Massimo Cocchi

Massimo Cocchi
University of Bologna | UNIBO · Department of Veterinary Medical Sciences DIMEVET

MD

About

162
Publications
50,652
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1,958
Citations
Additional affiliations
January 1990 - December 2011
University of Bologna
Position
  • Contract Professor
January 1985 - December 2000
Scottish Agricultural College
Position
  • Professor

Publications

Publications (162)
Article
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This Special Issue included articles discussing several important psychiatric phenomena whose elucidation can be provided by cellular and subcellular molecular mechanisms [...]
Article
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Multiple Sclerosis is a chronic neurological disease characterized by demyelination and axonal loss. This pathology, still largely of unknown etiology, carries within it a complex series of etiopathogenetic components of which it is difficult to trace the origin. An inflammatory state is likely to be the basis of the pathology. Crucial elements of...
Article
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The aim of this brief narrative commentary is to discuss some aspects involved in depression. It is increasingly evident that the phenomenon of mood disorders, despite its unequivocal genetic origin, slips into a multifactorial set of biochemical and molecular events that involve the whole organism. A vast literature has provided evidence that reco...
Article
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Evidence support that brain membrane fatty acids play a crucial role in psychopathologies such as depression and anxiety disorders. Although the pathogenesis of depression is not still defined, drugs commonly used to reduce arachidonic turnover in the brain can control mood disorders, such as depression. Both astrocytes and mast cells release arach...
Preprint
Full-text available
We investigate the possible influence of poly unsaturated fatty acids (PUFAs) in the lipid bilayer of cell membranes on the conduction properties of the selectivity filter of voltage gated ion channels. Any change of this conductivity can have major consequences on electrical signalling in brain and other cells. At the microscopic level a change in...
Article
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Accompanying human beings since the Paleolithic period, dogs has been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses on the connections between the gut microbiome layout and host behavior, we profiled the phylogenetic composition and structure of the c...
Article
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Behavioral studies demonstrate that not only humans, but all other animals including dogs, can suffer from depression. A quantitative molecular evaluation of fatty acids in human and animal platelets has already evidenced similarities between people suffering from depression and German Shepherds, suggesting that domestication has led dogs to be sim...
Article
The question about Linoleic Acid, which remains arguable, is whether the Linoleic Acid is inversely correlated to the Cardiovascular Disease or not and whether increasing the intake over the Recommended Daily Allowance (RDA) is positive or negative. The scientific literature, past and recent, is still controversial about the matter. To try to answe...
Article
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Lifespan has been a topic of scientific interest for about a century and, in this regard, hundreds of theories have been expressed, calling into question numerous causes of aging, but none of which appears to be decisive. Different species can have hugely different species-specific life spans, but several eusocial species, e.g. honey bees, show ver...
Article
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Mammalian gastrointestinal tract is colonized by a large number of microorganisms, known as gut microbiota, that play a key role in the physiological and pathological states. In particular, the gastrointestinal tract of dogs and cats harbors a complex and highly biodiverse microbial ecosystem. Recent studies see it involved in a wide range of life...
Preprint
Full-text available
Accompanying human beings since the Paleolithic period, dogs have been recently regarded as a reliable model for the study of the gut microbiome connections with health and disease. In order to provide some glimpses of the connections between the gut microbiome layout and host behavior, we profiled the phylogenetic composition and structure of the...
Article
Autism spectrum disorder (ASD) subjects can present temporary behaviors of acute agitation and aggressiveness, named problem behaviors . They have been shown to be consistent with the self-organized criticality (SOC), a model wherein occasionally occurring “catastrophic events” are necessary in order to maintain a self-organized “critical equilibri...
Article
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Living organisms tend to find viable strategies under ambient conditions that optimize their search for, and utilization of, life-sustaining resources. For plants, a leading role in this process is performed by auxin, a plant hormone that drives morphological development, dynamics, and movement to optimize the absorption of light (through branches...
Article
Full-text available
Living organisms tend to find viable strategies under ambient conditions that optimize their search for, and utilization of, life-sustaining resources. For plants, a leading role in this process is performed by auxin, a plant hormone that drives morphological development, dynamics, and movement to optimize the absorption of light (through branches...
Article
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The Autism Spectrum Disorder (ASD) represents a set of lifelong disorders. In particular, subjects with ASD can display momentary behaviors of acute agitation and aggressiveness called crisis behaviors. These events are problematic for the subject and care providers but little is known about their occurrence, namely, possible relations among intens...
Article
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Consciousness is the greatest enigma in human history. For centuries scientists and researchers have tried to describe it without coming to conclusions. In the last years with the neurosciences development, consciousness has become the common goal of numerous studies. But consciousness has always been studied only in humans, but after "Cambridge De...
Article
In this paper, we present some diverse points of view on the issue of the quantum brain.The paper is structured in the form of opening statements by each of the co-authors followed by comments and critique presented by the other co-authors. The main focus of the discussion is on the interplay between the state of being alive and consciousness, both...
Article
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In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely tuned in a healthy brain. We also argue that subtle changes in the composition of the membrane’s fatty acids may lead to down-stream effects c...
Article
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Time is what might be called a perception, just a quantum, which is measured only on the recall of the already experienced emotions and that makes divine existence credible. With the creation, God has designed the future time, he gave dimension to it and only God is awareness keeper. This consideration opens a critical prerequisite to the understan...
Article
Despite numerous studies carried out over the last 15 years in veterinary medicine, the pathogenesis of canine Inflammatory Bowel Disease (IBD) has still not been completely elucidated. In particular, unlike what has been demonstrated in human medicine, the influence of serotonin on clinical signs in canine IBD has not yet been clarified. The objec...
Article
The accepted paradigms of mainstream neuropsychiatry appear to be incompletely adequate and in various cases offer equivocal analyses. However, a growing number of new approaches are being proposed that suggest the emergence of paradigm shifts in this area. In particular, quantum theories of mind, brain and consciousness seem to offer a profound ch...
Article
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The present work deals with the complexity of the arguments underlying the meaning of the quantum paradigm of psychopathology. In particular, the quantum approach to the understanding of the brain and consciousness, seems to present convergence of thinking of many scientists and also seems to be the most promising way in the approach of future rese...
Article
Full-text available
In this paper we present a mechanistic model that integrates subneuronal structures, namely ion channels, Membrane fatty acids, lipid rafts, G proteins and the cytoskeleton in a dynamic system that is finely tuned in a healthy brain. We also argue that subtle changes in the composition of the membrane’s fatty acids may lead to down-stream effects c...
Article
Full-text available
This Editorial highlights how difficult is the correlation between Mood Disorder and Ischemic Heart Disease. In particular, it highlights the serious problem of suicide risk. This long-standing problem, object of controversy in the scientific literature, requires insights that should avoid simple surveys entrusted to the questionnaires, and the sub...
Article
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The aim of this letter is to highlight some new aspects of the "cholesterol" risk pointing out some experimental evidences, which seem to reduce its importance in Cardiovascular Disease.
Article
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Objectives: Alcoholism is one of the most devastating diseases with high incidence, but knowledge of its pathology and treatment is still plagued with gaps mostly because of the inherent limitations of research with patients. We developed an animal model for studying liver histopathology, Hsp (heat-shock protein)-chaperones involvement, and respon...
Article
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Cell membrane's fatty acids (FAs) have been carefully investigated in neurons and platelets in order to study a possible connection to psychopathologies. An important link between the FA distribution and membrane dynamics appears to emerge with the cytoskeleton dynamics. Microtubules (MTs) in particular have been implicated in some recent quantum c...
Chapter
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To remain in the distinction, often denied only in the intentions, between erklären (causal explanation) and verstehen (psychological comprehension) means ignoring the prolific acquisitions of complexity theory; above all it means remaining prisoner to the “myth of the sense”, on whose basis life experiences, the phenomenological approaches, the ph...
Article
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In this paper we discuss the role of the fatty acid composition of brain cells and in platelets in the emergence of psychiatric disorders such as major depression and the bipolar disorder. We argue that the linoleic acid concentration plays the role of a control parameter and there is a critical value of the linoleic acid concentration that determi...
Article
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The aim of this letter is to stimulate the psychiatrists to a greater awareness on the biomolecular aspects of the psychopathology. The letter highlights the inconsistencies of the DSM-V, where, and once again, it ignores the biological consistency of the “psychopathological” phenomenon. It is also underlined that the diagnostic error, in course of...
Article
After 40 years since I entered the glorious Institute of Biochemistry, University of Bologna and began to deal with lipids, fatty acids and their tissue and cellular metabolism. That was the time of the demonization of saturated fat and cholesterol; substances that were considered "hurt" the body. I must say, for intellectual honesty, that our "Sch...
Article
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The pathogenesis of Hashimoto's thyroiditis includes autoimmunity involving thyroid antigens, autoantibodies, and possibly cytokines. It is unclear what role plays Hsp60, but our recent data indicate that it may contribute to pathogenesis as an autoantigen. Its role in the induction of cytokine production, pro- or anti-inflammatory, was not elucida...
Article
L'articolo è disponibile gratuitamente qui: http://www.economiaediritto.it/neurodiritto-lo-sviluppo-di-una-nuova-disciplina/
Article
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Probiotics (PB) are living microorganisms that act as a commensal population in normal intestines and confer numerous beneficial effects on the host. The introduction of probiotics in the treatment of inflammatory bowel disease (IBD) prolongs remission. The aim of this study was to investigate the intestinal and hepatic effects of PB supplementatio...
Article
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Recent research on the contiguity between man and animal provides strong evidence for the studies carried out by Paolo Sotgiu Institute for Research in Quantitative & Quantum Psychiatry & Cardiology, L.U.de.S. University, Lugano, Switzerland, in collaboration with the Department of Veterinary Medical Science, University of Bologna, Italy. The works...
Article
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The purpose of this paper is to connect the experimental evidence concerning brain phospholipids fatty acids composition by comparing the first warm-blooded animal in the phylogeny (birds) with the human brain at various ages of life (from the fetal period until the eightieth year of age). The particularity of our investigation is an almost unique...
Article
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Aim of the study: The main purpose of this work was to verify, through the study of three fatty acids of platelets (namely: Palmitic Acid—PA, Linoleic Acid—LA, Arachidonic Acid—AA) the ability to distinguish adult subjects with Major Depression (MD) from those with Bipolar Disorder (BD), using an artificial neural network (Self Organizing Map—SOM)...
Article
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Inflammatory bowel disease (IBD) consists of two distinct clinical forms, ulcerative colitis (UC) and Crohn’s disease (CD), with unknown aetiology, which nevertheless are considered to share almost identical pathophysiological backgrounds. Up to date, a full coherent mechanistic explanation for IBD is still lacking, but people start to realize that...
Article
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In this work, we propose that for further studies of the physiopathology and treatment for inflammatory bowel diseases, an integral view of the conditions, including the triad of microbiota-heat shock proteins (HSPs)-probiotics, ought to be considered. Microbiota is the complex microbial flora that resides in the gut, affecting not only gut functio...
Article
Chitosan can favorably modulate plasma lipids, but the available data are not conclusive. We evaluated the effect of chitosan on plasma lipids and lipoproteins in 28 patients with plasma triglyceride levels >150 mg/dL (mean age: 63 ± 12 years), not taking other lipid-lowering agents. All patients received a chitosan derived from fungal mycelium (Xa...
Conference Paper
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The QPP conference in Palermo has marked a definite turning point in the foundational perspective of many of the group’s participants regarding the study of psychopathology, particularly mood disorders. One reason for this turning point stems from a realization that two of the most common forms of psychopathology, major depression and bipolar disor...
Article
The history of epilepsy appears to be mainly a progressive detachment from gods. Hippocratic medicine, for its part, stands out as the first technique (techne) able of unfettering men from the divine by explaining illness with natural and rational laws: the sacred disease, that is to say epilepsy, does not have divine characteristics, but rather a...
Article
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This work suggests the possibility of the existence of contiguity in the molecular evolution of consciousness, between man and animal. From the experimental point of view and in terms of hypotheses, it seems that many elements lead to considerations about a common molecular evolutionary origin of the consciousness in animals and humans. It seems, a...
Article
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The evolution in the history of nutrition knowledge towards dairy products, is strictly related to the socio-cultural development of humans. In fact, milk and butter have accompanied humans since ancient times, which traces of the consumption of such products are dated back about the earliest times after the last (glaciation) ice age, while the app...
Article
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In this paper we consider the results obtained by biochemical experimental data on platelet membrane fatty acids processed by a Self Organizing Map (SOM) from apparently healthy, bi-polar (BD) and major depressive subjects (MDD). The SOM shows that major depressive subjects belong to an area which is completely disconnected from that of healthy and...
Article
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The purpose of this paper is to discuss the biological plausibility of the pace of creation written in the genesis. A fascinating hypothesis is made on the central role of serotonin as a guide, as the director of the phenomena that enable the best use of light by the plant world, the growth, the regulation of mood in the complex molecular interacti...
Article
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This work aims to be a reflection concerning a remarkable similarity between platelet and neuron. Through a series of experimental tests which have affected the fatty acid composition of the membrane of platelets, it was possible to pro-vide a contribution to the scientific literature, which had already reported strong similarities between platelet...
Article
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This paper shares the history of a researcher and his groundbreaking discoveries which have been discussed for a long time that started during a conversation with a dear friend, Kary Mullis. Using biological markers, the research involved the ability to classify and differentiate depressive disorders from apparent normality. This research crossed t...
Article
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This paper focuses on aspects of quantitative and quantum approaches to the phenomenon of hallucination. Consideration is given to the molecular hypothesis of consciousness, to consciousness as perception of the self, and to hallucinatory perception as consciousness detached from reality. The possible transitional sequence viscosity of membrane / G...