Matthias G. Friedrich

Matthias G. Friedrich
McGill University Health Centre · Medicine and Diagnostic Radiology

Professor of Medicine

About

461
Publications
39,092
Reads
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19,546
Citations
Introduction
Matthias Friedrich is Full Professor and staff cardiologist at the McGill University Health Centre, where he is also Chief of Cardiovascular Imaging and Scientific Director of the Courtois Cardiovascular Signature Program. His research interest is focused on cardiovascular magnetic resonance (CMR) imaging. He is working with novel methods to visualize tissue pathology using native CMR techniques. He has more than 15,000 citations of his published papers. He is also involved in medical software development (cvi42, CMR Atlas for the iPad). Currently, he and his team are working on optimized, fast protocols for comprehensive CMR scans and on oxygenation-sensitive CMR for assessing coronary vascular function.
Additional affiliations
June 2015 - January 2017
McGill University Health Centre
Position
  • Professor (Full)
September 2012 - present
Montreal Heart Institute
Position
  • Oxygen-Sensitive CMR of Myocardial Ischemia
Description
  • Assessment of the utility of oxygen-sensitive CMR to detect hemodynamically significant coronary artery stenosis (as defined by FFR)
July 2011 - present
Université de Montréal
Position
  • Professor (Full)
Education
May 1998 - February 2004
Humboldt-Universität zu Berlin
Field of study
  • Medicine, Cardiology
October 1983 - May 1990

Publications

Publications (461)
Article
Full-text available
Background Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of...
Article
Full-text available
Purpose Diagnostic imaging techniques have to be selected for their accuracy, efficiency, cost-efficiency, and impact on outcome. But beyond that, the choice of non-invasive cardiovascular imaging tests for diagnosing coronary artery disease also has to respect patient safety and comfort. In this study, we investigated patient and physician prefere...
Article
Full-text available
Background Myocardial strain imaging has gained importance in cardiac magnetic resonance (CMR) imaging in recent years as an even more sensitive marker of early left ventricular dysfunction than left-ventricular ejection fraction (LVEF). fSENC (fast strain encoded imaging) and FT (feature tracking) both allow for reproducible assessment of myocardi...
Preprint
Full-text available
Background Long-term exposure to air pollution, even at levels below regulatory standards, has been associated with higher risk of cardiovascular-related mortality. Less is known about the association of air pollution and initial development of CVD in low-exposure settings in generally healthy human populations. Objective In the Canadian Alliance...
Article
Funding Acknowledgements Type of funding sources: Public hospital(s). Main funding source(s): Research Institute of the McGill University Health Centre. Background Oxygenation-Sensitive Cardiac Magnetic Resonance (OS-CMR) has emerged as a powerful tool to investigate the underlying physiology of a number of disease states through the assessment of...
Article
Full-text available
In patients with suspected acute coronary syndrome high-sensitivity cardiac tropnonin T is used for rapid patient triage. Some acute coronary syndrome patients assigned to the observe zone based on high-sensitivity cardiac troponin T after 1 h require further diagnostic testing. Fast-strain encoded CMR imaging with breathing maneuvers may accelerat...
Article
Full-text available
Epipericardial fat necrosis (EPFN) is a rare, benign cause of acute chest pain imitating symptoms of life-threatening diseases, such as acute coronary syndrome. Here We report a 37-year-old, healthy male presented to the emergency department (ED) with sudden-onset pleuritic chest pain after an isometric physical training. Initial cardiac workup inc...
Preprint
Background In patients with suspected acute coronary syndrome (ACS) high-sensitivity cardiac tropnonin T (hscTnT) is used for rapid patient triage. Fast-strain encoded (fSENC) CMR imaging with breathing maneuvers may accelerate diagnostic work-up and identify patients suffering from ACS. Methods Patients presenting with ACS (hscTnT level 5-52ng/L)...
Article
Pulmonary hypertension (PH), a chronic and complex medical condition affecting 1% of the global population, requires clinical evaluation of right ventricular maladaptation patterns under various conditions. A particular challenge for clinicians is a proper quantitative assessment of the right ventricle (RV) owing to its intimate coupling to the lef...
Preprint
Aims: Dobutamine and adenosine stress cardiac magnetic resonance imaging (CMR) are relatively contraindicated in patients with moderate to severe AS. We aimed to determine the safety of dobutamine and adenosine stress CMR in patients with moderate to severe AS. Methods: In this retrospective study patients with AS who underwent either dobutamine or...
Article
Inflammatory cardiomyopathy (I-CMP) is defined as myocarditis in association with cardiac dysfunction and/or ventricular remodelling. It is characterized by inflammatory cell infiltration into the myocardium and has heterogeneous infectious and non-infectious aetiologies. A complex interplay of genetic, autoimmune, and environmental factors contrib...
Article
Importance: Excess adipose tissue increases other cardiovascular risk factors, which may be associated with vascular brain injury and cognitive impairment. However, the extent to which the amount and distribution of adipose tissue may be associated with lower cognitive scores, independent of its association with cardiovascular risk factors, is not...
Article
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Background The pathophysiology of heart failure with preserved ejection fraction is not well understood, but evidence strongly suggests involvement of microvascular dysfunction. We studied the myocardial oxygenation reserve as a direct marker of coronary vascular function and its relation to myocardial deformation and tissue characteristics by card...
Article
Full-text available
Background In the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the manage...
Article
Full-text available
Background: Cardiac magnetic resonance (CMR) pharmacological stress-testing is a well-established technique for detecting myocardial ischemia. Although stressors and contrast agents seem relatively safe, contraindications and side effects must be considered. Substantial costs are further limiting its applicability. Dynamic handgrip exercise (DHE) m...
Article
Full-text available
Various data sharing platforms are being developed to enhance the sharing of cohort data by addressing the fragmented state of data storage and access systems. However, policy challenges in several domains remain unresolved. The euCanSHare workshop was organized to identify and discuss these challenges and to set the future research agenda. Concern...
Article
Introduction: Adequate glycemic control can prevent or delay complications of diabetes. Little is known about the role of glycemic control trajectories on early markers of CVD in youth. Hypothesis: Poor glycemic control trajectory will be associated with increased vascular ageing and altered myocardial structure. Methods: Cross-sectional study of 1...
Article
Full-text available
Cardiovascular magnetic resonance imaging is one of the most important diagnostic modalities in the evaluation of cardiomyopathies. However, significant limitations are the complex and time-consuming workflows and the need of contrast agents. The aim of this multi-center retrospective study was to assess workflows and diagnostic value of a short, c...
Poster
Background: Modifiable determinants of cardiovascular disease (CVD) remain largely understudied in pediatric type 1 diabetes (T1D). We estimated associations of physical activity and sedentary behavior with markers of CVD in adolescents and tested whether associations differed based on T1D status. Methods: Cross-sectional study of 100 adolescents...
Article
Full-text available
Purpose of Review Cardiac magnetic resonance imaging (CMR) use in the context of heart failure (HF) has increased over the last decade as it is able to provide detailed, quantitative information on function, morphology, and myocardial tissue composition. Furthermore, oxygenation-sensitive CMR (OS-CMR) has emerged as a CMR imaging method capable of...
Article
COVID-19 is associated with myocardial injury caused by ischemia, inflammation, or myocarditis. Cardiovascular magnetic resonance (CMR) is the noninvasive reference standard for cardiac function, structure, and tissue composition. CMR is a potentially valuable diagnostic tool in patients with COVID-19 presenting with myocardial injury and evidence...
Article
Full-text available
Objective To determine whether cognitive reserve attenuates the association of vascular brain injury with cognition. Methods Cross-sectional data were analyzed from two harmonized studies: the Canadian Alliance for Healthy Hearts and Healthy Minds (CAHHM) and the Prospective Urban and Rural Epidemiology (PURE) study. Markers of cognitive reserve w...
Article
Full-text available
Introduction Little is known regarding associations between potentially modifiable lifestyle habits and early markers of cardiovascular disease (CVD) in pediatric type 1 diabetes (T1D), hindering early prevention efforts. Specific objectives are: (1) compare established risk factors (dyslipidemia, hypertension) with novel early markers for CVD (car...
Preprint
Full-text available
Various data sharing platforms are being developed to enhance the sharing of cohort data by addressing the fragmented state of data storage and access systems. However, policy challenges in several domains remain unresolved. The euCanSHare workshop was organized to identify and discuss these challenges and to set the future research agenda. Concern...
Article
Various data sharing platforms are being developed to enhance the sharing of cohort data by addressing the fragmented state of data storage and access systems. However, policy challenges in several domains remain unresolved. The euCanSHare workshop was organized to identify and discuss these challenges and to set the future research agenda. Concern...
Article
Full-text available
Funding Acknowledgements Type of funding sources: None. Background Premature ventricular complexes (PVCs) in the absence of underlying structural heart disease are considered to be benign. However, cardiac dysfunction has been observed in patients with a high PVC burden. The characterization of a PVC-induced cardiomyopathy with structural remodeli...
Poster
Full-text available
Synopsis Cardiovascular magnetic resonance cine imaging is utilised to give comprehensive information on ventricular function. Arrhythmia obstructs acquisition of these images, where the use of faster acquisition protocols with deep learning reconstruction methods may aid in solving the problem. We evaluated cine images of three patients in atrial...
Article
Full-text available
The emergence of deep learning has considerably advanced the state-of-the-art in cardiac magnetic resonance (CMR) segmentation. Many techniques have been proposed over the last few years, bringing the accuracy of automated segmentation close to human performance. However, these models have been all too often trained and validated using cardiac imag...
Preprint
Full-text available
Purpose: CMR pharmacological stress-testing is well-established to detect myocardial ischemia. Despite stressor and contrast agents appear rather save, contraindications and side effects have to be considered. Substantial costs are further limiting its applicability. Dynamic handgrip exercise(DHE) may have the potential to address these shortcoming...
Article
Full-text available
Background Systemic effects of altered serum copper processing in Wilson Disease (WD) might induce myocardial copper deposition and consequently myocardial dysfunction and structural remodeling. This study sought to investigate the prevalence, manifestation and predictors of myocardial tissue abnormalities in WD patients. Methods We prospectively...
Article
Full-text available
Objectives: This study sought to identify predictors of major clinically important atrial fibrillation endpoints in hypertrophic cardiomyopathy. Background: Atrial fibrillation (AF) is a common morbidity associated with hypertrophic cardiomyopathy (HCM). The HCMR (Hypertrophic Cardiomyopathy Registry) trial is a prospective natural history study...
Article
Full-text available
Background Cardiovascular magnetic resonance (CMR) is the current reference standard for the quantitative assessment of ventricular function. Fast Strain-ENCoded (fSENC)-CMR imaging allows for the assessment of myocardial deformation within a single heartbeat. The aim of this pilot study was to identify obstructive coronary artery disease (oCAD) wi...
Article
Objectives The purpose of this study was to evaluate the diagnostic accuracy of a fast, needle-free test for myocardial ischemia using fast Strain-ENCoded (fSENC) cardiovascular MR (CMR) after a hyperventilation/breath-hold maneuver (HVBH). Background Myocardial stress testing is one of the most frequent diagnostic tests performed. Recent data ind...
Article
Full-text available
Background To differentiate effects of ventricular asynchrony from an underlying hypocontractile cardiomyopathy this study aimed to enhance the understanding of functional impairment and structural remodeling in idiopathic left bundle-branch block (LBBB). We hypothesize, that functional asynchrony with septal flash volume effects alone might not en...
Article
Full-text available
Funding Acknowledgements Type of funding sources: None. Background Safety concerns for gadolinium-containing contrast agents and pharmacological stressors, together with tremendous costs and inconsistent reimbursement modalities are still limiting a widespread application of CMR stress testing despite proven benefits. Like the effect of adenosine,...
Article
Full-text available
Background: T1 mapping using modified Look-Locker inversion recovery (MOLLI) provides quantitative information on myocardial tissue composition. T1 results differ between sites due to variations in hardware and software equipment, limiting the comparability of results. The aim was to test if Z-scores can be used to compare the results of MOLLI T1...
Article
Full-text available
The aim of this document is to provide general guidance and specific recommendations on the practice of cardiovascular magnetic resonance (CMR) in the era of the COVID-19 pandemic. There are two major considerations. First, continued urgent and semi-urgent care for the patients who have no known active COVID-19 should be provided in a safe manner f...
Article
Full-text available
Severe acute respiratory syndrome corona virus 2(SARS-CoV-2), the cause of coronavirus disease- 2019 (COVID-19) after emerging in china in late 2019 is spreading rapidly across the world. The most common cause of death in patient with COVID-19 is the rapid progression of acute respiratory distress syndrome (ARDS) shortly after the beginning of dysp...
Article
Full-text available
The Society for Cardiovascular Magnetic Resonance (SCMR) last published its comprehensive expert panel report of clinical indications for CMR in 2004. This new Consensus Panel report brings those indications up to date for 2020 and includes the very substantial increase in scanning techniques, clinical applicability and adoption of CMR worldwide. W...
Article
Background Diabetes is a risk factor for cerebrovascular disease and cognitive impairment. The anatomical basis for this is uncertain. Methods The Canadian Alliance for Healthy Hearts and Minds (CAHHM) collected brain and carotid magnetic resonance imaging (MRI) and two cognitive tests (DSST and MoCA) in a cross-sectional sample of men and women....
Article
Myocarditis is an inflammatory disease of the heart that may occur because of infections, immune system activation, or exposure to drugs. The diagnosis of myocarditis has changed due to the introduction of cardiac magnetic resonance imaging. We present an expert consensus document aimed to summarize the common terminology related to myocarditis mea...
Article
Background Cardiomyopathies (CMP) may cause impairment of cardiac function and structure. Cardiac Magnetic Resonance Imaging (CMR) is used for analysis and risk stratification of CMP by Late Gadolinium Enhancement (LGE). However, T1 mapping (T1) and fast strain encoded (f-SENC) sequences allow contrast-free and faster exams. The aim of this study w...
Presentation
Introduction Hyper- and hypocapnia have known vaso-modulatory effects in the coronary circulation. Oxygenation-sensitive cardiovascular magnetic resonance (OS-CMR) detects changes in tissue oxygenation and can provide a comprehensive assessment of the impact of systemic blood gas changes on the myocardium. The purpose of this study was to compare t...
Chapter
Cardiovascular magnetic resonance (CMR) is generally recognized as the most informative imaging technology for assessing patients with non-ischaemic cardiomyopathies. Beyond its standard-of-reference-quality quantitative data, it provides unique information on myocardial tissue characteristics that allows for the detection, localization, and spatia...
Article
Full-text available
BACKGROUND Gadolinium-based contrast agents were not approved in the United States for detecting coronary artery disease (CAD) prior to the current studies. OBJECTIVES The purpose of this study was to determine the sensitivity and specificity of gadobutrol for detection of CAD by assessing myocardial perfusion and late gadolinium enhancement (LGE)...
Article
Background: Coronary vascular function is related to adverse outcomes following cardiac transplant (CTx) in patients with or without coronary allograft vasculopathy (CAV). The noninvasive assessment of the myocardial vascular response using oxygenation-sensitive cardiac magnetic resonance (OS-CMR has not been investigated in stable long-term CTx r...
Article
Coronary vascular function is related to adverse outcomes following cardiac transplant (CTx) in patients with or without coronary allograft vasculopathy (CAV). The noninvasive assessment of the myocardial vascular response using oxygenation-sensitive cardiac magnetic resonance (OS-CMR has been investigated in stable long term CTx recipients).
Article
Full-text available
Background The intent of the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort is to understand the early determinants of subclinical cardiac and vascular disease and progression in adults selected from existing cohorts; the Canadian Partnership for Tomorrow Project (CPTP), the Prospective Urban and Rural Evaluation (PURE) cohort and, t...
Article
Objectives: To compare traditional risk factors for CVD (adiposity, dyslipidemia, hypertension), and novel early markers (arterial stiffness and myocardial structure), between youth with type 1 diabetes (T1D) and healthy controls. Methods: We compared 100 youth with T1D (14-18 yrs) and 97 age- and sex-matched controls. BMI z-scores were computed an...
Article
Background and Purpose— Little is known about the association between covert vascular brain injury and cognitive impairment in middle-aged populations. We investigated if scores on a cognitive screen were lower in individuals with higher cardiovascular risk, and those with covert vascular brain injury. Methods— Seven thousand five hundred forty-se...