Matthew Wosnitzer

Matthew Wosnitzer
Columbia University | CU

MD

About

75
Publications
6,158
Reads
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906
Citations
Additional affiliations
July 2012 - present
Weill Cornell Medical College
Position
  • Instructor, Fellow

Publications

Publications (75)
Article
Full-text available
Research Questions Can a previously defined relationship between sperm capacitation and the probability of a man to generate pregnancy within three cycles, prospectively predict male fertility in diverse clinical settings? What is the prevalence of impaired sperm fertilizing ability in men questioning their fertility (MQF)? Does this relate to trad...
Article
Penile prosthesis implant surgery is an effective management approach for a number of urological conditions, including medication refractory erectile dysfunction (ED). Complications encountered post-operatively include infection, bleeding/hematoma, and device malfunction. Since the 1970s, modifications to these devices have reduced complication rat...
Article
Full-text available
Posterior nutcracker syndrome occurs when a retroaortic left renal vein becomes compressed between the abdominal aorta and the lumbar spine. Although open surgical approaches remain the treatment of choice, endovascular stenting has been used successfully. We describe a case of a 28-year-old man who presented with microscopic hematuria, left-sided...
Article
Full-text available
Opioid-induced androgen deficiency (OPIAD) was initially recognized as a possible consequence of opioid use roughly four decades ago. Long-acting opioid use carries risks of addiction, tolerance, and systemic side effects including hypogonadotropic hypogonadism with consequent testosterone depletion leading to multiple central and peripheral effect...
Article
Full-text available
To examine human microRNA expression in fertile men and subsequently to compare expression patterns of miRNAs in fertile and infertile men, specifically men with Sertoli Cell Only (SCO) histopathology. Testicular tissues from men with azoospermia and SCO, as well as those of men with normal spermatogenesis, were analyzed. MicroRNA was isolated usin...
Article
Purpose To describe the clinical course of patients that achieved a clinical complete response (cT0) following neoadjuvant chemotherapy (NC) for muscle-invasive bladder cancer (MIBC), as there is no established treatment paradigm for management of these patients. Materials and Methods We performed a retrospective review of 109 patients with MIBC (...
Article
Full-text available
Ubiquitin specific protease 26 (USP26), a deubiquitinating enzyme, is highly expressed early during murine spermatogenesis, in round spermatids, and at the blood-testis barrier. USP26 has also been recognized as a regulator of androgen receptor (AR) hormone-induced action involved in spermatogenesis and steroid production in in vitro studies. Prior...
Article
Full-text available
Azoospermia is classified as obstructive azoospermia (OA) or non-obstructive azoospermia (NOA), each having very different etiologies and treatments. The etiology, diagnosis, and management of azoospermia were reviewed and relevant literature summarized. Differentiation between these two etiologies is of paramount importance and is contingent upon...
Article
Men with severe oligospermia (<5 million sperm/mL ejaculate fluid) or azoospermia should receive genetic testing to clarify etiology of male infertility prior to treatment. Categorization by obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is critical since genetic testing differs for the former with normal testicular function, tes...
Article
Full-text available
Background Fertility preservation in adolescents undergoing sterilizing radiation and/or chemotherapy is the standard of care in oncology. The opportunity for patients to provide a semen sample by ejaculation is a critical issue in adolescent fertility preservation. Methods Fifty males with no medical or sexual developmental abnormalities were eva...
Article
Full-text available
Serum testosterone does not correlate with androgen tissue activity, and it is critical to optimize tools to evaluate such activity in males. Ultrasound measurement of bulbocavernosus muscle (BCM) was used to assess the relationship between the number of CAG repeats (CAGn) in the androgen receptor (AR) and the BCM size; the changes in the number of...
Article
Obstructive azoospermia accounts for 40% of azoospermia and results from obstruction of the excurrent ducts (due to many causes) at any location between the rete testis and the ejaculatory ducts. The diagnosis of obstructive azoospermia (OA) requires a stepwise approach to differentiate it from nonobstructive OA and to formulate management options....
Article
Men with azoospermia or severe oligospermia (< 5 x 10(6)/ml) should have genetic testing to identify the reason for male infertility before treatment. Identification of obstructive azoospermia (OA) or non-obstructive azoospermia (NOA) is essential because genetic testing differs for OA (which has normal testicular function, testicular volume, and F...
Chapter
Aside from the NCCN guidelines described in the primary chapter, no guidelines exist for the follow-up of patients after treatment for prostate cancer. What follows here is what is commonly done in our urology practice and likely in most urology practices in the United States. Patient follow-up is guided by risk stratification for risk of recurrenc...
Article
Accumulating evidence suggests that varicocele, long associated with male infertility, is also a risk factor for low testosterone levels. The exact pathophysiology of the negative effects of varicocele on testicular function is not well understood, but theories include venous stasis, increased testicular temperature, oxidative stress, and resulting...
Article
Full-text available
Introduction: Fertility preservation in adolescents undergoing sterilizing radiation and/or chemotherapy is the standard of care in oncology. The opportunity for patients to provide a semen sample by ejaculation is a critical issue in adolescent fertility preservation. Materials and methods: Fifty males with no medical or sexual developmental abnor...
Article
47, XXY or Klinefelter syndrome (KS), the most common chromosomal aberration in males, is characterized by either absolute or relative hypogonadism with frequent decline in serum testosterone (T) following the onset of puberty. Decreased T levels are the result of testicular dysfunction with decrease in size of Leydig cells, and loss of germs and S...
Chapter
Highly active antiretroviral therapy (HAART) for the treatment of HIV-positive patients has delayed progression of HIV to AIDS and promoted immune system restoration thereby reducing AIDS-related mortality. Non-AIDS-defining malignancies such as prostate cancer (PCa) have been diagnosed more frequently given such extended survival. However, the act...
Article
Background: Despite evidence supporting perioperative chemotherapy, few randomized studies compare neoadjuvant and adjuvant chemotherapy for bladder cancer. Consequently, the standard of care regarding the timing of chemotherapy for locally advanced bladder cancer remains controversial. We compared patient outcomes following neoadjuvant or adjuvan...
Article
To compare the outcomes of patients treated in the perioperative setting with methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) versus gemcitabine and cisplatin (GC). Systemic cisplatin-based chemotherapy regimens are the mainstay of treatment for patients with advanced bladder cancer. GC has often been used interchangeably with MVAC in n...
Article
Recent studies suggest a consistent decline of formal urological education in medical schools. We sought to determine whether a standardized urology curriculum improves student clinical knowledge. A confidential questionnaire was distributed to two groups of clinical medical students following the completion of their third year: one with no urology...
Article
Bioimpedance spectroscopy (BIS) is a novel, precise quantification of body composition (BC) using low electrical currents through tissue. Accurate BC quantification may better predict postoperative outcomes. We compared BIS-BC and body mass index (BMI) for correlation with post-surgical outcomes in robotic assisted radical prostatectomy (RARP) pati...
Article
After encouraging results from 2 clinical trials performed at our institution to test intravesical taxane based chemotherapy for bacillus Calmette-Guérin refractory, nonmuscle invasive bladder cancer we designed a study to identify molecular markers linked to the optimal response to such treatment modality. Included in the institutional review boar...
Article
A clear set of guidelines has not been defined in the use of antibiotics in penile prosthesis implantation. Aim.  We surveyed urologists throughout the United States to determine current practice patterns regarding antibiotic use in primary and revision penile prosthesis surgery. Fifty-two Sexual Medicine Society of North America (SMS) member urolo...
Article
OBJECTIVE •To investigate preoperative platelet level (PLT) as a prognostic factor for pathologic and clinical outcomes following surgery for renal cortical malignancy. PATIENTS AND METHODS • 1422 patients underwent radical or partial nephrectomy at our institution from 1988-2009 for renal cortical lesions. • The cohort with available PLT values wa...
Article
Improved medical therapy for HIV-positive patients has helped delay the progression of HIV to AIDS and reduce AIDS deaths. This dramatically prolonged survival has resulted in increased detection of non-AIDS-defining malignancies, such as prostate cancer, in people with HIV. Reported prostate cancer incidences in HIV-positive men compared with the...
Article
Laser-based treatments have emerged in the past 15 years as an alternative to transurethral resection of the prostate (TURP) for treatment of symptomatic benign prostatic hyperplasia. Increasing demand for a minimally invasive procedure to alleviate lower urinary tract symptoms with greater efficacy and fewer side effects has led to the introductio...
Article
Guillain-Barré syndrome, an acute autoimmune polyneuropathy and demyelinating disease, is characterized by weakness, sensory loss, areflexia, pain, autonomic dysfunction, and occasionally, micturition disturbances including voiding difficulty, urinary retention, nocturnal urinary frequency, and urge incontinence. Typically, urinary dysfunction reso...
Article
e16025 Background: Patients with ESRD on long term hemodialysis are known to be at an increased risk for renal cell carcinoma. We postulate that some component of chronic renal failure not corrected by dialysis might be the tumor-inducing factor. We sought to determine if chronic renal insufficiency is a risk factor for developing renal cell carcin...
Article
e16045 Background: Partial nephrectomy (PN) is an effective option for the treatment of renal cell carcinoma (RCC) in patients who need to preserve renal function. However, the oncologic safety and functional outcome after PN in solitary kidneys have not been fully examined. We assessed the outcomes after PN, and evaluated predictors of post-operat...
Chapter
Similar to females, males have biological clocks that affect the quality of their sperm, fertility levels, and hormone levels. Advanced paternal age increases the risk for occurrence of spontaneous abortion as well as genetic abnormalities in offspring due to multiple factors including DNA damage from abnormal apoptosis and reactive oxygen species....
Article
Full-text available
The Accordion stone management device is a hydrophilic microcatheter-based tool that blocks stone migration. This instrument has been described for use during ureteroscopy to prevent retropulsion of stone fragments. We used this device during percutaneous nephrolithotomy (PCNL) in 30 patients to prevent antegrade migration of stone fragments (group...
Article
We determined whether motor and bladder recovery are correlated in children with acute transverse myelitis. From 1995 to 2004, 14 children (8 males and 6 females) with acute transverse myelitis were retrospectively evaluated to determine if there was a correlation between motor and bladder recovery following disease onset. During the acute phase of...
Article
To more clearly elucidate the relationship between prostate volume (PV) and prostate cancer parameters. The Urologic Oncology Database was reviewed. A total of 3460 patients had undergone radical prostatectomy from 1988 to 2006. Of these, 2600 with complete data were included in the study and were stratified by the PV: normal (0 to 40 cm(3)), moder...
Article
Full-text available
Dysregulated apoptosis of renal tubular epithelial cells (RTEC) is an important component of the pathogenesis of several renal diseases, including HIV-associated nephropathy (HIVAN), the most common cause of chronic kidney failure in HIV-infected patients. In HIVAN, RTEC become infected by HIV-1 in a focal distribution, and HIV-1 infection has been...
Article
We report what we believe to be the youngest patient with bladder rupture during voiding cystourethrography. If voiding cystourethrography needs to be done in a premature infant, the filling pressures should be minimized, multiple filling cycles should be avoided, and the voiding pressures should be minimized by using a small, balloon-less catheter...
Article
A regulatory era is taking shape under the Health Care Financing Administration (HCFA) which eventually will be implemented under the Clinical Laboratory Improvement Amendments of 1988 (CLIA '88). Sweeping changes are planned for all laboratories, including physician's office and group practice offices. Both of these groups have previously been exe...
Article
The Henly self-retaining retractor is a little known modification of the well-known Weitlaner retractor. It has a third adjustable retractor blade attached in the middle which allows improved exposure for the small oblique inguinal incision for varicocelectomy
Article
L'endoloupe augmente l'image cystoscopique standard par 2 environ, diminue la fatigue oculaire et ameliore la visualisation en maintenant le champ et la profondeur illimitee du champ. Elle est particulierement utile pour la prostatectomie transuretrale
Article
Urologists using the large and small Strauch clamps for microvasovasostomy have found that these clamps allow splendid visualization of the end and mucosa-lined lumen of each vas. However, an assistant must stabilize the clamp by holding it while in the "folded" position or else both the clamp and the ends of the vas will move when the sutures are...
Article
The rapid development of endourologic procedures and ultrasonic renal stone surgery has left most hospital operating rooms without a suitable radiolucent operating table and a safe up-to-date C-arm fluoroscopic unit for these operations. A new radiolucent operating room table top combined with a new mobile C-arm fluoroscopy unit will allow versatil...
Article
Varicocelectomy is usually considered a simple urologic operation. However, it is most frequently difficult to visualize and identify the 0.5 mm internal spermatic artery and tiny lymphatic channels when cutting and ligating the internal spermatic veins. The internal spermatic artery and tiny lymphatic channels can be damaged easily, cut, or ligate...

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