Matthias Walter

Matthias Walter
Universitätsspital Basel · Klinik für Urologie

MD, PhD, FEBU

About

85
Publications
8,109
Reads
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465
Citations
Additional affiliations
August 2020 - present
Universitätsspital Basel
Position
  • Consultant
Description
  • Associate Member, International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Canada
August 2019 - July 2020
Swiss Paraplegic Centre
Position
  • Consultant
November 2016 - present
University of British Columbia - Vancouver
Position
  • Associate Member
Education
December 2011 - March 2018
Maastricht University
Field of study
  • Neuro-Urology
October 2010 - January 2014
University of Zurich
Field of study
  • Pediatrics
July 2006 - September 2016
European Board of Urology (EBU)
Field of study
  • Urology

Publications

Publications (85)
Article
To investigate autonomic dysreflexia (AD) and repeatability of cardiovascular changes during same session repeat urodynamic investigation (UDI) in women with spinal cord injury (SCI). Prospective investigation of 33 consecutive women with suprasacral SCI suffering from neurogenic lower urinary tract dysfunction (NLUTD) undergoing same session repea...
Article
Full-text available
Objective: To evaluate the applicability and precision of a novel infusion-drainage device (IDD) for standardised filling paradigms in neuro-urology and functional magnetic resonance imaging (fMRI) studies of lower urinary tract (LUT) (dys)function. Subjects/patients and methods: The IDD is based on electrohydrostatic actuation which was previou...
Article
Full-text available
Objectives: To evaluate whether urodynamic investigation (UDI), the gold standard to assess refractory lower urinary tract symptoms (LUTS), is appropriate to select healthy volunteers with apparent normal lower urinary tract function as control subjects for comparative studies. Subjects and methods: 42 healthy subjects (22 women, mean age 32±10...
Article
Full-text available
Purpose: To examine the value of surveillance urethro-cystoscopy in patients with neurogenic lower urinary tract dysfunction (NLUTD) in regard to the conflicting literature as it is generally agreed that patients with NLUTD are at increased risk for bladder cancer. Materials and methods: In a cross-sectional study, a consecutive series of 129 pa...
Article
Intradetrusor onabotulinumtoxinA (BoNT-ONA) injections have become a well-established therapy for refractory neurogenic detrusor overactivity (NDO). However, little is known about long-term outcome and patients’ adherence to this treatment.
Preprint
Full-text available
Cervical and upper-thoracic spinal cord injury (SCI) commonly results in autonomic cardiovascular impairments. These impairments can lead to alterations in blood flow, cerebral perfusion pressure and ultimately tissue perfusion, which can lead to an elevated risk of stroke and global cognitive deficits. The aim of this study was to assess cerebrova...
Article
Study design: Secondary data analysis. Objective: To characterize heart rate (HR) changes during autonomic dysreflexia (AD) in daily life for individuals with chronic spinal cord injury (SCI). Setting: University-based laboratory/community-based outpatient. Methods: Cardiovascular data, previously collected during a 24-h ambulatory surveilla...
Article
Full-text available
Individuals with cervical spinal cord injury (SCI) experience deleterious changes in cardiac structure and function. However, knowledge on when cardiac alterations occur and whether this is dependent upon neurological level of injury remains to be determined. Transthoracic echocardiography was used to assess left ventricular structure, function, an...
Article
Study design: Cohort prospective study. Objectives: Epidural spinal cord stimulation (eSCS) improves volitional motor and autonomic function after spinal cord injury (SCI). While eSCS has an established history of safety for chronic pain, it remains unclear if eSCS in the SCI population presents the same risk profile. We aimed to assess safety a...
Article
Objective: Individuals with spinal cord injury (SCI) report using cannabis to self-manage chronic pain and spasticity. However, its safety and efficacy are not well understood. As more women with SCI are pursuing motherhood, clinicians must consider the possibility of maternal cannabis use and its impact on fetal development. Moreover, due to the...
Article
Full-text available
Spinal cord injury chronically alters cardiac structure and function and is associated with increased odds for cardiovascular disease. Here, we investigate the cardiac consequences of spinal cord injury on the acute-to-chronic continuum, and the contribution of altered bulbospinal sympathetic control to the decline in cardiac function following spi...
Article
Systematic Review. To review systematically the clinical evidence of the effectiveness of various intermittent catheter cleaning methods that have been proposed as methods to prepare catheters for reuse. A keyword search in Medline, Excerpta Medica dataBASE, the Cumulative Index to Nursing and Allied Health Literature, Web of Science and Cochrane C...
Article
Full-text available
Urodynamic studies (UDS) can provoke autonomic dysreflexia (AD) in individuals with spinal cord injury (SCI) at and above the sixth thoracic spinal segment potentially leading to profound vagally mediated heart rate (HR) reductions. In this study, ¹ we test the hypothesis that intradetrusor onabotulinumtoxinA injections will improve HR and its vari...
Preprint
Full-text available
Background: Intermittent catheterization (IC), considered the gold standard for bladder management for individuals with spinal cord injury (SCI) with sufficient dexterity, is usually performed using hydrophilic (HPC) or non-hydrophilic (non-HPC) catheters. Currently, there is no evidence on the temporal burden associated with IC with either cathete...
Article
Full-text available
Objective: The primary aim of this study was to determine the feasibility of delivering an exoskeleton-assisted walking intervention targeting lower urinary tract function in people with motor-complete spinal cord injury. Secondary aims were to determine if exoskeleton walking activates the pelvic floor muscles, and compare 2 exoskeleton programme...
Chapter
Penile cancer is rare but associated with a high morbidity and mortality once metastasized. Besides presenting a fundamental overview of penile cancer, the current literature on key players associated with the pathogenesis of penile cancer including common labor chemistry parameters [neutrophil to lymphocyte ratio (NLR) and C-reactive protein CrP)]...
Preprint
Full-text available
Objective: To characterize heart rate (HR) changes during autonomic dysreflexia (AD) in daily life for individuals with chronic spinal cord injury (SCI). Design: Data analysis of two prospective clinical studies and one cross-sectional study. Setting: Single-center study. Participants: Forty-five individuals (including 8 females) with a chronic SCI...
Preprint
Full-text available
This systematic review provides an up to date and comprehensive summary of the clinical evidence of the effectiveness of various cleaning methods of intermittent catheterization that have been proposed to prepare catheters for reuse. This systematic review is registered at PROSPERO (registration number: CRD42020176065). A key word search of Medline...
Preprint
Full-text available
Importance Urodynamic studies (UDS) can provoke autonomic dysreflexia (AD) in individuals with spinal cord injury (SCI) at and above the sixth thoracic (T6) spinal segment potentially leading to profound vagally mediated heart rate reductions. Intradetrusor onabotulinumtoxinA injections have been shown to reduce AD events during UDS in this cohort...
Preprint
Full-text available
Purpose Autonomic dysreflexia, often accompanied by heart rate changes, increases the risk of cardio-cerebrovascular complications in individuals with spinal cord injury. Thus, our aim was to characterize these changes during penile vibrostimulation and urodynamics. Materials and Methods We analyzed the cardiovascular (i.e. blood pressure and he...
Article
Objectives: To better understand the neuropathophysiology of overactive bladder (OAB) in women by characterizing supraspinal activity in response to bladder distention and cold stimulation. Subjects/patients and methods: We recruited 24 female participants, 12 with OAB [median age 40 years (interquartile range 32 - 42)] and 12 healthy controls (...
Article
Full-text available
Study design: Cross-sectional study. Objectives: To identify the prevalence of complications associated with intermittent catheterization in wheelchair athletes with spinal cord injury (SCI). Setting International and national sporting events. Methods: A total 130 competitive wheelchair athletes living with SCI completed a self-reported questionn...
Article
Full-text available
Introduction Since December 2019, a novel coronavirus (SARS-CoV-2) has triggered a world-wide pandemic with an enormous medical and societal-economic toll. Thus, our aim was to gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with coron...
Article
Full-text available
Pilot data of our phase IV clinical trial (pre/post study design) highlighted a beneficial effect of intradetrusor onabotulinumtoxinA (200 IU) injections to reduce autonomic dysreflexia (AD) in individuals with chronic spinal cord injury (SCI) at T6 or above. After trial completion, we assessed whether our primary expectation (i.e., decrease of AD...
Article
Full-text available
Coronavirus disease 2019 (COVID-19) can lead to considerable lung damage and even death. Less is known about the effects of COVID-19 on the cardiovascular system. In their recent JAMA Cardiology article, Shi and colleagues reported an association between cardiac injury and higher risk of in-hospital mortality in patients with COVID-19. Approximatel...
Preprint
Full-text available
Introduction Since December 2019, a novel coronavirus (SARS-CoV-2) has triggered a world-wide pandemic with an enormous medical, societal, and economic toll. Thus, our aim was to gather all available information regarding comorbidities, clinical signs and symptoms, outcomes, laboratory findings, imaging features, and treatments in patients with cor...
Article
Full-text available
Background: People with spinal cord injuries (SCI) commonly experience pain and spasticity, but limitations of current treatments have generated interest in cannabis as a possible therapy. Objectives: We conducted this systematic review to: 1) examine usage patterns and reasons for cannabinoid use, and 2) determine the treatment efficacy and safe...
Article
Currently, there is neither a regulatory foundation nor evidence-based medicine available to recommend catheter re-/multiple use for intermittent catheterization at present time. High-level evidence from studies comparing the effect of catheter re-/multiple use versus single use on symptomatic urinary tract infections (UTI), using an appropriate ca...
Article
Objective: To examine the prevalence of postpartum depression (PPD) and postpartum anxiety (PPA) in mothers with spinal cord injury (SCI). Design: Retrospective, cross-sectional study. Setting: Online multi-national study. Participants: We surveyed an international sample of 102 women who gave birth following cervical SCI (C1–C8, n = 30), upper tho...
Article
Full-text available
Context: Individuals with spinal cord injury (SCI) suffering from autonomic dysreflexia (AD) due to neurogenic detrusor overactivity (NDO) can effectively be treated with intradetrusor onabotulinumtoxinA. We present a complex case to highlight the treatment's potential limitations to ameliorate AD and improve lower urinary tract (LUT) function in...
Article
Full-text available
This case report describes a unique manifestation of a primary urethral squamous cell carcinoma (SCC) as the underlying pathology in an 80-year-old male patient who underwent partial penectomy due to an enlarging penile mass. Persistent pain in the right knee was discovered to be a pathologic fracture using magnetic resonance imaging. Computed tomo...
Article
Full-text available
Previous functional neuroimaging studies provided evidence for a specific supraspinal network involved in lower urinary tract (LUT) control. However, data on the reliability of blood oxygenation level-dependent (BOLD) signal changes during LUT task-related functional magnetic resonance imaging (fMRI) across separate measurements are lacking. Proof...
Article
Full-text available
This case report presents a unique manifestation of complications in a 71-year-old man following blunt renal trauma. Initially, computed tomography (CT) revealed a traumatic left kidney laceration. Hematuria ceased quickly after ureteral stent placement. One week later, hematuria reoccurred while the patient was treated for pulmonary embolism. Mult...
Article
Full-text available
Regaining control of autonomic functions such as those of the cardiovascular system, lower urinary tract and bowel, rank among the most important health priorities for individuals living with spinal cord injury (SCI). Recently our research provided evidence that epidural spinal cord stimulation (ESCS) could acutely modulate autonomic circuits respo...
Article
Full-text available
Introduction: Baseline urodynamic characterization in patients with neurogenic lower urinary tract dysfunction (NLUTD) allows detection of unsafe storage and voiding pressures and optimization of these parameters through medical or surgical intervention. Surveillance urodynamics (sUDS) studies are performed in the ambulatory setting after baseline...
Article
Full-text available
Introduction: Managing and preventing risk factors associated with cardiovascular and cerebrovascular impairment is well studied in able-bodied individuals. However, individuals with spinal cord injury (SCI) at or above the spinal segment T6 are prone to experience autonomic dysreflexia (AD) but also to suffer from neurogenic detrusor overactivity...
Article
Full-text available
Background: Autonomic dysreflexia is a severe and potentially life-threatening condition in patients with spinal cord injury, as it can lead to myocardial ischemia, brain hemorrhage, or even death. Urodynamic investigation is the gold standard to assess neurogenic lower urinary tract dysfunction due to spinal cord injury and reveal crucial patholo...
Article
Full-text available
During the last few years, the international community debated on urinary tract infection and re-use of catheters when managing neurogenic lower urinary tract dysfunction among individuals with SCI. In this respect, the 2014 Cochrane review by Prieto et al, 'Intermittent Catheterisation for Long-Term Bladder Management', became one of the leading d...
Article
Individuals sustaining a spinal cord injury (SCI) frequently suffer from sensorimotor and autonomic impairment. Damage to the autonomic nervous system results in cardiovascular, respiratory, bladder, bowel, and sexual dysfunctions, as well as temperature dysregulation. These complications not only impede quality of life, but also affect athletic pe...
Data
STROBE Statement Checklist. (DOC)
Data
TREND Statement Checklist. (PDF)
Data
Translation of the study protocol relevant parts. (DOCX)
Article
Full-text available
Many of the patients undergoing intradetrusor onabotulinumtoxinA injections for refractory neurogenic detrusor overactivity (NDO) present with chronic bacteriuria. In these patients, antibiotic prophylaxis has been widely recommended since bacteriuria might impair treatment efficacy and cause urinary tract infections (UTI) but the evidence is limit...
Article
Full-text available
Renal cell carcinomas (RCC), mostly occurring in adults aged 60–70 years, can result from well-known factors like cigarette smoking, obesity and hypertension. However, they have been associated with genetic alterations in children and young adults. A 28 year-old male patient with a confirmed RCC underwent biomolecular and immunohistochemical analys...
Article
Background: Intradetrusor onabotulinumtoxinA (BoNT-ONA) injections have become a well-established therapy for refractory neurogenic detrusor overactivity (NDO). However, little is known about long-term outcome and patients' adherence to this treatment. Objective: To assess long-term outcomes of intradetrusor BoNT-ONA injections and patients' adh...