Mattia Glauber

Mattia Glauber
Centro Cardio-toracico Sant'Ambrogio - Gruppo Ospedaliero San Donato

MD

About

365
Publications
24,502
Reads
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5,986
Citations
Citations since 2017
83 Research Items
3321 Citations
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Introduction
I was trained in Germany, Switzerland, France, Bergamo. In Massa (Monasterio Foundation), I created a center of excellence with a prestigious international reputation. I moved to Milan as Director of the Cardiovascular Dept at the Humanitas Research Hospital. then, I took the position of Director at the Cardiothoracic Center Sant Ambrogio in Milan. I performed over 10 000 cardiac procedures, of which 3000 in MICS. I promote innovation in clinical practice, research program, training surgeons.
Additional affiliations
January 2016 - November 2018
Centro Cardio-toracico Sant'Ambrogio - Gruppo Ospedaliero San Donato
Position
  • Chief of Minimally Invasive Cardiac Surgery Dept.
November 2014 - present
I.R.C.C.S. Policlinico San Donato - Istituto Clinico S.Ambrogio
Position
  • Chief of Cardiac Surgery and Great Vessel Dept
May 2014 - October 2014
Istituto Clinico Humanitas IRCCS
Position
  • Head of Department

Publications

Publications (365)
Article
Full-text available
The intra-aortic balloon pump (IABP) is the most widely available mechanical support device, but its use has been disputed in recent decades. Although several efforts have been made to reduce the associated complication rate, contemporary data on this matter is lacking. The present study aims to evaluate the differences in vascular complications be...
Chapter
Minimally invasive cardiac surgery has emerged as a safe and feasible alternative to the traditional surgical technique, embraced by an always-growing number of cardiac surgeons. In this context, myocardial revascularization can be performed without cardio-pulmonary bypass (CPB) and through a left mini-thoracotomy, sufficient for left internal mamm...
Article
Objective We aim to show the step-by-step surgical technique of mitral valve re-repair by means of a repeated right anterior minithoracotomy in a case of a procedure-related early mitral valve repair failure due to left ventricular positive remodeling and chordal pseudo-elongation. Methods The patient was readdressed to our institution for an earl...
Article
Objectives: The aim of this study was to investigate the need for postoperative permanent pacemaker implantation (PPI) following sutureless and rapid-deployment aortic valve replacement (SuRD-AVR) in the context of a progress report from a large multicenter international registry (SURD-IR). Methods: We retrospectively analyzed 4,166 patients who...
Article
Full-text available
Coronary artery bypass grafting (CABG) remains the most commonly performed cardiac surgical procedure worldwide. The long saphenous vein (LSV) still presides as the first choice conduit as a second graft in multivessel CABG surgery. Traditionally, the long saphenous vein has been harvested with an open approach which can potentially result in signi...
Article
Full-text available
OBJECTIVES Although the intra-aortic balloon pump (IABP) has been the most widely adopted temporary mechanical support device in cardiac surgical patients, its use has declined. The current study aimed to evaluate the occurrence and predictors of early mortality and complication rates in contemporary cardiac surgery patients supported by an IABP....
Article
Full-text available
Objectives: As aortic valve repair (AVr) for aortic insufficiency (AI) expands, minimally invasive (Mi) approaches are increasingly being applied. Cardiac surgical techniques can be more difficult through small incisions, and this report analyzes medium-term outcomes for MiAVr facilitated by geometric ring annuloplasty. Methods: Since 2013, 58 p...
Article
Full-text available
After a median full sternotomy, cardiopulmonary bypass is installed in the usual manner. Apical ventriculotomy is performed through the infarcted myocardium. Polypropylene pledgeted mattress sutures are passed from the right to the left ventricular side through the ventricular septal defect, with the pledgets remaining on the right ventricle. Great...
Article
Background: To compare clinical and hemodynamic in-hospital outcomes of patients undergoing sutureless versus rapid deployment aortic valve replacement (SURD-AVR) in the large population of the Sutureless and Rapid Deployment International Registry (SURD-IR). Methods: We examined 4695 patients who underwent isolated or combined SURD-AVR. The "su...
Article
Full-text available
Sutureless aortic bioprostheses were introduced more than ten years ago, with the aim of decreasing cross‐clamp time and thus becoming the first choice in older patients for many surgeons. However, published data are limited to a 5‐year follow‐up, and some cases of deterioration have already been described. High‐risk patients who once have benefitt...
Article
Full-text available
Background Early treatment of aortic valve stenosis is recommended in eligible symptomatic patients with severe aortic valve stenosis who would otherwise have a poor prognosis. The sutureless aortic valve bioprosthesis offers an alternative to standard aortic valve replacement with a sutured valve, but limited data are available in patients who hav...
Article
Objective To report early and midterm results registry of patients undergoing repeated aortic valve replacement (RAVR) with sutureless prostheses from an international prospective registry (SURE-AVR). Methods Between March 2011 and June 2019, 69 patients underwent RAVR with self-expandable sutureless aortic bioprostheses at 22 international cardia...
Article
Since their introduction, it has been demonstrated that minimally invasive aortic valve replacement (MIAVR) approaches are safe and effective for the treatment of aortic valve diseases. To date, the main advantage of these approaches is represented by the reduced surgical trauma, with a subsequent reduced complication rate and faster recovery. This...
Article
Full-text available
Objectives: Healthcare systems worldwide have been overburdened by the coronavirus disease 2019 (COVID-19) outbreak. Accordingly, hospitals had to implement strategies to profoundly reshape both non-COVID-19 medical care and surgical activities. Knowledge about the impact of the COVID-19 pandemic on cardiac surgery practice is pivotal. The goal of...
Article
Trans-catheter valve-in-valve (ViV) is a treatment option for patients affected by bioprosthetic heart valve (BHV) failure. Both aortic and mitral ViV procedures present several challenges compared to native valve replacement. To date, no data concerning the balloon-expandable MyVal (Meril, Vapi, India) trans-catheter heart valve (THV) use in ViV p...
Article
Full-text available
The coronavirus disease 2019 (COVID-19) pandemic has profoundly affected all health care professionals. The outbreak required a thorough reorganization of the Italian regional local health care system to preserve resources such as ventilators, beds in intensive care units and surgical and anaesthesiological staff. Levels of priority were created, t...
Article
Full-text available
Permanent pacemaker implantation (PPI) represents a rare complication after cardiac surgery, with no uniform agreement on timing and no information on follow-up. A multicenter retrospective study was designed to assess pacemaker dependency (PMD) and long-term mortality after cardiac surgery procedures. Between 2004 and 2016, PPI-patients from 18 ce...
Article
Objective: The aim of this multicenter study was to evaluated whether cold or warm cardioplegia are associated with postoperative atrial fibrillation (POAF) and the prognostic role of the latter on early stroke and neurological mortality. Method: This was a retrospective analysis of prospective collected data from 9 cardiac centers in Italy and...
Article
Full-text available
In the last two decades, sutureless (Perceval, Livanova PLC, London, UK) and rapid deployment (INTUITY Elite, Edwards Lifesciences, Irvine, CA, USA) valves were introduced to the market as an innovative alternative to traditional valves for patients needing aortic valve replacement (AVR). These devices have been used and studied extensively across...
Article
Objective Cardiac conduction system disturbances potentially leading to permanent pacemaker implantation are significant postoperative complications after aortic valve replacement. The aim of this study was to assess the impact of sutureless prosthetic valve oversizing on permanent pacemaker implantation rate. Methods This multicenter retrospectiv...
Article
Full-text available
Background: Sutureless and rapid-deployment aortic valve replacement (SURD-AVR) has become a prominent area of research as the medical community evaluate its place amongst other aortic valve interventions. The main advantages of SURD-AVR established to date are the reduced cross-clamp and cardiopulmonary bypass (CPB) times, as well as facilitating...
Article
Full-text available
Background: Sutureless and rapid-deployment aortic valve replacement (SURD-AVR) has become a prominent area of research as the medical community evaluate its place amongst other aortic valve interventions. The main advantages of SURD-AVR established to date are the reduced cross-clamp and cardiopulmonary bypass (CPB) times, as well as facilitating...
Article
In the last two decades, sutureless (Perceval, LivaNova PLC, London, UK) and rapid deployment valves (RD) (Intuity, Edwards Lifesciences, Irvine, CA, USA) were introduced to the market as an innovative alternative to traditional valves for patients requiring an aortic valve replacement (AVR). These devices have been studied extensively and in use a...
Article
Full-text available
Background: Benefits of sutureless and rapid deployment (SURD) bioprostheses in bicuspid aortic valves (BAV) are controversial. The aim of this study is to report the outcomes of patients undergoing aortic valve replacement (AVR) for BAV from the Sutureless and Rapid-Deployment Aortic Valve Replacement International Registry (SURD-IR). Methods:...
Article
Full-text available
Background: A minimally invasive approach (MIA) reduces mortality and morbidity in patients referred for aortic valve replacement (AVR). Sutureless technology facilitates a MIA. We describe our experience with the sutureless Perceval (LivaNova, Italy) aortic bioprosthesis through a right anterior mini-thoracotomy (RAMT) approach. Methods: Betwee...
Article
Full-text available
Objectives: Minimally invasive surgical techniques with optimal outcomes are of paramount importance. Sutureless and rapid deployment aortic valves are increasingly implanted via minimally invasive approaches. We aimed to analyse the procedural outcomes of a full sternotomy (FS) compared with those of minimally invasive cardiac surgery (MICS) and...
Article
Full-text available
Background and aim of the study: The aim of this meta-analysis was to compare short- and long-term outcomes of patients undergoing mitral annuloplasty (MA) with or without papillary muscle surgery (PMS) for the treatment of ischemic mitral regurgitation (IMR). Methods: A systematic review and meta-analysis in accordance with the Preferred Report...
Chapter
Minimally invasive aortic valve surgery (MIAVS) is defined as aortic valve surgery through a small chest wall incision that does not include the conventional full sternotomy. MIAVS is increasing and has now become an alternative to full sternotomy with the aim to reduce the “invasiveness” of the surgical procedure, while maintaining the same effica...
Article
Mitral valve (MV) repair procedures have evolved over time and multiple approaches have been proposed also for the repair with neochords implantation. This article compiles the currently available approaches for implanting and sizing neochords, to restore a proper coaptation of the MV leaflets and a good systo-dyastolic movement. The described tech...
Article
Objective To report the early and mid-term results of patients who underwent minimally invasive aortic valve replacement (MI-AVR) with a sutureless prosthesis from an international prospective registry. Methods Between March 2011 and September 2018, among 957 patients included in the prospective observational SURE-AVR (Sorin Universal REgistry on...
Article
Full-text available
Background The impact of the coronary artery bypass grafting ( CABG ) technique (on‐ versus off‐pump, single versus multiple aortic clamping) on postoperative neurological outcome remains a matter of controversy. The aim of this study was to assess the association between the incidence of postoperative stroke and the degree of aortic manipulation i...
Article
Full-text available
Objective: To evaluate the aortic wall elasticity using the maximal rate of systolic distension (MRSD) and maximal rate of diastolic recoil (MRDR) and their correlation with the aortic size index (ASI). Methods: Forty-eight patients with thoracic aortic aneurysm were enrolled in this study. A standard magnetic resonance imaging (MRI) protocol wa...
Article
Full-text available
Objectives: The ideal strategy for the treatment of severe aortic valve stenosis in patients of varying risk categories has become a debated topic in the last years: should the transcatheter or surgical approach be adopted? The aim of this study was to evaluate the outcomes of low-, intermediate-, high- and very high-risk patients undergoing sutur...
Article
Full-text available
Atrial fibrillation is the most common type of arrhythmia with increasing burden for stroke and thromboembolic events. Medical treatment of atrial fibrillation has not shown promising results, so alternative method of treatment is emerging out. Cox-Maze procedure has been used for decades for the treatment of atrial fibrillation. Surgical treatment...
Article
Full-text available
Objectives: The impact of sutureless and rapid deployment (SURD) valves on the clinical outcomes of patients undergoing minimally invasive aortic valve replacement (MI-AVR) has still to be defined. The aim of this study was to assess clinical characteristics and in-hospital results of patients receiving SURD-AVR through less invasive approaches in...
Article
Full-text available
OBJECTIVES: The ideal strategy for the treatment of severe aortic valve stenosis in patients of varying risk categories has become a debated topic in the last years: should the transcatheter or surgical approach be adopted? The aim of this study was to evaluate the outcomes of low-, intermediate-, high-and very high-risk patients undergoing suturel...
Article
Full-text available
Background: Meta-analyses of studies comparing transcatheter aortic valve implants (TAVIs) and sutureless aortic valve replacement (SU-AVR) show differing effectiveness and safety profiles. The approaches also differ in their surgical cost (including operating room and device). Objective: The objective of this study was to assess the incremental...
Article
Objectives Increasing experience with minimally invasive cardiac (MIC) aortic valve (AV) replacement makes AV reoperations (rAVR) an appealing alternative to conventional redo surgery. The aim of the study was to compare the perioperative outcome after isolated MIC versus full-sternotomy (FS) rAVR. Methods We retrospectively analyzed data of 116 pa...
Article
The use of artificial polytetrafluoroethylene (PTFE) chordae has been widely adopted in the setting of mitral valve repair. In this tutorial, we present a modified technique for neochordae placement using a semi-rigid complete ring, with a chordal sizing system. This ring was introduced with the aim of standardizing neo-chordae implantation and we...
Article
A significant proportion of patients undergoing aortic valve replacement have a dilated ascending aorta; presence of an ascending aorta aneurysm is viewed as a contraindication for sutureless valve implantation for the potential risk of prosthesis dislodgment. We describe our technique of sutureless prosthesis implantation and concomitant ascending...
Article
A significant proportion of patients undergoing aortic valve replacement have a dilated ascending aorta; presence of an ascending aorta aneurysm is viewed as a contraindication for sutureless valve implantation for the potential risk of prosthesis dislodgment. We describe our technique of sutureless prosthesis implantation and concomitant ascending...
Article
Full-text available
Objectives: The Sutureless and Rapid-Deployment Aortic Valve Replacement International Registry (SURD-IR) was established by a consortium of 18 research centres-the International Valvular Surgery Study Group (IVSSG)-to overcome limitations of the literature and provide adequately powered evidence on sutureless and rapid-deployment aortic valves re...
Data
Table S1. List of Included Studies Figure S1. Risk of bias summary: Review authors’ judgments about each risk‐of‐bias item for the included study. Figure S2. Funnel plot for the meta‐analysis of mortality with the Perceval valve compared with conventional prostheses.
Article
Full-text available
Background: Aortic stenosis is the most common valvular disease and has a dismal prognosis without surgical treatment. The aim of this meta-analysis was to quantitatively assess the comparative effectiveness of the Perceval (LivaNova) valve versus conventional aortic bioprostheses. Methods and results: A total of 6 comparative studies were ident...
Article
Full-text available
Purpose: Sutureless aortic valve replacement (SU-AVR) has emerged as an innovative alternative for treatment of aortic stenosis. This technology aims to reduce cardiopulmonary bypass (CPB) and cross-clamp times and thereby facilitate minimally invasive approaches. The present report is a mini-review of the current literature about results of minima...
Article
Full-text available
Objective Goals of rapid deployment aortic valve replacement (RDAVR) include facilitation of minimally invasive surgery and reduced aortic cross clamp time (XCT). Herein we report short-term outcomes of a series of 493 patients undergoing RDAVR with the EDWARDS INTUITY valve system. Methods FOUNDATION was a prospective, multicenter (n = 26) Europe...