Matthew Lloyd Barker

• Doctor of Philosophy
• Research Fellow / Sr. Director level at Procter & Gamble

Background: Periodontal disease continues to be prevalent globally, but little clinical research has been undertaken to evaluate the long-term benefits of a daily oral hygiene regimen on progression of gingivitis/early periodontitis. The objective of this study was to evaluate the effects of an oral hygiene regimen (OHR) on the periodontal health...

Purpose: To compare clinical outcomes and oral fluid biomarkers in gingivitis subjects using an electric toothbrush/irrigator combination (test) or a manual toothbrush alone (control) over 8 weeks. Materials and methods: Subjects were randomly assigned to two groups of n = 30. In both groups, toothbrushing was performed twice daily at home and n...

Objectives: To assess plaque and gingivitis reduction in orthodontic patients after 4 weeks' use of an oscillating-rotating power brush, irrigator, and mouthrinse. Materials and methods: This was a randomized, examiner-blind, clinical trial comparing plaque and gingivitis outcomes for an experimental power brush/irrigator/mouthrinse oral hygiene...

Objectives: To evaluate the gingival health efficacy of an oscillating-rotating electric toothbrush, a stannous fluoride dentifrice, and dental floss in adults with mild-to-moderate gingivitis. Methods: This was a single-center, randomized, controlled, examiner-blind, two-treatment, eight-week parallel group study in adults with at least 20 ging...

Objectives: The aim of these investigations was to assess the ability of two fluoride dentifrices to protect against the initiation and progression of dental erosion using a predictive in vitro erosion cycling model and a human in situ erosion prevention clinical trial for verification of effectiveness. Materials and methods: A stabilized stanno...

This study investigated whether there was a difference in amounts of dentifrice ingested by children based on age using pea-sized instructions. The study had a randomized, single-blinded, 3-period, crossover design modelled after Barnhart et al. (1974) with one regular-flavored and two specially-flavored dentifrices used ad libitum. Subjects were e...

Partial least squares (PLS) was not originally designed as a tool for statistical discrimination. In spite of this, applied scientists routinely use PLS for classification and there is substantial empirical evidence to suggest that it performs well in that role. The interesting question is "why?" Why can a procedure that is principally designed for...

Purpose: To compare the clinical, microbiological and metabonomic profiles of subjects with high and low levels of chronic gingival bleeding during a controlled oral hygiene regimen intervention including sequential phases of rigorous therapeutic oral hygiene followed by experimental gingivitis (EG). Methods: Two cohorts of qualified study subje...

To compare the enamel protection efficacy of a stabilized stannous fluoride (SnF2 ) dentifrice to a sodium fluoride (NaF)/triclosan dentifrice following acidic erosive challenge. In this in situ, randomized, controlled, double-blind, two-treatment, four-period crossover clinical trial, subjects wore an appliance fitted with human enamel samples 6 h...

A method for determining the effective cleaning of bath tissue. The method can include providing at least one pair of worn underwear; optionally, cutting the pair of worn underwear and laying it flat with the inside surface exposed; scanning an image of the exposed, inside surface of the underwear, the image including at least a portion of the unde...

A method for determining the effective cleaning of bath tissue. The method can include providing at least one pair of worn underwear; optionally, cutting the pair of worn underwear and laying it flat with the inside surface exposed; scanning an image of the exposed, inside surface of the underwear, the image including at least a portion of the unde...

To compare the enamel protection efficacy of stannous-containing sodium fluoride and sodium monofluorophosphate (MFP)/triclosan dentifrices marketed in India in an in situ erosion model with acidic challenge. This randomised and controlled, in situ, supervised, double-blind clinical trial employed a two-treatment, four-period crossover design, wher...

Objective: To evaluate the effect of a marketed powered toothbrush/irrigator combination versus a manual toothbrush on plaque and gingivitis over a period of 8 weeks. Method: This was a single-center, randomized, parallel, examiner-blind, 8-week, controlled clinical trial. 60 adult subjects with evidence of dental plaque and gingivitis (minimum o...

Objective: To evaluate salivary and microbial biomarkers in gingivitis patients using a powered toothbrush/irrigator combination or a manual toothbrush over a period of 8 weeks. Method: This was a single-center, randomized, parallel, examiner-blind, 8-week, controlled clinical trial. 60 adult subjects with evidence of dental plaque and gingivitis...

Objective: To evaluate the efficacy of a marketed stabilized stannous fluoride (SnF2) dentifrice in reducing dentinal hypersensitivity as compared to a marketed sodium fluoride (NaF)/triclosan dentifrice over an eight-week period. Methods: Adults with confirmed dentinal hypersensitivity were enrolled in this randomized and controlled, parallel g...

Purpose: To assess the dentin hypersensitivity-reducing effectiveness of a 0.454% stannous-containing dentifrice as compared to a marketed negative control dentifrice after the first brushing as well as after 3 days and 2 weeks of twice daily use. Methods: This was a 2-week, randomized, double-blind, parallel group, single-center clinical invest...

Objective: A clinical study was conducted to evaluate images of marginal gingival tissue combined with calibrated L*a*b* color to assess clinical gingivitis response of a dental prophylaxis followed by a 2 week hygiene period. Method: After institutional review and informed consent, 59 healthy adults were enrolled with mild to moderate gingivitis...

Objective: A randomized, positively-controlled clinical trial was conducted to evaluate the early gingivitis effects of combination oral hygiene (brush, paste, rinse & floss) in a general population. Method: A total of 50 adults with mild-to-moderate gingival bleeding were randomly assigned to combination oral hygiene or a dental prophylaxis. The...

Objective: This meta-analysis was conducted to assess whether demographic parameters, behavioral factors or baseline stain levels impacted whitening dentifrice effectiveness in clinical trials with common study designs. Method: The pooled analysis was inclusive of all subjects in six clinical trials who were assigned a whitening dentifrice and ha...

Objective: To compare the dentinal hypersensitivity relief benefits of two marketed desensitizing dentifrices over an 8-week period. Method: This study was a randomized, parallel group, controlled, 8-week clinical trial. Subjects reporting moderate dentinal hypersensitivity on 2 teeth (Schiff Index of 2 or 3 and Yeaple Probe 10g) were enrolled an...

Objective: This clinical study assessed two methods for sensitivity provocation in a general population. Method: After institutional review and informed consent, 150 adult volunteers who reported natural tooth sensitivity were enrolled in a screening study to assess differential pain responses to two provocative stimuli (air and water). Oral hygi...

Objective: A randomized controlled trial compared use of a power brush and therapeutic dentifrice on overnight plaque accumulation and plaque removal. Method: Healthy adults with overnight plaque were randomly assigned to a combination paste-brush group or regular brushing control. Subjects received either the combination treatment with 0.454% st...

Objective: This study evaluated safety and short-term whitening efficacy of 1-hour whitening strips relative to a negative control. Method: This was a randomized, double-blinded, parallel design clinical study. Fifty six adult volunteers with no history of prior bleaching, no existing tooth sensitivity and the Vita shade of A2 or darker on maxill...

Objective: This research evaluated the between-visit reproducibility of sensitivity response to air stimulation with two different measurement methods. Method: Institutional review, informed consent and screening were conducted to identify subjects with evidence of gingival recession and moderate-to-severe dentinal hypersensitivity at one or two...

Objective: This research used image analysis to evaluate the distribution of overnight and post-prophylaxis dental plaque. Method: After institutional review and informed consent, healthy adults were enrolled in a study to assess plaque accumulation overnight and immediately after prophylaxis. Subjects with overnight (unbrushed) plaque swished wi...

Objective: A clinical trial was conducted to evaluate response of self-directed flexible/stretchable 10% hydrogen peroxide whitening strips relative to a professionally-administered, in-office laser-based whitening system. Method: Healthy adults with no previous history of vital tooth bleaching, who desired tooth whitening and provided informed c...

Objective: This meta-analysis was conducted to evaluate the safety of a 0.454% stannous fluoride dentifrice with sodium hexametaphosphate (SnF2 SHMP) under conditions of routine use from a diverse collection of clinical studies. Method: The meta-analysis consisted of data from 2664 healthy adult subjects who participated in 41 clinical studies. I...

Objective: To compare the anti-erosion benefits of two marketed dentifrices in a 15 day in situ model. Method: The present study utilized a single centre, double blind, randomised, two-treatment, and four period crossover design. Thirty-seven subjects were enrolled and 33 completed the study. Each study period took place over a span of 15 days. S...

Objective: To evaluate the extrinsic stain prevention efficacy of a pyrophosphate containing whitening dentifrice relative to a negative control. Method: This was a 5-week treatment, parallel groups, double-blind, randomized and controlled clinical trial in which the whitening dentifrice (Crest 3DWhite Luxe®) was compared with a negative control...

To determine if a stabilised, stannous-containing sodium fluoride dentifrice provides greater enamel protection in situ against intraoral dietary erosive challenges compared with a sodium fluoride/potassium nitrate dentifrice. A single-centre, investigator blind, randomised, supervised, two-treatment, non-brushing, four-period crossover in situ stu...

To compare the erosion protection efficacy of a stabilised, stannous fluoride (SnF2 ) dentifrice versus a sodium fluoride (NaF) dentifrice using a modified in situ clinical model. This study, a randomised parallel group in situ design with in vivo product use and ex vivo acid challenge, compared: A, a dentifrice containing 1,450 ppm F as NaF; B, a...

To compare the relative plaque control efficacy of a marketed 0.454% stabilized stannous fluoride (SnF2) dentifrice relative to a triclosan/copolymer dentifrice using digital plaque imaging analysis (DPIA). This was a randomized, two-treatment, double-blind, parallel group design study that compared SnF2 and triclosan/copolymer dentifrices over a p...

To compare three instruments for their ability to quantify enamel loss after acid erosion. 6 randomized parallel groups of bovine enamel samples were subjected to citric acid (higher acidity) or orange juice (lower acidity) erosion and remineralisation in a cycling model. Two protected shoulders were created on each of the samples using tape, to se...

Objective: A 4-week clinical study was conducted to evaluate the effects of a daily oral hygiene combination (advanced manual brush plus a therapeutic paste and rinse) on overnight natural plaque accumulation. Method: After IRB approval and informed consent, subjects were screened to identify healthy adults with overnight plaque. Baseline measure...

Objective: A clinical study was conducted to evaluate use of plaque and gingivitis image analysis methods to assess clinical response over a 6-week period following dental prophylaxis. Method: After institutional review and informed consent, healthy adults with overnight plaque were enrolled. Baseline measurements were obtained, a dental prophyla...

Objective: In a 28-day clinical study, dental hypersensitivity was assessed using clinician and self-assessment of dental pain. Method: Following institutional review, informed consent and baseline assessments, screened adult volunteers were enrolled in a prospective clinical trial. Of these, 13 subjects with evidence of dentinal hypersensitivity...

Objective: To investigate the ability of two marketed dentifrices (Oral-B Pro-Expert Sensitive + Gentle Whitening = Sn/F, Oral-B 1-2-3 = NaF) and water (negative control) to protect enamel from acid mediated erosion using a novel in-vitro technique. Method: 8 bovine enamel chips were randomly assigned to each treatment. The sides of each enamel c...

Objective: Evaluation of anti-erosion efficacy of various toothpastes containing stannous and fluoride vs. fluoride alone, using two novel in-vitro models: Detecting enamel dissolution by modified Enamel Solubility Reduction model (mESR, modified FDA 33# method); Measuring enamel surface loss by non-contact profilometer (NCP). Method: Enamel chip...

To evaluate the anti-gingivitis benefits of a 0.454% highly bioavailable stannous fluoride dentifrice (SnF2) relative to a 0.3% triclosan/copolymer dentifrice (triclosan/copolymer) among triclosan/copolymer dentifrice users with residual gingivitis. This was a randomized, controlled, double-blind, parallel group, 2-month clinical study. Self-report...

To compare the plaque inhibition efficacy of a novel stannous-containing sodium fluoride test dentifrice to a standard anticavity negative control dentifrice, when both were used in conjunction with an advanced oscillating-rotating (O/R) power toothbrush. This was a randomized, two-treatment, three-period, double-blind crossover study conducted in...

To compare the anti-plaque efficacy of a stabilized 0.454% stannous fluoride (referred to as SnF2) dentifrice versus a 0.3% triclosan dentifrice formulated with a copolymer and sodium fluoride (referred to as triclosan). The study had a randomized, double-blind, two-treatment, parallel-group design, and compared plaque reduction from baseline after...

Objective: A pilot clinical study was conducted to assess the safety and effectiveness of combination oral hygiene on plaque control during concurrent dental treatment. Method: After institutional review and informed consent, adults who were undergoing dental treatment (typically restorative, esthetic or prosthetic dentistry) were enrolled and di...

Objective: A 2-month randomized controlled trial was conducted to evaluate the safety and effectiveness of combination oral hygiene (brush, paste, floss) to treat existing gingival bleeding. Method: After institutional review and informed consent, adults with evidence of mild-to-moderate gingival bleeding were randomly assigned to combination ora...

Objectives: A 4-week randomized controlled trial used image analysis to quantify the effects of an oral hygiene regimen on plaque accumulation at recession sites. Methods: After consent, screening and acclimation, 43 adults with plaque and gingival recession were randomized to a hygiene regimen or regular control. The regimen consisted of an oscill...

While plaque mass/area is often used as a metric for assessing the efficacy of mechanical hygiene or antimicrobial therapies – molecular based microbiological techniques such as qPCR may permit more complete assessments of changes in plaque toxicity associated with therapeutic interventions. Objective: This study examined the effects of an antimi...

Objective: This clinical study assessed the variability in natural (uncontrolled) overnight plaque accumulation using an instrumental method. Method: After institutional review and informed consent, 97 adult volunteers were enrolled in a plaque reproducibility study, wherein a trained and calibrated image operator collected replicate plaque measu...

Metabonomics seeks an analytical description of complex biological samples through quantification of small molecule metabolites. The application of the technique in saliva holds promise for the evaluation of whole system microbiome response to health, disease and therapeutic intervention. Objectives: The objective of this study was to evaluate the...

Objective: This research used image analysis to evaluate the reproducibility of natural plaque accumulation and removal measured instrumentally. Method: After institutional review and informed consent, healthy adults were enrolled in a study to assess the between-visit consistency of plaque measurement for overnight and post-brush plaque. At Day...

Objective: A randomized controlled trial evaluated the combination effects of a therapeutic dentifrice, flexible manual brush and therapeutic rinse on post-prophylaxis plaque accumulation and plaque removal. Method: After acclimation, healthy adults with overnight plaque received a dental prophylaxis, and were randomly assigned to a combination p...

While mechanical hygiene and chemotherapeutic antimicrobial toothpastes and rinses remain the starting point for contemporary approaches to improve gingival health few studies have examined the effects of combined therapies. Objective: This clinical study was conducted to compare the effect of a combination of power brush with antimicrobial paste...

Objective: To evaluate the anti-plaque efficacy of a 0.454% stannous fluoride dentifrice relative to a 0.3% triclosan dentifrice in a 6-week clinical study. Method: This study utilized a randomized, two-treatment, double-blinded, parallel group design. Subjects who met the entrance criteria were randomly assigned to either the 0.454% highly b...

Objective: Controlled clinical research evaluated the effects of a high-adhesive peroxide gel on whitening strip response. Method: After informed consent, healthy adults randomly received one of two 6% hydrogen peroxide whitening strips: an experimental high-adhesive gel on strips or a control (Crest® Whitestrips®). Use was unsupervised twice dai...

Objectives: Two marketed combination regimens of therapeutic products were evaluated in a randomized, parallel 4-week clinical study to compare the safety and effectiveness of these co-branded regimens. Methods: 44 healthy adults with overnight plaque accumulation were randomly assigned to one of 2 combination paste-rinse-brush regimen groups. Th...

Objective: An inclusive cross-study meta-analysis was conducted to assess factors contributing to the effectiveness and safety of one variation of whitening strips. Method: The analysis was inclusive of subject-level responses from 21 clinical trials at 8 different sites over 7 years. Each subject had been randomly assigned whitening strips with...

To compare the relative performance of commercially available dentifrices containing different types of fluoride to reduce enamel erosion from citric acid. Two randomized parallel-group experiments were conducted, each with 48 bovine enamel samples randomly divided into six treatment legs. Each treatment leg went through 24 toothpaste treatment cyc...

To assess the plaque inhibition efficacy ofa novel 0.454% stabilized stannous fluoride test dentifrice (SnF2) to an amine fluoride/stannous fluoride marketed control dentifrice (AmF/SnF2) using digital plaque imaging analysis (DPIA). The 10-week study was a randomized, two-treatment, three-period, double-blind crossover design. Subjects brushed twi...

The purpose of this study was to evaluate the anti-gingivitis effectiveness of a 0.454% stannous fluoride test dentifrice relative to a marketed positive-control triclosan-containing dentifrice in adults with gingivitis. This was a two-month, randomized and controlled, double-blind, parallel group, single-center investigation involving 150 adults w...

Objective: A clinical study was conducted to evaluate effects of a combination oral hygiene regimen on concurrent gingival bleeding and dentinal hypersensitivity. Method: After informed consent and acclimation, adults with mild-to-moderate gingivitis and evidence of dentinal hypersensitivity were randomly assigned to a combination paste-rinse-bru...

Objective: The aim of the present clinical trial is to assess the anti-gingivitis effects of a 0.454% stannous fluoride dentifrice relative to a positive control dentifrice in a 2-month gingivitis treatment study. Method: This randomized, positive-controlled, double-blind, parallel-group study enrolled 150 healthy adult volunteers assigned equall...

To compare the anti-gingivitis efficacy of a novel 0.454% stannous fluoride dentifrice to a commercially available positive control triclosan-containing dentifrice in a population of adults with gingivitis. This single-center, randomized and controlled, double-blind, parallel group, 2-month trial enrolled 200 adults with mild-to-moderate gingivitis...

Objectives: This research evaluated overnight anti-plaque efficacy of a stannous containing sodium fluoride dentifrice compared to a chlorhexidine digluconate containing aluminum fluoride dentifrice using an objective Digital Plaque Image Analysis (DPIA). Methods: This study was a randomized, 4-period crossover design, which examined overnight an...

Objective: To compare the efficacy of a 0.454% stannous fluoride dentifrice and a 0.3% triclosan dentifrice in the reduction of dental plaque over a 6-week period. Method: This study utilized a randomized, two-treatment, double-blinded, parallel group design. Subjects who met the entrance criteria were randomly assigned to 6 weeks’ unsupervis...

Objective: Dental plaque is the primary cause of gingivitis. Plaque control and prevention of gingivitis is the main goal of the prevention of periodontal diseases. The present study evaluated the anti-plaque efficacy of a 0.454% stannous fluoride dentifrice using a 4-day plaque model. Method: This was a controlled, double-blind, randomized, 2-tr...

Objectives: To evaluate the anti-plaque efficacy of two marketed dentifrice products. Methods: This was a controlled, randomized, double-blind, two-treatment, cross-over, 4 day partial brushing plaque study comprised of four study periods. Test dentifrice products included Crest® Pro-Health® containing 0.454% stannous fluoride and Colgate Total® co...

Objectives: To evaluate the impact of an oral health education program on study participants and their family members during a dentifrice study. Methods: The program was part of a longitudinal study combining oral health data collection and oral health promotion in an elementary school system in Guatemala. A modified Behavior Risk Factor Surveillan...

Objectives: This pilot study was conducted to evaluate relationships between visible bleeding upon brushing (subject and hygienist) and clinical gingivitis severity. Methods: Informed consent was obtained from generally healthy adults with gingival bleeding (10+ sites). Enrolled subjects brushed thoroughly under supervision using a regular antica...

Objective: This clinical trial compared the safety and effectiveness of combination oral hygiene (brush, paste, rinse, floss) or dental prophylaxis on clinical gingivitis. Method: After institutional review and informed consent, adults were evaluated for gingivitis, and enrolled subjects were randomly assigned to one of two interventions: combina...

Objectives: A pilot clinical study evaluated use of a combined power brush, therapeutic dentifrice and rinse, plus floss on plaque accumulation and clinical gingivitis during orthodontic treatment. Methods: After IRB review, informed consent and child assent were collected from adolescents who were undergoing routine orthodontics at a university...

Objectives: In this study the effectiveness of two silica based stannous fluoride hexametaphosphate dentifrices was compared to a silica based triclosan/gantrez dentifrice for the prevention of dental plaque. Methods: This study followed a randomized double blind 4-treatment, 4-period cross-over design. Twenty eight subjects were provided a standar...

Objectives: The present clinical trial compared the treatment of gingivitis for a 0.454% stannous fluoride dentifrice relative to a positive control dentifrice after 2 months use. Methods: This randomized, positive-controlled, double-blind, parallel-group study enrolled 200 healthy adult volunteers assigned equally to either a highly bioavailable 0...

Objective: Dental plaque is the primary cause of gingivitis. This study was to assess the anti-plaque efficacy of two therapeutic dentifrices using Digital Plaque Image Analysis (DPIA) Measures. Method: This study employed a 2-treatment, parallel group, double blind, and randomized clinical study design. Ninety-six healthy adult subjects were e...

Objectives: A 3-week randomized controlled clinical trial was conducted to evaluate concurrent use of plaque and gingivitis image analysis methods to assess clinical response. Methods: After IRB review, informed consent was obtained from healthy adults with overnight plaque. Subjects were randomly assigned to a combination oral hygiene regimen wi...

To demonstrate the robustness of the Featherstone pH cycling model when tested in three independent laboratories and to evaluate the use of "non-inferiority" testing at those laboratories. The fundamental principles for the Featherstone laboratory pH cycling model to be an appropriate alternative to animal testing is that it must demonstrate equiva...

Objective: This research evaluated the reproducibility of tooth color measured with a digital imaging system by different operators. Methods: Anterior facial tooth color was measured by digital image analysis by an experienced standard operator and two new operators (N1 & N2). Digital images were collected from 20 healthy dentate adults on each of...

Objectives: Comparison of coronal caries present at baseline and after 3 years of being in a clinical trial in a medicated population 40-80 with at least 10 teeth. Methods: 394 subjects had coronal noncavitated and cavitated coronal caries measured at baseline and 3 years later compared. Patients included had to be taking at least one medication....

Objectives: To evaluate the onset of sensitivity relief for an experimental 0.454% stannous fluoride dentifrice relative to a regular sodium fluoride negative control over a 2-week period. Methods: This study was a randomized, parallel group, negative-controlled, 2-week clinical trial. After institutional review and consent, subjects reporting dent...

Objective: Comparison of root caries present at baseline and after 3 years of being in a clinical trial in a population on medications aged 40-80 with at least 10 teeth. Methods: 393 subjects had noncavitated and cavitated root caries measured at baseline and 3 years later compared. Patients included had to be taking at least one xerogenic medicati...

Objectives: Multi-center single visit clinical research conducted at 6 professional meetings was used to assess the relationship between the daytime plaque levels of dental professionals relative to time since brushing, age, gender, meeting location, and profession type. Methods: After informed consent was obtained, healthy adult volunteers from 6...

Objectives: A 4-week randomized controlled trial was conducted to evaluate combination use of a therapeutic dentifrice, power brush and floss on post-prophylaxis plaque accumulation. Methods: Healthy adults with overnight plaque received a thorough dental prophylaxis and were randomized to a combination paste-brush-floss group or control. Subjects...

Objective: This research assessed reproducibility of a digital image analysis method used to measure natural tooth color. Methods: After training, a nave operator collected replicate tooth color measures from 20 healthy dentate adult volunteers over a two-day period. At each visit, subjects were oriented using a chin rest, and images were collected...

Objective: To evaluate the epidemiology of denture adhesive consumption and denture fit among frequent adhesive users with complete dentures. Methods: The study was a single-center, blinded, single-treatment design. Study population was limited to adults with complete dentures (either maxillary, mandibular or both) who were frequent adhesive users...

Objectives: To assess the anti-erosion properties of an experimental stannous containing sodium fluoride dentifrice relative to a conventional dentifrice in a 15 day in situ model. Methods: The present study utilized a single centre, double blind, randomised, supervised, two-treatment, and four period crossover design. Thirty-five healthy adults we...

Objectives: This clinical study was conducted to evaluate the effect of a dental prophylaxis on oral malodor as determined by the measurement of intra-oral volatile sulfur compounds (VSC). Methods: Institutional review and informed consent were obtained from healthy adult volunteers. Seventy-seven subjects were assessed for VSC emissions using a co...

Objectives: A 6-week randomized controlled trial was conducted to evaluate effects of 0.454% stannous fluoride dentifrice on established gingivitis. Methods: After institutional review and informed consent, healthy adults with established moderate-to-severe gingivitis were randomly assigned in a 1:1 ratio to brushing with a 0.454% stannous fluoride...

Objectives: To evaluate the extrinsic stain removal benefit of a novel 0.454% Stannous Fluoride (SnF2)/sodium hexametaphosphate dentifrice. Methods: This was a 6-week, parallel groups, double-blind, randomized and controlled clinical trial in which the SnF2 dentifrice (Crest Pro-health Clinical Gum Protection) was compared with a marketed positive...

Objectives: A clinical study was conducted to evaluate the anti-plaque level of the combination use of a therapeutic dentifrice and rinse plus power brush. Methods: Adults who demonstrated disclosed plaque growth overnight were randomly assigned to a combination paste-rinse-brush group or control. Subjects received either the combination treatment...

Objectives: This research evaluated the effects of a daily oral hygiene combination on existing gingivitis. Methods: A randomized controlled trial was conducted to evaluate the safety and effectiveness of a daily oral hygiene combination on gingival bleeding in adults with mild-to-moderate gingivitis. After informed consent, gingivitis and bleeding...

Objective: A randomized controlled trial evaluated the combined power brush use with therapeutic dentifrice and rinse products on overnight plaque accumulation and removal. Methods: After IRB review, informed consent was obtained from the study population consisted of healthy adult volunteers with plaque. During an acclimation phase, subjects brush...

Objectives: The 4-day plaque model has been well established in the literature to assess the anti-plaque efficacy of oral hygiene products, and this research was conducted to systematically evaluate the anti-plaque efficacy of 0.454% stannous fluoride dentifrices. Methods: A meta-analysis was conducted using an inclusive dataset from 3 clinical tri...

Objectives: To evaluate the anti-plaque efficacy of a stannous containing sodium fluoride dentifrice using a 4-day partial brushing plaque model. Methods: This was a controlled, double-blind, randomized, 2-treatment, 3-period, cross-over 4-day lingual brushing plaque study. Test dentifrice contained stannous chloride and sodium fluoride (Blend-A-Me...

Objectives: Supra-gingival dental calculus formation is a common problem for consumers. The present study was undertaken to evaluate the anti-calculus efficacy of a 0.454% Stannous Fluoride (SnF2)/sodium hexametaphosphate dentifrice relative to a marketed positive control dentifrice. Methods: This was a 3-month, parallel-group, double-blind, rand...

Objectives: To evaluate the effect of a Stannous-containing sodium fluoride dentifrice in the reduction of dentinal hypersensitivity relative to a negative control. Methods: This was a 3-day, parallel-group, examiner-blind, randomized and controlled clinical trial. A total of 88 healthy adults with at least two teeth demonstrating moderate hypersen...

Objectives: The present study evaluated the anti-plaque efficacy of various dentifrices using a 4-day plaque model. Methods: This was a controlled, double-blind, randomized, 4-treatment, 4-period, cross-over 4-day partial brushing plaque study. Thirty-one subjects were enrolled into the study. Test products included a novel 0.454% stannous fluoride...

Objective: A crossover study was conducted to compare plaque treatment effects with antimicrobial dentifrices among twins. Methods: After informed consent and child assent (where indicated), twin pairs were randomly assigned to a 3-period crossover sequence, where each period involved 2-weeks use of one of two therapeutic dentifrices. Subjects used...

To compare the plaque inhibition efficacy of a novel 0.454% stannous fluoride (SnF2) test dentifrice with sodium hexametaphosphate and stannous chloride to a chlorhexidine digluconate (0.05%), aluminium lactate (0.8%), and aluminium fluoride marketed control dentifrice (Lacalut Aktiv or AlF3/Chx). This was a randomized, two-treatment, two-period, d...

To evaluate the efficacy ofa stannous fluoride dentifrice as compared to a negative control dentifrice in the reduction of dentinal hypersensitivity after immediate use, and after three days and two weeks of use. This was a controlled, randomized, examiner-blind, two-treatment, parallel group study conducted among healthy adult male and female subj...

While gingivitis and caries continue to be prevalent issues, there is growing concern about dental erosion induced by dietary acids. An oral hygiene product that protects against all these conditions would be beneficial. This study investigated the potential of two anti-erosion dentifrices to inhibit plaque. This was a randomized, three-period, two...

Objectives: To compare plaque removal determined from digital images captured before and after brushing with Blend-a-med Pro-Expert Gums Protection (GP) and Elmex Anti-Caries (EAC) in a crossover design using examiners grading with the modified Quigley-Hein (mQH) index to Digital Plaque Image Analysis (DPIA). Methods: In a 5-day double-blind, 2-tre...