Mathieu Tiret

Mathieu Tiret
French National Institute for Agriculture, Food, and Environment (INRAE) | INRAE · Institut de Génétique Environnement et Protection des Plantes (IGEPP)

PhD

About

14
Publications
1,279
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Citations
Introduction
My work aims on understanding the link between quantitative genetics and population genetics - through modelisation, simulations, and data analyses. The corner stone of my projects has been the study of linkage disequilibrium - as a tool to link phenotypic and molecular level. All my projects have been developed in a breeding framework - leveraging the breeding experimental designs and the quantitative genetics know-how.
Additional affiliations
April 2021 - December 2021
Swedish University of Agricultural Sciences
Position
  • PostDoc Position
Description
  • For tree specis, in the competition for light and space, wood is an important tissue, since radial growth of the woody stem provides the mechanical support for woody plants to grow tall and gain a competitive advantage. In this project funded by Bio4Energy, we inferred the evolutionary story - demographic and adaptive - of wood properties of Picea abies - analysing genomic and phenotypic data.
November 2019 - August 2022
Uppsala University
Position
  • PostDoc Position
Description
  • n forests managed in the context of breeding, performance of a selected candidates highly depends on biotic and abiotic conditions. Though we cannot control everything, we can partly influence the biotic conditions by choosing the individuals we plant together. This project, founded by the H2020 European consortium B4Est, aims on implementing group selection in forest tree breeding - in the study cases of Populus nigra, Eucalyptus globulus and Quercus Petraea.
September 2018 - October 2019
French National Institute for Agriculture, Food, and Environment (INRAE)
Position
  • PostDoc Position
Description
  • In order to sustain long-term genetic gain, genomic selection has to incorporate genetic diversity in its objectives. Optimal Contribution Selection (OCS) is one of the most efficient and well approuved method to do so, but due to its simplicity it cannot incorporate mating information, that is essential for a precise overview on the Bulmer effect and inbreeding depression over time. I then extended this method to efficiently incorporate matings - in the study case of Populus nigra.
Education
September 2011 - July 2014
AgroParisTech
Field of study
  • Ecology, Biodiversity and Evolution

Publications

Publications (14)
Article
Vast population movements induced by recurrent climatic cycles have shaped the genetic structure of plant species. During glacial periods species were confined to low latitude refugia from which they recolonized higher latitudes as the climate improved. This multi‐pronged recolonization led to many lineages that later met and formed large contact z...
Article
Full-text available
Background and aims: The colonization success of a species depends on the interplay between its phenotypic plasticity, adaptive potential and demographic history. Assessing their relative contributions during the different phases of a species range expansion is challenging, and requires large-scale experiments. Here, we investigated the relative co...
Article
Full-text available
Background and aims The colonization success of a species depends on the interplay between its phenotypic plasticity, adaptive potential and demographic history. Assessing their relative contributions during the different phases of a species range expansion is challenging, and requires large-scale experiments. Here, we investigated the relative con...
Preprint
Full-text available
To a large extent, the current distribution and population structure of many species were shaped by the cycles of isolation in glacial refugia and subsequent population expansions. Isolation in, and post-glacial expansion through, heterogeneous environments led to either neutral or adaptive divergence. Norway spruce is no exception, and its current...
Preprint
Full-text available
Vast population movements induced by recurrent climatic cycles have shaped the genetic structure of plant species. This is especially true in Scandinavia that was repeatedly glaciated. During glacial periods trees were confined to refugia, south and east of the ice sheet, from which they recolonized Scandinavia as the ice melted away. This multi-pr...
Article
Full-text available
In breeding, Optimal Contribution Selection (OCS) is one of the most effective strategies to balance short‐ and long‐term genetic responses, by maximizing genetic gain and minimizing global coancestry. Considering genetic diversity in the selection dynamic – through coancestry – is undoubtedly the reason for the success of OCS, as it avoids prelimi...
Preprint
Full-text available
In breeding programs, balancing short-term genetic gain and loss of diversity per generation is essential to sustain a long-term genetic response. Depending on the dynamic of the species, the acceptable trade-off will be different. One of the most common and successful tools to achieve this management is the Optimal Contribution Selection (OCS), wh...
Preprint
Full-text available
The colonization success of a species depends on phenotypic plasticity, adaptive potential and population structure. Assessing their relative contributions during a colonization process is challenging, and a large-scale experiment had yet to be done. In this study, we attempted to tease apart their effects on the fitness of one of the most common p...
Article
Full-text available
Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is an arterivirus responsible for highly contagious infection and huge economic losses in pig industry. Two species, PRRSV-1 and PRRSV-2 are distinguished, PRRSV-1 being more prevalent in Europe. PRRSV-1 can further be divided in subtypes. PRRSV-1.3 such as Lena are more pathogenic than PR...
Article
Full-text available
Lung inflammation is frequently involved in respiratory conditions and it is strongly controlled by mononuclear phagocytes (MNP). We previously studied porcine lung MNP and described a new population of cells presenting all the features of alveolar macrophages (AM) except for their parenchymal location, that we named AM-like cells. Herein we showed...
Thesis
Full-text available
La génétique des populations est l’étude de l’évolution des fréquences alléliques au sein d’une population et de l’influence des pressions évolutives sur ces fréquences. Au sein de cette discipline, des modèles de population et des mesures génétiques sont développés pour pouvoir expliquer et prédire les données génétiques. Toutefois, au fur et à me...
Article
Full-text available
With the highly dense genomic data available nowadays, ignoring linkage between genes would result in a huge loss of information. One way to prevent such a loss is to focus on the blocks of chromosomes shared identical by descent (IBD) in populations. The development of the theoretical framework modelling IBD processes is essential to support the a...
Poster
How inbreeding accumulate over time in population? How could we model it? We proposed a theoretical framework in population genomics, through the study case of identity-by-descent (IBD). We can derive mathematical predictions for IBD blocks, that we confronted to computer simulations. The overall dynamic seems to depend highly on the ancestral eff...

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Projects

Project (1)
Archived project
How could identity-by-descent be modelled in the context of population genomics - considering a multilocus approach?