Matthias Büttner

Universitätsmedizin der Johannes Gutenberg-Universität Mainz · Institute for Medical Biometry, Epidemiology and Computer Science

Purpose: Hypoparathyroidism is a rare endocrine disorder for which replacement therapy of the missing parathyroid hormone is not the standard therapeutic option. Current standard treatment consists of calcium and vitamin D supplementation. The intake of calcium and vitamin D supplementation can lead to complications and therefore might negatively...

Opinion statement: Quality of life measurements are well established in cancer clinical trials. In daily clinical practice, where cancer patients often suffer from disease-specific symptoms and report unmet needs regarding their treatment, these measurements are not systematically implemented. The systematic (often computer-based) assessment of qu...

Purpose Cancer patients in Germany often face payments related to their disease or treatment which are not covered by their health insurance. The aim of this study was to analyze the amount of out-of-pocket payments (OOPPs) among cancer patients in Germany, to explore potential socioeconomic determinants of OOPPs, and to identify how cancer patient...

Purpose The number of total hip (THA) and knee arthroplasties (TKA) grows constantly which causes enormously rising costs for healthcare systems. The aim of this systematic literature review was to evaluate whether a cost reduction can be achieved by THA or TKA fast-track protocols, which is a multidisciplinary approach aiming at faster recovery....

Purpose: The aim of this study was to investigate whether an association between retinal vessel diameters with blood pressure and other risk factors exists in a healthy working population and whether current risk factors can be used as predictors for retinal vessel changes over time. Methods: Retinal photographs and medical data were obtained du...

Introduction To consider the inherent respondent burden of PROMs, the HOOS-12 as a shortform of the well-established HOOS questionnaire has been published. While the HOOS-12 has been validated in an initial study, further evaluation in other, non-English speaking cohorts is necessary. We therefore aimed to evaluate responsiveness, convergent constr...

Currently, exchange of information between the geriatric clinic and the attending general practitioner (GP) occurs primarily through the doctor's letter after discharging from the clinic. The aim of our study was to reduce readmissions of multimorbid, geriatric patients to the clinic by establishing a new form of care via an electronic case file (E...

Purpose Hypoparathyroidism is defined by hypocalcemia with inappropriately normal or low parathyroid hormone levels. The current standard treatment consists of lifelong calcium and/ or vitamin D supplementation. Even while on stable treatment regimens, hypoparathyroid patients might still suffer from symptoms that can negatively impact their qualit...

Rural out-migration is changing agrarian political economies and natural resource governance worldwide, and gender and social relations play an important mediating role. The aim of this study is to investigate the impact of rural out-migration on collective action in farmer-managed irrigation systems, with a particular focus on household structure...

Purpose The purpose of this study was to investigate the impact of the type of data capture on the time and help needed for collecting patient-reported outcomes as well as on the proportion of missing scores. Methods In a multinational prospective study, thyroid cancer patients from 17 countries completed a validated questionnaire measuring qualit...

Aims To investigate the association between cumulative social disadvantage and cardiovascular burden and mortality in a large cohort of the general population. Methods and results Cross-sectional (n = 15 010, aged 35 to 74 years, baseline investigation period 2007 to 2012) and longitudinal data (5- and 10-year follow-ups from 2012 to 2022) from th...

Aims To investigate the association between cumulative social disadvantage and cardiovascular burden and mortality in a large cohort of the general population. Methods and results Cross-sectional (n = 15 010, aged 35 to 74 years, baseline investigation period 2007 to 2012) and longitudinal data (5- and 10-year follow-ups from 2012 to 2022) from the...

Purpose To investigate the quality of life (QoL) in patients with hypoparathyroidism (hypoPT) compared to the general population and to identify sociodemographic and clinical factors that are associated with symptom burden. Methods Patients with a diagnosis of hypoPT participated in an online survey. Information regarding the survey was distribute...

Purpose The aim of this study was to validate the new European Organisation for Research and Treatment of Cancer Quality of Life Thyroid Cancer Module (EORTC QLQ-THY34). Methods We enrolled 437 thyroid cancer patients from 17 countries. One group (n=303), undergoing treatment or best supportive care, completed the questionnaires at three time point...

Purpose: Hypoparathyriodism (hypoPT) is a rare endocrine disorder. It is not known how hypoPT is managed in Germany or whether patients have unmet information needs or impairments in their daily living. Methods: HypoPT patients at a minimum of 6 months' post-diagnosis were invited to participate in an online survey through their treating physici...

Background Multimorbidity is a common phenomenon among patients treated in general practices. Key challenges within this group include functional difficulties, polypharmacy, treatment burden, fragmentation of care, reduced quality of life and increased health care utilization. These problems cannot be solved in the short consultation time of a gen...

Despite universal health insurance and a well-established social security system in Germany, it is possible that cancer survivors will experience a financial burden. Objective financial burdens such as out-of-pocket payments and income losses can lead to subjective financial burden in cancer patients. Subjective financial burden can be observed at...

Background Multimorbidity is a common phenomenon in patients treated in general practices. Key challenges of this group are functional difficulties, polypharmacy, treatment burden, fragmentation of care, reduced quality of life and increased healthcare utilisation. These problems cannot be solved in the short consultation time of a general practiti...

Purpose We investigated the association between social inequality and participation in a mammography screening program (MSP). Since the German government offers mammography screening free of charge, any effect of social inequality on participation should be due to educational status and not due to the financial burden. Methods The ‘Gutenberg Healt...

Fragestellung: Vor dem Hintergrund der Debatte um eine mögliche Festlegung des Leistungsumfangs für ambulante Psychotherapie anhand der Diagnose haben wir untersucht, ob in der aktuellen Versorgungspraxis bei Patienten mit Depressionen die Anzahl der beantragten sowie die der vom Gutachter befürworteten Stunden mit dem Schweregrad der Erkrankung z...

Purpose: Post-operative outcome after total knee arthroplasty (TKA) in the treatment of end-stage osteoarthritis correlates strongly with pre-operative impairment-driven patient treatment goals. However, a clinical tool for measuring patient treatment goals in correlation to impairments is still missing, which impedes patient-oriented indication i...

Background and Objectives: Tonsillar infections are a common reason to see a physician and lead to a reduction in the patients’ health-related quality of life (HRQoL). HRQoL may be an important criterion in decision science and should be taken into account when deciding when to perform tonsillectomy, especially for chronic tonsillitis. The aim of t...

Background: While there is evidence on the effectiveness of optimized treatment processes for patients receiving hip and knee endoprostheses, feasibility in various settings has not been adequately investigated. The multicenter PROMISE Trial (Process optimization by interdisciplinary and cross-sectoral care using the example of patients with hip an...

Zusammenfassung Hintergrund Für Deutschland werden im Rahmen optimierter Behandlungsprozesse rund um die Implantation einer Knie- oder Hüftendoprothese stationäre Aufenthaltszeiten angegeben, die die international publizierten Zeiten deutlich übertreffen. Die vorliegende Analyse von Daten der PROMISE-Studie beschäftigt sich in diesem Zusammenhang...

Context: Hypoparathyroidism (hypoPT) is a rare endocrine disorder. Little is known about what factors are associated with potential quality of life (QOL) impairments. Design: HypoPT patients at a minimum of six months' post diagnosis were invited to participate in an online survey through their treating physician or through self-help organizatio...

Purpose Cancer patients have been shown to frequently suffer from financial burden before, during, and after treatment. However, the financial toxicity of patients with sarcoma has seldom been assessed. Therefore, the aim of this study was to evaluate whether financial toxicity is a problem for sarcoma patients in Germany and identify associated ri...

Zusammenfassung Hintergrund Im Dezember 2019 begann sich die COVID-19-Pandemie weltweit auszubreiten und sorgte für massive Einschränkungen im täglichen Leben. Viele Bildungseinrichtungen und logopädische Praxen wurden vorübergehend geschlossen (sog. Lockdown). Kinder mit einer Sprachentwicklungsstörung waren gezwungen, ihre Therapie zu pausieren....

Objective Little is known on optimal screening population for detecting new atrial fibrillation (AF) in the community. We describe characteristics and estimate cost-effectiveness for a single timepoint electrocardiographic screening. Methods We performed a 12-lead ECG in the German population-based Gutenberg Health Study between 2007 and 2012 (n=1...

Background and purpose — Knee and hip replacement are common and increasing procedures, and an optimized care process that could be implemented in different settings would be useful. The PROMISE trial investigates whether a new care process works equally in different German settings and how the results compare with current non-standardized care. Pa...

The disease and treatment of patients with head and neck cancer can lead to multiple late and long-term sequelae. Especially pain, psychosocial problems, and voice issues can have a high impact on patients’ health-related quality of life. The aim was to show the feasibility of implementing an electronic Patient-Reported Outcome Measure (PROM) in pa...

Objective Various national and international guidelines for the management of thyroid cancer exist. The aim of this survey was to evaluate whether patients experience differences regarding the management of thyroid cancer in Germany and in France.Methods An online survey addressing diagnosis, treatment, aftercare, and information needs of thyroid c...

Keywords: HYPOPARATHYROIDISM; THYROID CANCER; QUALITY OF LIFE

Purpose Surgical complications such as hypoparathyroidism (HPT) or vocal cord palsy are seldom assessed when the quality of life (QOL) in thyroid cancer patients is investigated. The aim of this study was to measure the QOL difference in thyroid cancer survivors with and without HPT. Methods Participants for this analysis were enrolled in 13 count...

PurposePatients with thyroid cancer are often assumed to have no quality of life (QOL) impairments after treatment because of thyroid cancer’s good prognosis. However, the QOL implications of surgical complications and the necessity to take lifelong medication are seldom assessed.Methods Patients who had surgery due to thyroid cancer at the Univers...

Hypoparathyreoidismus (HPT) ist eine der häufigsten Komplikationen einer Schilddrüsenkrebsoperation. Die Lebensqualität von Patienten mit HPT ist im Vergleich zu Normpopulationen oder gematchten Kontrollindividuen stark eingeschränkt. Eine reduzierte Lebensqualität zeigt sich gleichermaßen in physischen und psychischen Bereichen. Wenige Studien hab...