Matthijs oude Lohuis

Matthijs oude Lohuis
University of Amsterdam | UVA · Graduate School Neurosciences Amsterdam

M.Sc.

About

15
Publications
1,675
Reads
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130
Citations
Introduction
Matthijs oude Lohuis currently works at the Graduate School Neurosciences Amsterdam, University of Amsterdam. Matthijs does research in Systems Biology, Physiology and Neuroscience.
Additional affiliations
October 2015 - May 2016
Champalimaud Neuroscience Program
Position
  • Technician

Publications

Publications (15)
Preprint
Primary sensory cortices respond to crossmodal stimuli, for example auditory responses are found in primary visual cortex (V1). However, it remains unclear whether these responses reflect sensory inputs or behavioural modulation through sound-evoked body movement. We address this controversy by showing that sound-evoked activity in V1 of awake mice...
Article
The posterior parietal cortex (PPC) plays a key role in integrating sensory inputs from different modalities to support adaptive behavior. Neuronal activity in PPC reflects perceptual decision making across behavioral tasks, but the mechanistic involvement of PPC is unclear. In an audiovisual change detection task, we tested the hypothesis that PPC...
Article
Full-text available
Primary sensory areas constitute crucial nodes during perceptual decision making. However, it remains unclear to what extent they mainly constitute a feedforward processing step, or rather are continuously involved in a recurrent network together with higher-order areas. We found that the temporal window in which primary visual cortex is required f...
Article
Full-text available
Over the past few years, the various areas that surround the primary visual cortex (V1) in the mouse have been associated with many functions, ranging from higher order visual processing to decision-making. Recently, some studies have shown that higher order visual areas influence the activity of the primary visual cortex, refining its processing c...
Preprint
Full-text available
Neurons in primary visual cortex (V1) may not only signal current visual input but also relevant contextual information such as reward expectancy and the subject's spatial position. Such location-specific representations need not be restricted to V1 but could participate in a coherent mapping throughout sensory cortices. Here we show that spiking a...
Preprint
Full-text available
The transformation of sensory inputs into behavioral outputs is characterized by an interplay between feedforward and feedback operations in cortical hierarchies. Even in simple sensorimotor transformations, recurrent processing is often expressed in primary cortices in a late phase of the cortical response to sensory stimuli. This late phase is en...
Preprint
Full-text available
Over the past few years, the various areas that surround the primary visual cortex in the mouse have been associated with many functions, ranging from higher-order visual processing to decision making. Recently, some studies have shown that higher-order visual areas influence the activity of the primary visual cortex, refining its processing capabi...
Article
Full-text available
Essential features of the world are often hidden and must be inferred by constructing internal models based on indirect evidence. Here, to study the mechanisms of inference, we establish a foraging task that is naturalistic and easily learned yet can distinguish inference from simpler strategies such as the direct integration of sensory data. We sh...
Preprint
Full-text available
Essential features of the world are often hidden and must be inferred by constructing internal models based on indirect evidence. Here, to study the mechanisms of inference we established a foraging task that is naturalistic and easily learned, yet can distinguish inference from simpler strategies such as the direct integration of sensory data. We...
Article
Full-text available
Neuronal activity is markedly different across brain states: it varies from desynchronized activity during wakefulness to the synchronous alternation between active and silent states characteristic of deep sleep. Surprisingly, limited attention has been paid to investigating how brain states affect sensory processing. While it was long assumed that...
Article
Full-text available
The neuromodulator serotonin (5-HT) has been implicated in a variety of functions that involve patience or impulse control. Many of these effects are consistent with a long-standing theory that 5-HT promotes behavioral inhibition, a motivational bias favoring passive over active behaviors. To further test this idea, we studied the impact of 5-HT in...
Preprint
Full-text available
The neuromodulator serotonin (5-HT) has been implicated in a variety of functions that involve patience or impulse control. For example, activation of 5-HT neurons promotes waiting for delayed rewards. Many of these effects are consistent with a long-standing theory that 5-HT promotes behavioral inhibition, a motivational bias favoring passive over...

Questions

Question (1)
Question
We are looking at various approaches to inhibit cortico-cortical feedback projections only in mice. Ideally the approach would be source-area specific and target-area specific (only those that project from one area to the other). 
The most straightforward approach would be to inhibit axonal terminals in the target area. However, this is notoriously hard and recently elaborately stated (Mahn et al. 2016 Nat Neurosci). 
Therefore one would like to inhibit the somatas of projecting neurons (e.g. with a retrograde virus without inhibiting other back-projecting regions)
Anyone ideas and/or experience with current approaches?

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