Matheus Costa

Matheus Costa
University of Saskatchewan | U of S

DVM, PhD, DABVP

About

32
Publications
7,725
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195
Citations
Additional affiliations
September 2011 - present
University of Saskatchewan
Position
  • PhD Student

Publications

Publications (32)
Article
Full-text available
Swine ear-tip necrosis (ETN) is a disease of global presence and unclear aetiology. Little evidence is available regarding the nature of this disease. The aim of this work was to investigate if ETN is an infectious disease that could be replicated using a lesion macerate inoculum. A source farm with a history of ear-tip necrosis was identified and...
Article
Full-text available
Purpose The ocular surface microbiome has been described as paucibacterial. Until now, studies investigating the bacterial community associated with the ocular surface through high-throughput sequencing have focused on the conjunctiva. Conjunctival samples are thought to reflect and be representative of the microbiome residing on the ocular surface...
Article
Full-text available
Historically described as a commensal of the swine upper respiratory tract, Streptococcus equi subspecies zooepidemicus was previously reported as an important swine pathogen only in Asia. Here we report the isolation and whole genome characterization of S. equi subsp. zooepidemicus associated with a sudden death outbreak in pigs in Canada.
Article
Full-text available
Swine dysentery (SD) is a global, production-limiting disease of pigs in commercial farms. It is associated with infection by Brachyspira hyodysenteriae and B. hampsonii, and characterized by mucohaemorrhagic diarrhea and colitis, SD prevention, treatment or control relies heavily on antimicrobials as no commercial vaccines are available. This is l...
Article
Full-text available
Salmonella enterica serovar Typhimurium is an animal welfare and public health concern due to its ability to parasite livestock and potentially contaminate pork products. To reduce Salmonella shedding and the risk of pork contamination, antibiotic therapy is used and can contribute to antimicrobial resistance. Here we hypothesized that immune syste...
Preprint
Full-text available
Historically described as a commensal of the swine upper-respiratory tract, Streptococcus equi subsp. zooepidemicus was only reported previously in Asia as an important swine pathogen. Here we report the isolation and whole genome characterization of Streptococcus equi subsp. zooepidemicus associated with a sudden death outbreak in pigs in North Am...
Conference Paper
Full-text available
Santa Catarina (SC) raises approximately 30% of all pigs produced in Brazil, and is responsible for 50% of total pork exports. In recent years, Salmonella 4,[5],12:i:- which is considered to be a serologic variant of S. enterica serovar Typhimurium, has emerged as an important cause of salmonellosis in pigs. Between 2012 and 2016, 62.85% (22/35) of...
Article
Objective To characterize the bacterial community residing on the conjunctiva of clinically healthy dogs. Methods Bacterial DNA from conjunctival swabs of 10 dogs with normal ocular examinations (both OD and OS, n = 20) was extracted, and 16S rRNA amplicons were sequenced using Illumina MiSeq 600. Resulting data were subjected to quality control s...
Chapter
Models have been extensively used to investigate disease pathogenesis. Animal models are costly, require extensive logistics for animal care, and samples are not always suitable for different analytical techniques or to answer the research question. In vitro cell culture models are generally focused on recreating a specific characteristic of an org...
Article
Full-text available
Background Most interactions between pathogenic microorganisms and their target host occur on mucosal surfaces of internal organs such as the intestine. In vitro organ culture (IVOC) provides an unique tool for studying host-pathogen interactions in a controlled environment. However, this technique requires a complex laboratory setup and specialize...
Article
Full-text available
Background The development of a mouse model as an in vivo pathogenicity screening tool for Brachyspira spp. has advanced the study of these economically important pathogens in recent years. However, none of the murine models published to date have been used to characterize the clinical signs of disease in mice, instead focusing on pathology followi...
Article
Full-text available
Introduction Swine dysentery caused by Brachyspira hyodysenteriae is a production limiting disease in pig farming. Currently antimicrobial therapy is the only treatment and control method available. Objective The aim of this study was to characterize the metabolic response of porcine colon explants to infection by B. hyodysenteriae. Methods Porci...
Article
Mucohaemorrhagic diarrhea in pigs caused by Brachyspira spp. has a global distribution, and an economic impact on affected farms due to poor performance of animals. Demonstrations that "B. hampsonii" is pathogenic have been achieved using in vivo animal models, but a critical knowledge gap exists regarding the pathogenic mechanisms employed by Brac...
Article
The intestinal mucosa comprises a complex assemblage of specialized tissues that interact in numerous ways. In vitro cell culture models are generally focused on recreating a specific characteristic of this organ and do not account for the many interactions between the different tissues. In vitro organ culture (IVOC) methods offer a way to overcome...
Article
Full-text available
"Brachyspira hampsonii" causes disease indistinguishable from swine dysentery, and the structure of the intestinal microbiome likely plays a role in determining susceptibility of individual pigs to infection and development of clinical disease. The objectives of the current study were to determine if the pre-inoculation fecal microbiota differed be...
Article
Full-text available
Background “Brachyspira hampsonii”, discovered in North America in 2010 associated with dysentery-like illness, is an economically relevant swine pathogen resulting in decreased feed efficiency and increased morbidity, mortality and medication usage. “B. hampsonii” clade II strain 30446 has been shown to be causally associated with mucohemorrhagic...
Article
Full-text available
Brachyspira associated diarrhea is a re-emerging concern for Canadian swine producers. To identify critical control points for reducing the impact of Brachyspira on production, improved diagnostic tools and a better understanding of the on-farm epidemiology of these pathogens are required. A cross-sectional study was conducted for the detection of...
Article
Full-text available
Mucohaemorrhagic diarrhea caused by swine dysentery, is a severe production limiting disease of swine. Recently, pigs in western Canada with clinical signs indistinguishable from swine dysentery were observed. Despite the presence of spirochetes on fecal smears, recognized spp. including could not be identified. A phylogenetically distinct , called...

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