Mathieu Edouard Rebeaud

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Swiss Federal Institute of Technology in Lausanne | EPFL · Institute of Theoretical Physics

Significance Across the Tree of Life, life’s phenotypic diversity has been accompanied by a massive expansion of the protein universe. Compared with simple prokaryotes that harbor thousands of proteins, plants and animals harbor hundreds of thousands of proteins that are also longer, multidomain, and comprise a variety of folds and fold combination...

Climate change is increasingly affecting the quality of life of organisms on Earth. More frequent, extreme, and lengthy heat waves are contributing to the sixth mass extinction of complex life forms in the Earth’s history. From an anthropocentric point of view, global warming is a major threat to human health because it also compromises crop yields...

The 70-kD heat shock protein (Hsp70) chaperone system is a central hub of the proteostasis network that helps maintain protein homeostasis in all organisms. The recruitment of Hsp70 to perform different and specific cellular functions is regulated by the J-domain protein (JDP) co-chaperone family carrying the small namesake J-domain, required to in...

The Hsp70 chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) co-evolved with Hsp70s to trigger ATP-hydrolysis and catalytically upload various substrate polypeptides in need to be structurally modified by the chaperone. Here, we measured the protein disaggregation and refolding activities of...

Hsp70 chaperones are central components of the cellular network that ensures the structural quality of proteins. Despite crucial roles in processes such as protein disaggregation and protein translocation into organelles, their physical mechanism of action has remained hotly debated. To the best of our knowledge, no experimental data has directly p...

Hsp70 chaperones are central components of the cellular network that ensure the structural quality of proteins. Despite their crucial roles in processes as diverse as the prevention of protein aggregation and protein translocation into organelles, their molecular mechanism of action has remained a hotly debated issue. Due to a lack of suitable meth...

The Hsp70 chaperones control protein homeostasis in all ATP-containing cellular compartments. J-domain proteins (JDPs) co-evolved with Hsp70s to trigger ATP-hydrolysis and catalytically upload various substrate polypeptides in need to be structurally modified by the chaperone. Here, we measured the protein disaggregation and refolding activities of...

J-domain proteins (JDPs) are the largest family of chaperones in most organisms, but much of how they function within the network of other chaperones and protein quality control machineries is still an enigma. Here, we report on the latest findings related to JDP functions presented at a dedicated JDP workshop in Gdansk, Poland. The report does not...

Background Global warming is a major challenge for plant survival and growth. Understanding the molecular mechanisms by which higher plants sense and adapt to upsurges in the ambient temperature is essential for developing strategies to enhance plant tolerance to heat stress. Here, we designed a heat-responsive Arabidopsis thaliana reporter line th...

Background: Global warming is a major challenge for plant survival and growth. Understanding the molecular mechanisms by which higher plants sense and adapt to upsurges in the ambient temperature, is essential for developing strategies to enhance plant tolerance to heat stress. Here, we designed a special heat-responsive Arabidopsis thaliana report...

The 2021 Nobel prize was awarded for the discovery of the animal thermosensory channel TRPV1. We highlight notable shared features with the higher plant thermosensory channel CNGC2/4. Both channels respond to temperature-induced changes in plasma membrane fluidity, leading to hyperphosphorylation of the HSF1 transcription factor via a specific heat...

The 70 kDalton Heat shock protein (Hsp70) chaperone system is emerging as a central node of the proteostasis network that supervises protein homeostasis in all organisms. Hsp70 recruitment to perform a vast array of different cellular functions is regulated by a family of co-chaperones known as J-domain proteins (JDP) that bear a small namesake J-d...

Life is a non-equilibrium phenomenon. Owing to their high free energy content, the macromolecules of life tend to spontaneously react with ambient oxygen and water and turn into more stable inorganic molecules. A similar thermodynamic picture applies to the complex shapes of proteins: While a polypeptide is emerging unfolded from the ribosome, it m...

Objectives We conducted a systematic literature review and meta-analysis of observational studies to investigate the association between diabetes, hypertension, body mass index (BMI) or smoking with the risk of death in patients with COVID-19 and to estimate the proportion of deaths attributable to these conditions. Methods Relevant observational...

The authors and the co-signatories of this open letter are scientists dedicated to transparency and integrity of research. We support the work needed to investigate potential errors and possible misconduct and believe the scientific community can do more to protect whistleblowers against harassment and threats. Individual researchers can provide vo...

Background: Patients who smoke and with preexisting comorbidities have a greater risk of developing severe coronavirus disease 2019 (COVID-19) and have a higher mortality rate. However, the number of deaths attributable to diabetes, hypertension, obesity, or smoking have never been estimated. We conducted a systematic literature review and meta-ana...

In the same way Ektorp describes the response to Lacerda's trial, aggressive communication and an online campaign of misinformation against the meta-analysis were shared by certain medical and scientific professors, as well as French politicians, going beyond the framework of scientific debate and involving the political sphere. This behaviour has...

Mortality in COVID-19 patients predominantly results from an acute respiratory distress syndrome (ARDS), in which lungs alveolar cells undergo programmed cell death. Mortality in a sepsis-induced ARDS rat model is reduced by adenovirus over-expression of the HSP70 chaperone. A natural rise of body temperature during mild fever can naturally accumul...

ATTENTION ! Cet artilce n'est pas un artilce sur le cyclimse. Pour le détail, vous pouvez lire ce billet de blog : http://www.mimiryudo.com/blog/2020/08/le-meilleur-article-de-tous-les-temps/

Voici la version de notre article anglais traduit en français par Robin Alais (merci !) Avoir son article traduit le jour de sa sortie est un privilège rare, confirmant l'importance de notre découverte. Comme de grands éditeurs de revue, nous avons choisi un nom clair pour notre fichier.

Background Hydroxychloroquine or chloroquine with or without azithromycin have been widely promoted to treat COVID-19 following early in vitro antiviral effects against SARS-CoV-2 Objective The aim of this systematic review and meta-analysis was to assess whether chloroquine or hydroxychloroquine with or without azithromycin decreased COVID-19 mor...

Background: Global COVID-19 deaths reached at least 400,000 fatalities. Hydroxychloroquine is an antimalarial drug that elicit immunomodulatory effects and had shown in vitro antiviral effects against SRAS-CoV-2. This drug divided opinion worldwide in the medical community but also in the press, the general public and in public health policies. The...

Across the Tree of Life (ToL), the complexity of proteomes varies widely. Our systematic analysis depicts that from the simplest archaea to mammals, the total number of proteins per proteome expanded ~200-fold. Individual proteins also became larger, and multi-domain proteins expanded ~50-fold. Apart from duplication and divergence of existing prot...

In December 2019, a newly discovered SARS-CoV-2 virus emerged from China and propagated worldwide as a pandemic, becoming a major global public health issue. Different publications have discussed the possible efficacy of the antimalarial drug chloroquine (CQ) and its derivatives as a possible treatment against the disease, and, as the drug has ofte...

Since its outbreak in December 2019, Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) has spread worldwide and is considered a pandemic. Coronavirus disease (COVID-19) can lead to acute respiratory distress syndrome (ARDS) or death. Many efforts have been made to identify risk factors predisposing to a severe issue. In the first SARS-Co...

In eukaryotes, Hsp110s are unambiguous cognates of the Hsp70 chaperones, in primary sequence, domain organization, and structure. Hsp110s function as nucleotide exchange factors (NEFs) for the Hsp70s although their apparent loss of Hsp70‐like chaperone activity, nature of interdomain communication, and breadth of domain functions are still puzzling...

Objective: Infectious disease (ID) is accompanied by an immune response of the host. MALDI-TOF MS is an emerging method of analysis of ID. The MS-based method is routinely applied for identification of the infectious agent including bacterial pathogens. The current Master Thesis aims to elaborate and evaluate further applications of this peptidomic...

The production of hydrogen with microalgae is considered as one of the most promising field of research in new biofuels. It consists of the use of biophotolysis coupled or not with dark fermentation. Organisms as microalgae (green microalgae, brown, blue…) of oxygenic photosynthesis oxidize water molecules to extract electrons and protons. They use...

Poster for the Research Day of the Institute of Life Technologies at EPFL Energypolis Switzerland

Presentation done during the Research Day of the Institute of Life Technologies