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My work aims on understanding the link between quantitative genetics and population genetics - through modelisation, simulations, and data analyses. The corner stone of my projects has been the study of linkage disequilibrium - as a tool to link phenotypic and molecular level. All my projects have been developed in a breeding framework - leveraging the breeding experimental designs and the quantitative genetics know-how.
April 2021 - December 2021
- PostDoc Position
- For tree specis, in the competition for light and space, wood is an important tissue, since radial growth of the woody stem provides the mechanical support for woody plants to grow tall and gain a competitive advantage. In this project funded by Bio4Energy, we inferred the evolutionary story - demographic and adaptive - of wood properties of Picea abies - analysing genomic and phenotypic data.
November 2019 - August 2022
- PostDoc Position
- n forests managed in the context of breeding, performance of a selected candidates highly depends on biotic and abiotic conditions. Though we cannot control everything, we can partly influence the biotic conditions by choosing the individuals we plant together. This project, founded by the H2020 European consortium B4Est, aims on implementing group selection in forest tree breeding - in the study cases of Populus nigra, Eucalyptus globulus and Quercus Petraea.
September 2018 - October 2019
- PostDoc Position
- In order to sustain long-term genetic gain, genomic selection has to incorporate genetic diversity in its objectives. Optimal Contribution Selection (OCS) is one of the most efficient and well approuved method to do so, but due to its simplicity it cannot incorporate mating information, that is essential for a precise overview on the Bulmer effect and inbreeding depression over time. I then extended this method to efficiently incorporate matings - in the study case of Populus nigra.
Vast population movements induced by recurrent climatic cycles have shaped the genetic structure of plant species. During glacial periods species were confined to low latitude refugia from which they recolonized higher latitudes as the climate improved. This multi‐pronged recolonization led to many lineages that later met and formed large contact z...
Background and aims: The colonization success of a species depends on the interplay between its phenotypic plasticity, adaptive potential and demographic history. Assessing their relative contributions during the different phases of a species range expansion is challenging, and requires large-scale experiments. Here, we investigated the relative co...
Background and aims The colonization success of a species depends on the interplay between its phenotypic plasticity, adaptive potential and demographic history. Assessing their relative contributions during the different phases of a species range expansion is challenging, and requires large-scale experiments. Here, we investigated the relative con...
To a large extent, the current distribution and population structure of many species were shaped by the cycles of isolation in glacial refugia and subsequent population expansions. Isolation in, and post-glacial expansion through, heterogeneous environments led to either neutral or adaptive divergence. Norway spruce is no exception, and its current...
Vast population movements induced by recurrent climatic cycles have shaped the genetic structure of plant species. This is especially true in Scandinavia that was repeatedly glaciated. During glacial periods trees were confined to refugia, south and east of the ice sheet, from which they recolonized Scandinavia as the ice melted away. This multi-pr...
In breeding, Optimal Contribution Selection (OCS) is one of the most effective strategies to balance short‐ and long‐term genetic responses, by maximizing genetic gain and minimizing global coancestry. Considering genetic diversity in the selection dynamic – through coancestry – is undoubtedly the reason for the success of OCS, as it avoids prelimi...
In breeding programs, balancing short-term genetic gain and loss of diversity per generation is essential to sustain a long-term genetic response. Depending on the dynamic of the species, the acceptable trade-off will be different. One of the most common and successful tools to achieve this management is the Optimal Contribution Selection (OCS), wh...
The colonization success of a species depends on phenotypic plasticity, adaptive potential and population structure. Assessing their relative contributions during a colonization process is challenging, and a large-scale experiment had yet to be done. In this study, we attempted to tease apart their effects on the fitness of one of the most common p...
Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is an arterivirus responsible for highly contagious infection and huge economic losses in pig industry. Two species, PRRSV-1 and PRRSV-2 are distinguished, PRRSV-1 being more prevalent in Europe. PRRSV-1 can further be divided in subtypes. PRRSV-1.3 such as Lena are more pathogenic than PR...
Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed...
La génétique des populations est l’étude de l’évolution des fréquences alléliques au sein d’une population et de l’influence des pressions évolutives sur ces fréquences. Au sein de cette discipline, des modèles de population et des mesures génétiques sont développés pour pouvoir expliquer et prédire les données génétiques. Toutefois, au fur et à me...
With the highly dense genomic data available nowadays, ignoring linkage between genes would result in a huge loss of information. One way to prevent such a loss is to focus on the blocks of chromosomes shared identical by descent (IBD) in populations. The development of the theoretical framework modelling IBD processes is essential to support the a...
How inbreeding accumulate over time in population? How could we model it? We proposed a theoretical framework in population genomics, through the study case of identity-by-descent (IBD). We can derive mathematical predictions for IBD blocks, that we confronted to computer simulations. The overall dynamic seems to depend highly on the ancestral eff...