Mathew Piero Ngugi

Mathew Piero Ngugi
Kenyatta University · Department of Biochemistry Microbiology and Biotechnology

Bsc (Biochemistry Major) Msc (Biochemistry) PhD (Biochemistry and Molecular Biology)

About

179
Publications
85,886
Reads
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1,585
Citations
Introduction
Dr. Ngugi Mathew Piero has strong research interests in Medical Biochemistry with strong bias towards bioscreening of medicinal plant extracts mainly against biochemical and neurodegenerative disorders viz; Obesity, Diabetes Mellitus, Cancer, Alzheimer's disease, Epilepsy, Rheumatoid Arthritis, Depression, Anxiety, and Oxidative Stress. He also does research on possible role of plant extracts in exercise physiology like exercise endurance. Read more on https://ngugimathewpiero.com/
Additional affiliations
September 2019 - present
Kenyatta University
Position
  • Senior Lecturer
Description
  • Teaching, Research and Postgraduate student supervision
February 2014 - September 2019
Kenyatta University
Position
  • Lecturer
Description
  • Teaching, Research and postgraduate students supervision
September 2010 - February 2014
Kenyatta University
Position
  • Fellow
Description
  • Teaching and Research
Education
May 2007 - December 2013
Kenyatta University
Field of study
  • Biochemistry and Molecular Biology
September 2002 - July 2006
Kenyatta University
Field of study
  • Biochemistry and Molecular Biology
August 1998 - October 2002
Kenyatta University
Field of study
  • Biochemistry

Publications

Publications (179)
Article
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Groundnut (Arachis hypogaea L.) is an important crop in terms of income and nutrition. Despite its importance, groundnut yield is limited by environmental factors such as drought. This work reports the genetic transformability of Kenyan groundnut (Arachis hypogaea L.) genotypes with isopentenyl transferase (IPT) gene towards drought tolerance. The...
Article
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The root and leaf extracts of Launaea cornuta have been locally used in traditional medicine for decades to manage inflammatory conditions and other oxidative-stress-related syndromes; however, their pharmacologic efficacy has not been scientifically investigated and validated. Accordingly, we investigated the in vitro antioxidant activity, anti-in...
Article
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The function of innate hemostasis aids the body in bleeding control, preventing the loss of excessive amounts of blood following low-degree injuries. However, injuries of a higher degree may require extrinsic intervention to stop life-threatening blood loss. Astringent agents’ actions result in mechanical constriction of small blood vessels and shr...
Article
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Eastern Africa is currently infested with dodders-highly invasive vines that threaten agriculture and biodiversity. We describe historical and ecological factors that have potentially shaped dodder invasion in this region. Our results reveal high levels of genetic diversity within dodder populations, which could enhance their ability to colonize ne...
Article
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Maize weevil (Sitophilus zeamais) infestation results in a substantial reduction in the quantity and deterioration of the quality of stored maize. Most farmers control weevils using conventional pesticides which are usually associated with several human health risks as well as intoxication of the fauna and flora. However, bioinsecticides form an al...
Article
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Hemostasis is the natural mechanism by which blood is kept in a fluid state in circulation with the ability to cause clotting at an injury site. The effects of Croton megalocarpus Hutch and Lantana camara Linn plants leaves on blood coagulation has not been scientifically tested despite their common use in bleeding control. The current study invest...
Article
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The effects of Cissampelos pareira (Linn), Lantana camara (Linn) and Ocimum gratissimum (African basil) leaf extracts on pain have not been biologically determined despite their frequent traditional use in pain management. The present study evaluated the effects of methanol leaf extracts of these three plants on formalin-induced pain in Swiss albin...
Article
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Persistent hyperglycaemia is the hallmark of diabetes and is accountable for the devastating complications, which cause high morbidity and mortality. Conventional anti-diabetic agents are only palliative and characterised with limited efficacy, adverse effects, high costs, inaccessibility, prompting the need for better alternatives. Therefore, we i...
Preprint
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Persistent hyperglycaemia is the hallmark of diabetes and is accountable for the devastating complications, which cause high morbidity and mortality. Conventional anti-diabetic agents are only palliative and characterised with limited efficacy, adverse effects, high costs, inaccessibility, prompting the need for better alternatives. Therefore, we i...
Article
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Improved agricultural production of essential crops through advanced breeding is important for increasing access to nutritious food for the world's rapidly growing population, which is expected to reach 9.8 billion by 2050. Recent advancements in the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein9 (CRISPR/Cas9)...
Article
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Oxidative stress causes and drives many agonising inflammatory conditions, which cause disability, financial burden, and emotional stress. The current anti-inflammatory, analgesic, and antioxidant agents are associated with adverse effects, inaccessibility, high costs, and low efficacies, thereby warranting the need for alternatives, especially fro...
Article
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Background: Inflammation is an immune response characterized by swelling, redness, pain and heat. Inflammation is mainly managed using conventional medicines that are associated with many side effects. Plant-based remedies are considerably better alternative therapies for they have fewer side effects. Objective: This study aimed at determining t...
Article
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Background Arsenic poisoning affects millions of people. The inorganic forms of arsenic are more toxic. Treatment for arsenic poisoning relies on chelation of extracellularly circulating arsenic molecules by 2,3-dimecaptosuccinic acid (DMSA). As a pharmacological intervention, DMSA is unable to chelate arsenic molecules from intracellular spaces. T...
Article
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Background: Finger millet blast disease, caused by Pyricularia oryzae, is a serious constrain of finger millet production which is threatening global food security especially to the resource poor smallholder farmers in arid and semiarid regions. The disease adversely affects finger millet production and consumption due to its wide distribution and...
Article
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Introduction. Sitophilus zeamais infestation is among the major setbacks to sustainable maize farming and availability. It causes an estimated annual loss of 5–10% and 20–30% of the total maize grains loss in the temperate and tropical zones, respectively. Although synthetic pesticides are quick and effective in managing crop pests, their overuse a...
Article
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Invasive holoparasitic plants of the genus Cuscuta (dodder) threaten African ecosystems due to their rapid spread and attack on various host plant species. Most Cuscuta species cannot photosynthesize and hence rely on host plants for nourishment. After attachment through a peg-like organ called a haustorium, the parasites deprive hosts of water and...
Article
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Friable embryogenic callus (FEC) currently forms the tissue of choice for gene transfer to cassava tissues. However, this technology has not been sufficiently adopted in most laboratories, partly because of the challenging protocols involved in FEC production. Therefore, the development of transformation systems targeting readily accessible explant...
Preprint
Full-text available
Invasive holoparasitic plants of the genus Cuscuta (dodder) threaten Africa’s ecosystems, due to their rapid spread and attack on various host plant species. Most Cuscuta species cannot photosynthesize, hence rely on host plants for nourishment. After attachment through a peg-like organ called a haustorium, the parasites deprive hosts of water and...
Article
Pistacia aethiopica and Warbugia ugandensis are medicinal plants used in folk medicine among the Embu, Kenya. Despite being in use since antiquity, no empirical data is available to validate their claimed use in pain management. This study evaluated the antinociceptive effects of methanolic extracts of these plants in mice. Qualitative phytochemica...
Article
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Over 50 million persons are living with cognitive deficits worldwide, with over 80% of these individuals living in the developing world. The number of affected persons is projected to go over 152 million by the year 2050. Current drugs used for cognitive impairment are debatably ineffective, costly, inaccessible, and associated with undesirable eve...
Article
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Oxidative stress is the result of the disparity between pro-oxidants and antioxidants in an organism, and it is important in the pathogenesis of several degenerative disorders, such as arthritis, Alzheimer's, cancer, and cardiovascular diseases. Free radicals can damage biomolecules, such as nucleic acids, lipids, proteins, polyunsaturated fatty ac...
Preprint
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Introduction Antibiotic resistance is a serious threat to humankind. There is need for the development of new therapeutic options. Ocimum basilicum has been used traditionally as a medicinal herb against infectious diseases and as a food additive. Objective This study aimed at evaluating the phytochemical composition and in vitro antibacterial acti...
Article
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Groundnuts are among the principle economic oilseed largely cultivated in warm regions of Kenya and contribute to domestic food security and cash revenue. The study aimed at evaluating genetic diversity and phenotypic characterization of groundnut varieties grown in some parts of Kenya. Six varieties (ICG83708, ICGV99568, CG7, ICGV12991, RV and Cha...
Article
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Oxidative stress has been recognized as a key driver of many ailments affecting humankind. Free radicals attack biologically important biomolecules, impairing their functioning, thereby initiating and exacerbating diseases. As a comeback, antioxidant therapies have been proposed as novel approaches to ameliorating oxidative stress–associated diseas...
Article
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Bacterial infections are responsible for a large number of deaths every year worldwide. On average, 80% of the African population cannot afford conventional drugs. Moreover, many synthetic antibiotics are associated with side effects and progressive increase in antimicrobial resistance. Currently, there is growing interest in discovering new antiba...
Article
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Introduction : Pain is managed using conventional drugs like paracetamol, aspirin and diclofenac among others. Synthetic drugs have many side effects. This study aimed at evaluating the analgesic potential of the dichloromethane leaf extracts of Eucalyptus globulus and Senna didymobotrya in mice. Methods : The dichloromethane leaf extracts of E. gl...
Article
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Oxidative stress is a metabolic disorder characterised by overproduction of the highly reactive free radicals that damage body tissues. Such radicals include the unstable and destructive reactive oxygen and nitrogen species among other free radicals. A reduction in the immunological antioxidant defences of the body coupled to a declining tissue ant...
Article
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Finger millet is a food crop that provides nutritional security and is climatically resilient for farming and agricultural diversification. However, its quality and yield remain low due to biotic and abiotic factors, the greatest of which is blast disease caused by Magnaporthe oryzae. We surveyed the occurrence, distribution and severity of finger...
Presentation
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A video talk about medicinal properties of Carissa edulis as claimed by a Tanzanian herbalist/pastor. Dr. Mathew Piero Ngugi disputes the alleged claims after empirical research.
Article
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Cognitive impairment (CI) is among the leading causes of disability in humans. It is estimated that over 35.6 million people are suffering from Alzheimer’s disease- (AD-) associated cognitive deficits globally with these statistics projected to rise over 115.4 million by the year 2050. There is no specific etiology for this cognitive impairment; ho...
Article
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Obesity is the main component of metabolic syndromes involving distinct etiologies that target different underlying behavioral and physiological functions within the brain structures and neuronal circuits. An alteration in the neuronal circuitry stemming from abdominal or central obesity stimulates a cascade of changes in neurochemical signaling th...
Article
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Introduction: Fever is managed using synthetic drugs such as aspirin, paracetamol among others. Synthetic drugs are associated with many side effects. Herbal medicines form alternative therapy since they possess fewer side effects and are readily available. This study aimed to determine antipyretic potential of DCM extracts of E. globulus and S. d...
Article
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Background: Obesity is a chronic metabolic disorder characterized by increased adipose tissue mass due to positive energy balance. Prescription of anti-obesity drugs can be useful adjuncts to diet and exercise for obese patients who have failed to achieve weight loss. However, these drugs are ineffective and are associated with adverse effects. In...
Article
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The acquisition of ethnobotanical information from traditional practitioners remains an empirical aspect of understanding the ethnopharmacology research. However, integration of information on chemical composition of plant extracts and their pharmacological activities forms a key resource for synthesis of new and effective therapeutics. In traditio...
Preprint
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Obesity is the main component of metabolic syndromes involving distinct etiologies which target different underlying behavioral and physiological functions within the brain structures and neuronal circuits. An alteration in the neuronal circuitry stemming from abdominal or central obesity stimulates a cascade of changes in neurochemical signaling t...
Article
Full-text available
Chronic exposures to high-fat diets are linked to neuropathological changes that culminate in obesity-related cognitive dysfunction and brain alteration. Learning, memory performance, and executive function are the main domains affected by an obesogenic diet. There are limited effective therapies for addressing cognitive deficits. Thus, it is impor...
Article
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Khat (Catha edulis Vahl) is an evergreen shrub habitually ingested for its euphoric and stimulatory effects. The crop is grown in the Middle East, Somalia, East Africa and Ethiopia. It is referred to as Miraa in Kenya, while in Yemen it has several names like Qat, Kat, Kath, Gat, Chat and Tschat. It belongs to the sub-order Rosidae, family Celastra...
Article
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Cassava (Manihot esculenta Crantz) is a tropical root crop that serves as a food staple and a vital income source to resource deprived farmers in the tropics. Despite its importance, cassava production and consumption is faced by a myriad of biotic/abiotic constraints. Genetic transformation which can be applied to mitigate these challenges however...
Preprint
Full-text available
Cassava (Manihot esculenta Crantz) is a tropical root crop that serves as a food staple and a vital income source to resource deprived farmers in the tropics. Despite its importance, cassava production and consumption is faced by a myriad of biotic/abiotic constraints. Genetic transformation which can be applied to mitigate these challenges however...
Article
Full-text available
A simple and efficient plant regeneration system via direct organogenesis was established in finger millet using in vitro derived shoot apical meristems. Six varieties; GBK-043128, GBK-043094, GBK-043050, GBK-043137, GBK-043122 and GBK-043124 were evaluated. MS medium was used for cotyledonary germination. Maximum number of shoots (84.33%) was obse...
Article
Full-text available
A simple and efficient plant regeneration system via direct organogenesis was established in finger millet using in vitro derived shoot apical meristems. Six varieties; GBK-043128, GBK-043094, GBK- 043050, GBK-043137, GBK-043122 and GBK-043124 were evaluated. MS medium was used for cotyledonary germination. Maximum number of shoots (84.33%) was obs...
Article
Full-text available
In the present study, an efficient protocol for somatic embryogenesis and plant regeneration was established in six finger millet varieties (GBK-043137, GBK-043128, GBK-043124, GBK-043122, GBK-043094 and GBK-043050). Shoot tips from 3 days in vitro grown plants were inoculated on MS supplemented with various concentrations and combinations of α-nap...
Article
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Sweetpotato (Ipomoea batata) is an important, nutritionally rich vegetable crop, but severely affected by environmental stresses, pests and diseases which cause massive yield and quality losses. Genetic manipulation is becoming an important method for sweetpotato improvement. In the present study, a reproducible and highly efficient protocol for in...
Article
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The plant of the species Caesalpinia volkensii has diverse traditional use. This review aims at providing an overview of the plants traditional utility and scientific potential in managing both infectious and lifestyle diseases. It focuses on the plants hypoglycaemic activity, anti-malarial, anti-nociceptive and anti-inflamatory activity. The revie...
Article
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Khat (Catha edulis Vahl) is a plant that is habitually ingested for its euphoric and stimulatory effects. This study aimed at evaluating genetic diversity of selected khat cultivars grown in Embu and Meru Counties Mt Kenya region. This will ensure that genetic resources are preserved and secured for future so that benefits from such plants continue...
Article
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Amaranthus dubius , Vigna unguiculata, and Cucurbita pepo are traditionally used to manage obesity in Kenya but lack scientific validation to support their use. The aim of this study was to determine the antiobesity activity of methanolic leaf extracts of these plants in progesterone-induced obese mice. The activity of the methanolic leaf extracts...
Article
Full-text available
The present study was designed to assess the in vivo antiinflammatory, analgesic and antipyretic effect of the dichloromethane stem bark extract of Acacia mellifera on experimental animal model at three different dose levels of 50, 100 and 150mg/kg body weight respectively. In addition, phytochemical screening of the extract was done. The inflammat...
Article
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Lantana camara has been used traditionally to manage several diseases such as wound healing, inflammation and pain. However, its efficacy and safety has not been scientifically evaluated and clarified. The aim of this study was to determine the anti-inflammatory and antinociceptive activity as well as toxicity of aqueous extract of the plant using...
Article
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Introduction: Ximenia americana is a highly branched shrub mainly found in tropics of Asia, Africa, New Zealand, Central and South America among others. In most parts of Africa, X. americana is used in folklore to treat various disorders such as oedema, pain, fever, helminthiasis, diarrhea and burns among others. There is no published data on anti-...
Article
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Citation: Ouko RO, Koech SC, Arika WM, Njagi SM, Oduor RO, et al. (2017) Bioefficacy of Organic Extracts of Ocimum basilicum against Sitophilus zeamais. Abstract Ocimum basilicum plant extracts in methanol, hexane and methanol: hexane solvent blend were evaluated for their fumigant toxicities, repellent and adult emergence inhibition activities aga...
Article
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The indiscriminate use of Allium sativum in treatment of various diseases can pose a great danger to various body functions. Assessment of the effect of the extract on haematological and biochemical parameters can be used to explain the blood, liver and kidney related functions. Sub-chronic toxicity evaluation was done by orally administering extra...