Matthew Varga

Matthew Varga
Johns Hopkins University | JHU · Department of Biophysics

8.41
 · 
PhD - Chemistry
About
3
Research items
54
Reads
10
Citations
Research Experience
Jan 2013
The University of Arizona
Position
  • Graduate Research Assistant
Description
  • Studying the role of coupled motion in enzymatic reactions.
Aug 2009 - May 2012
College of Wooster
Position
  • Undergraduate Research Assistant
Description
  • Developed and analyzed swellable glass (OSORB) for the use in organic cross-coupling reactions.
Education
Aug 2012 - May 2017
The University of Arizona
Field of study
  • Physical Chemistry
Aug 2009 - May 2013
College of Wooster
Field of study
  • Chemistry
Network
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Research
Research items (3)
Article
We present new findings on how primary and secondary structure affects the role of fast protein motions in the reaction coordinates of enzymatic reactions. Using transition path sam- pling (TPS) and committor distribution analysis, we examined the difference in the role of these fast protein motions in the reaction coordinate of lactate dehydrogena...
Chapter
Full-text available
The mechanisms of enzymatic reactions are studied via a host of computational techniques. While previous methods have been used successfully, many fail to incorporate the full dynamical properties of enzymatic systems. This can lead to misleading results in cases where enzyme motion plays a significant role in the reaction coordinate, which is espe...
Article
Full-text available
In this study, we develop and test a method to determine the rate of particle transfer and kinetic isotope effects in enzymatic reactions, specifically yeast alcohol dehydrogenase (YADH), from first principles. Transition path sampling (TPS) and normal mode centroid dynamics (CMD) are used to simulate these enzymatic reactions without knowledge of...