Matthew Knight

Matthew Knight
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Matthew verified their affiliation via an institutional email.
Verified
Matthew verified their affiliation via an institutional email.
  • Bachelor of Medicine
  • Consultant at West Hertfordshire Hospitals NHS Trust

About

37
Publications
9,899
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2,258
Citations
Introduction
I am interested in clinical evaluation of the role of technology and pathways in remote patient monitoring. My main clinical work is in the areas of Complex/ Difficult to treat asthma, Unexplained Dyspnoea and Cardio-Pulmonary Exercise testing
Current institution
West Hertfordshire Hospitals NHS Trust
Current position
  • Consultant

Publications

Publications (37)
Article
Full-text available
Objectives The objective of this study is to report the pilot phase of the Targeted Prostate Health Check programme that aims to identify men in the Surrey and Sussex region who have prostate cancer and who failed to be detected during the Covid era. Subjects and methods Men aged 50 to 70, or 45 to 70 if Black or with a family history of prostate...
Article
Full-text available
Introduction In the midst of a global climate emergency and with health care systems across the world facing extreme pressure, interest in digital approaches as a potential part-solution to these challenges has increased rapidly. The evidence base to support the role that digitalization can play in moving towards more sustainable models of healthca...
Article
Full-text available
Desaturation on exercise has been suggested as a predictive feature for deterioration in COVID-19. The objective of this paper was to determine the feasibility and validity for the 40-steps desaturation test.A prospective observational cohort study was undertaken in patients assessed in hospital prior to discharge. One-hundred and fifty-two partici...
Article
Full-text available
https://onlinelibrary.wiley.com/share/author/FQ3QEKVFJX62Z7AMQYFV?target=10.1111/anae.15635 link to the paper
Article
Full-text available
Background Even when resting pulse oximetry is normal in the patient with acute Covid-19, hypoxia can manifest on exertion. We summarise the literature on the performance of different rapid tests for exertional desaturation and draw on this evidence base to provide guidance in the context of acute Covid-19. Main research questions What exercise te...
Article
Full-text available
Introduction Risk factors of adverse outcomes in COVID-19 are defined but stratification of mortality using non-laboratory measured scores, particularly at the time of prehospital SARS-CoV-2 testing, is lacking. Methods Multivariate regression with bootstrapping was used to identify independent mortality predictors in patients admitted to an acute...
Article
Full-text available
Objective Identify predictors of clinical deterioration in a virtual hospital (VH) setting for COVID-19. Design Real-world prospective observational study. Setting VH remote assessment service in West Hertfordshire NHS Trust, UK. Participants Patients with suspected COVID-19 illness enrolled directly from the community (postaccident and emergenc...
Conference Paper
Full-text available
Introduction and Objectives The disease spectrum of COVID-19 ranges from mild viral illness to devastating lung injury that heralds the acute respiratory distress syndrome. Different risk factors of adverse outcomes have been identified but prospectively stratified and externally validated studies of prognosis are lacking. We set out to identify in...
Article
Full-text available
Objective Secondary spontaneous pneumothorax (SSP) is traditionally managed with an intercostal chest tube attached to an underwater seal. We investigated whether use of a one-way flutter valve shortened length of patients’ stay (LoS). Methods This open-label randomised controlled trial enrolled patients presenting with SSP and randomised to eithe...
Article
Full-text available
Objectives Digital remote patient monitoring (RPM) can add value to virtual wards; this has become more apparent in the context of the COVID-19 pandemic. Healthcare providers are overwhelmed resulting in clinical teams spread more thinly. We aim to assess the impact of the introduction of an app-based RPM (Huma Therapeutics) on a clinician's worklo...
Preprint
Full-text available
Objectives To assess the real-world diagnostic accuracy of the Livzon point-of-care rapid test for antibodies to SARS-COV-2 Design Prospective cohort study Setting District general hospital in England Participants 173 Patients and 224 hospital staff with a history of COVID-19 symptoms, and who underwent PCR and/or reference antibody testing for...
Preprint
Full-text available
Objective Identify predictors of adverse outcome in a Virtual Hospital (VH) setting for COVID 19. Design Real-world prospective observational study. Setting Virtual hospital remote assessment service in West Hertfordshire NHS Trust, UK. Participants Patients with suspected COVID-19 illness enrolled directly from the community (post-accident and...
Preprint
Full-text available
Background Even when resting pulse oximetry is normal in the patient with acute Covid-19, hypoxia can manifest on exertion. We sought to summarise the literature on the performance of different rapid tests for exertional desaturation. Main research question What tests have been formally evaluated for the rapid assessment of exertional hypoxia in pa...
Preprint
Full-text available
Background Even when resting pulse oximetry is normal in the patient with acute Covid-19, hypoxia can manifest on exertion. We summarise the literature on the performance of different rapid tests for exertional desaturation and draw on this evidence base to provide guidance in the context of acute COVID-19. Main research questions 1. What exercise...
Article
Full-text available
Ambulatory management of PSP significantly reduced duration of hospitalisation, including re-admissions in the first 30 days, but at the expense of increased adverse events. This data suggests PSP can be managed as an outpatient using ambulatory devices in those who require intervention.
Preprint
Full-text available
Background Even when resting pulse oximetry is normal in the patient with acute Covid-19, hypoxia can manifest on exertion. We sought to summarise the literature on the performance of different rapid tests for exertional desaturation. Research question What tests have been formally evaluated for the rapid assessment of exertional hypoxia? What is...
Preprint
Full-text available
Risk stratification of patients presenting with Covid-19 to urgent care/ hot hub settings to idnetify suitablility for out of hospital remote monitoring versus escalation to hospital assessment or admission. Introduction Risk factors of adverse outcomes in COVID-19 are defined but stratification of mortality using non-laboratory measured scores,...
Article
Full-text available
Provides a clear framework for primary care practitioners reviewing patients with ongoing symptoms following infection with SARS-COV-2
Conference Paper
Abstract Introduction The complication rate of Pleural procedures is reduced from 8% to 1% when managed by a pleural specialist. We reviewed pleural disease managed by the department of medicine at our hospital in London to assess the potential effect a dedicated pleural service on patient safety, doctor training and on reducing length of stay. M...
Preprint
Full-text available
BACKGROUND Digital remote patient monitoring (RPM) can add value to virtual wards; this has become more apparent in the context of the COVID-19 pandemic. Healthcare providers are overwhelmed resulting in clinical teams spread more thinly. We aim to assess the impact of the introduction of an app-based RPM (Huma Therapeutics) on a clinician's worklo...
Article
Full-text available
Background Digital remote patient monitoring can add value to virtual wards; this has become more apparent in the context of the COVID-19 pandemic. Health care providers are overwhelmed, resulting in clinical teams spread more thinly. We aimed to assess the impact of introducing an app-based remote patient monitoring system (Huma Therapeutics) on a...
Article
Full-text available
Background Primary spontaneous pneumothorax occurs in otherwise healthy young patients. Optimal management is not defined and often results in prolonged hospitalisation. Data on efficacy of ambulatory options are poor. We aimed to describe the duration of hospitalisation and safety of ambulatory management compared with standard care. Methods In t...
Technical Report
Full-text available
Two tests have potential: the 1-minute sit-to-stand test (in which the patient goes from sit to stand as many times as they can in one minute) and the 40-step test (in which the patient takes 40 steps on a flat surface). The former correlates well with the validated 6-minute exercise test. The latter is less demanding (hence safer) and in more wide...
Conference Paper
Introduction Respiratory infection, predominantly due to viral pathogens, poses a huge burden on the NHS especially during winter. An earlier definitive microbiological diagnosis should allow more rapid clinical decision-making on aspects of care, including hospital admission (versus discharge) and antibiotic use, and prevention of nosocomial infec...
Poster
Introduction Primary Hyperparathyroidism (PHPT) has a prevalence of 1/1000, with only 20% of patients being symptomatic, and was previously considered to be a benign condition. Recent evidence shows increased mortality in PHPT patients, primarily from cardiovascular disease, peptic ulcers and osteoporotic fractures. Parathyroidectomy reduces morta...

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