Matthew Ikhuoria Arhewoh

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Verified

Matthew verified their affiliation via an institutional email.

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• PhD
• Professor at University of Benin

Purpose: To investigate excipient properties of oxidized extracted keratin (OEK) compared to extracted keratin (EK) obtained from chicken feathers. Methods: Keratin from whole chicken (Gallus gallus domesticus) feathers was extracted under conditions of optimum yield. Oxidation was carried out with hydrogen peroxide (H2O2) for 15 mins, washed, filt...

Extraction parameters are important in determining the physicochemical properties of extracts. This work aimed to investigate the effect of extraction parameters on the physicochemical properties of keratin powder obtained from chicken feather wastes. Keratin was extracted using alkaline hydrolysis under different experimental conditions viz: conce...

Background and objectives: Biopharmaceutics explores the physicochemical properties of actives alongside their excipients in that complex and projects at adjusting the delivery of drugs in a manner that gives optimal therapeutic activity for safety and efficacy. Prescribing considerations, therefore, involve careful evaluation of the potential risk...

Introduction: Omeprazole is a first-line therapy drug for the treatment of peptic ulcer disease. The availability of numerous generic brands in the market raises doubts about their quality. Purpose: This study aimed to assess the pharmaceutical quality of various brands of omeprazole capsules marketed in three states of southern Nigeria. Methods: O...

The knowledge on the extraction parameters is an important aspect for researchers in converting feathers waste to resourceful keratin. This work aims at investigating the effect of extraction parameters on the yield of keratin obtained from waste chicken feathers as well as carrying out some characterization of the extracted keratin. Keratin was ex...

Chemical modification of excipients to confer better functionalities

Background: In addition to lifestyle modifications, metformin is the recommended first-line pharmacotherapy for patients with type 2 diabetes mellitus (T2DM). The use of glimepiride or linagliptin as add-on to metformin (GM or LM) has been noticed on prescriptions in major pharmacies in Nigeria. Aims: The aim of this study was to compare the effica...

Objective: This research was carried out to synthesize and characterize copper oxide nanoparticles (CuONPs) using Vernonia amygdalina leaf extract and investigate the in vitro antimicrobial properties using clinical microbial isolates. Methods: The CuONPs were synthesized by heating a mixture of copper sulfate pentahydrate and V. amygdalina aqueous...

Background: This study was carried out to determine the antimicrobial effect of propolis ointment formulations against Staphylococcus aureus. Methods: Propolis was extracted with 70 ml Ethanol (99 %) and the ointment was prepared by incorporating the extract into emulsifying ointment BP. Formulations were evaluated against Staphylococcus aureus usi...

There is a growing interest among researchers in the field of nanotechnology. This is because of its diverse applications especially in medicine. Materials at the nanoscale exhibit different and improved physical, chemical, and biological properties from the bulk material. This is because of the increased surface area of the material at the nanosca...

Propolis hydrogel made of carbopol has been shown to provide better contact with the wounded site and reduce wound healing time. This study explored the physicochemical properties of Nigerian propolis hydrogel and its wound healing activity. Propolis was obtained from bee hives using standard techniques and macerated in absolute ethanol at 40 o C f...

Purpose: To investigate the incidence of methicillin-resistant Staphylococcus aureus (MRSA) and carry out molecular characterization in selected nasal isolates from healthy students in Abraka, Nigeria.Methods: Three hundred (300) samples were obtained from apparently healthy 150 female and 150 male students and were cultured in suitable media for i...

Multivitamins accounts for a high percentage of prescribed medicines in tertiary health institution and over the counter (OTC) drugs in pharmacies in Benin City, Edo State. The aim of this study was to determine the organoleptic and physicochemical qualities of some liquid multivitamin products available in Edo State, Nigeria. Fifteen different bra...

Aims: This study was aimed to determine the effect of varying parameters on the properties of effervescent paracetamol tablets for paediatrics. Study Design: This analytical study was carried out on effervescent paracetamol tablets formulated with differing formulation parameters. Place and Duration of Study: This study was carried out in the Metho...

Background: Multivitamins are generally considered safe medicines but little attention have been paid to assessing the quality and label claims of their dosage forms. Objectives: The study investigated the pharmaceutical quality of some multivitamin capsules available in Edo State, Nigeria. Method: Fifteen capsule formulations were purchased from p...

Background: The World Health Organization describes universal health coverage as ensuring that individuals have access to needed health services in a manner ensuring non exposure to financial hardship. This is particularly important for patients with chronic conditions like hypertension. Objectives: To assess the cost burden due to management of hy...

Dispensing remains a key component of the pharmacy undergraduate curriculum, teaching skills in the individualized preparation of medicines. In hospitals, pharmacists compound medicines to improve access for patients who would otherwise not have the medicine in the suitable formulation. Current trends suggest that the dispensing curriculum needs to...

This study was aimed at assessing the readiness for drug information service (DIS) provision at community pharmacies in Akwa Ibom state using a cross sectional, observational study approach. A pretested, validated questionnaire was adapted for the study. A total of 187 premises were enlisted for visits with questionnaires targeted at the superinten...

Internet pharmacy has been the focus of heightened interest over the past 10 years. The unfolding and increasing trend and availability of online health information and drug sourcing are becoming of palpable concerns as the internet is known to be characteristically porous in terms of legislature and regulatory control. This prevalence and pattern...

ABSTRACT Background: The concept of β-lactam antibiotics in combination with β-lactamase inhibitor to combat β-lactamase producing organism is a scientific norm for therapeutic success. This study seeks to compare some biopharmaceutical and microbiological parameters of selected ceftriaxone-sulbactam brands available in Nigeria with Rocephin® , as...

Background: The transdermal delivery of insulin involving the use of polymers has been extensively reported. More recently, the use of mucoadhesive or bioadhesive polymers as an insulin base in its formulation is gaining attention possibly due to the penetration enhancing properties of the polymers. Objectives: This study aimed at determining the e...

Multivitamins accounts for a high percentage of prescribed medicines in tertiary health institution and over the counter (OTC) drugs in pharmacies in Benin City, Edo State. The aim of this study was to determine the organoleptic and physicochemical qualities of some liquid multivitamin products available in Edo State, Nigeria. Fifteen different bra...

Background: The study aimed to evaluate the effect of arachis oil and liquid paraffin on metoclopramide release from transdermal films. Objectives: Batches of metoclopramide films were prepared with hydroxypropyl methyl cellulose (HPMC), arachis oil or liquid paraffin and Tween 80 as plasticizer. The films were evaluated for their physiochemical pr...

The study investigated the effects of eucalyptus oil and shea butter on the physicochemical and bioadhesion properties as well as on the ex vivo drug release of metoclopramide from transdermal patch. Metoclopramide patches were formulated using hydroxypropyl methylcellulose (HPMC) in combination with varied proportions of shea butter and eucalyptus...

Ambroxol hydrochloride (AH), a secretion-releasing expectorant, is a good candidate for sustained delivery. Mucilages are biodegradable, inexpensive carriers in microsphere formulations. The study aimed to prepare microspheres of AH using Okra mucilage obtained from pods of Abelmoschus esculentus combined with sodium alginate at various polymer/dru...

The binding properties of banana (Musa paradisiaca) starchwas investigated using maize starch BP and polyvinylpyrrolidone (PVP) as standards in the formulation of metformin tablets. Starch from unripe banana fruits was extracted with distilled water. Mucilages of the banana and maize starches and solutions of PVP at 5 and 10 %w/v were used to produ...

The study investigated the combination effects of the mixture of croscarmellose sodium and Pleurotus tuber-regium powder on the granules and tableting parameters of paracetamol tablets. Five batches (A-E) of paracetamol tablets were formulated using wet granulation method with various combination ratios of croscarmellose sodium and Pleurotus tuber-...

This work evaluates in vitro interaction of food components with artemether-lumefantrine (AL) in tablet. Pelletized food components (i.e., starch, albumin, sunflower oil and carbonated drink) with AL tablet were observed using Fourier transform infra-red (FTIR) spectroscopy while spectra obtained were compared using essential FTIR (eFTIR) software....

This work assesses tablets of artemether and lumefantrine in vitro drug interaction with lamivudine or metronidazole. Spectra changes on artemether or lumefantrine vibration bands were evaluated using Fourier transform infrared spectroscopy (FTIR) and analyzed with essential FTIR (eFTIR) software. Instantaneous pH changes and acid buffering capacit...

The aim of the study was to investigate the properties of microcrystalline cellulose (MCC) obtained from cassava stems using the nitric acid and sodium hydroxide methods of extraction in comparison with Avicel® PH 101 in metronidazole tablet formulations. Alpha-cellulose from cassava stems was extracted with nitric acid and sodium hydroxide methods...

Purpose: To investigate the interactions between metformin and Yoyo Bitters® including some of its constituents in the management of diabetes mellitus. Method: Using the generic form of metformin (Glucophage®) tablets, tests such as disintegration time, dissolution profile, Fourier transform infrared (FTIR) spectroscopy and in vivo hypoglycaemia te...

Background: Metformin hydrochloride tablets are the most commonly prescribed drug for the management of Type II Diabetes Mellitus. This has resulted in increased importation and manufacturing of various brands of the tablets in Nigeria. Objective: To evaluate the pharmaceutical quality of different brands of metformin hydrochloride tablets availabl...

Starch is a naturally occurring polymer that is present in many green plants. Its nontoxic and nonirritant properties as well as low costs, ease of modification and versatility in uses have placed starch in a leading position among polymers used as pharmaceutical excipient. In many conventional tablets and capsules, starch is used as diluent, disin...

The aim of the study was to formulate bi-layer tablets of ibuprofen for sustained release using wet granulation and coacervation methods. Five batches (A1-A5) of tablets were prepared using varying concentrations of Eudragit RL100 (10, 12.5, 15, 17.5 and 20 %w/v) by coacervation for the matrix layer and wet granulation for the immediate release lay...

This study investigates the properties of microparticles prepared from Andrographis paniculata (AP) and Annona muricata (AM) aqueous extracts for controlled release. Extracts obtained by maceration of the dried powdered plant leaves were microencapsulated by counterion coacervation method. Microcapsules were characterized using Fourier-transform in...

The study intended to demonstrate the effects of arachis and eucalyptus oils as release modifiers in insulin transdermal patches. Patches were prepared by solvent casting technique using hydroxypropyl methylcellulose solution as the aqueous phase and polysorbate 80 as emulsifying agent. Various batches (TD1-TD5) were prepared using varying proporti...

The purpose of this study was to carry out a comparative evaluation of the physicochemical properties of mucin powders extracted from three different sources. Mucin powders was extracted from the African giant snails and the intestines of cow and pigs by the wet rendering process and differential precipitation with chilled acetone. The precipitates...

Objective: This study investigates microcapsulated aqueous extracts of Garcinia kola (GK) and Hunteria umbellata (HU) seeds.Method: Extracts obtained after maceration of dried powdered seeds were prepared as microcapsules with chitosan-alginate by counterion coacervation method. Microcapsules were characterized using differential scanning calorimet...

The objective of this study was to investigate the effect of alkali treatment of mucin on the mucoadhesive properties and tablet parameters of metronidazole tablets. Mucin was extracted from the African giant snails (Archachatina maginata) by differential precipitation using acetone, air-dried and pulverized. Different portion of the mucin powder w...

Aim: To formulate a sustained release tablet dosage form of metronidazole using carnauba wax as matrix former and binder. Methods: Batches of metronidazole tablets were formulated by using a combination of melt and wet granulation techniques. The formulated granules were evaluated for their flow properties, while the tablets for their friability, h...

Physicochemical properties bothering on the quality of powder for paediatric suspension (PPS) of artemether-lumefantrine (AL) were evaluated. The moisture content, viscosity, total solid and chemical contents were determined. The assay was analyzed simultaneously for artemether and lumefantrine using high pressure liquid chromatography (chromosil C...

The present study was aimed at formulating and evaluating tablet dosage form of Hunteria umbellata (HU) seed aqueous and purified extracts. HU seeds were dried, pulverized and the powder macerated in water to obtain aqueous extract, while alkaloidal extraction process was used to obtain purified extract. Extracts obtained were formulated into table...

Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets (400 mg) purchased from pharmacies in Benin City, Nigeria. Methods: The drug samples were subjected to uniformity of weight, crushing strength, friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The i...

Objective: To characterise a novel multifunctional pharmaceutical excipient and investigate its effect on paracetamol release from tablets prepared by direct compression. Methods: The excipient was prepared by co-processing gelatinized maize starch with sodium carboxymethyl cellulose and microcrystalline cellulose in a ratio of 2:1:1, dried and pul...

The composition of elemental impurities in paediatric powder for suspension (PPS) and double strength tablet (DST) commercial anti-malarial formulations of artemether-lumefantrine (AL) were determined. Six randomly selected PPS and DST products from a list of marketed products were purchased from a registered Pharmacy outlet and analyzed using flam...

To evaluate the effects of mucin extraction method and plasticizer concentration on the bioadhesive strength and metronidazole release profile from mucin-based mucoadhesive patches. Mucin was extracted from the giant African snail Archachatina marginata by differential precipitation with acetone and alum. Various batches of metronidazole loaded muc...

The effect of polymer concentrations on some of the physicochemicalproperties of Vernonia amygdalina (Linn) and Garcinia kola (Heckel) extracts loaded microspheres was evaluated. Microspheres of the aqueous extracts was prepared by emulsion solvent evaporation using polyethylene glycol (PEG) mixtures of molecular weight 4000 and 6000 at different r...

This work was designed to evaluate the influence of various methods such as dry granulation (DG), wet granulation (using the polymer in an ethanolic solution (WGO) or aqueous dispersion (WGA) and solid dispersion (SD) techniques, on properties of paracetamol matrix tablets prepared using varying concentrations of acrylate methacrylate copolymer. Ta...

The study was aimed at comparatively evaluating the mechanical properties of some brands of artemether – lumefantrine double strength tablet (DST) products. The friability, hardness, disintegration tests, compressive stress, strain, extension and energy release at break of six randomly selected brands of DST products were evaluated using convention...

Aims: To develop a powder dosage form of insulin for intranasal administration and investigate its glucose-lowering effect in albino rabbits. Methods: Nine different powder formulations, each containing 500 mg powder equivalent to 50 IU of insulin were prepared by adsorbing soluble insulin solution mixed with varying amounts of polysorbate 80, guar...

The effects of polymer concentration on the flow properties of granules and in-vitro release profiles from matrix tablets of three model drugs formulated from pegylated mucin base was investigated. Mucin was extracted from the African giant snail and in combination with PEG was used to produce a copolymer matrix base, which was mixed with the model...

Objective: To determine the effect of thermal treatment of mucin on the mucoadhesive and tablet parameters of metronidazole tablets. Methods: Mucin was extracted from the giant African snails (Archachatina maginata) by differential precipitation using acetone, air-dried and pulverized. Modification of the mucin powder was carried out using a regula...

The objective of this study was to determine the effect of acid treatment of mucin on the mucoadhesive properties and tablet parameters of metronidazole tablets. Mucin was extracted from the African giant snails (Archachatina maginata) by differential precipitation using acetone, air-dried and pulverized. Different portion of the mucin powder was t...

Fast disintegrating tablets of nifedipine prepared by superdisintegrant addition and sublimation methods were evaluated. Twelve batches of tablets were formulated by direct compression using varying concentrations of crospovidone and croscarmellose sodium. Camphor was incorporated into six of the batches. Their granules were evaluated for pre-compr...

Objective: To develop UV spectrophotometric assay validation methods for some selected medicinal plant extracts.Methods: Dried, powdered leaves of Annona muricata (AM) and Andrographis paniculata (AP) as well as seeds of Garcinia kola (GK) and Hunteria umbellata (HU) were separately subjected to maceration using distilled water. Different concentra...

Objective: Herbal medicines contribute in no small measure to health care the world over, especially for rural dwellers and developing countries. The extracts of Phyllanthus amarus have been reported to be medicinal. In this study, herbal ointment containing methanol extract of the aerial part of Phyllanthus amarus was formulated and evaluated for...

Objective: Herbal ointment containing methanol extract of the aerial part of Phyllanthus amarus was formulated and parameters including antimicrobial properties against some human pathogens such as Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Aspergilus niger were evaluated. Method: The extract was obtained...

The effect of preparation method on some physicochemical and release properties of Hibiscus sabdariffa extract loaded microspheres was investigated. Microspheres of the extract was prepared by solvent evaporation and emulsion solvent evaporation using polyethylene glycol 4000 and 6000 at different ratios of 1:1, 1:2 and 2:1 while the amounts of the...

The study aimed at evaluating the bioadhesion properties and penetration enhancing effect of mucin-based bovine serum albumin (BSA) transdermal patches. Mucin was extracted from the giant African snail Archachatina maginata by differential precipitation with acetone and alum. Various batches of BSA loaded transdermal film patches were prepared with...

Optimization of different superdisintegrants using the simplex lattice design in the formulation of fast disintegrating tablets of ibuprofen was studied. Seven formulations (F1 to F7) were prepared by direct compression of ibuprofen as the model drug and a combination of superdisintegrants–pre-gelatinized starch, croscarmellose sodium and crospovid...

Purpose: To evaluate the bioadhesion properties and drug release profile of mucin-based ibuprofen (IBF) transdermal patches. Methods: Mucin was extracted from the giant African snail, Archachatina maginata by differential precipitation with acetone and alum. Various batches of IBF loaded transdermal film patches were prepared with the precipitated...

Crushed leaves of Mitracapus villosus is used in traditional medicine practice for the treatment of skin diseases and its ethnomedicinal use has been established. This study therefore investigated the antimicrobial activities of the crude extract and the cream formulation of Mitracapus villosus aerial parts (leaves, inflorescences and stem) by agar...

ABSTRACT Effective treatment of tuberculosis is achieved through the Directly Observed Treatment Short-course (DOTS) chemotherapy. The objective of this study was to investigate the perceptions of practitioners on DOTS therapy as well as the effects of the therapy on vital organs such as the liver and kidney, of patients in General Hospital Minna,...

The effect of different maize variety and bacteria starter culture on maize fermentation process was evaluated. Eleven varieties of maize were subjected to fermentation both naturally and in the presence of bacteria starter culture (bactocell). One variety was further fermented with different bacteria starter cultures. The cultures used were; Pedio...

Therapeutic proteins/peptides are mostly administered as parenteral (injectable) preparations as a result of their poor oral bioavailability which is due to degradation by proteolytic enzymes, poor membrane permeability and large molecular size. However, the oral route would be preferred to theparenteral administration because it is more convenient...

Stem and root barks of Diospyrus monbuttensi. Gurke are used in ethnomedicine for their antimicrobial activity. But only studies on the leaves and seeds are documented. The in vitro antimicrobial activity of crude extracts of root and stem barks of D. monbuttensis were evaluated against four reference bacteria (S. aureus, B. subtilis, E. coli and P...

Purpose: To use specific parameters to evaluate the in vitro quality assurance of ten generics of amlodipine besylate (10mg) tablets commonly sold in the Nigerian drug market. Methods: Organoleptic and physicochemical properties of 10 brands of the amlodipine besylate tablets were assessed according to official and unofficial standards. Basic quali...

The powdered leaves of Anona muricata (AME), and Andrographis paniculata (APE) and seeds of Garcinia kola (GK) were separately subjected to ultrasonic and conventional (maceration) extraction methods. The antioxidant potency of their extracts were evaluated on the basis of their DPPH (2,2-Diphenyl-1-picrylhydrazyl) scavenging activity. The results...

Chloroquine-induced pruritus remains one of the most common side-effects in the use of chloroquine in the prophylaxis and treatment of uncomplicated malaria before the advent of artemisinin-based combination therapies. It has been reported to vary from a tolerable to intolerable intensity among susceptible individuals resulting in disruption of tre...

This work aims at classifying, grouping and ranking binders based on their abilities to ameliorate capping and lamination in lactose tablets using BFI as a tool. Binders from different "families" (for example, starches, celluloses, natural gums, and synthetic gums) were employed via the wet granulation process at concentrations ranging from 1.0 -12...

The purpose of this study was to determine the pharmaceutical quality of some Ibuprofen tablets dispensed in Nigerian. 19 different brands of Ibuprofen tablets were purchased from pharmacies and open markets in 3 states in Nigeria. The organoleptic and physicochemical properties of these Ibuprofen tablets were assessed according to British Pharmaco...

Oral delivery of proteins and peptides poses one of the greatest challenges in controlled drug delivery due to degradation by proteolytic enzymes, poor membrane permeability and large molecular size. Therapeutic proteins/peptides are useful in correcting metabolic disorders (e.g., insulin in diabetes mellitus), as antineoplastic agents (e.g., cyclo...

The purpose of this study was to determine the pharmaceutical quality of quinine preparations sold in Nigerian markets. The organoleptic and physicochemical properties of quinine tablets, as well as oral liquids and parenteral quinine preparations, were assessed according to British Pharmacopoeia (BP) and unofficial standards as recommended by the...

A widely used approach for the microencapsulation of drugs especially for controlled drug delivery is emulsion polymerization. The purpose of this study was to comparatively evaluate chitosan-alginate microcapsules for oral delivery of ibuprofen using two techniques. Alginate-based microcapsules were prepared using the emulsion/internal gelation an...

La présente étude examine la libération in vitro de Vibrio bacterin, un vaccin pour les poissons produit à partir de microcapsules chitosan-alginate modifiées de HPMCAS pour l\'administration par voie orale chez les poissons. Les microcapsules ont été préparées avec la méthode de coacervation counterion en utilisant un générateur électrostatique de...