Matthew Brantley

Matthew Brantley
Baylor University | BU · Department of Chemistry and Biochemistry

B.S. Chemistry (UT Tyler)

About

32
Publications
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106
Citations

Publications

Publications (32)
Article
Untargeted mass spectrometry (MS) workflows are more suitable than targeted workflows for high throughput characterization of complex biological samples. However, analysis workflows for untargeted methods are inadequate for characterization of complex samples that contain multiple classes of compounds as each chemical class might require a differen...
Article
The conformations of glycans are crucial for their biological functions. In-electrospray ionization (ESI) hydrogen/deuterium exchange-mass spectrometry (HDX-MS) is a promising technique for studying carbohydrate conformations since rapidly exchanging functional groups, e.g., hydroxyls, can be labeled on the timeframe of ESI. However, regular applic...
Article
Full-text available
): Comprehensive characterization and structural elucidation of specific chemical sub-classes within a complex mixture often require analyte separation, a variety of spectroscopic techniques, and inquiry into reactivity patterns. Crude oil is one of the most challenging and highly complex mixtures and, for classification purposes, it is typically s...
Article
Chemical identification often relies on matching measured chemical properties and/or spectral “fingerprints” of unknowns against their precompiled libraries. Chromatography, absorption spectroscopy, and mass spectrometry are all among analytical approaches that provide chemical measurement databases amenable to library searching. Occasionally, usin...
Poster
Here, we introduce the use of variable wave velocities as a charge-state independent method for identifying IM co-elution in traveling wave ion mobility spectrometry (TWIMS)
Article
Full-text available
High resolving power ion mobility (IM) allows for accurate characterization of complex mixtures in high-throughput IM mass spectrometry (IM-MS) experiments. We previously demonstrated that pure component IM-MS data can be extracted from IM unresolved post-IM/collision-induced dissociation (CID) MS data using an Automated Ion Mobility Deconvolution...
Article
For wide class characterizations of volatile organic compounds (VOCs), conventional gas chromatography mass spectrometry (GC-MS)-based techniques are utilized. These GC-MS-based chemical identification approaches typically rely on library searches against ion fragmentation patterns of known compounds. Although MS library searches can often provide...
Article
Peak broadening in ion mobility (IM) is a relatively predictable process and abnormally broad peaks can be indicative of the presence of unresolved species. Here, we introduce a new ion mobility peak fitting (IM_FIT) software package for automated and systematic determination of traveling wave ion mobility (TWIM) unresolved species. To identify IM...
Poster
Peak Width Analysis for Automated Detection of Unresolved Isomers in Ion Mobility
Article
Details of coupling a catalytic reaction chamber to a liquid nitrogen-cooled cryofocuser/triple quadrupole mass spectrometer for online monitoring of nitric oxide (NO) photocatalytic reaction products are presented. Cryogenic trapping of catalytic reaction products, via cryofocusing prior to mass spectrometry analysis, allows unambiguous characteri...
Article
Full-text available
Existing instrumental resolving power limitations in ion mobility spectrometry (IMS) often restrict adequate characterization of unresolved or co-eluting chemical isomers. Recently, we introduced a novel chemometric deconvolution approach that utilized post-IM collision-induced dissociation (CID) mass spectrometry (MS) data to extract “pure” IM pro...
Poster
A Cryofocuser/Quadrupole Mass Spectrometry Coupled to a Catalysis Unit for Detection of Nitrogen Oxide Catalysis Products
Poster
Utilizing Ion Mobility Profiles for Rapid Identification of Co-eluting Multiple Conformers and Structural Isomers
Poster
The Influence of Variable Light Condition on the Nitrogen-Starvation Stress Reaction of Chlamydomonas reinhardtii
Article
Presence of unresolved ion mobility (IM) profiles limits the efficient utilization of IM mass spectrometry (IM-MS) systems for isomer differentiation. Here, we introduce an automated ion mobility deconvolution (AIMD) computer software for streamlined deconvolution of overlapped IM-MS profiles. AIMD is based on a previously reported post-IM/collisio...
Poster
Use of Multivariate Curve Resolution and Ion Mobility-Mass Spectrometry for Isomer Differentiation
Poster
Developing Custom-Designed Automated Computer Software for High-Throughput Chemometric Analysis of Mass and Ion Mobility Spectrometry Data
Poster
Developing Custom-Designed Automated Computer Software for High-Throughput Chemometric Analysis of Mass Spectrometry and Ion Mobility Data

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