Matthieu Landreau

Matthieu Landreau
Seattle Children’s Research Institute · Global Infectious Disease

PhD in Microbiology

About

7
Publications
931
Reads
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60
Citations
Citations since 2016
7 Research Items
60 Citations
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Introduction
I am a dynamic and motivated microbiologist highly experienced in cell immobilization and continuous flow systems (chemostat, flow cell) applied to the culture of aerobic, anaerobic and microaerophilic microorganisms. I have extensive knowledge in molecular biology (dna extraction, sequence analysis) and demonstrated exceptional communication and teamwork skills. Adaptable and creative, I am always willing to improve and apply my knowledge to new topics. With an engineer background in food, marine and wastewater microbiology, I can be a versatile asset to different projects.
Additional affiliations
September 2020 - March 2021
Seattle Children’s Research Institute
Position
  • PostDoc Position
Description
  • Screening of broadly neutralizing antibody repertoires and identification of HIV integration sites involved in cervical cancer and low-level viremia using single cell sequencing
November 2017 - August 2019
University of Washington Seattle
Position
  • PostDoc Position
Description
  • Implementation of a synthetic AOA/Anammox bio-granular technology in the main wastewater treatment line
October 2012 - March 2016
Université de Bretagne Occidentale
Position
  • Ph.D student in Microbiology
Description
  • Development of a cell immobilization method for the continuous culture of thermophilic marine anaerobic microorganisms in a gas-lift bioreactor and application to natural samples (hydrothermal vent rocks)
Education
October 2012 - March 2016
Université de Bretagne Occidentale - Laboratoire de Microbiologie des Environnements Extrêmes - LM2E (UMR 6197)
Field of study
  • Marine Microbiology
September 2011 - June 2012
Université de Bretagne Occidentale
Field of study
  • Fundamental and applied microbiology
September 2009 - June 2012
Ecole Supérieure d’Ingénieurs en Agroalimentaire de Bretagne atlantique (ESIAB)
Field of study
  • Microbiology and Food Quality assurance

Publications

Publications (7)
Article
Full-text available
Ammonia-oxidizing archaea (AOA) are major players in the nitrogen cycle but their cultivation represents a major challenge due to their slow growth rate and limited tendency to form biofilms. In this study, AOA was embedded in small (~2.5 mm) and large (~4.7 mm) poly(vinyl alcohol) (PVA)—sodium alginate (SA) hydrogel beads cross-linked with four ag...
Article
This study investigates the effect of physicochemical conditions on the partial nitritation and anammox treatment by immobilized ammonia oxidizers under ammonium-deplete conditions. The impact of oxygen and temperature was studied by measuring the activity of immobilized aerobic and anaerobic ammonia-oxidizing organisms (Ammonia-oxidizing bacteria...
Article
Full-text available
Cultivation in a bioreactor of immobilized deep-sea hydrothermal microbial community was tested in order to assess the stability and reactivity of this new system. A community composed of 8 hydrothermal strains was entrapped in a polymer matrix that was used to inoculate a continuous culture in a gas-lift bioreactor. The continuous culture was perf...
Article
Full-text available
Aims: The aims of this study were (i) to develop a protocol for the entrapment of anaerobic (hyper)thermophilic marine microorganisms; (ii) to test the use of the chosen polymers in a range of physical and chemical conditions and; (iii) to validate the method with batch cultures. Methods and results: The best conditions for immobilization were o...
Article
The discovery of anaerobic ammonia-oxidizing bacteria (Anammox) and, more recently, aerobic bacteria common in many natural and engineered systems that oxidize ammonia completely to nitrate (Comammox) have significantly altered our understanding of the global nitrogen cycle. A high affinity for ammonia (Km(app),NH3 ≈ 63nM) and oxygen place Comammox...
Preprint
Full-text available
The discovery of complete aerobic and anaerobic ammonia-oxidizing bacteria (Comammox and Anammox) significantly altered our understanding of the global nitrogen cycle. A high affinity for ammonia ( K m(app),NH3 ≈ 63nM) and oxygen place the first described isolate, Comammox Nitrospira inopinata in the same trophic category as organisms such as some...
Thesis
Full-text available
Depuis la découverte des cheminées hydrothermales, de multiples travaux ont été menés afin d’en étudier la diversité microbienne. Les inventaires moléculaires réalisés ont ainsi mis en évidence une grande diversité d’espèces qui contraste avec la faible proportion (1 %) d’espèces isolées par approche culturale. Une nouvelle approche d’immobilisatio...

Network

Cited By

Projects

Projects (2)
Project
This highly collaborative project takes advantage of expertise in three disciplines (bioprocess engineering, computer science and material science engineering) to envision an implementation pathway for the game-changing Anammox technology in existing municipal waste water facilities. The foremost aims of the proposed research are: (a) enhance mainstream nitrogen removal capacities at minimal aeration costs, (b) determine conditions fostering the growth of ammonium-oxidizing archaea (AOA) with Anaerobic ammonium-oxidizing bacteria (Anammox) within single granules using controlled laboratory reactor systems, and (c) use the knowledge gained for improved process control to broaden applicability and cost efficiency in engineered treatment technologies.
Archived project
The objective of the MaCuMBA project is to uncover the untold diversity of marine microbes using cultivation-dependent strategies. Furthermore, MaCuMBA aims to improve the isolation rate and growth efficiency of marine microorganisms from conventional and extreme habitats by applying innovative methods and using automated high-throughput procedures.