Matthieu Béreau

Université de Franche-Comté | UFC · UFR des Sciences Médicales et Pharmaceutiques

Background Motor imagery (MI) has emerged as a promising therapeutic approach for Parkinson’s disease (PD). MI entails mentally rehearsing motor actions without executing them. This cognitive process has garnered attention due to its potential benefits in aiding motor function recovery in patients. The purpose of this review was to highlight the fi...

To assess amantadine use and associated factors in the patients with Parkinson’s disease (PD). Immediate-release amantadine is approved for the treatment of PD and is largely used in clinical practice to treat “levodopa-induced dyskinesia (LIDs). Its use varies according to countries and PD stages. The prospective NS-Park cohort collects features o...

Background Motor Imagery (MI) has emerged as a promising therapeutic approach in the rehabilitation of individuals with Parkinson’s Disease (PD). MI entails mentally rehearsing motor actions without physically executing them. This cognitive process has garnered attention due to its potential benefits in aiding motor function recovery in PD patients...

Objective To assess the efficacy of dalfampridine in patients with neuromyelitis optica spectrum disorder. Methods We included 15 consecutive patients, who were started on a treatment of dalfampridine 10 mg twice daily for 2 weeks. Efficacy assessment was based on walking ability improvement using Timed-25-Foot Walk and 12-item Multiple Sclerosis...

Multidimensional, chronic, progressive and incurable, Parkinson's disease is, by definition, a palliative disease, and this from the moment of diagnosis. This vision, relatively new to neurology, calls for a paradigm shift, as well as a dual medical-paramedical and home-hospital alliance. This approach allows us to better understand the specificiti...

Background There are currently no recommendations on the therapeutic management of Parkinson’s disease (PD) patients at the end of life. Objective To describe a cohort of patients with PD who benefited from continuous subcutaneous apomorphine infusion (CSAI) initiation at the end of their life as comfort care. Methods This real-life cohort includ...

Few studies have considered the influence of motor sign asymmetry on motivated behaviors in de novo drug-naïve Parkinson’s disease (PD). We tested whether motor sign asymmetry could be associated with different motivated behavior patterns in de novo drug-naïve PD. We performed a cross-sectional study in 128 de novo drug-naïve PD patients and used t...

Parkinson’s disease (PD) is affecting about 1.2 million patients in Europe with a prevalence that is expected to have an exponential increment, in the next decades. This epidemiological evolution will be challenged by the low number of neurologists able to deliver expert care for PD. As PD is better recognized, there is an increasing demand from pa...

Postoperative apathy is a frequent symptom in Parkinson’s disease patients who have undergone bilateral deep brain stimulation of the subthalamic nucleus. Two main hypotheses for postoperative apathy have been suggested: i) dopaminergic withdrawal syndrome relative to postoperative dopaminergic drug tapering and ii) direct effect of chronic stimula...

Apathy is commonly defined as a loss of motivation leading to a reduction in goal-directed behaviors. This multidimensional syndrome, which includes cognitive, emotional and behavioral components, is one of the most prevalent neuropsychiatric features of Parkinson’s disease (PD). It has been established that the prevalence of apathy increases as PD...

Few studies have considered the influence of motor sign asymmetry on motivated behaviors in de novo drug-naïve Parkinson’s disease (PD). We tested whether motor sign asymmetry could be associated with different motivated behaviors patterns in de novo drug naïve PD. We performed a cross-sectional study in 149 de novo drug-naïve Parkinson’s disease p...

Body-worn sensors (BWS) could provide valuable information in the management of Parkinson’s disease and support therapeutic decisions based on objective monitoring. To study this pivotal step and better understand how relevant information is extracted from BWS results and translated into treatment adaptation, eight neurologists examined eight virtu...

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment option for Parkinson's disease (PD). Recent work has shown that using low- and high-frequency DBS can have a different effect on axial and distal limb functions suggesting that the frequency might affect pathways differently. The STN is also a critical node in t...

Introduction La prise en charge thérapeutique des patients atteints de maladie de Parkinson (MP) au stade terminal ne fait aujourd’hui l’objet d’aucune recommandation. Objectifs Décrire le bénéfice de la pompe à apomorphine et du suivi conjoint neurologique et palliatif chez 7 patients MP au stade terminal. Patients et méthodes Les données cliniq...

Introduction Peu d’études se sont intéressées à la relation entre la latéralité des signes moteurs de la maladie de Parkinson (MP) et les troubles motivationnels. Objectifs Décrire et comparer le pattern des troubles motivationnels en fonction de la latéralité des signes moteurs chez des patients MP de novo non traités. Patients et méthodes Une é...

Background Fatigue is a frequent and troublesome symptom present from the early stages of Parkinson’s disease (PD). Objective To examine the relationship between fatigue and the neuropsychiatric triad, which includes apathy, depression, and anxiety, in de novo PD. Methods We performed a cross-sectional study including 197 patients with de novo PD...

Alzheimer’s disease (AD) is associated with progressive memory loss and decline in executive functions, as well as neuropsychiatric symptoms. Patients usually consider quality of life (QoL) and mood as more important for their health status than disease-specific physical and mental symptoms. In this open-label uncontrolled trial, 12 subjects diagno...

Hallucinations in Parkinson’s disease (PD) are disturbing and frequent non-motor symptoms and constitute a major risk factor for psychosis and dementia. We report a robotics-based approach applying conflicting sensorimotor stimulation, enabling the induction of presence hallucinations (PHs) and the characterization of a subgroup of patients with PD...

Background The etiology of Parkinson’s disease (PD) remains unknown. To approach the issue of PD’s risk factors from a new perspective, we hypothesized that coupling the geographic distribution of PD with spatial statistics may provide new insights into environmental epidemiology research. The aim of this case-control study was to examine the spati...

Background: Impact of subthalamic deep brain stimulation (DBS) on impulse control disorders (ICD) in Parkinson's disease (PD) remains controversial. Objectives: The objectives of this study were to analyze the natural history of ICD between baseline and 1 year after subthalamic DBS in patients with PD and to identify predictive factors, taking i...

Background: Modeling of deep brain stimulation electric fields and anatomy-based software might improve post-operative management of patients with Parkinson's disease (PD) who have benefitted from subthalamic nucleus deep brain stimulation (STN-DBS). Objective: We compared clinical and software-guided determination of the thresholds for current dif...

Hallucinations in Parkinson's disease (PD) are one of the most disturbing non-motor symptoms, affect half of the patients, and constitute a major risk factor for adverse clinical outcomes such as psychosis and dementia. Here we report a robotics-based approach, enabling the induction of a specific clinically-relevant hallucination (presence halluci...

Background Hemizygous mutations in GRIA3 encoding the GluA3 subunit of the amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor are known to be associated with neurodevelopmental disorders, including intellectual disability, hypotonia, an autism spectrum disorder, sleep disturbances, and epilepsy in males. Objective To describe a new and co...

Introduction A strategy based on targeted gene panel sequencing identifies possibly pathogenic variants in fewer than 20% of cases in early-onset and familial form of dystonia. By using Whole Exome Sequencing (WES), we aimed to identify the missing genetic causes in dystonic patients without diagnosis despite gene panel sequencing. Material and me...

Objective To foster trial‐readiness of COQ8A‐ataxia, we map the clinico‐genetic, molecular and neuroimaging spectrum of COQ8A‐ataxia in a large worldwide cohort, and provide first progression data, including treatment response to coenzyme Q10 (CoQ10). Methods Cross‐modal analysis of a multicenter cohort of 59 COQ8A patients, including genotype–phe...

Freezing of gait (FOG) in Parkinson disease (PD) is common and disabling. It has 3 phenotypes,¹ the least common one being akinetic freezing (a lack of discernible leg movements despite an intention to walk). The other phenotypes can be characterized as freezing with attempted but ineffective stepping: one involves alternating-leg trembling with a...

Impulse control disorders (ICDs) and other impulsive-compulsive related behaviours are frequent and still under recognized non-motor complications of Parkinson’s disease (PD). They result from sensitization of the mesocorticolimbic pathway that arose in predisposed PD patients concomitantly with spreading of PD pathology, non-physiological dopamine...

Background: Acute dyskinesias elicited by STN-DBS, here referred to as stimulation-induced dyskinesias, predict optimal clinical outcome in PD. However, it remains elusive whether stimulation-induced dyskinesias can guide DBS programming. Objectives: Here, we characterized stimulation-induced dyskinesias clinically and anatomically. We then test...

Objectives: We aim to (1) determine the frequency and distinctive features of short myelitis (SM) and longitudinally extensive transverse myelitis (LETM) in a cohort of adults with myelin oligodendrocyte glycoprotein (MOG)-antibody (Ab)-associated myelitis and (2) determine baseline prognostic factors among MOG-Ab-positive patients whose disease s...

Impulse control disorders (ICDs) and other related behaviors, such as punding and dopamine dysregulation syndrome, are frequent yet underrecognized non-motor complications of dopamine replacement therapy (DRT) in Parkinson's disease (PD); they can also have a major negative impact on quality of life. They result from complex interactions between a...

Advanced Parkinson's disease (PD) is characterized by severe motor and non-motor complications that negatively impact on patients' autonomy and health-related quality of life. In early disease, the therapeutic strategy consists of gradual increase in dopaminergic treatment and levodopa dose fragmentation. In more advanced stages, this approach beco...

Unlike most basal ganglia disorders, which usually progress slowly and relentlessly, a number of movement disorders may develop as acute or subacute conditions. Their occurrence commonly prompts patients to rush into the emergency room. A proper diagnosis is not always straightforward and requires a detailed analysis of the movement disorder phenom...

Immune mediated diseases (IMDs) are complex chronic inflammatory diseases involving genetic and environmental factors. Salt intake has been proposed as a diet factor that can influence the immune response. Indeed, experimental data report the influence of sodium chloride on the differentiation of naive CD4⁺ T cells into IL-17 secreting T helper (Th...

Little is known about the neurological control of human sexual behavior. Investigating and measuring this behavior by using quantitative and objective methods is difficult. Insights from lesion studies contribute to analyze the effects of neurological disorders on human sexual behavior. In this chapter, we focus on frontal lobe lesions, brain injur...

Different eponyms such as “Wood syndrome,” Meige syndrome, “Brueghel syndrome,” “Blepharospasm plus syndrome” have been used to describe segmental craniocervical dystonias. These facial and/or oromandibular movement disorders are characterized by muscle contractions and spasms involving eyes, facial region, and sometimes pharynx, jaw, floor of the...

Résumé Les mouvements anormaux (tremblement, chorée, dystonie, tics, myoclonies) sont des symptômes liés à un dysfonctionnement des noyaux gris centraux et/ou de leurs connexions. L’examen clinique est une étape essentielle permettant de caractériser le mouvement anormal (MA) et d’identifier des signes associés qui peuvent orienter le diagnostic ét...

Movement disorders (tremor, chorea, dystonia, tics, and myoclonus) are related to basal ganglia and/or interconnected brain areas dysfunction. Clinical examination is a key point in order to characterize the abnormal movement and identify associated signs that can guide etiological approach. Iatrogenic diseases will be systematically ruled out befo...

We conducted the present study to evaluate the serum levels of adipokines (leptin, total and high molecular adiponectin, resistin), a marker of cartilage breakdown (C2C), and ghrelin together with body composition in patients with knee osteoarthritis (OA). Fifty patients and 50 sex-matched healthy subjects (HS) were evaluated. Knee OA was scored ac...

The management of sporadic late-onset cerebellar ataxias represents a very heterogeneous group of patients and remains a challenge for neurologist in clinical practice. We aimed at describing the different causes of sporadic late-onset cerebellar ataxias that were diagnosed following standardized, exhaustive investigations and the population charac...

Introduction Nous decrivons une serie de 7 patients horlogers presentant une dystonie focale du membre superieur, du cou ou de la face. Objectifs Decrire et analyser les particularites semiologiques des dystonies focales de l’horloger. Patients et methodes Il s’agit d’un travail retrospectif regroupant des patients adresses en consultation dystonie...

Introduction L’hypotension orthostatique est une manifestation frequente de l’atteinte neurovegetative au cours des syndromes parkinsoniens degeneratifs. La connaissance des caracteristiques fonctionnelles de la dysautonomie oriente la prise en charge therapeutique. Objectifs Evaluer la regulation neurovegetative hemodynamique chez des patients att...

Background/aims: High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer's disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD. Method: hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perf...

The aims of this study were to describe the spectrum of recessively inherited POLG-related disorders, to report new POLG mutations and to discuss genotype-phenotype correlations in order to propose a strategy for diagnosis. Twenty eight patients diagnosed with two POLG mutations at 12 tertiary European centers of adult neurology were studied. Exhau...

Vaccines have been suspected of playing a role in inducing autoimmune disease (AID) for a long time. However, apart from certain specific vaccine strains and complications (such as the swine flu vaccine and Guillain- Barré syndrome in 1976, thrombocytopenia and the Measles-Mumps-Rubella vaccine), this role has not been established. In spite of this...

Introduction La prévalence des troubles cognitifs dans la sclérose en plaques (SEP) au stade débutant varie entre 40 % et 70 % selon les études. Cependant, ces études se caractérisent par une grande hétérogénéité en termes méthodologiques. Objectifs Étudier le profil cognitif d’une population homogène de patients SEP en utilisant la batterie fixe...

Introduction Le diméthylfumarate (DMF) est un traitement par voie orale de la sclérose en plaques (SEP) rémittente récurrente. Son efficacité et sa tolérance ont été évaluées par 2 études de phase III. Objectifs L’objectif de ce travail était d’évaluer le profil de tolérance du DMF, en vie réelle, au sein de la cohorte régionale Franc-Comtoise. M...

Our aim was to support the use of dalfampridine as a treatment for patients affected with hereditary spastic paraplegia (HSP). We performed a prospective, uncontrolled, proof of concept, open trial. We included 12 HSP patients defining the total group (TG) who received dalfampridine 10 mg twice daily for 2 weeks. Efficacy assessment was based on wa...

Interferon beta (IFN- β ) is the first line therapy of relapsing-remitting multiple sclerosis. IFN- β is a cytokine that can contribute to the development of systemic autoimmune disease including psoriasis. The development or the exacerbation of psoriasis during IFN- β treatment has been previously observed. We report the occurrence of arthritis an...

Biological agents such as monoclonal antibodies and soluble cytokine receptors have taken on an expanding role in the treatment of chronic immune mediated diseases. Progressive multifocal leukoencephalopathy (PML) is a rare central neurological disease caused by JC virus infection that has been described in the setting of conditions with severe imp...

Ustekinumab is a fully human monoclonal antibody targeting the common p40 subunit shared by interleukin (IL)-12 and IL-23. Ustekinumab prevents the interaction of IL-12 and IL-23 with their cell surface receptors, and thus blocks T helper (Th)-1 IL-12 and Th-17 IL-23 inflammatory pathways. Ustekinumab has been evaluated in the treatment of various...