Matyas Czepan

University of Szeged · First Department of Internal Medicine

Objective: The coincidence of chronic pancreatitis and liver cirrhosis in alcoholic patients is comparatively rare. Our aim was to assess liver fibrosis in patients with alcoholic chronic pancreatitis (ACP) by measuring noninvasive fibrosis scores and liver stiffness. Methods: Fifty-five patients with ACP were enrolled in the study. Eight healthy v...

Gastrointestinal myofibroblasts are contractile, electrically non-excitable, transitional cells, which play role in extracellular matrix production, in ulcer healing and in pathophysiological conditions they contribute to chronic inflammation and tumor development. Sodium-calcium exchangers (NCX) are known to have a crucial role in Ca(2+) homeostas...

Tumor progression has been linked to changes in the stromal environment. Myofibroblasts are stromal cells that are often increased in tumors but their contribution to cancer progression is not well understood. Here, we show that the secretomes of myofibroblasts derived from gastric cancers [cancer-associated myofibroblasts (CAMs)] differ in a funct...

Myofibroblasts play central roles in wound healing, deposition of the extracellular matrix and epithelial function. Their functions depend on migration and proliferation within the subepithelial matrix, which results in accelerated cellular metabolism. Upregulated metabolic pathways generate protons which need to be excreted to maintain intracellul...