Matteo Lusi

Matteo Lusi
University of Limerick | UL · Department of Chemical Science

PhD

About

118
Publications
14,742
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
3,977
Citations
Additional affiliations
February 2014 - January 2018
University of Limerick
Position
  • PostDoc Position
August 2013 - March 2014
New York University Abu Dhabi
Position
  • Researcher
June 2012 - August 2013
New York University Abu Dhabi
Position
  • PostDoc Position

Publications

Publications (118)
Article
Non-stoichiometric molecular crystals have the potential to afford tuneable materials for pharmaceutical and technological applications. Unfortunately, these poorly understood phases are difficult to obtain and, hence, to study. In fact, commonly accepted empirical rules prescribe that only molecules of similar size and electron distribution are mu...
Article
Full-text available
The control of structures and properties in crystalline materials has many returns that justify the increasing efforts in this direction. Traditionally, crystal engineering focused on the rational design of single component molecular crystals or supramolecular compounds (i.e. cocrystals). More recently, reports on crystalline solid solutions have b...
Article
Crystalline solid solutions are a long known class of materials that enables the fine tuning of a material structure and properties. Some of them like metal alloys have been employed in everyday life for thousands of years. As result, these phases represent an important part of materials science. On the contrary solid solutions that involve organic...
Article
Full-text available
Despite the difference in size and chemistry, lithium and sodium form a solid solution as isoorotate salt. Such behaviour, which represents an exception to the Hume-Rothery rules, can be exploited in the preparation of novel lithium drugs.
Article
The comparison of new structural data with crystal structures stored in the Cambridge Structural Database (CSD) is becoming ordinary when dealing with recognition and identification of new solid forms. Indeed, this is a consequence of the ever-increasing number of deposited crystal structures and of the development of new structural comparison tool...
Article
Full-text available
Long-duration energy storage (LDES) systems play a critical role in the integration of intermittent renewable energy sources into the grid. Thermochemical energy storage (TCES) systems, particularly Limestone ones, offer promising solutions due Limestone's high energy storage density and cost-effectiveness. However, the cycling performance of Limes...
Article
Full-text available
Guest transport through discrete voids (closed pores) in crystalline solids is poorly understood. Herein, we report the gas sorption properties of a nonporous coordination network, {[Co(bib)2Cl2] ⋅ 2MeOH}n (sql‐bib‐Co‐Cl‐α), featuring square lattice (sql) topology and the bent linker 1,3‐bis(1H‐imidazol‐1‐yl)benzene (bib). The as‐synthesized sql‐bi...
Article
Guest transport through discrete voids (closed pores) in crystalline solids is poorly understood. Herein, we report the gas sorption properties of a nonporous coordination network, [Co(bib)2Cl2]n·2MeOH (sql‐bib‐Co‐Cl‐α), featuring square lattice (sql) topology and the bent linker 1,3‐bis(1H‐imidazol‐1‐yl)benzene (bib). The as‐synthesized sql‐bib‐Co...
Article
Full-text available
This study outlines a route to producing a novel polymorphic form of chlorothiazide (CTZ). CTZ was spray dried using three different atomising gas flowrate settings to determine whether it has any effect on the solid-state of CTZ. At a lower atomising gas flowrate, a new form of CTZ, CTZ form IV, was obtained in pure form, whereas at the highest at...
Article
Full-text available
Griseofulvin represents a rare case of a close‐packed organic apohost that can clathrate selected volatile guests in a solid‐gas fashion. Inclusion mechanisms and solvent exchange were investigated by a combination of single crystal and powder X‐ray diffraction, coupled to optical microscopy and thermal analyses. In particular, gas diffusion and di...
Article
The prevalence of poor solubility in active pharmaceutical ingredients (APIs) such as celecoxib (CEL) is a major bottleneck in the pharmaceutical industry, leading to a low concentration gradient, poor passive diffusion, and in vivo failure. This study presents the synthesis and characterization of a new cocrystal of the API CEL. CEL is a nonsteroi...
Article
Full-text available
Propane (C3H8) is a widely used fuel gas. Metal–organic framework (MOF) physisorbents that are C3H8 selective offer the potential to significantly reduce the energy footprint for capturing C3H8 from natural gas, where C3H8 is typically present as a minor component. Here we report the C3H8 recovery performance of a previously unreported lonsdaleite,...
Article
The search for solid solutions of class-two insulin secretagogues, tolbutamide and chlorpropamide, reveals a rare case of monotropic polymorphism for the mixed crystals. At any stoichiometry, two crystal forms are...
Article
This work presents two new solid forms, a polymorph and a solvate, of the antifungal active pharmaceutical ingredient griseofulvin (GSF). The novel forms were characterized by powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric analysis, and their crystal structures were determined by single-crystal X-ray diffraction....
Article
Full-text available
Chiral metal–organic materials, CMOMs, are of interest as they can offer selective binding sites for chiral guests. Such binding sites can enable CMOMs to serve as chiral crystalline sponges (CCSs) to determine molecular structure and/or purify enantiomers. We recently reported on the chiral recognition properties of a homochiral cationic diamondoi...
Article
Full-text available
Chiral metal−organic materials (CMOMs), can offer molecular binding sites that mimic the enantioselectivity exhibited by biomolecules and are amenable to systematic fine-tuning of structure and properties. Herein, we report that the reaction of Ni(NO 3) 2 , S-indoline-2-carboxylic acid (S-IDECH), and 4,4′-bipyridine (bipy) afforded a homochiral cat...
Article
Praziquantel (PZQ) is a chiral class-II drug, and it is used as a racemate for the treatment of schistosomiasis. The knowledge of several cocrystals with dicarboxylic acids has prompted the realization of solid solutions of PZQ with both enantiomers of malic acid and tartaric acid. Here, the solid form landscape of such a six-component system has b...
Article
Full-text available
The ΔpKa rule is commonly applied by chemists and crystal engineers as a guideline for the rational design of molecular salts and co-crystals. For multi-component crystals containing acid and base constituents, empirical evidence has shown that ΔpKa > 4 almost always leads to salts, ΔpKa < -1 almost always leads to co-crystals and ΔpKa between -1 a...
Article
Full-text available
Approximately 80% of active pharmaceutical ingredients (APIs) studied as lead candidates in drug development exhibit low aqueous solubility, which typically results in such APIs being poorly absorbed and exhibiting low bioavailability. Salts of ionizable APIs and, more recently, pharmaceutical cocrystals can address low solubility and other relevan...
Article
Full-text available
Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug–prodru...
Article
Full-text available
A new 1:1 co-crystal of sulfamethazine (API, SMT) and 3-methylsalicylic acid (coformer, 3mSA) has been synthesized and its crystal structure solved by single crystal X-ray diffraction (XRD). The co-crystal has been thoroughly characterized by powder XRD, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Pure co-crystal c...
Article
Closed-to-open structural transformations in flexible coordination networks are of potential utility in gas storage and separation. Herein, we report the first example of a flexible SiF62--pillared square grid material, [Cu(SiF6)(L)2] n (L = 1,4-bis(1-imidazolyl)benzene), SIFSIX-23-Cu. SIFSIX-23-Cu exhibits reversible switching between nonporous (β...
Article
Two sulfa drugs, sulfamethazine and sulfamerazine, have been used as model compounds in the evaluation of microwave assisted slurry conversion crystallization for manufacturing of co-crystals. It is shown that the formation of the co-crystals is much faster using microwaves than simple conductive/convective heating to the same temperature. The favo...
Article
The co-crystallization of lamotrigine and valproic acid affords an ionic-cocrystal with improved dissolution rate and mechanical properties. The multidrug crystal has a stoichiometry that is known to positively impact on the pharmacokinetics of the parent compounds. As such, the new form is a suitable epileptic treatment. From a crystal engineering...
Article
Full-text available
The investigation of mechanical properties in molecular crystals is emerging as a novel area of interest in crystal engineering. Indeed, good mechanical properties are required to manufacture pharmaceutical and technologically relevant substances into usable products. In such endeavour, bendable single crystals help to correlate microscopic structu...
Article
Effective desymmetrization in copper catalyzed intramolecular C–H insertion reactions of α-diazo-β-oxosulfones in the formation of fused thiopyran dioxides is described for the first time. The use of a copper–bis(oxazoline)–NaBARF catalyst complex system leads to formation of the major thiopyran dioxide stereoisomer with up to 98:2 dr and up to 98%...
Article
Coordination polymers (CP) of active pharmaceutical ingredients (APIs) are relatively rare, though recent study show how these forms can afford improved solubility and stability. Here the hygroscopicity of two coordination polymers of lithium and their solid solutions is investigated. The two systems exhibit different behaviour, impacting their pot...
Article
A new methanol solvate of clozapine base (CPB) has been identified. It exhibits different molecular arrangements and bonding environments at low and room temperatures, while still maintaining the same PXRD pattern throughout. Slurry experiments confirmed this CPB-MeOH solvate to be the thermodynamically stable form in suspension relative to CPB. Th...
Article
Full-text available
Some porous materials can reversibly change their crystal structure in response to interfacial sorbate/sorbent interactions. Here, we report that a new flexible coordination network, NiL2 (L = 4‐(4‐Pyridyl)‐biphenyl‐4‐carboxylic acid), with diamondoid, dia, topology switches between non‐porous (closed) and several porous (open) phases at specific c...
Article
Some porous materials can reversibly change their crystal structure in response to interfacial sorbate/sorbent interactions. Here, we report that a new flexible coordination network, NiL2 (L = 4‐(4‐Pyridyl)‐biphenyl‐4‐carboxylic acid), with diamondoid, dia, topology switches between non‐porous (closed) and several porous (open) phases at specific c...
Article
Full-text available
Clofazimine is an antimycobacterial agent that is routinely used for the treatment of leprosy. Clofazimine has also been shown to have high clinical potential for the treatment of many Gram-positive pathogens, including those that exhibit high levels of antibiotic resistance in the medical community. The use of clofazimine against these pathogens h...
Article
Fine-tuning of Hybrid Ultramicroporous Materials (HUMs) can significantly impact their gas sorption performance. This study reveals that offset interpenetration can be antagonistic with respect to C 2 H 2 separation from C 2 H 2 /C 2 H 4 gas...
Article
Morphology influences the functionality of covalent organic networks and determines potential applica-tions. Here, we report for the first time the use of Zincke reaction to fabricate, under either solvothermal or microwave conditions, a viologen-linked covalent organic network in the form of hollow particles or nanosheets. The synthesized material...
Article
A mechanochemical strategy for the synthesis of N-heterocyclic carbene complexes is described, in which 1,3-dibenzylimidazole complexes of palladium and platinum are produced in a two-step process by grinding together the reactants with a mortar and pestle. Crystallographic characterization reveals that unlike the solution syntheses, which produces...
Article
The aromatic core in dipyridyl linker ligands is found to impact the mode of 2-fold interpenetration in hybrid ultramicroporous materials formed by pillared square grid networks. An analysis of the crystal structures suggests that linker conformation and weak interactions between the linkers in adjacent networks might explain this phenomenon.
Article
A series of seven crystalline inclusion compounds (CICs) in which 5-hydroxyisophthalic acid (HPA) serves as a host has been isolated. HPA self-assembles to consistently form 2-D hydrogen bonded networks with distorted honeycomb (hcb) topology when crystallized in the presence of guest molecules that contain a carbonyl moiety. In each of the seven s...
Article
Full-text available
Sequestration of CO 2 , either from gas mixtures or directly from air (direct air capture), is a technological goal important to large-scale industrial processes such as gas purification and the mitigation of carbon emissions. Previously, we investigated five porous materials, three porous metal–organic materials (MOMs), a benchmark inorganic mater...
Chapter
Nonstoichiometric systems are often found in mineralogy and metallurgy but more rarely in molecular and network crystals. These solids are characterized by a variable composition that affects structural and physicochemical properties in a predictable manner. In this view, nonstoichiometric systems can contribute to the scope of crystal engineering...
Article
Acetylene (C2H2) is an important fuel gas and chemical intermediate used in oxy-fuel welding and cutting and polymer production. CO2 is present as a major impurity in C2H2 production, and the similar size and physicochemical properties of these two gases make their separation difficult. Current purification technology involves chemical extraction o...
Article
Clofazimine is an anti-mycobacterial agent used as part of a multidrug treatment for leprosy. Recently clofazimine has shown promising activity against multidrug resistant tuberculosis. Clofazimine has been previously known to exist in two different crystal forms, or polymorphs, which are triclinic (F I) and monoclinic (F II) in crystal structure....
Article
Vinpocetine is a poorly water soluble weakly basic drug (pKa = 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improved pharmacokinetic properties is highly desirable. Cocrystallization represents a promising approach...
Article
Full-text available
Hydrates are technologically important and ubiquitous yet they remain a poorly understood and understudied class of molecular crystals. In this work, we attempt to rationalize propensity towards hydrate formation through crystallization studies of molecules that lack strong hydrogen-bond donor groups. A Cambridge Structural Database (CSD) survey in...
Article
Full-text available
The crystal structure containing (±)-3-methyl-2-phenylbutyramide with salicylic acid is the first example of a kryptoracemate co-crystal. It exhibits the first temperature mediated reversible single-crystal to single-crystal transition between two kryptoracemate forms, in addition to crystallising in another, racemic, form. Theoretical calculations...
Article
Classical Grand Canonical Monte Carlo (GCMC), classical Molecular Dynamics (MD), and Density Functional Theory (DFT) have been employed to study the effect of pore-size and pore-chemistry on the adsorption of carbon dioxide in the SIFSIX-3-M family of Hybrid Ultramicroporous Materials (HUMs), where M = Zn2+, Ni2+ or Cu2+. These HUMs have been shown...
Article
Three topologically non-trivial cadmium(II)-based complexes-Cd-[2]C, Cd-TK and Cd-SL-were simultaneously self-assembled in a dynamic library, individually isolated and fully characterized by solid-state, gas-phase and solution-phase techniques. Post-synthetic modifications, including reduction and transmetalation, were subsequently achieved. Imine...
Article
Thermosalient crystals are solids that exhibit motion at macroscale as a consequence of a thermally induced phase transition. They represent an interesting scientific phenomenon and could be useful as actuators for the conversion of thermal energy into motion or mechanical work. The potential utilization of these miniature transducers in real-world...
Article
A rare 8-connected cationic building block, [Cu2L8(μ-MF6)]2+ (L = pyridyl ligand, M = Si, Ti, Ge, Zr or Sn), enables the formation of a small cubicuboctahedral supramolecular building block, SBB, when complexed by 2,4,6-tris(4-pyridyl)pyridine. The coordination network resulting from fusing the square faces of the SBBs can be described as a pto top...
Article
Full-text available
Two synthetic approaches—temperature variation and anion templation—allowed for the selective formation of a [2]catenane ([2]C2+) or a trefoil knot (TK6+), or for the enhanced formation of a Solomon link (SL8+), all from a simple set of starting materials (Zn(II)acetate, diformylpyridine (DFP) and a diamino-2,2-bipyridine (DAB)) in mixed aqueous s...
Article
Sequestration of CO2, either from gas mixtures or directly from air (direct air capture), is a technological goal important to large-scale industrial processes such as gas purification and the mitigation of carbon emissions. Previously, we investigated five porous materials, three porous metal-organic materials (MOMs), a benchmark inorganic materia...
Article
Full-text available
Sequestration of CO2, either from gas mixtures or directly from air (direct air capture), is a technological goal important to large-scale industrial processes such as gas purification and the mitigation of carbon emissions. Previously, we investigated five porous materials, three porous metal-organic materials (MOMs), a benchmark inorganic materia...
Data
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and...
Data
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and...
Article
Sequestration of CO2 , either from gas mixtures or directly from air (direct air capture, DAC), could mitigate carbon emissions. Here five materials are investigated for their ability to adsorb CO2 directly from air and other gas mixtures. The sorbents studied are benchmark materials that encompass four types of porous material, one chemisorbent, T...
Article
Full-text available
Capture of CO2 from flue gas is considered to be a feasible approach to mitigate the effects of anthropogenic emission of CO2. Herein we report that an isostructural family of metal organic materials (MOMs) of general formula [M(linker)2(pillar)], linker = pyrazine, pillar = hexaflourosilicate and M = Zn, Cu, Ni and Co exhibits highly selective rem...
Article
The two-step mechanochemical preparation of carbene—pyridine complexes of palladium and platinum is reported.
Article
Herein, we report shape control in the CZTSSe nanocrystal system by tuning the occurrence of polytypism between wurtzite and zinc-blende phases. We have isolated the key control factors in this system and show that the choice of solvents/surfactants and precursors and how they are introduced can allow shape control from dots to ellipsoids to arrows...
Article
Crystalline solid solutions (mixed crystals) formed from molecular compounds are a long-known class of multicomponent solids whose composition can be varied, at least in principle, in continuum. Should such control occur in mixed crystals over a wide range of compositions then it follows that some structural and physical properties would also be tu...