV) produces a wide spectrum of clinical illness ranging from asymptomatic infection to mild febrile illness, and to severe forms of the disease. Type I interferons (IFNs) represent an initial and essential host defense response against viruses. DENV has been reported to trigger a robust type I IFN respon...
Article
Objective: The aim of this review was to address advances in management and treatment of acute viral bronchiolitis in infants. Sources: A systematic review search was made including all articles published in English between 2010 and 2017, and available in the electronic databases PubMed and Cochrane Central Register of Controlled Trials (CENTRAL...
Article
Objective Delineate risk factors associated with severe hypoxemia (O2 sat ≤87%) in infants and children younger than 2 years hospitalized with single pathogen HRV infection. Study Design Prospective study in a yearly catchment population of 56 560 children <2 years old between 2011 and 2013 in Argentina. All children with respiratory signs and O2...
Article
Full-text available
Dengue is the most prevalent arthropod-borne viral disease worldwide and is caused by the four dengue virus serotypes (DENV-1-4). Sequential heterologous DENV infections can be associated with severe disease manifestations. Here, we present an immunocompetent mouse model of secondary DENV infection using non mouse-adapted DENV strains to investigat...
Article
Full-text available
Clinical manifestations of acute bronchiolitis (AB) vary from minimal disease to severe respiratory failure. The response to respiratory viral infections is possibly influenced by genetic polymorphisms linked to the regulation of the inflammatory response. In the present study, we investigated whether interleukin-8 (IL-8) and interleukin-17 (IL-17)...
Article
Full-text available
Background: Respiratory syncytial virus (RSV) is the global leading cause of lower respiratory tract infection in infants. Nearly 30% of all infected infants develop severe disease including bronchiolitis, but susceptibility mechanisms remain unclear. Methods: We infected a panel of 30 inbred strains of mice with RSV and measured changes in lung di...
Article
Rationale: Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization and an important cause of death in infants in the developing world. The relative contribution of social, biological, and clinical risk factors to RSV mortality in low-income regions is unclear. Objectives: To determine the burden and risk factors for morta...
Article
Full-text available
In 1967, infants and toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (RSV) experienced an enhanced form of RSV disease characterized by high fever, bronchopneumonia and wheezing when infected with wild type virus in the community. Hospitalizations were frequent and two immunized toddlers died upon wtRSV in...
Article
AIM: This study explored whether alcohol consumption during pregnancy increased the risk of life-threatening respiratory infections in children. METHODS: We prospectively evaluated children under the age of two years admitted to hospitals in Buenos Aires, Argentina, with severe acute respiratory infections during the winters of 2011 and 2012. Infor...
Article
This study explored whether alcohol consumption during pregnancy increased the risk of life-threatening respiratory infections in children. We prospectively evaluated children under the age of two years admitted to hospitals in Buenos Aires, Argentina, with severe acute respiratory infections during the winters of 2011 and 2012. Information on mate...
Article
Full-text available
While 30%-70% of RSV-infected infants develop bronchiolitis, 2% require hospitalization. It is not clear why disease severity differs among healthy, full-term infants; however, virus titers, inflammation, and Th2 bias are proposed explanations. While TLR4 is associated with these disease phenotypes, the role of this receptor in respiratory syncytia...
Article
Full-text available
Rationale: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death in infants worldwide. Most RSV deaths occur in developing countries, where burden and risk factors for life-threatening illness are unclear. Objectives: We defined the burden of life-threatening (O(2) saturation [O(2) sat] ≤ 87%) and fatal RSV infecti...
Article
Full-text available
While the Northern Hemisphere experiences the effects of the 2009 pandemic influenza A (H1N1) virus, data from the recent influenza season in the Southern Hemisphere can provide important information on the burden of disease in children. We conducted a retrospective case series involving children with acute infection of the lower respiratory tract...

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Cited By

Projects

Projects (9)
Project
To determine the excess of RSV related ARLI and all-cause ARLI deaths after the release of non pharmacological interventions and circulation restrictions due to COVID-19 pandemic in the Buenos Aires Metropolitan Area in 2021-2023 compared to the years prior to the declaration of the pandemic by the WHO in children under five.
Project
Primary Objective: To determine the direct and indirect healthcare and household costs associated with acute RSV and long-term RSV-associated wheeze in hospitalized and non-hospitalized children in urban low-resource settings in Argentina. Secondary Objective: Cost estimates from this study may be used to parameterize an existing cost-effectiveness model to assess the potential value of RSV maternal vaccination in Argentina.
Project
To determine the physio-pathogenic mechanisms of death due to SARS CoV 2 infection in hospitalized adults in Buenos Aires. To explore RNAm expression in tissues sampling from deaths adults due to COVID 19. To investigate the role of immunocomplex disease in COVID 19 death adults.