Mathilde ChevinBiospective, Inc. · in vivo studies
Research Scientist, in vivo studies at Biospective Inc
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Citations since 2017
12 Research Items
Mathilde Chevin currently works as Research Scientist at Biospective Inc. Current projects involve CNS diseases modelization in mice and rats, treatment and characterization by imaging and histology. Mathilde does research in Biochemistry, Neuroscience and Immunology.
Aim To test the association between perinatal inflammation exposure and Full-Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS). Method We conducted a cross-sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy-three...
Neonatal encephalopathy (NE) caused by hypoxia-ischemia (HI) affects around 1 per 1000 term newborns and is the leading cause of acquired brain injury and neurodisability. Despite the use of hypothermia (HT) as a standard of care, the incidence of NE and its devastating outcomes remains a major issue. Ongoing research surrounding add-on neuroprotec...
Résumé L'accident vasculaire cérébral (AVC) regroupe six catégories nosologiques qui diffèrent par leurs causes et mécanismes, leur temporalité et mode de présentation clinique et l’évolution. Par définition, l'AVC néonatal – lui-même divisé en infarctus cérébral artériel néonatal, thrombose néonatale des sinus et des veines cérébraux, et hémorragi...
Necroptosis is emerging among possible mechanisms underlying cell death in neurodegenerative diseases. In this line, we hypothesize that necroptosis might be implicated in neuronal cell death in amyotrophic lateral sclerosis (ALS). To support this hypothesis, we hereby provide pilot data as well as some findings from the literature about the expres...
Background: There is currently no targeted treatment available for neonatal arterial ischemic strokes (NAIS). Epidemiological studies demonstrated that perinatal infection/inflammation, peripartum hypoxia, and occlusion of the internal carotid tree are the main determinants of NAIS. The well-established benefit of therapeutic hypothermia (HT) in n...
Introduction Aucun traitement n’est actuellement disponible pour l’infarctus cérébral artériel néonatal (NAIS). Les études épidémiologiques ont montré que l’infection/inflammation périnatale, l’hypoxie perpartum associées à l’occlusion d’une artère cervico-encéphalique sont les principaux déterminants du NAIS. L’effet neuroprotecteur de l’hypotherm...
Background: Hypothermia is increasingly tested in several neurological conditions, such as neonatal encephalopathy, stroke, traumatic brain injury, subarachnoid hemorrhage, spinal cord injury, and neurological outcomes of cardiac arrest. Current studies aim to increase benefits of hypothermia with new add-on therapies including immunomodulatory ag...
Based on the review of the literature, perinatal inflammation often induced by infection is the only consistent independent risk factor of neonatal arterial ischemic stroke (NAIS). Preclinical studies show that acute inflammatory processes take place in placenta, cerebral arterial wall of NAIS-susceptible arteries and neonatal brain. A top research...
Effects of IL-1 blockade on LPS+HI-induced brain injury and motor impairments in a rat model.
Background: Despite the recent introduction of hypothermia as a mandatory standard of care, the incidence of neonatal encephalopathy in full-term newborns and its devastating neuro-behavioral outcomes continues to be a major individual, familial and social issue. Neonatal encephalopathy is mainly due to the compounding and interacting effects of h...
Poster presented at the International Society for Developmental Neuroscience (ISDN) meeting, May 11-14, 2016.
Poster presented at the sfn meeting (Chicago, 17-21 oct 2015)
It is known that gestational and/or perinatal inflammation combined or not with hypoxia-ischemia (HI) is a risk factor for brain injuries, but the mechanisms underlying are still unclear. This chapter discusses about animal models mimicking those conditions, allowing scientists to uncover mechanisms involved and to study the adverse effects on the...
Inflammation due to remote pathogen exposure combined to hypoxia/ischemia (HI) is one of the most common causes of neonatal encephalopathy affecting at-term or near-term human newborn, which will consequently develop cerebral palsy. Within term-equivalent rat brains exposed to systemic lipopolysaccharide (LPS) plus HI, it was previously showed that...
Pro-inflammatory cytokines involved in such materno-fetal activation