Máté Mackei

Máté Mackei
University of Veterinary Medicine Budapest · Department of Physiology and Biochemistry

Doctor of Veterinary Medicine

About

19
Publications
1,136
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44
Citations

Publications

Publications (19)
Article
Short chain fatty acid (SCFA) butyrate has various beneficial effects on the gut microbiota as well as on the overall health status and metabolism of the host organism. The modulatory role of butyrate on gut barrier integrity reflected by tight junction protein expression has been already described in mammalian species. However, there is limited in...
Article
Full-text available
The intestinal microbiome of dogs can be influenced by a number of factors such as non-starch polysaccharides as well as some non-digestible oligo- and disaccharides. These molecules are only decomposed by intestinal anaerobic microbial fermentation, resulting in the formation of volatile fatty acids (VFAs), which play a central role in maintaining...
Article
Virus induced damage triggered by excessive inflammation and free radical production is a major threat in the poultry industry, leading to low productivity even in vaccinated flocks. The purpose of the study was to induce inflammation with the viral double-stranded RNA analog polyinosinic-polycytidylic acid (poly I:C) on chicken primary hepatocyte...
Article
Full-text available
Influencing the endocrine metabolic regulation of chickens by nutritional factors might provide novel possibilities for improving animal health and productivity. This study was designed to evaluate the impact of dietary cereal type (wheat-based (WB) vs. maize-based (MB) diets), crude protein level (normal (NP) vs. lowered (LP)), and sodium (n-)buty...
Article
Full-text available
The liver with resident tissue macrophages is the site of vivid innate immunity, activated also by pathogen-associated molecular patterns (PAMPs) leaking through the intestinal barrier. As gut-derived inflammatory diseases are of outstanding importance in broiler chickens, the present study aimed to establish a proper hepatic inflammatory model by...
Article
As heat stress is a major emerging issue in poultry farming, investigations on the molecular mechanisms of the heat-triggered cellular response in chickens are of special importance. In the present study, 32-day-old Ross 308 broiler chickens were subjected to 37 °C environmental temperature combined with 50% relative humidity for 4 or 8 h respectiv...
Article
Full-text available
The function of the transmembrane serine protease matriptase is well described in mammals, but it has not been elucidated in avian species yet. Hence, the aim of the present study was to assess the effects of the 3-amidinophenylalanine (3-AphA)-type matriptase inhibitors MI432 and MI460 on the inflammatory and oxidative state of chicken primary hep...
Article
Full-text available
The intestinal microbiome can influence the efficiency and the health status of its host's digestive system. Indigestible non-starch polysaccharides (NSP) serve as substrates for bacterial fermentation, resulting in short-chain fatty acids like butyrate. In broiler's nutrition, dietary crude protein (CP) and butyrate's presence is of particular int...
Article
Full-text available
Bioactive compounds such as benzoquinone derivates presented in fermented wheat germ extract (FWGE) have several positive effects on overall health status of humans and animals alike. Since available data regarding the antioxidant activity of FWGE are limited, the aim of our study was to investigate its effects on the cellular redox homeostasis app...
Article
Full-text available
Heat stress is one of the most important issues in broiler flocks impairing animal health and productivity. On a cellular level, excess heat exposure can trigger heat shock response acting for the restoration of cell homeostasis by several mechanisms, such as affecting heat shock protein synthesis, redox homeostasis and pro-inflammatory cytokine pr...
Article
Full-text available
Trichothecene mycotoxins such as T-2 toxin cause severe problems for agriculture, as well as for veterinary medicine. As liver is one of the key organs in metabolism, the main aim of our study was to investigate the immunomodulatory and cytotoxic effects of T-2 toxin, using primary hepatocyte mono-culture and hepatocyte—nonparenchymal cell (predomi...
Article
Full-text available
Drug-metabolizing cytochrome P450 (CYP) enzymes are especially important in wild animals as they are directly exposed to environmental pollutants and bioactive molecules of plants. Our main goal was to monitor the activity of certain CYP enzymes in wild boar compared to domestic swine, and to assess various modulatory factors of xenobiotic biotrans...
Article
Full-text available
The pancreatic secretion of insulin, a key endocrine regulator of metabolism and growth, can be greatly influenced by the gut-derived incretin hormones, namely by GIP (Glucose-dependent Insulinotropic Peptide) and GLP-1 (Glucagon-like Peptide 1). As insulin is a major stimulator of growth, affecting its producion may be of special importance in foo...
Data
Concentration of glucose, insulin, GLP-1 and GIP in the blood plasma of chickens at different time points (raw data). (XLSX)
Data
Concentration of glucose, insulin, GLP-1 and GIP in the blood plasma of rabbits at different time points (raw data). (XLSX)
Article
Full-text available
This study investigates the metabolic effects of maize- or wheat-based diets with normal (NP) and lowered (LP) dietary crude protein level [the latter supplemented with limiting amino acids and sodium (n-)butyrate at 1.5 g/kg diet] at different phases of broiler fattening. Blood samples of Ross 308 broilers were tested at the age of 1, 3 and 6 week...
Article
In the present literature review, the authors discuss the various general and specific effects of the T-2 toxin on animal health, focusing on poultry. T-2 toxin is one of the most toxic trichothecene mycotoxin produced by various Fusarium species. These are destructive pathogens on cereal crops and other commodities and produce the toxins before an...
Article
A szerzők jelen dolgozatukban bemutatják az általuk fejlesztett, ingyenesen felhasználható, internetes hőstressz-előrejelzési rendszert. A globális klímaváltozás egyik következménye, hogy a hőstresszes napok számának növekedése kedvezőtlenül befolyásolja az állati termelést. A bemutatott rendszer célja, hogy információkkal támogassa a gyakorló koll...
Article
Background: The global climate change has numerous negative effects on human and animal health. The Intergovernmental Panel on Climate Change (IPCC) reported that - beside the spatial distribution changes of vector-borne infections - one of the most threatening consequences of global warming on the health is the increased occurrence of heat stresse...

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