
Matija CvetnicUniversity of Zagreb · Department of Analytical Chemistry
Matija Cvetnic
PhD
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Publications (54)
The COVID-19 pandemic has intensified the development of new antiviral agents specifically intended for the SARS-CoV-2 virus, but has also increased the use of some already known antiviral agents originally intended for other viruses. Although the pandemic has ended, the SARS-CoV-2 virus is expected to be present in the human population forever, as...
The environmental impact of plastic waste is a growing global challenge, primarily due to non-biodegradable plastics from fossil resources that accumulate in ecosystems. Biodegradable polymers like polyhydroxyalkanoates (PHAs) offer a sustainable alternative. PHAs are microbial biopolymers produced by microorganisms using renewable substrates, incl...
Essential oils from star anise, nutmeg, clove buds, oregano, bay leaves, and lemon peel were extracted via hydrodistillation. GC-MS, UV–Vis, FTIR, and 1H NMR spectroscopy were used to identify the major compounds (trans-anethole, sabinene, eugenol, carvacrol, eucalyptol and limonene, for star anise, nutmeg, clove buds, oregano, bay leaves, and lemo...
Conventional distillation methods cannot effectively separate the components of an azeotropic mixture since both phases have the same composition, thereby preventing further separation. Additional techniques such as pressure swing distillation or distillation with entrainers are often employed to overcome this limitation and achieve separation. The...
Microplastics are an emerging class of recalcitrant organic pollutants that are of general scientific and public interest nowadays. It would be ideal to remove microplastics from the environment through biodegradation, as biodegradation is a highly ecological and economically acceptable approach. Unfortunately, the efficiency of biodegradation of c...
The global problem of microplastics in the environment is “inspiring” scientists to find environmentally friendly and economically viable methods to remove these pollutants from the environment. Advanced oxidation processes are among the most promising methods. In this work, the potential of Fenton, photo-Fenton, and Fenton-like processes for the d...
Graphene, a two-dimensional carbon allotrope with a honeycomb structure, has emerged as a material of immense interest in diverse scientific and technical domains. It is mainly produced from graphite by mechanical, chemical and electrochemical exfoliation. As renewable energy and source utilization increase, including bioenergy from forest and wood...
Biodegradation is the most environmentally friendly and, at the same time, economically acceptable approach to removing various pollutants from the environment. However, its efficiency in removing microplastics (MPs) from the environment is generally low. The successful biodegradation of MPs requires microorganisms capable of producing enzymes that...
The phenolic profile of wines is often used to evaluate their quality and authenticity. The phenolic composition of twenty-five commercial wines produced in different Croatian regions from eight red and nine white grape varieties was studied. A total of twenty-four polyphenols were analyzed using HPLC-DAD and classified into five groups based on th...
In the last two decades, microplastics (MP) have been identified as an emerging environmental pollutant. Due to their small size, MP particles may easily enter the food chain, where they can have adverse effects on organisms and the environment in general. The common methods for the removal of pollutants from the environment are not fully effective...
Biomimetic calcium phosphate (CaP) systems mono-substituted with zinc (Zn²⁺) and magnesium (Mg²⁺) ions were prepared from a biogenic source (cuttlefish bone) by wet precipitation method. The results revealed that the as-prepared powders were composed of calcium-deficient carbonated hydroxyapatite (HAp), octacalcium phosphate (OCP), and amorphous ca...
Microplastics (MP) are a global environmental problem because they persist in the environment for long periods of time and negatively impact aquatic organisms. Possible solutions for removing MP from the environment include biological processes such as bioremediation, which uses microorganisms to remove contaminants. This study investigated the bio...
This paper examines the removal of mineral oil from oily wastewater by a hybrid ultrasonic and electrochemical circulating flow process. The Box-Behnken design was used to study the effects of number of cycles, current density, flow rate and the presence of ultrasound on the efficiency of mineral oil removal and process optimization. A reduced cubi...
The study of the structural features affecting the adsorption of organics, especially contaminants of emerging concern (CECs), onto TiO2 P25 in aqueous medium has far-reaching implications for the understanding and modification of TiO2 P25 in the roles such as an adsorbent and photocatalyst. The effect of pH and γ(TiO2 P25) as variables on the exte...
Since oxidative stress has been linked to several pathological conditions and diseases, drugs with additional antioxidant activity can be beneficial in the treatment of these diseases. Therefore, this study takes a new look at the antioxidant activity of frequently prescribed drugs using the HPLC-DPPH method. The antioxidative activity expressed as...
The pharmaceutical contamination in aquatic environment has arisen increasing concern due to its potentially chronic toxicity. In recent years, HO° and SO4°⁻ based advanced oxidation processes (AOPs) have been widely applied in water and wastewater treatments due to their highly efficiency on contaminant removal. Here, the response surface modeling...
The harmful effects of microplastics are not yet fully revealed. This study tested harmful effects of polyethylene (PE), polypropylene (PP), polystyrene (PS), polyvinyl chloride (PVC), and polyethylene terephthalate (PET) microplastics were tested. Growth inhibition tests were conducted using three microorganisms with different characteristics: Sce...
Zooplankton is an essential part of the simulation in ecological process-based models and rigorous calibration of the zooplankton module lacks relevant modeling research that can predict the response of zooplankton biomass to varied environmental factors. The paper therefore builds a one-dimensional lake ecology model PCLake, which quantifies the d...
Research on plastic pollution has recently evidenced the ubiquitous presence of tiny plastic particles called microplastics. Microplastics alter organisms because microplastics tend to bioaccumulate, they contain hazardous additives, and they carry other contaminants and pathogens adsorbed on their surface. Here, we review the biodegradation of the...
Fosamprenavir calcium is an active pharmaceutical ingredient (API) in which trace elements must be monitored by ICH Q3D Guideline. It delivers appropriate method to ensure the quality of the product and its safe use. Elemental impurities in API are separated in three classes based on their toxicity and probability of their occurrence in the product...
Fixed-dose combinations have shown to be a great alternative to traditional polytherapy; however, development of such formulation requires thorough physicochemical compatibility investigation of active pharmaceutical ingredients to provide a stable, safe and therapeutically effective product. In this work, differential scanning calorimetry, X-ray p...
An extensive use of plastic material, which is a characteristic of modern society, is increasing the amount of plastic waste in the environment. Accordingly, plastic pollution has become a global environmental problem. The problem is particularly related to microsized and nanosized plastic particles which have become environmental contaminants of e...
Microplastic particles (MPs) are widely distributed pollutants in the environment. While a growing number of studies have shown that MPs are toxic to plant and animal life, systemic efforts to reduce their presence have been scarce. Low-density polyethylene (LDPE) and polystyrene (PS) are one of the most common among all plastic-forming MPs. In thi...
This review has four major objectives: I) to present the problem of phthalate pollution, II) to highlight common techniques for quantification of phthalate compounds in
water, III) to summarize current trends in determination of phthalates toxicity and point
out the major adverse effects, and IV) to discuss and critically compare modern approache...
The aim of this study was to prepare a biomimetic selenium substituted calcium phosphate system for potential application in osteosarcoma therapy. Calcium phosphate (CaP) systems substituted with selenite ions were prepared by the wet precipitation method, using biogenic CaCO3 (derived from cuttlefish bone), CO(NH2)2-H3PO4, and Na2SeO3·5H2O as reag...
The simultaneous administration of sulfasalazine and folic acid is regular practice in the therapy of inflammatory bowel diseases in order to maintain sufficient folate concentration in patients. Having multiple drugs in the therapy increases the possibility of patients failing adherence, thus unintentionally endangering their health. A fixed-dose...
In this work, a systematical compatibility investigation of 6-mercaptopurine and folic acid, two commonly used medications in the treatment of inflammatory bowel disease, for the needs of a fixed-dose combination development strategy is shown. Various techniques and approaches, such as differential scanning calorimetry, isothermal stress testing, a...
This study is focused on oxytetracycline (OTC) degradation by direct photolysis (UV-C) and photobased advanced oxidation processes (AOPs) (UV-C/H2O2 and UV-C/S2O8²⁻). OTC degradation pathways were revealed by LC-MS/MS and GC-MS/MS analyses. The evolution/degradation profiles of 12 detected byproducts were correlated with changes in biodegradability...
The occurrence of contaminants in natural waters is a potential threat to the environment. Since contaminants are commonly present as mixtures, numerous interactions may occur, resulting in lower or, more dangerously, higher toxicity, by comparison with single substances. The toxicity of multicomponent systems can be determined experimentally, but...
High living standards and a comfortable modern way of life are related to an increased usage of various plastic products, yielding eventually the generation of an increased amount of plastic debris in the environment. A special concern is on microplastics (MPs), recently classified as contaminants of emerging concern (CECs). This review focuses on...
Pollutants in real aquatic systems commonly occur as chemical mixtures. Yet, the corresponding risk assessment is still mostly based on information on single-pollutant toxicity, accepting the assumption that pollutant mixtures exhibit additive toxicity effect which is often not the case. Therefore, it is still better to use the experimental approac...
Nanocomposite structure of the bone can be mimicked by chitosan/hydroxyapatite (CS/HAp) composite scaffold. Biological hydroxyapatite (HAp) contains various ions,
which have a crucial role in bone growth. The aim of the present work was to synthesize biomimetic hydroxyapatite and prepare composite scaffolds based on chitosan, where HAp was synthesi...
The objective was to determine the content of trace elements (Na, K, Ca, Mg, P, B, Fe) in waste fats and cooking oil and to examine adsorption and extraction as methods for purification of oils and fats for their further use as biodiesel feedstocks. Adsorption was conducted using two bentonite-based adsorbents and extraction was conducted with four...
Biomimetic triphasic strontium‐substituted calcium phosphate (CaP) powders were prepared by wet precipitation method at 50°C, using CaCO3, (NH2)2COH3PO4, and Sr(NO3)2 as reagents. Calcite was prepared from biogenic source (cuttlefish bone). The synthesized powders have been characterized by elemental analysis, Fourier transform infrared spectromet...
U ovom radu provedena je biološka obrada agroindustrijskog otpada (P1), biootpada (P2) i biorazgradljivog komunalnog otpada (P3) procesom kompostiranja u adijabatskom reaktoru tijekom 21 dana. U pokusima P1, P2 i P3 postignuta je maksimalna temperatura od 52, 55 i 57 °C, a termofilna faza je trajala 8, 5 i 6 dana. Ukupno je nastalo 122, 407 i 389 g...
Current risk assessment in many countries, including European Union, is still placing focus on single substances rather than their mixtures, although mixtures are commonly found in the environment. To overcome this problem and gain new insights, six pharmaceuticals, namely: azithromycin (AZM), erythromycin (ERM), carbamazepine (CBA), oxytetracyclin...
Pesticides are the chemicals of increased concern regarding their adverse environmental effects. In particular, the reports on their joint toxicity effects are scarce in the literature. Therefore, this paper describes the experiments on toxicities of four pesticides: alachlor, chlorfenvinphos, diuron, and isoproturon, toward Vibrio fischeri. In par...
Diuron is a selective and the most persistent herbicide. Widespread use of this compound has led to the elevated concentrations of diuron in groundwater and wastewater. The main objectives of this study were to investigate biodegradation of diuron by Pseudomonas aeruginosa FN and evolved degradation product, 3,4‐dichloroanilines (3,4‐DCA). The infl...
Extensive commercial use of aromatic hydrocarbons results with significant amounts of these chemicals and related by-products in waters, causing a severe ecological and health threat, thus requiring an increased attention.
This study was aimed at developing models for prediction of the initial toxicity of the aromatic water-pollutants (expressed as...
Diverse contaminants of emerging concern (CECs) can be found in nowadays aquatic environment, possessing high potential to cause adverse ecological and human health effects. Due to their recalcitrance, conventional water treatment methods are shown to be inadequately effective. Thus, their upgrade by advanced oxidation processes, involving the gene...
This work aimed the influence of inoculation of Pseudomonas aeruginosa BSW, Bacillus subtilis and zeolite on a biowaste composting process. The composting process of biowaste was conducted without (experiment P1) and with (experiment P2) inoculation of selected bacteria and zeolite. The addition of 4% of zeolite into biowaste displayed the retentio...
Bisfenol A (BPA) je sveprisutni organski spoj koji se primjenjuje u proizvodnji polikarbonata, epoksi smola i raznih drugih materijala. Polikarbonati se koriste u proizvodnji plastičnih ambalaža za hranu i piće, bočica za djecu, kuhinjskih pomagala, pakiranju lijekova, elektroničke opreme. BPA dospijeva u okoliš, odnosno u tlo i vode, tijekom kemij...
Quantitative structure-property relationship (QSPR) methodology was tested in prediction of second-order kinetics of hydroxyl-radical oxidations.
Water is the curtail resource for sustainable life on Earth, yet it is subjected increasing pollution. Advanced oxidation processes showed a good performance in removing the micropollutants from water environment. In this study, 2-the authors evaluated UV-C/H2O2 and UV-C/S2O8²⁻ photooxidative processes for treatment of 14 emerging contaminants (pha...
Development of new chromatographic method is often time-consuming and may be shortened by mathematical modeling. Unfortunately, many of the models are limited for predefined elution programs only. The integral model uses iso-to-grad approach to transfer information from isocratic to gradient elution without such limitations, which was successfully...
In refinery plants key process variables, like contents of process stream and various fuel properties, need to be continuously monitored using adequate on-line measuring devices. Such measuring devices are often unavailable or malfunction and, hence, laboratory assays which are irregular and time consuming and therefore not suitable for process con...
In this study, UV-C/H2O2 and UV-C/ processes as photooxidative Advanced oxidation processes were applied for the treatment of seven pharmaceuticals, either already included in the Directive 2013/39/EU “watch list” (17α- ethynylestradiol, 17β-estradiol) or with potential to be added in the near future due to environmental properties and increasing c...
The study was aimed at developing models for predicting the biodegradability of aromatic water pollutants. For that purpose, 36 single-benzene ring compounds, with different type, number and position of substituents, were used. The biodegradability was estimated according to the ratio of the biochemical (BOD5) and chemical (COD) oxygen demand value...
The conventional water treatment technologies, mostly relying on physical and biological processes, seem to be inadequate for effective removal of priority substances such as pesticides, while advanced oxidation processes showed a good performance for the same purpose. The aim of the study was to evaluate UV-C/H2O2 and UV-C/S2O82– processes for tre...