Masoumeh Emamghoreishi

Shiraz University of Medical Sciences | SUMS · Department of Pharmacology

Abstract Background: This study aimed to determine the effect of Salvia officinalis extract and Vitex agnus-castus extract on anxiety in postmenopausal women. Methods: This study was a triple-blind randomized controlled clinical trial on 99 eligible postmenopausal women in Shiraz, Iran. Sampling was done using convenience sampling from among wome...

Purpose: Neuroinflammation was indicated in the pathophysiology of Alzheimer’s disease. Previous reports have also signified that spironolactone has anti-inflammatory effects. Therefore, the aim of this study was to assess the modulatory effects of spironolactone on neuroinflammation and memory loss in a rat model of Alzheimer’s disease. Methods: T...

Substantia nigra pars reticulata (SNpr) has been implicated in modulation, propagation and cessation of seizures. This study aimed to determine whether structural changes occur in SNpr during kindling. Male mice were randomly divided into four groups including early and late-phase kindled groups and their time-matched controls. Kindling was induced...

Objectives: This study aimed at investigating the effect of serotonergic 5-HT4 receptor agonist/antagonist on memory consolidation deficit induced by ACPA (a potent, selective CB1 cannabinoid receptor agonist) in the pre-limbic (PL) cortex. Materials and methods: We used the step-through passive avoidance test to evaluate memory consolidation of...

Background: During menopause, women undergo biological, social, and psychological changes and are sensitive to stressors, especially anxiety and depression. Decreased estrogen in postmenopausal women causes mood swings, especially depression and anxiety. Objectives: We aimed to determine the effect of the Vitex agnus-castus extract on depression in...

Background The insulin-like growth factor 2 (IGF-2) is a growth factor and anti-inflammatory cytokine that plays a crucial role in memory consolidation. However, the precise role of this factor in acute brain damage is still unclear. The present study aimed to evaluate the variations in hippocampal IGF-2 distribution on different days and investiga...

Ethnopharmacological relevance: Traditional manuscripts refer to plants such as Apium graveolens L. Fruit (celery seed), which could be used to improve sexual function among women. Since that time, local herbal shops in Iran continue to provide this herb as a natural aphrodisiac product. Aim of the study: This study aimed to evaluate the efficac...

Background: Complications of hormone therapy (as replacement) during menopause prompted us to research on alternative therapies including herbal therapy in this regard. Objectives: The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women on Namazi Hospital...

Introduction: Global Cerebral Ischemia (GCI) causes neuronal damage with subsequent neurological and cognitive impairments. Curcumin has anti-inflammatory, antioxidant, and neuroprotective properties, which makes it a potential candidate for improving GCI-induced impairments. This study aimed to investigate the effects of curcumin on the neurologic...

INTRODUCTION: Quercetin, a natural flavonoid, has been suggested as a stimulant of endogenous neural stem cell proliferation; but, its underlying mechanism is unclear. Considering the important roles of Nrf2 and proteasome pathways in cell proliferation, the objective of this study was to evaluate the effects of different concentrations of querceti...

Abstract Introduction: Quercetin, a natural flavonoid, has been suggested as a stimulant of endogenous neural stem cell proliferation; but, its underlying mechanism is unclear. Considering that Nrf2 and proteasome pathways have important role in cell proliferation, the objective of this study was to evaluate the effects of different concentrations...

Objective: This study was designed to compare the effect of aromatherapy with Rosa Damascena and Citrus Aurantium blossom on psychological and physical symptoms and social functions of females with premenstrual syndrome. Materials and methods: This double-blind clinical trial was conducted on 95 students. They were randomly divided into three ar...

Background: There is no universally accepted behavioral scoring to define the early development of pentylenetetrazole (PTZ) kindling. Therefore, studies investigating alterations of neurogenesis in the PTZ model were mainly focused on full kindled animals rather than early stages of kindling. This study aimed to determine an appropriate behavioral...

Background: There is no universally accepted behavioral scoring to define the early development of phenothiazine (PTZ) kindling. Therefore, studies investigating alterations of neurogenesis in the PTZ model were mainly focused on full kindled animals rather than early stages of kindling. This study aimed to determine an appropriate behavioral index...

Objective Cinnamaldehyde may be responsible for some health benefits of cinnamon such as its neuroprotective effects. We aimed to investigate the cinnamaldehyde neuroprotective effects against amyloid beta (Aβ) in neuronal SHSY5Y cells and evaluate the contribution of N-methyl-D-aspartate (NMDA), ryanodine, and adenosine receptors and glycogen synt...

Background: National Institute of Health Stroke Scale (NIHSS) and Modified National Institute of Health Stroke Scale (mNIHSS) are two valid and reliable questionnaires that assess stroke severity. This study aimed to examine and compare the validity and reliability of Persian versions of NIHSS and mNIHSS in hospitalized patients. Materials and me...

Background: Insulin-like growth factor 2 (IGF-2) is a growth factor and an anti-inflammatory cytokine that plays a pivotal role in memory. In this study, we examined the effect of recombinant IGF-2 on memory impairment due to intracerebral hemorrhage (ICH). Avoidance and recognition memory, locomotor activity, neurological deficit score (NDS), and...

BACKGROUND Cardiovascular diseases are the major public health problem in many countries and are responsible for more than half of the deaths in above 50-year-old women. The most common curable risk factor of these disorders is hypoestrogenemia resulting from menopause. The present study aimed to investigate the effect of melatonin on plasma lipid...

Background: Insulin-like growth factor 2 (IGF-2) is a growth factor and an anti-inflammatory cytokine that plays a pivotal role in memory. In this study, we examined the effect of recombinant IGF-2 on memory impairment due to intracerebral hemorrhage (ICH). Avoidance and recognition memory, locomotor activity, neurological deficit score (NDS), and t...

Objectives Vaginal Candidiasis with an approximate prevalence of 30% is the second cause of vaginal infections. Antifungal azole is the first treatment for Vaginal Candidiasis; however, some side effects have been reported for this chemical medicine. Based on the antifungal activity of Inner Stratum of Quercus Brantii (Q. Brantii), the aim of our s...

Objective: To investigate the efficacy of aromatherapy with essential oils of Rosa damascena for the management of premenstrual syndrome (PMS). Methods: The present triple-blind randomized clinical trial was conducted between March 5, 2016, and February 20, 2017, among female students attending Shiraz University of Medical Sciences, Shiraz, Iran...

Background According to traditional herbal medicine, chamomile has been considered as one of the herbal remedies for patients with polycystic ovary syndrome (PCOS). The study aimed to investigate the effect of chamomile on lipid and hormonal parameters in women of reproductive age with PCOS. Materials and Methods This study is a randomized clinica...

Introduction In spite of its importance, the psychological health requirements of adolescents are ignored; due to the occurrence of mental disorders in this age group and also public interest in the use of supplementary and alternative treatments such as herbal drugs for mental disorders, this study was carried out aimed at examining the impact of...

Objectives: Premenstrual syndrome (PMS) is one of the psychosomatic problems related to women>s reproductive function, which is associated with emotional and mood symptoms such as anger, anxiety and irritability. The current study aimed to compare the effect of Melissa officinalis capsule and care educational programs on the intensity of physical,...

This study performed to investigate the influence of bilateral post-training intra-pre limbic (PL) microinjections of serotonergic 5-HT4 receptor agents (RS67333, as a 5-HT4 receptor agonist and RS23597-190, as a 5-HT4 receptor antagonist) upon amnesia induced by a cannabinoid CB1 receptor agonist, Arachidonylcyclopropylamide (ACPA) in rats. The st...

This study performed to investigate the influence of bilateral post-training intra-pre limbic (PL) microinjections of serotonergic 5-HT4 receptor agents (RS67333, as a 5-HT4 receptor agonist and RS23597-190, as a 5-HT4 receptor antagonist) upon amnesia induced by a cannabinoid CB1 receptor agonist, Arachidonylcyclopropylamide (ACPA) in rats. The st...

Objective: This study aimed to assess the impact of olive leaf extract ointment on pain intensity and early maternal complications in primiparous women. Methods: This randomized clinical trial was conducted on 90 primiparous women. The participants were randomly divided into three groups each containing 30 women. Groups A, B, and C used olive leaf...

Much of the beneficial effects of olive products have been attributed to oleuropein. This study examined the effects of oleuropein in rats with heart failure induced by permanent ligation of left coronary arteries. Twenty-four hours after the operation, the rats were assigned to five groups including a sham assigned to receive vehicle (1 ml/day) an...

Statement of the Problem: Oral mucositis (OM) is a common side effect of anti-cancer drugs and needs significant attention for its prevention. Purpose: This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster. Materials and Method: OM was induced in 63 male golden hamsters by the combinat...

Background and objective: Enalapril and valsartan have been used to treat vascular complications in diabetes. Considering the role of disturbed calcium hemostasis in vascular dysfunction in diabetes,the aim of this study was to evaluate the effects of enalapril and valsartan on vascular response in type 2 diabetic rats in relation to store-operated...

Background: Carum carvi L. (caraway), known as black zeera in Iran, has been indicated for the treatment of epilepsy in Iranian folk medicine. This study evaluated whether the aqueous extract and essential oil of caraway seeds have anticonvulsant effects in mice. Methods: The anticonvulsant effects of the aqueous extract (200, 400, 800, 1600, an...

The serotonergic system has often been defined as a neumodulator system, and specifically involved in learning and memory via its various receptors. Serotonin is involved in many of the same processes affected by cannabinoids. The present study investigated the influence of bilateral post-training intra-prelimbic (PL) administrations of serotonergi...

Growing evidence suggests that serotonin plays an important role in learning and memory and all its receptors might be implicated in this process. The present study aimed at investigating and comparing the possible involvement of 5-HT 3 and 5-HT 4 receptor (R) agonists/antagonists upon consolidation of inhibitory avoidance memory in the pre-limbic...

Lithium and valproate modulate disturbances in intracellular calcium homeostasis implicated in the pathophysiology of bipolar disorder, but the molecular mechanisms are not fully understood. Two subtypes of transient receptor potential (TRP) channel family, i.e. TRPC3 and TRPM2, are potential candidates involved in calcium signaling and implicated...

Background: Several studies are conducted on Premenstrual Syndrome (PMS). However, a few herbal surveys exist on the treatment of PMS in Iran. Due to the sedative effects of Melissa officinalis (M. officinalis), this question comes to mind that “can it be used in the treatment of PMS symptoms?” Objectives: The current study aimed to assess the effe...

N-acetylcysteine (NAC) has been indicated against experimental seizures, but with relatively inconclusive results. This study was undertaken to evaluate whether NAC exerts a dose-dependent anticonvulsant effect and to determine NAC safe therapeutic dose range and its muscle-relaxant activity in both acute and chronic uses. Following intraperitoneal...

Objective(s): The neuroprotective effect of lithium has been attributed to its therapeutic action. However, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. Thus, the aim of this study was to evaluate the direct effects of lithi...

The neuroprotective effect of lithium has been attributed to its therapeutic action. However, the role of glial cells particularly astrocytes, and the possible interactions between neurons and astrocytes in neuroprotective effects of lithium have been disregarded. Thus, the aim of this study was to evaluate the direct effects of lithium on brain de...

S100ß a neurotrophic factor mainly released by astrocytes, has been implicated in the pathogenesis of bipolar disorder. Thus, lithium may exert its neuroprotective effects to some extent through S100ß. Furthermore, the possible effects of lithium on astrocytes as well as on interactions between neurons and astrocytes as a part of its mechanisms of...

Menopause is one of the most critical periods of woman's life. With reducing of ovarian estrogen; women are more prone to psychological and physical symptoms. The present study aimed to investigate the effect of melatonin on the climacteric symptoms. The present double blind, placebo randomized controlled clinical trial was conducted on 240 menopau...

Myocardial infarction causes a cascade of events, which leads to heart failure, debilitation and death. This study examined possible cardioprotective effect of oleuropein in rats with acute myocardial infarction. Male Sprague-Dawly rats were allocated to five groups: sham, myocardial infarction receiving vehicle, and three myocardial infarction rec...

Recent advances in brain and cognitive science studies have revolutionized concepts in neural dynamics, regulating mechanisms, coding systems and information processing networks which govern our function and behavior. Hidden aspects of neurological and psychiatric diseases are being understood and hopes for their treatment are emerging. Although...

Background: Sexuality constitutes an important part of women’s life. Healthy and proper sexual functioning is one of the signs of physical and mental health. The present study aimed to identify the effect of education on sexual health of women with hypoactive sexual desire disorder. Methods: In this randomized clinical trial, 80 married women at r...

Background: B cell CLL/lymphoma 2 protein, bcl-2, is an important anti-apoptotic factor that has been implicated in lithium’s neuroprotective effect. However, most studies have focused on assessing the effects of lithium in neurons, ignoring examination of bcl-2 in astrocytes, which also influence neuronal survival and are affected in bipolar disor...

Background: There have been some reports about the possible N-methyl-D-aspartate (NMDA) antagonist activity of Guaifenesin. As drugs with a similar structure to Guaifenesin (i.e. Felbamate) and those with NMDA antagonist activity have been clinically used as anticonvulsants, the aim of this study was to determine whether Guaifenesin has an anticonv...

Introduction:Prangos ferulacea has been used for GI disorders in traditional medicine. It has been known as an analgesic and anti-inflammatory herb among the communities. However, the analgesic effect of this plant has not been scientifically evaluated. Therefore, the aim of this study was to investigate the analgesic effect of Prangos ferulacea in...

Background: In Iranian and other traditional medicines, an antidepressant effect has been indicated for Melissa officinalis (Lamiaceae). However, studies showing its antidepressant effect is lacking. Therefore, the present study was undertaken to examine whether the aqueous extract and essential oil from leaves of Melissa officinalis have an antide...

Introduction: Nicotine is the psychoactive substance responsible for establishing and maintaining smoking dependence. CYP2A6 is the primary enzyme that converts nicotine to its inactive metabolite cotinine. Genetic variations in CYP2A6 accounts for some of the inter-individual variability in nicotine metabolism and has been indicated to influence s...

Genetic polymorphism of CYP2A6 gene is a major causal factor in the large interindividual differences in nicotine metabolism. It may have an impact on smoking behavior and smoke-related cancer susceptibility. Until now, there are no reports of CYP2A6 allele frequencies in Iranian population. In the present study, we investigated the frequencies of...

Background: Coriandrum sativum L. has been recom- mended for relief of insomnia in Iranian traditional medi- cine. However, no pharmacological studies have yet evalu- ated its sedative effects. The aim of this study was to de- termine if extracts and essential oil of coriander seeds have sedative-hypnotic activity. Methods: The aqueous or hydro-alc...

The clinical applications of benzodiazepines as anxiolytics are limited by their unwanted side effects. Therefore, the development of new pharmacological agents is well justified. Among medicinal plants, Coriandrum sativum L. has been recommended for relief of anxiety and insomnia in Iranian folk medicine. Nevertheless, no pharmacological studies h...

Evidence of extensive cross-talk between calcium (Ca(2+))- and cAMP-mediated signaling systems suggests that previously reported abnormalities in Ca(2+) homeostasis in bipolar I (BP-I) patients may be linked to disturbances in the function of G proteins that mediate cAMP signaling. To test this hypothesis, the beta-adrenergic agonist, isoproterenol...