Matthew D Moore

Matthew D Moore
University of Massachusetts Amherst | UMass Amherst · Department of Food Science

PhD

About

56
Publications
6,700
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807
Citations
Additional affiliations
February 2007 - May 2010
Cornell University
Position
  • Student

Publications

Publications (56)
Article
Asthma is associated with significant morbidity. The gut microbiome has been shown to effect asthma development and exacerbation. In this study, we tested an oral supplement containing Boswellia serrata (Indian frankincense) tree resin on allergic pulmonary inflammation and gut microbiome. An OVA based allergic airway model was used and mice were o...
Article
Full-text available
Human norovirus is the leading cause of foodborne illness in the United States. Among many of the challenges related to understanding and controlling noroviruses, the influence of host microbiota on viral pathogenesis has continued to remain the subject of increased focus. Foundational work previously suggested that some bacteria may directly inter...
Article
Certain types of metal-based nanoparticles are effective antiviral agents when used in their original form ("bare") or after their surfaces have been functionalized ("modified"), including those comprised of metals (e.g., silver) and metal oxides (e.g., zinc oxide, titanium dioxide, or iron dioxide). These nanoparticles can be prepared with differe...
Article
Full-text available
The continuing cases of COVID-19 due to emerging strains of the SARS-CoV-2 virus underscore the urgent need to develop effective antiviral technologies. A crucial aspect of reducing transmission of the virus is through environmental disinfection. To this end, a nanotechnology-based antimicrobial platform utilizing engineered water nanostructures (E...
Article
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The risk of potential SARS-CoV-2 transmission by infected mothers during labor and delivery has not been investigated in-depth. This work collected air samples close to (respiratory droplets) and more distant from (aerosol generation) unvaccinated patients who had previously tested positive for SARS-CoV-2 during labor within 5 days of a positive te...
Article
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The antinoroviral effect of copper ions is well known, yet most of this work has previously been conducted in copper and copper alloy surfaces, not copper ions in solution. In this work, we characterized the effects that Cu ions have on human norovirus capsids' and surrogates' integrity to explain empirical data, indicating virus inactivation by co...
Article
Full-text available
Foodborne and enteric viruses continue to impose a significant public health and economic burden globally. As many of these viruses are highly transmissible, the ability to detect them portably, sensitively, and rapidly is critical to reduce their spread. Although still considered a gold standard for detection of these viruses, real time polymerase...
Article
Full-text available
Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the e...
Chapter
This book answers the question “What is it that viruses do?” by presenting three aspects of viral ecology. The first aspect explains how viruses affect the population diversity and energetics of their host communities. Perhaps the most notable example of this concept is our understanding that primary production within ecosystems often depends upon...
Article
Currently no standard benchtop preparation method exists for simulated produce wash water, which makes it challenging to compare sanitizer efficacy reports and provide guidance for growers regarding water quality monitoring and free chlorine quantification. This work compares benchtop preparation methods for spinach-based model wash water (blender...
Article
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Aflatoxins are toxic secondary metabolites produced mainly by Aspergillus flavus and A. parasiticus, which are fungal contaminants found in several foodstuffs, including spices. In this study 40 cinnamon samples were collected in November and December 2020 in the Iranian province of Yazd and analysed for the presence of aflatoxin B 1 (AFB 1) by hig...
Article
This communication summarizes the presentations given at the 1st international conference of the World Society for Virology (WSV) held virtually during 16–18 June 2021, under the theme of tackling global viral epidemics. The purpose of this biennial meeting is to foster international collaborations and address important viral epidemics in different...
Article
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Background: Secondary infections pose tremendous challenges in Coronavirus disease 2019 (COVID-19) treatment and are associated with higher mortality rates. Clinicians face of the challenge of diagnosing viral infections because of low sensitivity of available laboratory tests. Case Presentation: A 66-year-old woman initially manifested fever and s...
Article
Full-text available
Human norovirus is the leading cause of foodborne illness globally. One of the challenges in detecting noroviruses is the identification of a completely broadly reactive ligand; however, all detection ligands generated to date target the viral capsid, the outermost of which is the most variable region of the genome. The VPg is a protein covalently...
Article
Full-text available
Human norovirus (NoV) is the leading cause of acute viral gastroenteritis and a major source of foodborne illness. Detection of NoV in food and environmental samples is typically performed using molecular techniques, including real-time reverse transcription polymerase chain reaction (RT-PCR) and less frequently, nested real-time PCR. In this study...
Article
Full-text available
The COVID-19 pandemic has resulted in unprecedented increases in sickness, death, economic disruption, and social disturbances globally. However, the virus (SARS-CoV-2) that caused this pandemic is only one of many viruses threatening public health. Consequently, it is important to have effective means of preventing viral transmission and reducing...
Article
Aflatoxins are one of the most important mycotoxins that are harmful to public health. Aspergillus flavus and A. parasiticus are the known moulds which produce mutagenic and carcinogenic compounds named aflatoxins. These compounds are naturally considered to be toxic and dangerous for humans and animals. In this review, toxicology of these compound...
Article
Here, we report a novel, “dry”, nano-aerosol based, antimicrobial technology using Engineered Water Nanostructures (EWNS) for leafy vegetable disinfection. These EWNS based nano-sanitizers are synthesized using a combined process of electrospray and ionization of aqueous solutions of generally recognized as safe active ingredients (AIs). A novel ap...
Article
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Food allergies are increasing at an alarming rate, with 6.5% of the general population affected. It has been hypothesized that the increase in allergies stems from the “hygiene hypothesis”. The gut microbiome, a collection of microbiota and their genetic contents from the gastrointestinal tract, has been shown to play a part in the development of f...
Article
As SARS-CoV-2 is spreading rapidly around the globe, adopting proper actions for confronting and protecting against this virus is an essential and unmet task. Reactive oxygen species (ROS) promoting molecules such as peroxides are detrimental to many viruses, including coronaviruses. In this paper, metal decorated single-wall carbon nanotubes (SWCN...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged early in December 2019 and currently affects most of the countries in all continents. As was very well highlighted by Correia, 1 there are a number of major scientific uncertainties underpinning the nature of SARS-CoV-2 that must be addressed; one of which is the degree to whi...
Article
Objectives Butyrate is considered as an important mediator in the complex etiology of colorectal cancer (CRC) that integrates gut microbiota with dietary factors and genetic components. However, how microbial-derived butyrate mediates colonic tumorigenesis remains unclear, with contradictory results from only limited experimental studies. Methods...
Article
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As the leading cause of acute gastroenteritis worldwide, human noroviruses (HuNoVs) have caused around 685 million cases of infection and nearly $60 billion in losses every year. Despite their highly contagious nature, an effective vaccine for HuNoVs has yet to become commercially available. Therefore, rapid detection and subtyping of noroviruses i...
Article
Full-text available
The World Society for Virology (WSV) was founded and incorporated as a nonprofit organization in the United States in 2017. WSV seeks to strengthen and support both virological research and virologists who conduct research of viruses that affect humans, other animals, plants, and other organisms. One of the objectives of WSV is to connect virologis...
Article
Full-text available
Objective: Research suggests human norovirus binding to histo-blood group antigen (HBGA)-like molecules on enteric bacteria may enhance viral pathogenesis; however, the properties of these bacterial ligands are not well known. Previous work identified, but did not characterize, seven norovirus-binding bacteria. To further examine this bacteria-vir...
Article
Hand hygiene is a critical public health issue associated with disease transmission worldwide. Here, a nanotechnology-based approach has been employed to enhance hand hygiene using Engineered Water Nanostructures (EWNS) synthesized by electrospray and ionization of antimicrobial aqueous solutions. The EWNS possess unique properties: have a tunable...
Preprint
Objective: Research suggests human norovirus binding to Histo-Blood Group Antigen (HBGA)-like molecules on enteric bacteria may enhance viral pathogenesis; however, the properties of these bacterial ligands are not well known. Previous work identified, but did not characterize, seven norovirus-binding bacteria. To further examine this bacteria-viru...
Preprint
Objective: Research suggests human norovirus binding to Histo-Blood Group Antigen (HBGA)-like molecules on enteric bacteria may enhance viral pathogenesis; however, the properties of these bacterial ligands are not well known. Previous work identified, but did not characterize, seven norovirus-binding bacteria. To further examine this bacteria-viru...
Article
Full-text available
Human norovirus is the leading cause of foodborne illness globally. Detection and quantification of norovirus commonly involves the use of reverse transcriptase quantitative polymerase chain reaction (RT-qPCR); however, the presence of inhibitory compounds in foods limit detection and accurate quantification. Although some studies have been done on...
Preprint
Objective Research suggests human norovirus binding to histo-blood group antigen (HBGA)-like molecules on enteric bacteria may enhance viral pathogenesis; however, the properties of these bacterial ligands are not well known. Previous work identified, but did not characterize seven norovirus-binding bacteria. To further characterize this bacteria-v...
Article
Full-text available
Human noroviruses are the leading cause of foodborne illness globally. Numerous challenges in control of these viruses exist due to multiple viral characteristics: the ability to environmentally persist for over a month; relatively low infectious dose; lack of extremely effective, non-corrosive inactivation agents; and considerable inhibitory effec...
Article
Background: Trimethoprim/sulfamethoxazole is a synthetic antibiotic combination recommended for the treatment of complicated non-typhoidal Salmonella infections in humans. Resistance to trimethoprim/sulfamethoxazole is mediated by the acquisition of mobile genes, requiring both a dfr gene (trimethoprim resistance) and a sul gene (sulfamethoxazole...
Article
Human norovirus is the leading cause of foodborne illness globally, imposing a considerable public health and economic burden. Historically, one of the major obstacles to the study of human noroviruses has been the lack of an in vitro cultivation system. In addition to hindering elucidation of viral pathogenesis, research efforts have been limited...
Article
A single stranded (ss) DNA aptamer, specific to members of Listeria genus, was used to develop a two-site binding sandwich assay for capture and detection of L. monocytogenes. Antibody-immobilized immunomagnetic beads were used to capture L. monocytogenes, followed by their exposure to the aptamer detector. Detection was achieved by amplification o...
Article
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Eukaryotic virus–bacteria interactions have recently become an emerging topic of study due to multiple significant examples related to human pathogens of clinical interest. However, such omnipresent and likely important interactions for viruses and bacteria relevant to the applied and agricultural sciences have not been reviewed or compiled. The fu...
Article
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Histo-blood group antigens (HBGAs) are commonly accepted as the cellular receptors for human norovirus. However, some human noroviruses have been found not to bind any HBGA ligand, suggesting potential additional co-factors. Some ligands have been found to bind noroviruses and have the potential to be additional cellular receptors/attachment factor...
Article
Human norovirus exacts considerable public health and economic losses worldwide. Emerging in vitro cultivation advances are not yet applicable for routine detection of the virus. The current detection and quantification techniques, which rely primarily on nucleic acid amplification, do not discriminate infectious from non-infectious viral particles...
Article
Full-text available
Viral enteric disease imposes a considerable public health and economic burden globally in both humans and livestock. Because enteric viruses are highly transmissible and resistant to numerous control strategies, making early in-field or point-of-care detection is important. There are problems with ligand-based detection strategies (e.g., sensitivi...
Article
Human norovirus is a leading cause of gastroenteritis worldwide. Although two in vitro cultivation methods have been reported, they cannot provide mechanistic insights into viral inactivation. Receptor-binding assays supplement these assays and give insight into capsid integrity. We present a streamlined version of receptor-binding assays with mini...
Article
Full-text available
Bacteria and viruses often occupy the same niches, however, interest in their potential collaboration in promoting wellness or disease states has only recently gained traction. While the interaction of some bacteria and viruses is well characterized (e.g., influenza virus), researchers are typically more interested in the location of the infection...
Chapter
Nucleic acid aptamers are a class of alternative ligands increasingly growing in importance in the face of contemporary detection challenges. Aptamers offer multiple advantages over traditional ligands like antibodies; however, their ability to specifically bind target molecules must first be confirmed after their generation. Use of a plate-based e...
Article
Full-text available
Recent reports describe the ability of select bacterial strains to bind human norovirus, although the specificity of such interactions is unknown. The purpose of this work was to determine if a select group of bacterial species representative of human gut microbiota bind to human norovirus, and if so, to characterize the intensity and location of t...
Data
Raw 16S sequence information for bacteria isolated from human stool. Data is provided for both forward and reverse reads and isolate names refer to isolates described in S1 Table. Raw forward and reverse reads of the isolates relevant to this paper are provided in FASTA format below. (PDF)
Data
Top matches for 16S rRNA sequences of bacteria isolated from human stool samples. Different samples of human stool were streak plated and grown in both aerobic and anaerobic conditions. Specific colonies were isolated, further cultured and their 16S rRNA region sequenced. Below is a summary table of the top sequence isolates selected for further an...
Article
Full-text available
Human norovirus is a leading cause of viral gastroenteritis worldwide. Rapid detection could facilitate control, however widespread point-of-care testing is infrequently done due to the lack of robust and portable methods. Recombinase polymerase amplification (RPA) is a novel isothermal method which rapidly amplifies and detects nucleic acids using...
Article
Full-text available
Although two in vitro cultivation methods have been reported, discrimination of infectious human norovirus particles for study of viral inactivation is still a challenge, as both rely on reverse transcriptase quantitative PCR. Histo-blood group antigen (HBGA) binding assays serve as a proxy for estimation of infectious particles; however, they are...
Article
Aims: Human norovirus is a major public health burden and is resistant to numerous sanitizers and disinfectants. In this study, we tested the efficacy of an antimicrobial product containing a blend of silver ions and citric acid (silver dihydrogen citrate; SDC) against GI.6 and GII.4 HuNoV. Methods and results: Pure(®) hard surface disinfectant...
Article
Full-text available
Human noroviruses (NoV) are the leading cause of acute viral gastroenteritis worldwide. Significant antigenic diversity of NoV strains has limited the availability of broadly reactive ligands for design of detection assays. The purpose of this work was to produce and characterize single stranded (ss)DNA aptamers with binding specificity to human No...
Article
Full-text available
Human norovirus (HuNoV) represents a significant public health burden worldwide and can be environmentally transmitted. Copper surfaces have been shown to inactivate the cultivable surrogate murine norovirus, but no such data exist for HuNoV. The purpose of this study was to characterize the destruction of GII.4 HuNoV and virus-like particles (VLPs...
Article
Full-text available
Human noroviruses (NoVs) are the leading cause of foodborne illness in the United States, and they exact a considerable human and economic burden worldwide. In fact, the many challenging aspects of human NoV have caused some to call it the nearly perfect foodborne pathogen. In this review, a brief overview of NoVs and their genetic structure is pro...
Article
Full-text available
Human noroviruses (HuNoV) are the leading cause of acute viral gastroenteritis and an important cause of foodborne disease. Despite their public health significance, routine detection of HuNoV in community settings, or food and environmental samples, is limited, and there is a need to develop alternative HuNoV diagnostic reagents to complement exis...

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