Matthew C Simpson

Matthew C Simpson
Saint Louis University | SLU · Department of Otolaryngology

Master of Public Health

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83
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519
Citations

Publications

Publications (83)
Article
On the basis of their training, medical students are considered "the best case scenario" among university students in knowledge of the human papillomavirus (HPV). We evaluated differences in knowledge of HPV, HPV vaccine, and head and neck cancer (HNC) among medical students. A previously validated questionnaire was completed by 247 medical student...
Article
Objectives: Identify which delivery modality for skin reconstruction care, face-to-face (FTF) in-person versus two telemedicine modalities, store-and-forward (S&F) and live video chat (LVC), is patient preferred and how cost, access, wait time, and demographics influence this preference. Study design: Cross-sectional survey. Methods: A 16-ques...
Article
Objectives Lymphoma, categorized as either non-Hodgkin’s lymphoma or Hodgkin’s lymphoma, is the second most common malignancy in the head and neck. Primary tongue lymphoma is exceedingly rare, with only case reports or small case series in the literature. This population-based analysis is the first to report the epidemiology and prognostic factors...
Article
Importance Approximately 1 in 5 new patients with head and neck cancer (HNC) in the US belong to racial and ethnic minority groups, but their survival rates are worse than White individuals. However, because most studies compare Black vs White patients, little is known about survival differences among members of racial and ethnic minority groups....
Article
Objectives/Hypothesis Radiation-associated sarcomas of the head and neck (RASHN) are known but rare sequelae after radiation for squamous cell carcinoma. The purpose of this study was to characterize RASHN, estimate the risk of RASHN in head and neck squamous cell patients after therapeutic radiation, and compare their survival to that of patients...
Article
Full-text available
We examined the association between sexual orientation and human papillomavirus (HPV)-related risky sexual behaviors among high school students in the U.S. We used the 2015 Youth Risk Behavior Survey, a three-stage cluster sample, nationally representative, cross-sectional study. Participants were sexually active students (Grades 9–12) in public, p...
Article
Full-text available
Objectives Human papillomavirus (HPV)-associated cancers account for about 9% of the cancer mortality burden in the United States; however, survival differs among sociodemographic factors. We determine sociodemographic and clinical variables associated with HPV-associated cancer survival. Methods Data derived from the Surveillance, Epidemiology, a...
Article
Full-text available
Importance Patients with head and neck cancer (HNC) are known to be at increased risk of suicide compared with the general population, but there has been insufficient research on whether this risk differs based on patients’ rural, urban, or metropolitan residence status. Objective To evaluate whether the risk of suicide among patients with HNC dif...
Article
Purpose Privately insured patients with head and neck cancer (HNC) typically have better outcomes; however, differential outcome among Medicaid versus the uninsured is unclear. We aimed to describe outcome disparities among HNC patients uninsured versus on Medicaid. Methods A cohort of 18–64‐year‐old adults (n = 57 920) with index HNC from the Sur...
Article
Full-text available
The emergence of the human papillomavirus (HPV) as the primary etiology of oropharyngeal cancer has changed head and neck cancer (HNC) epidemiology. This study described change in the age at diagnosis of oropharyngeal and non-oropharyngeal HNC in the United States in the last four decades. Using a retrospective cohort analysis, the Surveillance, Ep...
Article
Objective/Hypothesis Early diagnosis and stage at presentation, two prognostic factors for survival among patients with head and neck cancer (HNC), are significantly impacted by a patient’s health insurance status. We aimed to assess the impact of the Patient Protection and Affordable Care Act (ACA) on stage at presentation across socioeconomic and...
Conference Paper
Objectives: Ovarian cancer is rare in children, accounting for 1% of childhood cancers. However, it is the most common cancer of the female genital tract in adolescents. Due to the rarity of the disease and the histologic and prognostic differences between pediatric and adult cases, there is a paucity of data describing incidence trends of pediatri...
Conference Paper
Objectives: In 2009, there were 48,010 new cases of head and neck cancer in the United States. A decade later, it is projected that there will be 65,410 new cases in 2019, a 36% increase in new cases of the disease. While this number represents the general head and neck cancer population in the United States, only a few studies have described incid...
Article
Background To describe sociodemographic factors associated with head and neck cancer (HNC) survival among patients with distant metastatic disease. Methods We retrospectively analyzed national data for 2889 adult patients with metastatic HNC (2007‐2015). We used Fine and Gray competing risks proportional hazard models, stratified by oropharyngeal...
Conference Paper
Introduction: Head and neck cancer epidemiology has historically focused on the burden of disease among males. Despite a concerning increase in the incidence of certain types of head and neck cancer among females, females with head and neck cancer continue to represent an understudied and overlooked patient population. While previous studies have e...
Conference Paper
Introduction: Factors such as anatomic complexity and extensive surgical procedures increase the risk of serious, sometimes fatal complications post-surgical treatment for head and neck cancer squamous cell carcinoma (HNSCC). Thirty-day (30-day) mortality is a common quality metric that evaluates short-term survival; however, no study has described...
Conference Paper
Background: The United States and other industrialized nations are experiencing what is known as the thyroid cancer epidemic. While there are studies of incidence trends among adult thyroid cancer patients in the United States, there is a paucity of data examining the relative contributions of different races/ethnicities and age groups, especially...
Conference Paper
p> Introduction: Suicide is a threat to cancer survivorship, and a known non-cancer competing cause of death among cancer survivors. In fact, the risk of suicide among cancer survivors is more than double that of the general population, depending on the cancer site. While several factors like age, gender, race, and cancer site are associated with s...
Conference Paper
Objective: The last three decades in the United States have seen oropharyngeal cancer emerge as an important human papillomavirus (HPV)-associated cancer, with about three-quarters of cases thought to be positive for HPV. It has dramatically increased in incidence and recently surpassed cervical cancer as the leading HPV-associated cancer. While po...
Article
e19113 Background: The risk of suicide among cancer survivors more than double that of the general population, highlighting the need to mitigating risk factors for suicide. While several studies have described marital status, a surrogate for social support, as associated with cancer mortality, it is inconclusive whether marital status impacts suici...
Article
7035 Background: Medicaid expansion has been associated with increased access to care and earlier stage at diagnosis among patients with head and neck cancer (HNC). However, it is unclear whether Medicaid expansion has impacted HNC mortality rates. We examined the associations between early Medicaid expansions (2010-2011) with mortality rates for H...
Article
6565 Background: The sinonasal tract is a lesser known “hot spot” for the human papillomavirus (HPV), compared with the oropharynx. Additionally, unlike the oropharynx, the role of HPV tumor status in the survival and overall prognosis of the sinonasal tract and other non-oropharyngeal head and neck cancer sites remains inconclusive. Understanding...
Article
Objective To determine sociodemographic factors associated with occupational, recreational and firearm-related noise exposure. Methods This nationally representative, multistage, stratified, cluster cross-sectional study sampled eligible National Health and Nutrition Examination Survey participants aged 20–69 years ( n = 4675) about exposure to oc...
Article
Background: Since the number of cancer survivors is increasing, it is imperative that we better understand the long-term consequences of these survivors. We assessed the risk of developing a second primary malignant neoplasm (SPMN) after an index potentially-HPV-associated cancers (P-HPV-AC). Methods: We constructed a population-based cohort of...
Article
Background: The current study was conducted to determine whether the incidence of late-stage head and neck cancer (HNC) is decreasing and to estimate the risk of late-stage HNC diagnosis based on race and sex. Methods: Age-adjusted incidence rates for patients aged ≥18 years with stage IV HNC were abstracted from the Surveillance, Epidemiology,...
Article
Importance Melanoma is one of the most common cancers worldwide, typically diagnosed in older adults. There is an increasing incidence in the younger population (age ≤40 years) in America. In addition, approximately 1 in 5 cases of melanoma affect the head and neck. However, there are limited data on the incidence of head and neck melanoma in the p...
Article
Full-text available
Annually, about 16,500 HPV-associated cancers occur in the US among men. Data regarding HPV vaccine uptake among men based on nativity status (i.e., US-versus foreign-born) is limited, yet potentially important for informing interventions. We assessed differences in HPV vaccine uptake by nativity status among men aged 18-34 years in the US. The 201...
Article
Objective: To describe comorbidity burden and nonclinical factors associated with all-cause mortality of sinonasal cancer in the United States. Methods: The National Cancer Database (2004-2013) was queried for adult cases of sinonasal cancer (n = 10,518). Outcome of interest was all-cause mortality. Independent variables included comorbidity sco...
Conference Paper
Introduction: Human papillomavirus (HPV) is the most common etiology of oropharyngeal squamous cell carcinoma (OPSCC), causing 70-90% of cases, and has continued to increase in incidence. While HPV-associated OPSCC has been associated with younger age at diagnosis compared to other head and neck cancers, research studies suggest that age of diagnos...
Conference Paper
Introduction: Human papillomavirus (HPV) is the most common etiology of oropharyngeal squamous cell carcinoma (OPSCC), causing 70-90% of cases, and has continued to increase in incidence. While HPV-associated OPSCC has been associated with younger age at diagnosis compared to other head and neck cancers, research studies suggest that age of diagnos...
Conference Paper
Introduction: The anatomical complexity of the sinonasal region contributes to the poor prognosis and relative rarity of sinonasal cancer. While several studies have focused on the major clinical factors associated with survival, the burden of comorbidities and its impact on all-cause mortality of sinonasal cancer is unknown. Objective: This study...
Conference Paper
Background: Despite steady declines in cigarette smoking prevalence, approximately one-third of cancer deaths in the United States are associated with smoking. This growing population of cancer survivors is at increased risk of developing second primary cancers (SPCs). We explored the incidence of SPC by latency period among survivors of the most c...
Article
Objectives: Thirty-day (30-day) mortality, a common posttreatment quality metric, is yet to be described following surgery for head and neck squamous cell carcinoma (HNSCC). This study aimed to measure 30-day postoperative mortality in HNSCC and describe clinical/nonclinical factors associated with 30-day mortality. Methods: In this retrospectiv...
Article
Background: There currently are no randomized studies examining if absorbable hemostatic packing (AHP) results in better objective and subjective outcomes than physiologic healing in sinus surgery with or without septoplasty. Objective: The objective of this study is to examine outcomes after functional endoscopic sinus surgery (FESS) with or wi...
Article
e17554 Background: There has been a shift in the epidemiologic landscape of head and neck cancer (HNC) with decreasing incidence of tobacco-related and increasing incidence of human papillomavirus (HPV)-related HNC. While it is often reported that ≥ 90% of HNC is considered squamous cell carcinoma (SCC), there is an apparent lack of recent populati...
Article
Background: Survival of head and neck cancer is impacted by known clinical factors, including anatomic subsite, stage of presentation, and treatment modality. An important clinical factor less explored is comorbidity burden. While it is known that a greater comorbidity burden is prognostic for poorer outcomes, it is unclear how the odds of presenti...
Article
A multitude of simulator systems for endoscopic sinus surgery (ESS) are available as training tools for residents preparing to enter the operating room. These include human cadavers, virtual reality, realistic anatomic models, and low-fidelity gelatin molds. While these models have been validated and evaluated as independent tools for surgical trai...
Article
Objectives Incidence trends and outcomes of head and neck cancer (HNC) among female patients are not well understood. The objective of this study was to estimate incidence trends and quantify the association between health insurance status, stage at presentation, and survival among females with HNC. Study Design Retrospective cohort study. Method...
Article
Objectives: To quantify head and neck cancer (HNC) mortality rates and identify racial and socioeconomic factors associated with 90-day mortality. Methods: The National Cancer Database (2004-2014) was queried for eligible HNC cases (n = 260,011) among adults treated with curative intent. Outcome of interest was any-cause 90-day mortality. Kaplan...
Conference Paper
Background: There are previous studies on the impact of socioeconomic status on head and neck cancer outcomes, but it is not clear whether these factors are associated with short-term mortality as most studies on risk factors for mortality have focused on long-term mortality and clinical factors. This study aimed to quantify 90-day mortality rates...
Conference Paper
Objective: To identify which racial/ethnic groups may be driving the incidence trends of thyroid cancer among pediatric, adolescent, and young adult populations (AYA). Background: The United States and other industrialized nations are experiencing what is known as the thyroid cancer epidemic. While there are studies of incidence trends among adult...
Article
While there are a growing number of cancer survivors, this population is at increased risk of developing second primary malignancies (SPMs). We described the incidence, most common tumor sites, and trends in burden of SPM among survivors of the most commonly diagnosed smoking‐related cancers. The current study was a population‐based study of patien...
Article
Objectives: To determine whether the impact of marital status on head and neck cancer (HNC) outcomes vary by gender. Methods: The Surveillance, Epidemiology, and End Results 18 database from 2007 to 2014 was queried for eligible cases of HNC (n=71,799). An interaction term (gender*marital status) was tested for each outcome of interest (cancer-spec...
Article
73 Background: Head and neck cancer (HNC) survivors with end-stage disease may receive multimodal treatment with non-curative intent. However, besides clinical indications for palliative care, there is a paucity of data describing nonclinical factors associated with receipt of palliative care. This study aimed at characterizing sociodemographic fac...
Article
181 Background: Suicide rate is among cancer survivors double that of the general United States population, and risk is significantly greater among males than females. Meanwhile, being married confers survival advantage across the cancer continuum, with males benefitting more than females. This study was aimed at determining whether marital status...
Article
18 Background: The impact of marital status on cancer survival, including head and neck cancer (HNC), has been previously described. However, no previous study has shown whether being married impacts head and neck cancer patients with end-stage disease. The objective of this study was to determine the impact of marital status on survival of patient...
Article
Objectives/Hypothesis To 1) examine the characteristics of patients who develop second primary malignancies (SPMs) from an index human papillomavirus (HPV)‐related head and neck squamous cell carcinoma (HNSCC) and HPV‐unrelated HNSCC and to 2) compare overall survival between those with HPV‐related and HPV‐unrelated index HNSCC among patients who d...
Article
Objective To determine if there are differences in mortality from oral cavity squamous cell carcinoma (OCSCC) based on oral cavity (OC) subsites. Methods Using the Surveillance, Epidemiology, and End Results Program (SEER) 9 database, patients with sequence number 0 or 1 squamous cell OCSCC were analyzed by OC subsite for 5‐year cause‐specific mor...
Conference Paper
Objective: To identify which racial/ethnic groups may be driving the incidence trends of thyroid cancer among pediatric, adolescent, and young adult populations (AYA). Background: The United States and other industrialized nations are experiencing what is known as the thyroid cancer epidemic. While there are studies of incidence trends among adult...
Conference Paper
Background: There are previous studies on the impact of socioeconomic status on head and neck cancer outcomes, but it is not clear whether these factors are associated with short-term mortality as most studies on risk factors for mortality have focused on long-term mortality and clinical factors. This study aimed to quantify 90-day mortality rates...
Article
Background Cancer survivors face psychosocial issues that increase their risk of suicide. This study examined the risk of suicide across cancer sites, with a focus on survivors of head and neck cancer (HNC). Methods The Surveillance, Epidemiology, and End Results 18‐registry database (from 2000 to 2014) was queried for the top 20 cancer sites in t...
Article
Objective Depression is a significant problem for patients with head and neck cancer (HNC). This study explored the prevalence of, and sociodemographic and clinical factors associated with, depression, among patients with HNC. Methods We performed a retrospective analysis of 71,541 cases of HNC using a national dataset, the Nationwide Inpatient Sa...
Article
Objective: The literature on nasopharyngeal carcinoma survival in the United States has focused mostly on Whites or Asians, and not much is known about survivorship in other minority racial and ethnic groups. We aimed to determine the disease-specific survival rate and prognostic factors for nasopharyngeal carcinoma survival across the minority Un...
Article
Objectives/Hypothesis Radiation is thought to increase risk of developing second primary thyroid cancer (SPTC). This study estimated the rate of SPTC following index head and neck cancer (HNC) and determined whether radiation treatment among HNC survivors increased SPTC risk. Study Design Retrospective data analysis. Method The Surveillance, Epid...
Article
Background: The human papillomavirus (HPV) is the most common sexually transmitted infection in the United States, with nearly 80 million people currently infected. It causes virtually all cervical cancers in the United States. There are three prophylactic HPV vaccines approved and recommended in the United States, and they protect against 70-90%...
Article
Purpose: An estimated 8,200 cases of anal cancer will be diagnosed in 2017, accounting for nearly 1,100 deaths. Though anal cancer is a relatively rare malignancy, its increasing incidence has coincided with the increase in prevalence of risky sexual practices associated with anal human papillomavirus (HPV) infection, especially among men. At least...
Article
Purpose: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. One in every four individuals-nearly 80 million-is infected. More than 38,000 new cases of HPV-associated cancers are diagnosed annually. However, factors related to HPV-associated cancer survivorship, based on primary anatomic site, remain u...
Conference Paper
Introduction: Although there are currently more than 430,000 head and neck cancer (HNC) survivors in the United States, it is accepted that many more patients would have survived longer if they presented at an earlier stage. Less than half of all head and neck cancer patients present with early-stage disease. One of the factors implicated in late s...
Conference Paper
Introduction: Head and neck squamous cell carcinoma (HNSCC) incidence and survivorship has been thoroughly described in the literature. Most of the literature has mainly focused on older adults. However, there are documented cases of early-onset HNSCC, typically in adolescents and young adults (AYA) aged 15-39 years. In fact, 12% of all pediatric c...
Conference Paper
Introduction: Among the known nonclinical prognostic factors for head and neck squamous cell carcinoma (HNSCC) survivorship, there has been recent focus on the potential benefits of being married. Several studies have shown that marriage confers a survival advantage for HNSCC patients. However, anecdotal evidence suggests that there may be marked d...
Article
Purpose: Adolescent and young adult (AYA) head and neck cancer (HNC) patients require longer term follow-ups as they age; yet, little is known about factors associated with survivorship in this population. We aimed to describe nonclinical factors associated with HNC survivorship among AYAs. Methods: In this retrospective cohort study, the Survei...
Article
146 Background: While head and neck cancer (HNC) only accounts for 4% of new cancer cases in the United States, incidence of HNC-associated suicide may be significantly higher due to quality of life issues associated with HNC survivorship. This study estimated incidence of HNC-associated suicide versus other common cancers, and quantified suicide r...
Article
Approximately 436 000 survivors of head and neck cancer (HNC) currently live in the United States, the number increasing because of decreasing smoking rates and increasing human papillomavirus incidence.¹ Survivors, however, face several comorbidities that increase their risk of death from competing causes other than primary HNC.
Article
Human papillomavirus-associated cancers contribute to the total cancer burden in the United States. Although they are mostly preventable, 5-year relative survival rates can be as low as 47% for penile cancer and as high as 66% for vulvar cancer. See also pages 000-000.