Matthias Kohl

Matthias Kohl
Furtwangen University | HFU · Faculty of Medical and Life Sciences

50.58
 · 
Prof. Dr. rer. nat. Dipl. Math. (Univ.)

About

216
Publications
60,165
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3,294
Citations
Research Experience
April 2011 - present
Furtwangen University
Position
  • Professor
Description
  • Professor of Mathematics in Biology and Medicine

Publications

Publications (216)
Book
Full-text available
Das Buch bietet eine Einführung in die statistische Datenanalyse unter Verwendung der freien Statistiksoftware R, der derzeit wohl mächtigsten Statistiksoftware. Die Analysen werden anhand realer Daten durchgeführt und besprochen. Nach einer kurzen Beschreibung der Statistiksoftware R werden wichtige Kenngrößen und Diagramme der deskriptiven Statis...
Book
Full-text available
The book offers an introduction to statistical data analysis applying the free statistical software R, probably the most powerful statistical software today. The analyses are performed and discussed using real data. After a brief description of the statistical software R, important parameters and diagrams of descriptive statistics are introduced. S...
Article
Full-text available
Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology. Technologies now exist to measure the abundance of many transcripts in parallel. The selection of the optimal reference gene for the normalisation of this data is a recurring problem, and several algo...
Article
Full-text available
We determine the increase of the maximum risk over the minimax risk in the case that the optimally robust estimator for the false radius is used.
Article
Zusammenfassung Ziel dieser Metaanalyse war es (1) den Effekt eines dynamischen Krafttrainings (DRT) auf die Knochendichte (BMD) der Lendenwirbelsäule (LWS) einzuschätzen, (2) günstige Belastungs-komponenten zu identifizieren und (3) Trainingsempfehlungen abzuleiten. Eine systematische Literaturrecherche schloss (a) kontrollierte Studien, (b) DRT ≥...
Article
Postmenopausal women face a high risk of bone loss. Exercise has a beneficial effect to prevent bone deterioration in elderly women. This study was conducted to investigate the effect of different types of exercise on bone mineral density at the lumbar spine and femoral neck in postmenopausal women. This review followed the guidelines recommended b...
Preprint
Full-text available
Assessment of hematotoxicity from environmental or xenobiotic compounds is of notable interest and is frequently assessed via the colony forming unit (CFU) assay. Identification of the mode of action of single compounds is of further interest, as such often enables transfer of results across different tissues and compounds. Metabolomics displays on...
Article
Full-text available
Cardiovascular and cardiometabolic diseases are leading causes of death worldwide. Exercise favorably affects this problem, however only few invest (enough) time to favorably influence cardiometabolic risk-factors and cardiac morphology/performance. Time-effective, high-intensity, low-volume exercise protocols might increase people's commitment to...
Article
Full-text available
Osteoporosis is a major health problem in post-menopausal women (PMW). Exercise training is considered a cost-effective strategy to prevent osteoporosis in middle aged-older people. The purpose of this study is to summarize the effect of exercise on BMD among PMW. A comprehensive search of electronic databases was conducted through PubMed, Scopus,...
Article
Full-text available
Purpose: Whole-body electromyostimulation (WB-EMS) especially in combination with a high-protein supplementation has been established as an efficient treatment against sarcopenia. However, there are several case reports of rhabdomyolysis after WB-EMS application. Thus, we asked if this training could potentially lead to deteriorations of the cardi...
Article
Full-text available
This systematic review and meta-analysis set out to determine the effect of dynamic resistance exercise (DRT) on areal bone mineral density (aBMD) in postmenopausal women and derive evidence-based recommendations for optimized training protocols. A systematic review of the literature according to the PRISMA statement included (a) controlled trials,...
Article
Dynamic resistance exercise (DRT) might be the most promising agent for fighting sarcopenia in older people. However, the positive effect of DRT on osteopenia/osteoporosis in men has still to be confirmed. In order to evaluate the effect of low volume/high intensity (HIT)‐DRT on bone mineral density (BMD) and skeletal muscle mass index (SMI) in men...
Technical Report
Full-text available
Similarity plots based on correlation and median absolute deviation (MAD); adjusting colors for heatmaps; aggregate technical replicates; calculate pairwise fold-changes and log fold-changes; compute one- and two-way ANOVA; simplified interface to package 'limma' (Ritchie et al. (2015), <doi:10.1093/nar/gkv007> ) for moderated t-test and one-way AN...
Article
Full-text available
The Acknowledgement Statement was incorrect in the original publication of this article [1] and the previous correction note [2]. The correct statement is as follows.
Technical Report
Full-text available
Power analysis and sample size calculation for Welch and Hsu (Hedderich and Sachs (2018), ISBN:978-3-662-56657-2) t-tests including Monte-Carlo simulations of empirical power and type-I-error. Power and sample size calculation for Wilcoxon rank sum and signed rank tests via Monte-Carlo simulations. Power and sample size required for the evaluation...
Article
Full-text available
Objective: To analyze the thermogenic effects of footbaths with medicinal powders in adolescents with anorexia nervosa (AN) in comparison to healthy controls (HCs). Intervention and Outcomes. Forty-one female participants (21 AN, 20 HCs; 14.22 ± 1.54 years) received three footbaths-warm water and mustard (MU, Sinapis nigra), warm water and ginger...
Article
Full-text available
Considerably decreased muscle mass and function are subsumed under "sarcopenia," a geriatric syndrome. Dedicated exercise programs maintain muscle mass and function; however, due to the limited enthusiasm of older adults to exercise, it is important to generate low-threshold interventions for this vulnerable cohort. Thus, the primary aim of this st...
Article
Full-text available
Accumulating evidence indicates that there is an interaction between the gut microbiota and endometriotic lesions. The new formation of these lesions is associated with stem cell recruitment, angiogenesis and inflammation, which may affect the composition of the gut microbiota. To test this hypothesis, we herein induced endometriotic lesions by tra...
Technical Report
Full-text available
Computation of various confidence intervals (Altman et al. (2000), ISBN:978-0-727-91375-3; Hedderich and Sachs (2018), ISBN:978-3-662-56657-2) including bootstrapped versions (Davison and Hinkley (1997), ISBN:978-0-511-80284-3) as well as Hsu (Hedderich and Sachs (2018), ISBN:978-3-662-56657-2), permutation (Janssen (1997), <doi:10.1016/S0167-7152(...
Article
Full-text available
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. PD patients suffer from gastrointestinal dysfunctions and alterations of the autonomous nervous system, especially its part in the gut wall, i.e., the enteric nervous system (ENS). Such alterations and functional gastrointestinal deficits often occur years before the cl...
Technical Report
Full-text available
Computation of standardized interquartile range (IQR), Huber-type skipped mean (Hampel (1985), <doi:10.2307/1268758>), robust coefficient of variation (CV) (Arachchige et al. (2019), ), robust signal to noise ratio (SNR), as well as functions that support graphical visualization such as boxplots based on quartiles (not hinges), negative logarithms...
Article
Full-text available
Background: Low back pain (LBP) affects almost everyone at least once in their lifetime. Various meta-analyses show promising effects on pain reduction for conventional exercise. However, the lack of time and, especially for pain patients, a fear of movement ("kinesiophobia") as well as functional limitations often oppose participation in such act...
Article
Full-text available
There is a variety of antineoplastic drugs that are based on natural compounds from ecological niches with high evolutionary pressure. We used two cell lines (Jurkat J16 and Ramos) in a screening to assess 300 different naturally occurring compounds with regard to their antineoplastic activity. The results of the compounds 4,6-dibromo-2-(2′,4′-dibr...
Article
Zusammenfassung Körperliches Training kann alle Größen des Frakturrisikos positiv beeinflussen, ein direkter Nachweis des frakturreduktiven Potentials fehlt indes. Ziel dieser Übersicht ist es, den frakturpräventiven Effekt körperlichen Trainings zu belegen und die trainings-wissenschaftlich/organisatorische Vorgehensweise am Beispiel der Erlanger...
Article
Full-text available
Purpose: Overweight and obesity are an increasing problem worldwide. However, most studies that focus on weight reduction by energy restriction and/or aerobic exercise reported considerable loss of muscle mass as well. Increased protein intake and/or resistance exercise might inhibit this detrimental effect during a negative energy balance. Whole-b...
Article
Zusammenfassung Ziel der Untersuchung war es, den Zusammenhang zwischen Sarkopenie und Osteoporose bei älteren Männern zu erfassen. Selbstständig lebende Männer, 72 Jahre + mit einer morphometrischen Sarkopenie (n = 78), wurden in die Untersuchung eingeschlossen. Mittels multipler Regressionsanalyse wurde insb. der Erklärungsbeitrag der Sarkopeniek...
Article
Full-text available
The “Acknowledgment Statement” of the published paper is incorrect. The correct statement should be the below: Acknowledgements We thank Sarah Vogel for her support in taste test realization and Yvonne Sauermann for preparation of the tastant solutions. The present work was carried out by Ms. Schalk in order to meet the requirements for the awardin...
Article
Full-text available
For modern approaches in precision medicine, fast and easy-to-use point-of-care diagnostics (POCs) are essential. Digoxin was chosen as an example of a drug requiring close monitoring. Digoxin is a cardiac glycoside used for the treatment of tachycardia with a narrow therapeutic window of 0.5–2.0 ng·mL⁻¹, and toxic effects are common for concentrat...
Article
Full-text available
Introduction. Recent meta-analyses on compression garments have reported faster recovery of muscle function particularly after intense eccentric power or resistance exercise. However, due to the complex interaction between cohorts included, exercises involved and compression applied, recovery length and modalities, and outcome parameters selected,...
Article
Full-text available
Abstract Background Sarcopenic Obesity (SO) is characterized by low lean and high fat mass; i.e. from a functional aspect a disproportion between engine (muscle) and mass to be moved (fat). At present, most research focuses on the engine, but the close “cross talk” between age-associated adipose and skeletal muscle tissue inflammation calls for com...
Article
Full-text available
Surfaces with regular contact with the human body are typically contaminated with microorganisms and might be considered as fomites. Despite spectacles being widespread across populations, little is known about their microbial contamination. Therefore, we swab-sampled 11 worn spectacles within a university setting as well as 10 worn spectacles in a...
Data
Number of isolates from the spectacles and the identified bacterial taxa. (XLSX)
Data
Germ counts of the cleaning tests. (XLSX)
Data
Germ counts of the spectacles at the different sample sites and environments. (XLSX)
Article
Full-text available
Age-related loss of muscle mass and function, also called sarcopenia, was recently added to the ICD-10 as an independent condition. However, declines in muscle mass and function are inevitable during the adulthood aging process. Concerning muscle strength as a crucial aspect of muscle function, maximum knee extension strength might be the most impo...
Article
Objective: To analyze the short-term thermogenic effects of footbaths with warm water alone (WA) versus when combined with medicinal powders. Design: Randomized controlled trial with cross-over. Interventions and Outcomes: Seventeen healthy volunteers (mean age 22.1 years, SD = 2.4; 11 female) received three footbaths with WA or WA combined with mu...
Article
Full-text available
Purpose Low back pain (LBP) is one of the most frequent chronic conditions worldwide. Data from a recent meta-analysis indicated that whole-body electromyostimulation (WB-EMS), a time-effective, joint–friendly, and highly individualized training technology, demonstrated promising effects on LBP; however, methodologic limitations prevent definitive...
Code
Package MKmisc includes a collection of functions that I found useful in my daily work. It contains several functions for statistical data analysis; e.g. for sample size and power calculations, computation of confidence intervals, and generation of similarity matrices.
Technical Report
Full-text available
Optimally robust estimation for extreme value distributions using S4 classes and methods (based on packages 'distr', 'distrEx', 'distrMod', 'RobAStBase', and 'ROptEst').
Article
Full-text available
Background The aim of this strictly statistical approach was to provide a figure discrimination in a homogeneous cohort that is based on a main component, which includes disability, physical performance, and autonomy parameters. Methods We used data of 939 community-dwelling men aged ≥70 years, living in the area of Erlangen-Nürnberg, Germany. Bri...
Technical Report
Full-text available
Includes 'sysdata.rda' file for packages of the 'RobASt' - family of packages; is currently used by package 'RobExtremes' only.
Article
Ceramide generation is involved in signal transduction of cellular stress response, in particular during stress-induced apoptosis in response to stimuli such as minimally modified Low-density lipoproteins, TNFalpha and exogenous C6-ceramide. In this paper we describe 48 diverse synthetic products and evaluate their lysosomotropic and acid sphingomy...
Article
The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protein supplementation (n = 33) or a...
Article
This systematic review detected only limited positive effects of exercise on bone mineral density in older men. Further, based on the present literature, we were unable to suggest dedicated exercise prescriptions for this male cohort that might differ from recommendations based on studies with postmenopausal women. The primary aim of this systemati...
Article
Full-text available
Aptamer-based lateral flow assays (LFAs) are an emerging field of aptamer applications due to numerous potential applications. When compared to antibodies, potential advantages like cost effectiveness or lower batch to batch variations are evident. The development of LFAs for small molecules, however, is still challenging due to several reasons, pr...
Chapter
Abstract Nanoparticles (NPs) and other nanomaterials are progressively studied for use in biomedical applications such as imaging, drug delivery, and hyperthermia therapies. Therefore, considering the interaction of nanomaterials with biological systems becomes vital for their safe and efficient application. It is increasingly being acknowledged th...
Book
Precision Medicine: Tools and Quantitative Approaches discusses precision and personalized medicine, two relevant topics that are revolutionizing diagnostics and treatment, while also providing a shift toward prevention. The book covers the most relevant features and explanations underlying developments in the field. A timely review on prerequisite...
Chapter
Abstract Statistical (machine) learning more and more becomes a key tool for precision medicine. In this chapter, we describe the most important components and steps involved in statistical learning for patient data. We start with the basics such as the data itself and the types of learning algorithms. Next, we explain in more detail how supervised...
Article
To determine the underlying mechanisms after one session of (intense) whole-body electromyostimulation (WB-EMS) on total energy expenditure (TEE) and resting metabolic rate (RMR), 16 subjects followed a standardized protocol of indirect calorimetry for up to 72h in 12h intervals. The single session significantly increased RMR about 25±10% (p<0.001)...
Article
Background: Low back pain (LBP) has a high priority in our predominately sedentary society. The aim of this meta-analysis of present data was to evaluate the effect of whole-body electromyostimulation (WB-EMS) on LBP in sedentary older people with relevant pain. › Methods: The present analysis based on four recently-conducted randomized controlled...
Article
Full-text available
In order to evaluate the favorable effect of whole-body electromyostimulation (WB-EMS) on low back pain (LBP), an aspect which is frequently claimed by commercial providers, we performed a meta-analysis of individual patient data. The analysis is based on five of our recently conducted randomized controlled WB-EMS trials with adults 60 years+, all...
Article
Purpose of review: Due to older people's low sports participation rates, exercise frequency may be the most critical component for designing exercise protocols that address fracture risk. The aims of the present article were to review and summarize the independent effect of exercise frequency (ExFreq) on the main determinants of fracture preventio...
Article
Full-text available
Purpose: Cancer patients are at high risk of malnutrition and tumor cachexia further increasing morbidity and mortality. Reasons for cachexia are not clear yet, but inflammatory processes as well as the occurrence of taste disorders reducing nutrient uptake are discussed to play key roles. The purpose of this study was to gain insight into causati...
Article
Full-text available
Background Sarcopenic obesity (SO) is a geriatric syndrome characterized by the disproportion between the amount of lean mass and fat mass. Exercise decreases fat and maintains muscle mass; however, older people fail to exercise at doses sufficient to affect musculoskeletal and cardiometabolic risk factors. The aim of this study was to evaluate the...
Article
Despite its frequent use in many religious institutions, the microbiological quality of holy water is clearly underinvestigated. We analyzed the microbial load of 54 holy water samples, repeatedly taken in five Roman Catholic churches in the greater area of Villingen-Schwenningen, Germany, by means of aerobic colony counting and Matrix-Assisted Las...
Article
Full-text available
High intensity (resistance exercise) training (HIT) defined as a “single set resistance exercise to muscular failure” is an efficient exercise method that allows people with low time budgets to realize an adequate training stimulus. Although there is an ongoing discussion, recent meta-analysis suggests the significant superiority of multiple set (M...
Article
Full-text available
Cardiac dysfunction, in particular of the left ventricle, is a common and early event in sepsis, and is strongly associated with an increase in patients’ mortality. Acid sphingomyelinase (SMPD1)—the principal regulator for rapid and transient generation of the lipid mediator ceramide—is involved in both the regulation of host response in sepsis as...
Article
Full-text available
There are more than 8000 rare diseases (RDs) that affect >5 % of the world’s population. Many of the RDs have no effective treatment and lack of knowledge creates delayed diagnosis making management difficult. The emerging concept of the personalized medicine allows for early screening, diagnosis, and individualized treatment of human diseases. In...
Article
Full-text available
Recently extreme increases in serum creatine-kinase (CK) concentration after initial whole-body electromyostimulation (WB-EMS) were reported that indicating a severe (exertional) rhabdomyolysis. Thus our aim was (1) to verify the reported WB-EMS induced CK-increases, (2) to determine the corresponding consequences for health and (3) to assess physi...
Article
Full-text available
Background Sarcopenic obesity (SO) is characterized by a combination of low muscle and high fat mass with an additive negative effect of both conditions on cardiometabolic risk. The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on the metabolic syndrome (MetS) in community-dwelling women aged ≥70 years wi...
Article
Full-text available
Objective: Multimorbidity related to menopause and/or increased age will put healthcare systems in western nations under ever-greater strain. Effective strategies to prevent diseases are thus of high priority and should be started earlier in life. The purpose of the study was to evaluate the long-term effect of exercise on different important heal...
Article
Full-text available
Background: Time-efficient exercise protocols may encourage subjects to exercise more frequently and could thus be excellent tools for health promotion. The aim of this study was to compare the effectiveness of the time-efficient methods HIT and/versus WB-EMS on cardio-metabolic risk factors in untrained middle-aged males. Methods: Untrained, healt...
Article
Full-text available
Introduction: The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on sarcopenic obesity (SO) in community-dwelling women more than 70 years with sarcopenic obesity. Methods: Seventy-five community-dwelling women ≥70 years with SO were randomly allocated to either a WB-EMS-application with (WB-EMS &P; 24....
Article
Background: Only few studies have examined the efficacy of musical intervals on psychological parameters. This study investigated the efficacy of specific musical intervals on mood change.Methods: Volunteers (n = 66) were randomized into three groups. Major seventh, fifth and minor third musical intervals were consecutively played in a randomized o...
Article
Full-text available
Plurality and individuality of hepatocellular carcinoma: PPPM perspectives Krishna Chander Sridhar, Olga Golubnitschaja Department of Radiology, Univeristy of Bonn, Bonn, Germany Correspondence: Olga Golubnitschaja (olga.golubnitschaja@ukb.uni-bonn.de) – Department of Radiology, Univeristy of Bonn, Bonn, Germany The EPMA Journal 2016, 7(Suppl 1)...
Article
Due to older people's low sports participation rates, exercise frequency may be the most critical component for designing exercise protocols that address bone. The aims of the present article were to determine the independent effect of exercise frequency (ExFreq) and its corresponding changes on bone mineral density (BMD) and to identify the minimu...
Article
Full-text available
Development of a dysregulated immune response discriminates sepsis from uncomplicated infection. Currently used biomarkers fail to describe simultaneously occurring pro- and anti-inflammatory responses potentially amenable to therapy. Marker candidates were screened by microarray and, after transfer to a platform allowing point-of-care testing, val...