Matthew Haren

• Doctor of Philosophy
• Research Professional at Université Laval

The use of the business process model notation (BPMN) in modeling health care trajectory has been applied in the last decades in health care organizations for several aims, such as increasing efficiency and efficacy, improving patient outcomes and reducing costs. In scientific literature, many systematic reviews have been published about this topic...

Chronic obstructive pulmonary disease (COPD) is a progressive disease of the airways, underpinned by inflammation and worsening lung function. Omega-3 polyunsaturated fatty acids (n-3PUFA) can modulate inflammatory mechanisms and may therefore impact lung function in people with COPD. This observational, cross-sectional study of 577 adults in the W...

Objective: The objective of this scoping review is to identify and map current recommendations and practices for the screening of depression and anxiety in acute coronary syndrome patients in the acute care setting.Specifically, the review questions are.

Growth factors can be isolated from bovine milk to form a whey growth factor extract (WGFE). This study examined whether WGFE promoted activation of the AKT/mTOR pathway enabling increased lean tissue mass and strength in resistance trained men. Forty six men with >6 months of resistance training (RT) experience performed 12 weeks of RT. Participan...

Introduction: In Australia, modifiable cardiometabolic risk factors are in excess in rural and remote communities. High-quality community-level health promotion is paramount for the management of population health risk in such settings, especially in the context of reduced access to healthcare services. Two indicators of quality of health promotion...

Introduction: In Australia, modifiable cardiometabolic risk factors are in excess in rural and remote communities. High-quality community-level health promotion is paramount for the management of population health risk in such settings, especially in the context of reduced access to healthcare services. Two indicators of quality of health promotion...

The Royal Flying Doctor Service (RFDS) provides aeromedical care to patients during fixed-wing transport over vast distances to healthcare unavailable in rural or remote communities. This study examined the relationship between changes in local accessibility to primary healthcare services and rates of aeromedical service use over time. This was a 1...

Purpose – Workplace health promotion enables the dissemination of health-related information to a large portion of society and provides a vehicle for translating results of efficacy studies to effective lifestyle interventions under less controlled real-world conditions. To achieve effectiveness there needs to be a systematic approach to the design...

We investigated whether residential environment characteristics related to food (unhealthful/healthful food sources ratio), walkability and public open spaces (POS; number, median size, greenness and type) were associated with incidence of four cardio-metabolic risk factors (pre-diabetes/diabetes, hypertension, dyslipidaemia, abdominal obesity) in...

We investigated whether residential environment characteristics related to food (unhealthful/healthful food sources ratio), walkability and public open spaces (POS; number, median size, greenness and type) were associated with incidence of four cardio-metabolic risk factors (pre-diabetes/diabetes, hypertension, dyslipidaemia, abdominal obesity) in...

Purpose We determined the metabolic, lifestyle and physical factors associated with progression or improvement of storage and voiding lower urinary tract symptoms in a population based cohort of men. Materials and Methods After the exclusion of men with prostate or bladder cancer and/or surgery from the study, progression and improvement of storag...

Understanding the conditions under which families try to influence members' health-related practices can provide information to build concepts adding to models of health promotion. This paper reports on an exploratory qualitative study examining the influences of intergenerational relationships in shaping beliefs, knowledge and practices about heal...

Objective: o assess the prevalence of complementary and alternative medicine (CAM) and service use for people with a chronic disease in rural and regional Australia, where reported prevalence of CAM use is higher. Methods: ata were from the Whyalla Intergenerational Study of Health, a population representative cross sectional study of 1146 peopl...

Aim: To develop prediction equations for total and regional (trunk, abdominal, arms and legs) body fat using surface anthropometric measures in children aged 6–17 years. Methods: This was a cross-sectional correlation study of 70 Caucasian children aged 6–17 years recruited from a larger randomly sampled population-based study. The independent vari...

Introduction. Erectile dysfunction (ED) and other related sexual dysfunctions in men have recently been shown to associate with a range of conditions and biopsychosocial factors. However, few studies have been able to control for these related factors simultaneously. Aim. To determine the prevalence of and associated risk factors for ED and low sol...

This study examined associations of abdominal adiposity with lung function, asthma symptoms and current doctor-diagnosed asthma and mediation by insulin resistance (IR) and sleep disordered breathing (SDB). A random sample of 2500 households was drawn from the community of Whyalla, South Australia (The Whyalla Intergenerational Study of Health, WIS...

Table S1. Respiratory, metabolic and socio-demographic characteristics, The Whyalla Intergenerational Study of Health (WISH, 2008-2009).

Objective: To examine the social and behavioural correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum. Design: Cross-sectional study of a random population sample. Participants: A total of 718 community-dwelling adults (57% female), aged 18-92 years from a regional South Australian city. Mea...

The role of endogenous testosterone in the pathogenesis of type 2 diabetes mellitus remains vague. We investigated whether associations between endogenous testosterone and diabetes prevalence in men could be partially explained by modifiable risk factors. A random population-based cross-sectional study of 1195 men aged 35-80 years living in the nor...

Testosterone regulates energy metabolism and skeletal muscle mass in males, but the molecular mechanisms are not fully understood. This study investigated the response of skeletal muscle to castration and testosterone replacement in 8-week-old male mice. Using microarray analyses of mRNA levels in gastrocnemius muscle, 91 genes were found to be neg...

To determine the prevalence of, and associated risk factors for, voiding and storage lower urinary tract symptoms (LUTS) in a population-based sample of Australian men. Data were collected from 1,103 men randomly selected, community-dwelling men, as part of the Florey Adelaide Male Ageing Study, after exclusion of men with prostate or bladder cance...

To define specific medical conditions associated with clinically significant depressive symptoms in men. A cross-sectional study was conducted in a community-based sample of Australian men (N = 1,195, aged 35-80 years; for 2002-2005). Depression was defined by: (1) symptomatic depression (current symptoms) or (2) current prescription for antidepres...

The interaction between overweight/obesity and alcohol intake on liver enzyme concentrations have been demonstrated. No studies have yet examined the interaction between metabolic syndrome or multiple metabolic risk factors and alcohol intake on liver enzymes. The aim of this study was to examine if alcohol consumption modifies the effect of metabo...

Expectation Maximisation Cluster analysis and Partial Least Squares expanded methods. This file contains an expanded discussion of the EM cluster and PLS analysis methods.

Disagreement between IDF metabolic syndrome classification and MR cluster membership. This file contains two tables that show (1) the level of disagreement between the metabolic syndrome classification and MR cluster membership, and (2) the demographic and metabolic characteristics of cases in which disagreement occurred.

This cohort of "late middle-aged" African Americans has an excess of disability. We aimed to determine associations of circulating cytokine receptors (sTNFR1, sTNFR2, and sIL-6R) and C-reactive protein (CRP) with disability, physical function, and body composition. Stratified sampling of two socioeconomically diverse strata of St Louis, Missouri, o...

Objective Plasma androgen levels are inversely associated with health in men, the age-related decline of which may result from factors other than ageing per se. This study aimed to determine the effects of demographic, physical and lifestyle factors on age-related androgen status in men. Design An observational survey of a regionally representative...

The metabolic syndrome (MetS) is a clustering of individual cardiovascular disease risk factors, which doubles the risk of early mortality. The authors' aimed to determine the prevalence and population attributable risk (PAR%) of the MetS among men according to demographic, physical, and lifestyle risk factors. A cross-sectional study was conducted...

To assess if a cell-based readout of androgen action in serum demonstrates a closer association with recognized classical parameters of androgen action in men than current measures of serum testosterone (T). To develop, validate and utilize a mammalian cell-based assay to measure specifically bioactive T and determine if this measure is a physiolog...

Table 2. Risk of type 2 diabetes, osteoarthritis and rheumatoid arthritis by personal, behavioural and socioeconomic factors (attached).

Table 3. Multivariate model of personal, behavioural and socioeconomic predictors of selected chronic diseases (attached).

Age-related change in body composition is associated with adverse health outcomes, including functional decline, disability, morbidity, and early mortality. Prevention of age-related changes requires a greater understanding of the associations among age, lifestyle factors, and body composition. We aimed to comprehensively determine lifestyle factor...

An increasing proportion of Australia's chronic disease burden is carried by the ageing male. The aim of this study was to determine the prevalence of asthma, cancer, diabetes, angina and musculoskeletal conditions and their relationship to behavioural and socio-demographic factors in a cohort of Australian men. Self-reports of disease status were...

There are few reported data on biochemical and functional correlates of androgen levels in African-American men. This study aimed at reporting physical and biochemical correlates of serum total testosterone (total T), bioavailable testosterone (BT) and dehydroepiandrosterone-sulphate (DHEAS) levels in community-dwelling, African-American men aged 5...

Changes in androgen levels and associations with chronic disease, physical and neuropsychological function and disability in women over the middle to later years of life are not well understood and have not been extensively studied in African American women. The present cross-sectional analysis reports such levels and associations in community dwel...

Recent evidence suggests that declining testosterone levels in ageing males may be associated with both normal and pathological cognitive ageing. The aim of the present analyses was to investigate whether endogenous gonadal steroid levels in males mediate or moderate the associations between age and performance on neuropsychological measures of ver...

Health Service Utilization Questionnaire

Sarcopenia can be defined as severe loss of muscle mass that is related to aging. Cachexia, on the other hand, is excessive weight loss associated with disease. The other major causes of weight loss in older persons are anorexia and dehydration. All causes of weight loss can lead to frailty and a decline in muscle strength.

The Florey Adelaide Male Ageing Study (FAMAS) examines the reproductive, physical and psychological health, and health service utilisation of the ageing male in Australia. We describe the rationale for the study, the methods used participant response rates, representativeness and attrition to date. FAMAS is a longitudinal study involving approximat...

Context: Adiponectin levels in African-Americans are poorly described. Objective: To assess predictors of serum adiponectin levels in obese and non-obese middle-aged African-American women. Methods: Serum adiponectin, testosterone (T), free androgen index (FAI), estradiol, dehydroepiandrosterone sulfate (DHEAS), leptin, sex hormone binding glo...

The novel peptide hormone insulin-like peptide 3 (INSL3) is a major secretory product of the Leydig cells of the testis, and in adult men is secreted into the blood, giving rise to circulating concentrations ranging from 0.5 to 2.5 ng/mL. We studied a large randomly recruited cohort of 1183 men from South Australia, comparing serum INSL3 concentrat...

Frailty is a common condition in older people. It now can be objectively defined by the Fried criteria. When recognized, early intervention should begin with the institution of endurance, resistance, and balance exercises. In men with testosterone deficiency a trial of testosterone replacement should be considered. Vitamin D deficiency needs to be...

Testosterone deficiency occurs commonly in men as they grow older. This deficiency often is associated with a decline in sexual activity and a loss of muscle mass. Testosterone replacement can reverse many of these effects. At present, no ideal form of testosterone replacement is available. Like the phosphodiesterase-5 inhibitors, testosterone repl...

Frailty occurs in aging males for a variety of reasons. It is less common in males than females. Diseases which are particularly associated with frailty are diabetes mellitus, atherosclerosis, anemia and chronic obstructive pulmonary disease. Insulin resistance syndrome plays a pathogenetic role in the "fat-frail" syndrome. Sarcopenia occurs predom...

Based on this definition, approximately 6.9% of community dwelling older persons are frail. Frailty is present more often in women than men. Frailty is a precursor for functional deterioration, falls and mortality. Functional deterioration is itself a strong predictor of institutionalization and death. There are many causes of frailty. Of these, al...

The effects of supplemental testosterone on cognition, mood and wellbeing in ageing men are unclear. This study aimed to assess the effect of 12-months of oral testosterone supplementation on cognitive function, mood and quality of life in elderly men with low-normal gonadal status, not specifically selected for cognitive or mood defects. A standar...

Testosterone levels decline over the lifespan. Many symptoms of hypogonadism are similar to age-related changes in older males. A small number of studies have suggested that some of these symptoms may be reversed by testosterone. Among them, one trial has suggested that decline in bioavailable testosterone may be related to the development of funct...

Loss of muscle mass (sarcopenia) leads to frailty in older men. The decline in testosterone over the life span may contribute to this muscle loss. We studied the ability of oral testosterone to prevent muscle loss in older men over a 12-month period. A standard dose (80 mg twice daily) of testosterone undecanoate or placebo was administered for 1 y...

In men, bioavailable and free testosterone levels decline by about 1.0 and 1.2% per year, respectively, after the age of 40. The definition of clinically relevant androgen deficiency in the aging male remains uncertain. Clinical features common to both aging and androgen deficiency include decreased muscle mass and strength, and increased fatigue,...