Mateusz Lukaszyk

Mateusz Lukaszyk
  • MD
  • Medical University of Białystok

About

33
Publications
3,897
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425
Citations
Current institution
Medical University of Białystok

Publications

Publications (33)
Article
Full-text available
Background: Allergen immunotherapy (AIT) is a well-established and efficient method of causative treatment for allergic rhinitis, asthma and insect venom allergy. Traditionally, a recent history of malignant neoplasm is regarded as a contraindication to AIT due to concerns that AIT might stimulate tumor growth. However, there are no data confirming...
Article
Introduction and objective: Evaluation of lanadelumab efficacy in preventing angioedema attacks in patients with severe hereditary angioedema due to C1-inhibitor deficiency in Poland and descriptive analysis of this group of patients. Materials and methods: Retrospective analysis of patients treated with lanadelumab in Poland. Data were acquired fr...
Article
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Oxygen therapy is the primary method of treating acute respiratory failure during Sars-CoV-2 infection. Depending on the patient’s condition, treatment may be carried out using traditional nasal cannulas, oxygen masks, non-invasive ventilation or mechanical ventilation. A relatively modern method that has been used worldwide for about 10 years is H...
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Aim The aim of our retrospective study was search for new prognostic parameters, which can help quickly and cheaply identify patients with risk for severe course of SARS-CoV-2 infection. Materials and Methods The following peripheral blood combination biomarkers were calculated: NLR (neutrophil/lymphocytes ratio), LMR (lymphocyte/monocyte ratio),...
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Introduction Various diagnostic tools are used to assess the severity of COVID-19 symptoms and the risk of mortality, including laboratory tests and scoring indices such as the Modified Early Warning Score (MEWS). The diagnostic value of inflammatory markers for assessing patients with different severity of COVID-19 symptoms according to the MEWS w...
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Background: Almond allergy is common and can manifest in two different forms. Primary almond allergy has been reported to be associated with sensitization to almond legumin Pru du 6. In birchendemic regions, there is a link between birch-pollinosis which is likely based on a cross-reactive Bet v 1 homologue, a yet unidentified allergen in almond....
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Background: Self-management is an appealing strategy for prevention of asthma exacerbations. This study aimed to evaluate the feasibility and safety of a portable spirometer for unsupervised home spirometry measurements among patients with asthma. Methods: A multi-center, prospective, single-arm, open study recruited 86 patients with controlled...
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Introduction: Progressing deterioration of the lung function, dyspnoea, cough, wheezing and chest tightness are the main features of asthma exacerbations. The first step in the prevention of severe asthma exacerbations is to intensify the anti-inflammatory treatment with high doses of inhaled corticosteroids (ICS). Aim: To assess the efficacy of...
Article
Idiopathic anaphylaxis is a severe, life-threatening systemic or generalized immediate hypersensitivity reaction with symptoms similar to resembling other forms of anaphylaxis. It concers approximately 30-60% of cases in adults and 20% of cases in children. In the pathogenesis of idiopathic anaphylaxis, alpha-gal syndrome, mastocytosis, diseases as...
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Background/aims: Zonulin is the only known regulator of intestinal permeability. It is also considered as a potential inflammatory marker in several conditions such as diabetes and inflammatory bowel syndrome. The aim of the study was to investigate zonulin levels in patients with early stages of CKD and its possible correlation with inflammation,...
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Purpose: The aim of the study was to assess GDF-15 and iron status in patients in early stages of chronic kidney disease with a particular emphasis on elderly population in association of classic iron status parameters with novel iron homeostasis biomarkers and inflammatory parameters. Methods: Serum concentrations of GDF-15, iron (Fe), transfer...
Article
Mepolizumab (Nucala) is a humanized monoclonal antibody against IL-5, which plays a significant role in inflammation in the airways of asthmatic patients. This drug has a high affinity and specificity to this interleukin. It inhibits the attachment of IL-5 receptor alpha subunit on the surface of eosinophils. The results of the clinical phase II an...
Article
Allergic rhinitis is defined as a clinical syndrome associated with IgE-dependent inflammation of the nasal mucosa caused by the environmental allergens. Antihistaminic drugs (AH) belong to the basic drugs used in the treatment of allergic rhinitis (including seasonal rhinitis). The effectiveness of modern oral AH is associated with both a potent r...
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Introduction: Fibroblast growth factor 23 (FGF-23) levels are elevated in impaired renal function. Inflammation and iron are potential regulators of FGF-23. The aim of the study was to evaluate the association between FGF-23 concentration, novel iron status biomarkers and inflammatory parameters among patients with early stages of chronic kidney di...
Article
Introduction. Omalizumab has a well-established role in treating severe allergic asthma. Despite many years of experience and research on the drug the optimal duration of treatment with anti-IgE has not been determined yet. Literature data on the subject reports cases of loss of asthma control after cessation of treatment, regardless of its duratio...
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One of the most common causes of anemia of chronic disease (ACD) is chronic kidney disease. The main pathomechanism responsible for ACD is subclinical inflammation. The key element involved in iron metabolism is hepcidin, however, studies on new indices of iron status are in progress.The aim of the study was to assess the iron status in patients in...
Article
Introduction. Angioedema symptoms include subcutaneous and submucosal edema,usually well demarcated,often asymmetric and most commonly affecting the face,the upper respiratory and the gastrointestinal tract. Aim. The aim of the study was to determine the prevalence and causes of angioedema (AE),with and without urticarial,among patients hospitalize...
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Anaphylaxis is a severe,life-threatening systemic or generalized immediate hypersensitivity reaction. The incidence of anaphylaxis has increased significantly over the past 20 years. Foods are the most common cause of anaphylaxis. The paper discusses the epidemiology of food-induced anaphylaxis and pathomechanism with particular reference to the ro...
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Introduction: Omalizumab is a monoclonal anti-immunoglobulin E antibody developed for the treatment of severe allergic asthma. The number of exacerbations used as a parameter of omalizumab therapy efficacy may be insufficient in many cases due to a relatively short time to first evaluation (16 weeks). Therefore, it is advisable to look for paramet...
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The recent data suggest that the asthma inflammation process located in the bronchi closely correlates with activation of the coagulation system. Blood platelets, the smallest and anucleated morphotic constituents of blood, are not merely an element of haemostasis. The platelets are also involved in allergic inflammation. In this article we discuss...
Article
Cough, wheezing and dyspnea followed by physical activity are the syndromes as well as control parameters typical of asthma. Strenuous exercise evokes a decrease in temperature of the air passing through lower airways, desiccating the airway’s mucus membrane and increasing it’s osmolarity leading to mast cells degranulation, mediator release, bronc...
Article
Physical exercise may cause exacerbation of asthma symptoms. In patients with asthma, regular recreational sport does not have a negative impact on the respiratory system, but rather improves overall health and physical development. However, this requires the proper asthma treatment, the skilful use of bronchospasm-preventing drugs, appropriate cho...
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Asthma is a heterogeneous disease with variable characteristics such as lung function, symptoms and control, body weight, pattern of inflammation, and response to treatment. Brittle asthma is one of clinical phenotypes of asthma with unclear pathogenic mechanisms and appropriate treatment. Analysis of 2 described cases suggests that omalizumab coul...
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Some hematological disorders are initially manifested by specific allergic reactions. The following review presents the hypereosinophilic conditions, elevated levels of IgE and increased levels of tryptase as markers of allergy observed in hematological diseases.
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Introduction. The assessment of exhaled nitric oxide (FENO) is a simple and noninvasive diagnostic test. Reports concerning the usefulness of exhaled nitric oxide determination for monitoring treatment in asthmatic patients are not unequivocal. Aim. The aim of this study was the assessment of usefulness of exhaled nitric oxide measurements in long...
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Asthma is a heterogeneous inflammatory disorder of the conducting airways. Owing to modern treatment methods, most of the asthmatic patients achieves the desirable level of disease control. However, there is a group of ca. 5% to 10% of patients with asthma who do not respond to the standard GINA treatment. The aim of this article is to present the...
Article
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Asthma is a chronic inflammatory disease of the airways. Nearly 60% of asthma cases have allergic background. About 5-10% of patients treated for asthma do not respond well to standard treatment suggested by GINA 2006 guidelines. The article reviews the anti-IgE therapy for patients with severe/difficult asthma as well as points out the prospects o...
Article
Full-text available
Introduction. Omalizumab is a humanized monoclonal anti-IgE antibody used in the treatment of patients with severe allergic asthma. Aim. The aim of this study was to evaluate the concentration of free IgE and omalizumab in serum of patients with severe allergic asthma during treatment with omalizumab. Materials and methods. The study was conducted...

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