Massimiliano Pierobon

Massimiliano Pierobon
University of Nebraska at Lincoln | NU · Department of Computer Science and Engineering

Ph.D. in Electrical and Computer Engineering

About

74
Publications
17,126
Reads
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3,219
Citations
Additional affiliations
August 2009 - August 2013
Georgia Institute of Technology
Position
  • Research Assistant

Publications

Publications (74)
Article
Molecular Communication (MC) is a communication paradigm based on the exchange of molecules. The implicit biocompatibility and nanoscale feasibility of MC make it a promising communication technology for nanonetworks. This paper provides a closed-form expression for the information capacity of an MC system based on the free diffusion of molecules,...
Article
Full-text available
The goal of a Drug Delivery System (DDS) is to convey a drug where the medication is needed, while, at the same time, preventing the drug from affecting other healthy parts of the body. Drugs composed of micro or nano-sized particles (particulate DDS) that are able to cross barriers which prevent large particles from escaping the bloodstream are us...
Article
Full-text available
Molecular communication (MC) will enable the exchange of information among nanoscale devices. In this novel bio-inspired communication paradigm, molecules are employed to encode, transmit and receive information. In the most general case, these molecules are propagated in the medium by means of free diffusion. An information theoretical analysis of...
Article
Full-text available
Molecular communication (MC) is a promising bio-inspired paradigm, in which molecules are used to encode, transmit and receive information at the nanoscale. Very limited research has addressed the problem of modeling and analyzing the MC in nanonetworks. One of the main challenges in MC is the proper study and characterization of the noise sources....
Article
Full-text available
Molecular communication is a promising paradigm for nanoscale networks. The end-to-end (including the channel) models developed for classical wireless communication networks need to undergo a profound revision so that they can be applied for nanonetworks. Consequently, there is a need to develop new end-to-end (including the channel) models which c...
Article
The human gut functions through a complex system of interactions between the host human tissue and the microbes which inhabit it. These diverse interactions are difficult to model or examine under controlled laboratory conditions.
Article
Full-text available
Information transmission and storage have gained traction as unifying concepts to characterize biological systems and their chances of survival and evolution at multiple scales. Despite the potential for an information-based mathematical framework to offer new insights into life processes and ways to interact with and control them, the main legacy...
Article
The COVID-19 pandemic in the last year has brought along numerous challenges on all fronts for humanity. Besides the high number of fatalities, economic and societal impact, the virus has also raised a question on the current approaches and methodologies for combatting pandemics. An important factor in this global fight against the pandemic, is the...
Article
Motivation Empowered by advanced genomics discovery tools, recent biomedical research has produced a massive amount of genomic data on (post-)transcriptional regulations related to transcription factors, microRNAs, long non-coding RNAs, epigenetic modifications and genetic variations. Computational modeling, as an essential research method, has gen...
Article
Full-text available
Hundreds of millions of people worldwide are affected by viral infections each year, and yet, several of them neither have vaccines nor effective treatment during and post-infection. This challenge has been highlighted by the COVID-19 pandemic, showing how viruses can quickly spread and impact society as a whole. Novel interdisciplinary techniques...
Preprint
Full-text available
Hundreds of millions of people worldwide are affected by viral infections each year, and yet, several of them neither have vaccines nor effective treatment during and post-infection. This challenge has been highlighted by the COVID-19 pandemic, showing how viruses can quickly spread and how they can impact society as a whole. Novel techniques that...
Article
Full-text available
The design of communication systems capable of processing and exchanging information through molecules and chemical processes is a rapidly growing interdisciplinary field, which holds the promise to revolutionize how we realize computing and communication devices. While molecular communication (MC) theory has had major developments in recent years,...
Chapter
Molecular communication (MC) is a new communication paradigm where, opposite to radio or optical communication, the information flow is based on the molecules exchange and chemical interactions. Thanks to the high biological compatibility and nano-scale feasibility, MC is a promising communication technology for health applications, from disease de...
Conference Paper
The natural communication ability of cells is explored in this paper by providing preliminary results in the estimation of the Mutual Information (MI) of signaling pathway communication channels. These results, based on an application of Molecular Communication (MC) and information theory concepts to multi-scale integrated Flux-Balance Analysis (iF...
Article
Full-text available
This article presents fundamental challenges in the development of a self-sustainable and biocompatible network infrastructure to interconnect the next-generation electrical and biological wearable and implantable devices, i.e., the Internet of Bio-NanoThings. The direct contact of IoBNT devices with the human body, where the cells naturally commun...
Article
The natural communication ability of cells is explored in this paper by providing preliminary results in the estimation of the Mutual Information (MI) of signaling pathway communication channels. These results, based on an application of Molecular Communication (MC) and information theory concepts to multi-scale integrated Flux-Balance Analysis (iF...
Article
Full-text available
The design of communication systems capable of processing and exchanging information through molecules and chemical processes is a rapidly growing interdisciplinary field, which holds the promise to revolutionize how we realize computing and communication devices. While molecular communication (MC) theory has had major developments in recent years,...
Preprint
Full-text available
The design of communication systems capable of processing and exchanging information through molecules and chemical processes is a rapidly growing interdisciplinary field, which holds the promise to revolutionize how we realize computing and communication devices. While molecular communication (MC) theory has had major developments in recent years,...
Article
Full-text available
The biocompatibility and nanoscale features of Molecular Communication (MC) make this paradigm, based on molecules and chemical reactions, an enabler for communication theory applications in the healthcare at its biological level (e.g., bimolecular disease detection/monitoring and intelligent drug delivery). However, the adoption of MC-based innova...
Article
Over the past 10 years, molecular communication (MC) has established itself as a key transformative paradigm in communication theory. Inspired by chemical communications in biological systems, the focus of this discipline is on the modeling, characterization, and engineering of information transmission through molecule exchange, with immediate appl...
Article
Molecular communication (MC) is an emerging paradigm in communication theory and systems engineering where information is encoded into properties of substances at the molecular level and then transmitted, propagated, received, and decoded by means of chemical reactions and molecule transport processes. The MC paradigm draws direct inspiration from...
Article
Full-text available
The birth of wireless communication systems nearly 1 century ago has transformed and redefined the way humans communicate and interact. This transformation, which has opened boundaries between societies and eliminated cultural barriers, has evolved from the original paradigm of wireless electromagnetic communication systems. This paradigm has exper...
Article
By interconnecting nanomachines and forming nanonetworks, the capacities of single nanomachines are expected to be enhanced, as the ensuing information exchange will allow them to cooperate towards a common goal. Nowadays, systems normally use electromagnetic signals to encode, send and receive information, however, in a novel communication paradig...
Conference Paper
Signal transduction pathways are chemical communication channels embedded in biological cells, and they propagate information from the environment to regulate cell growth and proliferation, among other cell's behaviors. Disruptions in the normal functionalities of these channels, mostly resulting from mutations in the underlying genetic code, can b...
Article
Full-text available
Synthetic biology, through genetic circuit engineering in biological cells, is paving the way toward the realization of programmable man-made living devices, able to naturally operate within normally less accessible domains, i.e. , the biological and the nanoscale. The control of the information processing and exchange between these engineered-cel...
Article
Full-text available
The outbreak of Ebola virus in recent years has resulted in numerous research initiatives to seek new solutions to contain the virus. A number of approaches that have been investigated include new vaccines to boost the immune system. An alternative post-exposure treatment is presented in this paper. The proposed approach for clearing Ebola virus ca...
Conference Paper
The opportunity to control and fine-tune the behavior of biological cells is a fascinating possibility for many diverse disciplines, ranging from medicine and ecology, to chemical industry and space exploration. While synthetic biology is providing novel tools to reprogram cell behavior from their genetic code, many challenges need to be solved bef...
Conference Paper
We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational framew...
Article
The opportunity to control and fine-tune the behavior of biological cells is a fascinating possibility for many diverse disciplines, ranging from medicine and ecology, to chemical industry and space exploration. While synthetic biology is providing novel tools to reprogram cell behavior from their genetic code, many challenges need to be solved bef...
Article
Years of research in software engineering have given us novel ways to reason about, test, and predict the behavior of complex software systems that contain hundreds of thousands of lines of code. Many of these techniques have been inspired by nature such as genetic algorithms, swarm intelligence, and ant colony optimization. In this paper we revers...
Conference Paper
Recent research advances in modifying and controlling DNA have created a booming field of biological engineering called synthetic biology. In synthetic biology engineers manipulate and modify living organisms to change (and produce entirely novel) functionality, which has led to new fuel sources or the ability to mitigate pollution. Synthetic biolo...
Conference Paper
The design of communication systems based on the transmission of information through neurons is envisioned as a key technology for the pervasive interconnection of future wearable and implantable devices. While previous literature has mainly focused on modeling propagation of electrochemical spikes carrying natural information through the nervous s...
Conference Paper
Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit the...
Article
The six papers in this special section focus on the Internet of nanotechnology things. While researchers are currently investigating these challenges to develop fully functional nano communication systems, a question remains as to whether they can represent an extended communication network that is part of the broader Internet. These papers address...
Article
Synthetic biology is providing novel tools to engineer cells and access the basis of their molecular information processing, including their communication channels based on chemical reactions and molecule exchange. Molecular communication is a discipline in communication engineering that studies these types of communications and ways to exploit the...
Conference Paper
Full-text available
Molecular Communication (MC) is a nanoscale interaction paradigm inspired by the natural ability of cells in biology to communicate through the processing, exchange, and transduction of information by biochemical reactions of molecules. The design and modeling of MC systems is the first step towards future applications based on the engineering of c...
Article
Full-text available
Targeted Drug Delivery Systems (TDDSs) are therapeutic methods based on the injection and delivery of drug-loaded particles. The engineering of TDDSs must take into account both the therapeutic effects of the drug at the target delivery location, and the toxicity of the drug while it accumulates in other regions of the body. These characteristics a...
Conference Paper
Full-text available
Novel emerging tools are allowing the manipulation and control of biological cells and their functions, e.g., sensing, actua-tion, and communication through biochemical stimuli. These tools have the potential to enable the implementation of man-made networks of biological computing devices, i.e., Internet of Bio-things. In this work, signal transdu...
Article
Full-text available
The Internet of Things (IoT) has become an important research topic in the last decade, where things refer to interconnected machines and objects with embedded computing capabilities employed to extend the Internet to many application domains. While research and development continue for general IoT devices, there are many application domains where...
Article
Full-text available
Molecular nanonetworks stand at the intersection of nanotechnology, biotechnology, and network engineering. The research on molecular nanonetworks proposes the interconnection of nanomachines through molecule exchange. Amongst different solutions for the transport of molecules between nanomachines, the most general is based on free diffusion. The o...
Article
Molecular Communication (MC), i.e., the exchange of information through the emission, propagation, and reception of molecules, is a promising paradigm for the interconnection of autonomous nanoscale devices, known as nanomachines. Synthetic biology techniques, and in particular the engineering of biological circuits, are enabling research towards t...
Article
Recent advances in synthetic biology, in particular towards the engineering of DNA-based circuits, are providing tools to program man-designed functions within biological cells, thus paving the way for the realization of biological nanoscale devices, known as nanomachines. By stemming from the way biological cells communicate in the nature, Molecul...
Article
Nanonetworks, the interconnection of nanosystems, are envisaged to greatly expand the applications of nanotechnology in the biomedical, environmental and industrial fields. However, it is still not clear how these nanosystems will communicate among them. This work considers a scenario of Diffusion-based Molecular Communication (DMC), a promising pa...
Article
Wireless NanoSensor Networks (WNSNs) will allow novel intelligent nanomaterial-based sensors, or nanosensors, to detect new types of events at the nanoscale in a distributed fashion over extended areas. Two main characteristics are expected to guide the design of WNSNs architectures and protocols, namely, their Terahertz Band wireless communication...
Conference Paper
Full-text available
Existing work in pharmacokinetics, the study of the movement of drugs in the body, has largely focused on multicompartmental models, based on ordinary first-order equations with constant flow. Nano-scale Particulate Drug Delivery Systems (PDDS) require better computational models. PDDS has been previously abstracted by the same authors as Molecular...
Conference Paper
Full-text available
Molecular Communication (MC) is a bio-inspired paradigm where information is exchanged by the release, the propagation and the reception of molecules. The objective of this paper is to analyze the effects of interference in the most general type of MC system, i.e., the diffusion of molecules in a fluidic medium. The study of the InterSymbol Interfe...
Article
Molecular communication (MC) is a promising bio-inspired paradigm for the interconnection of autonomous nanotechnology-enabled devices, or nanomachines, into nanonetworks. MC realizes the exchange of information through the transmission, propagation, and reception of molecules, and it is proposed as a feasible solution for nanonetworks. This idea i...
Conference Paper
Full-text available
Diffusion-based molecular communication is a promising bio-inspired paradigm to implement nanonetworks, i.e., the interconnection of nanomachines. The peculiarities of the physical channel in diffusion-based molecular communication require the development of novel models, architectures and protocols for this new scenario, which need to be validated...
Article
Nanonetworking is an emerging field of research at the intersection of nanotechnology and communication networks. Molecular Communication (MC) is a bio-inspired paradigm, where nanonetworks, i.e., the interconnection of nanodevices, are implemented based on the exchange of molecules. Within this paradigm, one of the most promising techniques is dif...
Article
Technology able to create devices the size of a human cell calls for new protocols.
Conference Paper
Full-text available
Nanonetworking is an emerging field of research, where nanotechnology and communication engineering are applied on a common ground. Molecular Communication (MC) is a bio-inspired paradigm, where Nanonetworks, i.e., the interconnection of devices at the nanoscale, are based on the exchange of molecules. Amongst others, diffusion-based MC is expected...
Conference Paper
Full-text available
Molecular Communication (MC) is a promising bio-inspired paradigm in which molecules are transmitted, propagated and received between nanoscale machines. One of the main challenges is the theoretical study of the maximum achievable information rate (capacity). The objective of this paper is to provide a mathematical expression for the capacity in M...
Conference Paper
Nanotechnology is enabling the development of devices in a scale ranging from one to a few hundred nanometers. Communication among these nano-devices will expand the capabilities and applications of individual devices both in terms of complexity and range of operation, enabling new applications of nanotechnology in the medical, environmental and mi...
Article
Full-text available
Markerless human tracking addresses the problem of estimating human body motion in non-cooperative environments. Computer Vision techniques combined with Pattern Recognition theory serve the purpose of extracting information on human body postures from video-sequences, without the need of wearable markers. Multi-camera systems further enhance this...
Conference Paper
Many human action definitions have been provided in the field of human computer interaction studies. These distinctions could be considered merely semantical as human actions are all carried out performing sequences of body postures. In this paper we propose a human action classifier based on volumetric reconstructed sequences (4-D data) acquired f...
Conference Paper
Full-text available
In this paper we present a novel approach to 3-D human action classification based on the analysis of volumetric data obtained form the joint processing of video sequences acquired by a multiple-camera system. The use of volumetric data makes the system very robust and avoids problems related the typical human body self-occlusions and motion ambigu...
Conference Paper
Full-text available
We propose a human action clustering method based on a 3D representation of the body in terms of volumetric coordinates. Features representing body postures are extracted directly from 3D data, making the system inherently insensitive to viewpoint dependence, motion ambiguities and self-occlusions. An invariant shape descriptor of human body is obt...
Article
Full-text available
We propose a human body action classifier based on a 3D representation of the body in terms of volumetric coordi-nates. Features representing body postures are extracted di-rectly from 3D data, making the system inherently insensi-tive to viewpoint dependence, motion ambiguities and self-occlusions. An Invariant Shape Descriptor of human body is ob...

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