Matthew South

• Snr Software Architect at University of Birmingham

Introduction Translating narrative clinical guidelines to computable knowledge is a long‐standing challenge that has seen a diverse range of approaches. The UK National Institute for Health and Care Excellence (NICE) Content Advisory Board (CAB) aims ultimately to (1) guide clinical decision support and other software developers to increase traceab...

Introduction To understand when knowledge objects in a computable biomedical knowledge library are likely to be subject to regulation as a medical device in the United Kingdom. Methods A briefing paper was circulated to a multi‐disciplinary group of 25 including regulators, lawyers and others with insights into device regulation. A 1‐day workshop...

Background User feedback is crucial in the development of electronic self-monitoring tools for bipolar spectrum disorders (BSD). Previous studies have examined user experiences in small samples self-monitoring over relatively short time periods. We aimed to explore the experiences of a large sample of individuals with BSD engaged in long-term remot...

Background Patient reported outcome measures (PROMs) are key to documenting outcomes that matter most to patients and are increasingly important to commissioners of healthcare seeking value. We report the first series of the ICHOM Standard Set for Inflammatory Bowel Disease (IBD). Methods Patients treated for ulcerative colitis (UC) or Crohn’s dis...

Objectives: Many studies have examined the impact of COVID-19 on the mental health of the public, but few have focused on individuals with existing severe mental illness with longitudinal data before and during the pandemic. Aims: To investigate the impact of the COVID-19 pandemic on the mental health of people with bipolar disorder (BD). Metho...

Background The SCCAI was designed to facilitate assessment of disease activity in ulcerative colitis (UC). We aimed to interrogate the metric properties of individual items of the SCCAI using item response theory (IRT) analysis, to simplify and improve its performance. Methods The original 9-item SCCAI was collected through TrueColours, a real-tim...

Background The SCCAI was designed to facilitate assessment of disease activity in ulcerative colitis (UC). We aimed to interrogate the metric properties of individual items of the SCCAI using item response theory (IRT) analysis, to simplify and improve its performance. Methods The original 9-item SCCAI was collected through TrueColours, a real-time...

Background The SCCAI was designed to facilitate assessment of disease activity in ulcerative colitis (UC). We aimed to interrogate the metric properties of individual items of the SCCAI using item response theory (IRT) analysis, to simplify and improve its performance. Methods The original 9-item SCCAI was collected through TrueColours, a real-time...

Objective OpenClinical.net is a way of disseminating clinical guidelines to improve quality of care whose distinctive feature is to combine the benefits of clinical guidelines and other human-readable material with the power of artificial intelligence to give patient-specific recommendations. A key objective is to empower healthcare professionals t...

To appear in BMJ Health and Care Informatics a. Objective OpenClinical.net is a way of disseminating clinical guidelines to improve quality of care whose distinctive feature is to combine the benefits of clinical guidelines and other human-readable material with the power of artificial intelligence (AI) to give patient-specific recommendations. A...

The Dementias Platform UK Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations with t...

The Dementias Platform UK (DPUK) Data Portal is a data repository facilitating access to data for 3 370 929 individuals in 42 cohorts. The Data Portal is an end-to-end data management solution providing a secure, fully auditable, remote access environment for the analysis of cohort data. All projects utilising the data are by default collaborations...

UNSTRUCTURED The True Colours remote mood monitoring system was developed over a decade ago by researchers, psychiatrists and software engineers at the University of Oxford to allow patients to report upon a range of symptoms via text messages, web interfaces, or smartphone applications. The system has evolved to encompass a wide range of measures...

The True Colours remote mood monitoring system was developed over a decade ago by researchers, psychiatrists, and software engineers at the University of Oxford to allow patients to report on a range of symptoms via text messages, Web interfaces, or mobile phone apps. The system has evolved to encompass a wide range of measures, including psychiatr...

The DPUK Data Portal hosts data from observational cohort studies from across the world, many of whom do not solely major in survey and screening data, but across multiple data modalities such as genomics, metabolomics, phenomics, and imaging. Such rich resources are key to unlocking a much wider understanding of the characteristics of dementia and...

IntroductionModern team science requires effective sharing of data and skills. The DPUK Data Portal is a collection of tools, datasets and networks that allows for epidemiologists and specialist researchers alike to access, analyse and investigate cohort and different modalities of routine data across UK and international sources. Objectives and Ap...

Background: Live donor nephrectomy is an operation that places the donor at risk of complications without the possibility of medical benefit. Rigorous donor selection and assessment is therefore essential to ensure minimisation of risk and for this reason robust national guidelines exist. Previous studies have demonstrated poor adherence to donor...

Objective: The purpose of this study was to explore whether patients with musculoskeletal conditions would agree to use digital technologies to learn about research registries and make a decision about signing up whilst in the clinic waiting room. Methods: Patients were recruited from four hospital clinics across Oxfordshire. We used an explanat...

It is well known that medical knowledge is growing so rapidly that it is difficult or impossible for healthcare professionals to keep up. More and more techniques for diagnosing and treating diseases are becoming available, yet new research findings and clinical practices are slow to spread. Information technology and the internet are providing imp...

Objective: Clinical practice guidelines (CPGs) could have a more consistent and meaningful impact on clinician behavior if they were delivered as electronic algorithms that provide patient-specific advice during patient-physician encounters. We developed a computer-interpretable algorithm for U.S. and European users for the purpose of diagnosis an...

In ‘‘Grand challenges for decision support” Sittig et al. set out 10 critical problems for ‘‘designing, developing, presenting,implementing, evaluating, and maintaining all types of clinical decision support capabilities for clinicians, patients and consumers”. Sittig et al.’s identification and prioritization of obstacles to the successful develop...

Research on computer interpretable clinical guidelines has largely focused on individual points of care rather than processes of care. Whether we consider simple aids like clinical alerts and reminders or more sophisticated data interpretation and decision-making, guideline developers tend to focus on specific tasks rather than processes like care...

Dungine is an open source Argumentation Engine and API implemented in the Java programming language. Dungine uses argument games to evaluate the acceptability of an argument given a constellation of arguments under grounded (sceptical) and preferred credulous semantics. Existing argumentation engines all rely on a companion logic programming langua...

A body of work centered on applications of argumentation in biomedicine, such as risk assessment and treatment planning, has led to a comprehensive view of argumentation as a form of evidential reasoning. This, in turn, has stimulated the development of a general formalization of argumentation for reasoning and decision making, which has served as...

The theory of argumentation is a rich, interdisciplinary area of research straddling the fields of artificial intelligence, philosophy, communication studies, linguistics and psychology. In the last few years, significant progress has been made in understanding the theoretical properties of different argumentation logics. However, one major barrier...

This document describes a strawman specification for an Ar- gument Interchange Format (AIF) that might be used for data exchange between Argumentation tools or communication in Multi-Agent Sys- tems (MAS). The document started life as a skeleton for contributions from participants in the Technical Forum Group meeting in Budapest in September 2005,...

In recent years a new paradigm has emerged in linear stability theory due to the recognition of the importance of non-normality in the Orr–Sommerfeld equation as derived from the method of normal modes. For single-fluid flows it has been shown that it is possible for the kinetic energy of certain stable mode combinations to grow transiently bef...

Argumentation Mark-up Languages have been formulated for exporting and storing argumentation knowledge described by use of argument editing and visualisation tools. These tools enable user struc- turing of arguments through diagramatic linkage of natural language sentences. Recent work has focussed on implementations of formal log- ical models of a...