Mathieu Branca

Mathieu Branca
Paris Diderot University | UP7 · Laboratoire d'Electrochimie Moléculaire (LEM) UMR 7591

PhD

About

25
Publications
1,608
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288
Citations
Additional affiliations
September 2012 - present
Paris Diderot University
Position
  • Research Assistant

Publications

Publications (25)
Article
Full-text available
The strength of autocatalytic reactions lies in their ability to provide a powerful means of molecular amplification, which can be very useful for improving the analytical performances of a multitude of analytical and bioanalytical methods. However, one of the major difficulties in designing an efficient autocatalytic amplification system is the re...
Preprint
Full-text available
The strength of autocatalytic reactions lies in their ability to provide a powerful means of molecular amplification, which can be very useful for improving the analytical performances of a multitude of analytical and bioanalytical methods. However, one of the major difficulties in designing an efficient autocatalytic amplification system is the re...
Preprint
The strength of autocatalytic reactions lies in their ability to provide a powerful means of molecular amplification, which can be very useful for improving the analytical performances of a multitude of analytical and bioanalytical methods. However, one of the major difficulties in designing an efficient autocatalytic amplification system is the re...
Article
Full-text available
Here we report a simple autocatalytic organic reaction network based on the redox chemistry of quinones and reactive oxygen species. Autocatalysis arises from the cross-activation between the H2O2-catalyzed deprotection of a pro-benzoquinone arylboronic ester probe and the benzoquinone-catalyzed H2O2 production through redox cyling with ascorbate i...
Article
Molecular based signal amplifications relying on an autocatalytic process may represent an ideal strategy for the development of ultrasensitive analytical or bioanalytical assays, the main reason being the exponential nature of the amplification. However, to take fully advantage of such amplification rates, high stability of the starting co‐reactan...
Article
Full-text available
Herein, we describe a new molecular autocatalytic reaction scheme based on a H2O2‐mediated deprotection of a boronate ester probe into a redox cycling compound, generating an exponential signal gain in the presence of O2 and a reducing agent or enzyme. For such a purpose, new chemosensing probes built around a naphthoquinone/naphthohydroquinone red...
Article
The first Faraday Discussion on halogen bonding was held in the beautiful capital city of Canada, Ottawa, from 10 th to 12 th July, 2017.
Article
Five N-phenylviologen (PV²⁺) derivatives have been synthesized and their electrochemical behavior in the presence of halide anions has been studied. Further investigations were carried out by ¹H and ¹⁹F NMR spectroscopy at different chloride concentrations. This is the first time a systematic study combines cyclic voltammetry and NMR spectroscopy i...
Article
The halogen bond donor properties of iodo-tetrathiafulvalene (I-TTF) can be electrochemically switched and controlled via reversible oxidation in the solution phase. Interestingly the activation of only one single halogen bond yielded already a strong and selective interaction, quantified by cyclic voltammetry. The standard potentials of the redox...
Article
Herein, we report the development of biohybrid catalysts that are capable of catalyzing the aldol reaction. The use of biotinylated imidazolium salts in combination with racemic or enantiomerically pure catalytic anions allowed us to study the adaptive and cooperative positioning of the anionic catalyst inside the protein. Supramolecular encapsulat...
Article
Full-text available
Cyclic voltammetry has been used for the first time to probe and to control the formation of non-covalent halogen bonding (XB) via redox switching. These results strongly encourage the use of electrochemistry as an economical and precisely controllable tool for the investigation of XB in solution.
Article
Ionic liquid self-assembled monolayers (SAM) were designed and applied for binding streptavidin, promoting affinity biosensing and enzyme activity on gold surfaces of sensors. The synthesis of 1-((+)-biotin)pentanamido)propyl)-3-(12-mercaptododecyl)-imidazolium bromide, a biotinylated ionic liquid (IL-biotin), which self-assembles on gold film, aff...
Article
Frozen: the spontaneous crystallization of an achiral compound in a chiral conformation is used as the unique source of chirality in an absolute asymmetric synthesis of tertiary amino acids. The dynamic axial chirality of tertiary aromatic amides is frozen in a crystal and is responsible for the stereoselectivity of the deprotonation/alkylation. α-...
Article
The alkylation of 4-substituted tetrazolo-pyridines bearing electron-withdrawing groups 7a–f to give the expected tetrazolo-pyridinium salts 7a–f,Me or 7a–f,Et as a mixture of two N3/N2 isomers in good to quantitative yields in toluene, has been investigated. The nature of the alkyl group did not significantly affect the chemical shifts of the salt...
Article
Full-text available
A simple anion metathesis in diluted aqueous carbonate at room temperature affords 1-(12-mercaptododecyl)-3-methyl-imidazolium carbonate (MDMI-HCO(3)) from MDMI salts self-assembled on gold films and nanoparticles. The properties of MDMI-SAM differ from MDMI in solution, for which the anion exchange reaction does not proceed.
Article
Full-text available
The properties of a surface modified with an ionic liquid self-assembled monolayer (IL-SAM) can be tuned by simply changing the deposition temperature. Mid-IR, SERS, and molecular modelling demonstrated that 1-(12-mercaptododecyl)-3-methylimidazolium bromide (MDMIBr) exhibited a crystalline monolayer for deposition temperatures below 25 °C. Above 2...
Article
A new methodology for the asymmetric synthesis of quaternary alpha-substituted amino acids using memory of chirality has been developed. The strategy utilizes the dynamic axial chirality of tertiary aromatic amides to memorize the initial chirality of an alpha-amino acid during an enolization step. Starting from five different l-amino acids, the co...
Article
A new methodology for the asymmetric synthesis of quaternary alpha-substituted amino acids using memory of chirality has been developed. This strategy employs dynamic axial chirality of tertiary aromatic amides to memorize the initial chirality of an alpha-amino acid during the enolization step. Starting from L-valine, an oxazolidin-5-one containin...
Article
The title molecule has been synthesised and the low temperature NMR spectrum recorded in CDCl 3 . The spectrum shows that four conformers lie within 0.08 eV at 210 K. We show that an accurate conformation analysis can be obtained with a full and consistent use of the DFT (B3LYP) and PCM methods. If the polarised StuttgarteDresden basis and a PCM ca...

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Project (1)
Project
In recent years, there has been growing interest in the development of exponential molecular amplification strategies based on self-induced or self-catalytic reaction schemes, taking advantage of so-called self-immolating molecular chemosensors, which, through a cascade of intramolecular deprotection reactions, trigger a self-catalytic amplification process. This relatively recent concept of autocatalysis by immolation remains however limited by the slow kinetics of cascade reactions, but also by problems of non-specific deprotection of the chemosensitive probes in solution, which has the effect of considerably reducing the analytical performance of these approaches. Partly inspired by this new paradigm in the field of molecular amplification, we propose for the coming years to explore novel auto-catalytic reaction schemes that do not use a self-immolation principle but a redox recycling coupled with auto-oxidation (see illustration) and whose rapid reactivity should allow exponential amplification performances much better than those proposed so far.